Bibi S, Habib R, Shafiq S, Abbas SS, Khan S, Eqani S, Nepovimova E, Khan MS, Kuca K, Nurulain SM (2023)
Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups
Sci Total Environ

Franca TCC, Valle da Silva JA, Dos Santos MC, Cavalcante SFA, Kuca K (2023)
Applications of the Near Attack Conformation (NAC) approach in the search for Acetylcholinesterase reactivators
Chemico-Biological Interactions 382: 110619

Jacevic V, Dumanovic J, Grujic-Milanovic J, Milovanovic Z, Amidzic L, Vojinovic N, Nezic L, Markovic B, Dobricic V, Milosavljevic P, Nepovimova E, Kuca K (2023)
Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes
Chemico-Biological Interactions

Kapitanov IV, Spulak M, Pour M, Soukup O, Marek J, Jun D, Novak M, Diz de Almeida JSF, Costa Franca TC, Gathergood N, Kuca K, Karpichev Y (2023)
Sustainable ionic liquids-based molecular platforms for designing acetylcholinesterase reactivators
Chemico-Biological Interactions

Kitagawa DAS, Dos Santos MC, Kuca K, Franca TCC, Cavalcante SFA (2023)
In vitro comparison of the acetylcholinesterase inhibition caused by V- and A-series nerve agents' surrogates
Chemico-Biological Interactions 383: 110678

Kuca K, Valle da Silva JA, Nepovimova E, Pham NL, Wu W, Valis M, Wu Q, Franca TCC (2023)
Pralidoxime-like reactivator with increased lipophilicity - Molecular modeling and in vitro study
Chemico-Biological Interactions

Valis M, Dlabkova A, Hort J, Angelucci F, Pejchal J, Kuca K, Pavelek Z, Karasova JZ, Novotny M (2023)
The measured CSF/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24h after donepezil treatment in patients with Alzheimer's disease
Biomed Pharmacother 159: 114223

Bondar D, Kapitanov I, Pulkrabkova L, Soukup O, Jun D, Diniz FB, Franca TCC, Kuca K, Karpichev Y (2022)
N-substituted arylhydroxamic acids as acetylcholinesterase reactivators
Chemico-Biological Interactions

Chrienova Z, Nepovimova E, Andrys R, Dolezal R, Janockova J, Muckova L, Fabova L, Soukup O, Oleksak P, Valis M, Korabecny J, Marco-Contelles J, Kuca K (2022)
Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities
J Enzyme Inhib Med Chem 37: 2605

Jokanovic M, Oleksak P, Kuca K (2022)
Multiple Neurological Effects Associated with Exposure to Organophosphorus Pesticides in Man
Toxicology

Khan SA, Leonel Javeres MN, Abbas Shah ST, Bibi N, Muneer Z, Hussain S, Nepovimova E, Kuca K, Nurulain SM (2022)
Dysregulation of butyrylcholinesterase, BCHE gene SNP rs1803274, and pro-inflammatory cytokines in occupational workers
Environ Research

Ramalho TC, de Castro AA, Leal DHS, Teixeira JP, de Cunha EFF, Kuca K (2022)
Assessing the therapeutic and toxicological profile of novel acetylcholinesterase reactivators: value of in silico and in vitro data
Curr Med Chem

Santos MC, Botelho FD, Goncalves AS, Kuca K, Nepovimova E, Cavalcante SFA, Lima ALS, Franca TCC (2022)
Theoretical assessment of the performances of commercial oximes on the reactivation of acetylcholinesterase inhibited by the nerve agent A-242 (novichok)
Food & Chemical Toxicology

Santos MC, Botelho FD, Goncalves AS, Kitagawa DAS, Borges CVN, Carvalho-Silva T, Bernardo LB, Ferreira CN, Rodrigues RB, Ferreira Neto DC, Nepovimova E, Kuca K, LaPlante SR, Lima ALS, Franca TCC, Cavalcante SFA (2022)
Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series?
Archives of Toxicology

Hamulakova S, Kudlickova Z, Janovec L, Mezencev R, Deckner ZJ, Chernoff YO, Janockova J, Ihnatova V, Bzonek P, Novakova N, Hepnarova V, Hrabinova M, Jun D, Korabecny J, Soukup O, Kuca K (2021)
Design and synthesis of novel tacrine-indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease
Future Med Chem

Hudacova M, Hamuakova S, Konkoova E, Jendzelovsky R, Vargova J, Sevc J, Fedorocko P, Soukup O, Janockova J, Ihnatova V, Kucera T, Bzonek P, Novakova N, Jun D, Junova L, Korabecny J, Kuca K, Kozurkova M (2021)
Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells
Int J Mol Sci 22:

Kitagawa DAS, Rodrigues RB, Silva TN, Dos Santos WV, da Rocha VCV, de Almeida JSFD, Bernardo LB, Carvalho-Silva T, Ferreira CN, da Silva AAT, Simas ABC, Nepovimova E, Kuca K, Franca TCC, Cavalcante SFA (2021)
Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators
J Enzyme Inhib Med Chem 36: 1370

Lorke DE, Nurulain SM, Hasan MY, Kuca K, Petroianu GA (2021)
Experimental and Established Oximes as Pretreatment before Acute Exposure to Azinphos-Methyl
Int J Mol Sci 22:

Botelho FD, Dos Santos MC, Goncalves ADS, Kuca K, Valis M, LaPlante SR, Franca TCC, de Almeida J (2020)
Ligand-Based Virtual Screening, Molecular Docking, Molecular Dynamics, and MM-PBSA Calculations towards the Identification of Potential Novel Ricin Inhibitors
Toxins (Basel) 12:

Cavalcante SFA, Simas ABC, Barcellos MC, de Oliveira VGM, Sousa RB, Cabral PAM, Kuca K, Franca TCC (2020)
Acetylcholinesterase: The Hub for Neurodegenerative Diseases and Chemical Weapons Convention
Biomolecules 10:

Figueroa-Villar JD, Petronilho EC, Kuca K, Franca TCC (2020)
Review about structure and evaluation of reactivators of Acetylcholinesterase inhibited with neurotoxic organophosphorus compounds
Curr Med Chem

Furqan T, Batool S, Habib R, Shah M, Kalasz H, Darvas F, Kuca K, Nepovimova E, Nurulain SM (2020)
Cannabis Constituents and Acetylcholinesterase Interaction: Molecular Docking, In Vitro Studies and Association with CNR1 rs806368 and ACHE rs17228602
Biomolecules 10:

Gorecki L, Andrys R, Schmidt M, Kucera T, Psotka M, Svobodova B, Hrabcova V, Hepnarova V, Bzonek P, Jun D, Kuca K, Korabecny J, Musilek K (2020)
Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors
ACS Med Chem Lett 11: 65

Karasova JZ, Hepnarova V, Andrys R, Lisa M, Jost P, Muckova L, Pejchal J, Herman D, Jun D, Kassa J, Kuca K (2020)
Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness
Toxicol Lett 320: 64

Karasova JZ, Hrabinova M, Krejciova M, Jun D, Kuca K (2020)
Donepezil and Rivastigmine: Pharmacokinetic Profile and Brain-targeting After Intramuscular Administration in Rats
Iran J Pharm Res 19: 95

Leonel Javeres MN, Habib R, Judith N, Iqbal M, Nepovimova E, Kuca K, Batool S, Nurulain SM (2020)
Analysis of PON1 gene polymorphisms (rs662 and rs854560) and inflammatory markers in organophosphate pesticides exposed cohorts from two distinct populations
Environ Research

Lorke DE, Nurulain SM, Hasan MY, Kuca K, Petroianu GA (2020)
Combined Pre- and Posttreatment of Paraoxon Exposure
Molecules 25:

Malinak D, Dolezal R, Hepnarova V, Hozova M, Andrys R, Bzonek P, Racakova V, Korabecny J, Gorecki L, Mezeiova E, Psotka M, Jun D, Kuca K, Musilek K (2020)
Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators
J Enzyme Inhib Med Chem 35: 478

Mbah Ntepe LJ, Habib R, Judith Laure N, Raza S, Nepovimova E, Kuca K, Batool S, Muhammad Nurulain S (2020)
Oxidative Stress and Analysis of Selected SNPs of ACHE (rs 2571598), BCHE (rs 3495), CAT (rs 7943316), SIRT1 (rs 10823108), GSTP1 (rs 1695), and Gene GSTM1, GSTT1 in Chronic Organophosphates Exposed Groups from Cameroon and Pakistan
Int J Mol Sci 21:

Nepovimova E, Svobodova L, Dolezal R, Hepnarova V, Junova L, Jun D, Korabecny J, Kucera T, Gazova Z, Motykova K, Kubackova J, Bednarikova Z, Janockova J, Jesus C, Cortes L, Pina J, Rostohar D, Serpa C, Soukup O, Aitken L, Hughes RE, Musilek K, Muckova L, Jost P, Chvojkova M, Vales K, Valis M, Chrienova Z, Chalupova K, Kuca K (2020)
Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimes drugs dealing with cholinergic, amyloid and mitochondrial systems
Bioorg Chem 107: 104596

Sharma S, Singh N, Nepovimova E, Korabecny J, Kuca K, Satnami ML, Ghosh KK (2020)
Interaction of Synthesized Nitrogen enriched Graphene Quantum Dots with Novel Anti-Alzheimer's Drugs: Spectroscopic Insights
J Biomol Struct Dyn 38: 1822

Sharma R, Upadhyaya K, Gupta B, Ghosh KK, Tripathi RP, Musilek K, Kuca K (2020)
Glycosylated-Imidazole Aldoximes as Reactivators of Pesticides Inhibited AChE: Synthesis and In-vitro Reactivation Study
Environ Toxicol Pharmacol

Wu Q, Qin Z, Kuca K, You L, Zhao Y, Liu A, Musilek K, Chrienova Z, Nepovimova E, Oleksak P, Wu W, Wang X (2020)
An update on T-2 toxin and its modified forms: metabolism, immunotoxicity mechanism, and human exposure assessment
Archives of Toxicology 94: 3645

da Silva JAV, Pereira AF, LaPlante SR, Kuca K, Ramalho TC, Franca TCC (2020)
Reactivation of VX-Inhibited Human Acetylcholinesterase by Deprotonated Pralidoxime. A Complementary Quantum Mechanical Study
Biomolecules 10:

de Castro AA, Assis LC, Soares FV, Kuca K, Polisel DA, da Cunha EFF, Ramalho TC (2020)
Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016-2019)
Biomolecules 10:

de Castro AA, Polisel DA, Pereira BTL, da Cunha EFF, Kuca K, Nepovimova E, Ramalho TC (2020)
Understanding the Interaction Modes and Reactivity of Trimedoxime toward MmAChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects
Int J Mol Sci 21:

Antonijevic E, Musilek K, Kuca K, Djukic-Cosic D, Andjelkovic M, Djordjevic AB, Antonijevic B (2019)
Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation
Chemico-Biological Interactions 308: 385

Bajgar J, Kassa J, Kucera T, Musilek K, Jun D, Kuca K (2019)
Some Possibilities to Study New Prophylactics against Nerve Agents
Mini Rev Med Chem 19: 970

Cardozo M, de Almeida J, Cavalcante SFA, Salgado JRS, Goncalves AS, Franca TCC, Kuca K, Bizzo HR (2019)
Biodegradation of Organophosphorus Compounds Predicted by Enzymatic Process Using Molecular Modelling and Observed in Soil Samples Through Analytical Techniques and Microbiological Analysis: A Comparison
Molecules 25:

Cavalcante SFA, Kitagawa DAS, Rodrigues RB, Bernardo LB, da Silva TN, Dos Santos WV, Correa ABA, de Almeida JSFD, Franca TCC, Kuca K, Simas ABC (2019)
Synthesis and in vitro evaluation of neutral aryloximes as reactivators of Electrophorus eel acetylcholinesterase inhibited by NEMP, a VX surrogate
Chemico-Biological Interactions 309: 108682

Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ, Nachon F, Pejchal J, Jarosova M, Hepnarova V, Jun D, Hrabinova M, Dolezal R, Karasova JZ, Mzik M, Kristofikova Z, Misik J, Muckova L, Jost P, Soukup O, Benkova M, Setnicka V, Habartova L, Chvojkova M, Kleteckova L, Vales K, Mezeiova E, Uliassi E, Valis M, Nepovimova E, Bolognesi ML, Kuca K (2019)
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
Eur Journal of Medicinal Chemistry 168: 491

Cruz JN, Costa JFS, Khayat AS, Kuca K, Barros CAL, Neto A (2019)
Molecular dynamics simulation and binding free energy studies of novel leads belonging to the benzofuran class inhibitors of Mycobacterium tuberculosis Polyketide Synthase 13
J Biomol Struct Dyn 37: 1616

Franca TCC, Kitagawa DAS, Cavalcante SFA, da Silva JAV, Nepovimova E, Kuca K (2019)
Novichoks: The Dangerous Fourth Generation of Chemical Weapons
Int J Mol Sci 20:

Gorecki L, Soukup O, Kucera T, Malinak D, Jun D, Kuca K, Musilek K, Korabecny J (2019)
Oxime K203: a drug candidate for the treatment of tabun intoxication
Archives of Toxicology 93: 673

Iqbal A, Malik S, Nurulain SM, Musilek K, Kuca K, Kalasz H, Fatmi MQ (2019)
Reactivation potency of two novel oximes (K456 and K733) against paraoxon-inhibited acetyl and butyrylcholinesterase: In silico and in vitro models
Chemico-Biological Interactions 310: 108735

Jacevic V, Nepovimova E, Kuca K (2019)
Toxic Injury to Muscle Tissue of Rats Following Acute Oximes Exposure
Sci Rep 9: 1457

Jacevic V, Nepovimova E, Kuca K (2019)
Interspecies and intergender differences in acute toxicity of K-oximes drug candidates
Chemico-Biological Interactions 308: 312

Janockova J, Korabecny J, Plsikova J, Babkova K, Konkolova E, Kucerova D, Vargova J, Koval J, Jendzelovsky R, Fedorocko P, Kasparkova J, Brabec V, Rosocha J, Soukup O, Hamulakova S, Kuca K, Kozurkova M (2019)
In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers
J Enzyme Inhib Med Chem 34: 877

Karasova JZ, Soukup O, Korabecny J, Hroch M, Krejciova M, Hrabinova M, Misik J, Novotny L, Hepnarova V, Kuca K (2019)
Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats
Drug & Chemical Toxicology

Kitagawa DAS, Cavalcante SFA, de Paula RL, Rodrigues RB, Bernardo LB, da Silva MCJ, da Silva TN, Dos Santos WV, Granjeiro JM, de Almeida JSFD, Barcellos MC, de ACAB, Franca TCC, Kuca K, Simas ABC (2019)
In Vitro Evaluation of Neutral Aryloximes as Reactivators for Electrophorus eel Acetylcholinesterase Inhibited by Paraoxon
Biomolecules 9:

Lorke DE, Nurulain SM, Hasan MY, Kuca K, Petroianu GA (2019)
Oximes as pretreatment before acute exposure to paraoxon
J Appl Toxicol 39: 1506

Mezeiova E, Chalupova K, Nepovimova E, Gorecki L, Prchal L, Malinak D, Kuca K, Soukup O, Korabecny J (2019)
Donepezil Derivatives Targeting Amyloid-beta Cascade in Alzheimer's Disease
Curr Alzheimer Res 16: 772

Nepovimova E, Korabecny J, Hepnarova V, Jun D, Dolezal R, Muckova L, Jost P, Soukup O, Janockova J, Pham NL, Nguyen TD, Valis M, Kuca K (2019)
N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy
Curr Alzheimer Res 16: 333

Nepovimova E, Janockova J, Misik J, Kubik S, Stuchlik A, Vales K, Korabecny J, Mezeiova E, Dolezal R, Soukup O, Kobrlova T, Pham NL, Nguyen TD, Konecny J, Kuca K (2019)
Orexin supplementation in narcolepsy treatment: A review
Med Res Rev 39: 961

Polisel DA, de Castro AA, Mancini DT, da Cunha EFF, Franca TCC, Ramalho TC, Kuca K (2019)
Slight difference in the isomeric oximes K206 and K203 makes huge difference for the reactivation of organophosphorus-inhibited AChE: Theoretical and experimental aspects
Chemico-Biological Interactions 309: 108671

Sharma R, Kuca K, Nepovimova E, Kabra A, Rao MM, Prajapati PK (2019)
Traditional Ayurvedic and herbal remedies for Alzheimer's disease: from bench to bedside
Expert Rev Neurother 19: 359

Tekes K, Karvaly G, Nurulain S, Kuca K, Musilek K, Adeghate E, Jung YS, Kalasz H (2019)
Pharmacokinetics of K117 and K127, two novel antidote candidates to treat Tabun poisoning
Chemico-Biological Interactions 310: 108737

Zorbaz T, Malinak D, Kuca K, Musilek K, Kovarik Z (2019)
Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes
Chemico-Biological Interactions 307: 16

da Silva JAV, Nepovimova E, Ramalho TC, Kuca K, Franca TCC (2019)
Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach
J Enzyme Inhib Med Chem 34: 1018

da Silva JAV, Nepovimova E, Ramalho TC, Kuca K, Franca TCC (2019)
Molecular modelling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime with VX-inhibited human acetylcholinesterase. A near attack approach to assess different spacer-lengths
Chemico-Biological Interactions 307: 195

de Almeida JSFD, Cavalcante SFA, Dolezal R, Kuca K, Musilek K, Jun D, Franca TCC (2019)
Surface screening, molecular modeling and in vitro studies on the interactions of aflatoxin M1 and human enzymes acetyl- and butyrylcholinesterase
Chemico-Biological Interactions 308: 113

de Castro AA, Soares FV, Pereira AF, Polisel DA, Caetano MS, Leal DHS, da Cunha EFF, Nepovimova E, Kuca K, Ramalho TC (2019)
Non-conventional compounds with potential therapeutic effects against Alzheimer's disease
Expert Rev Neurother 19: 375

de Oliveira CBJ, Neto DCF, de Almeida JSFD, Lima JA, Kuca K, Franca TCC, Figueroa-Villar JD (2019)
Synthesis of New Quinoline-Piperonal Hybrids as Potential Drugs against Alzheimer's Disease
Int J Mol Sci 20:

Affonso RS, Lima JA, Lessa BM, Caetano JVO, Obara MT, Nobrega AB, Nepovimova E, Musilek K, Kuca K, Slana G, Franca TCC (2018)
Quantification through TLC-densitometric analysis, repellency and anticholinesterase activity of the homemade extract of Indian cloves
Biomedical Chromatography 32:

Antonijevic E, Kotur-Stevuljevic J, Musilek K, Kosvancova A, Kuca K, Djukic-Cosic D, Spasojevic-Kalimanovska V, Antonijevic B (2018)
Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain
Archives of Toxicology 92: 745

Antonijevic E, Musilek K, Kuca K, Djukic-Cosic D, Curcic M, Miladinovic DC, Bulat Z, Antonijevic B (2018)
Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes
Food & Chemical Toxicology 121: 224

Arshad M, Fatmi MQ, Musilek K, Hussain A, Kuca K, Petroianu G, Kalasz H, Nurulain SM (2018)
In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication
Toxicol Mech Methods 28: 62

Hamulakova S, Janovec L, Soukup O, Jun D, Janockova J, Hrabinova M, Sepsova V, Kuca K (2018)
Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier
Curr Alzheimer Res 15: 1096

Hepnarova V, Korabecny J, Matouskova L, Jost P, Muckova L, Hrabinova M, Vykoukalova N, Kerhartova M, Kucera T, Dolezal R, Nepovimova E, Spilovska K, Mezeiova E, Pham NL, Jun D, Staud F, Kaping D, Kuca K, Soukup O (2018)
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease
Eur Journal of Medicinal Chemistry 150: 292

Janockova J, Dolezal R, Nepovimova E, Kobrlova T, Benkova M, Kuca K, Konecny J, Mezeiova E, Melikova M, Hepnarova V, Ring A, Soukup O, Korabecny J (2018)
Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods
Molecules 23:

Korabecny J, Nepovimova E, Cikankova T, Spilovska K, Vaskova L, Mezeiova E, Kuca K, Hroudova J (2018)
Newly Developed Drugs for Alzheimer's Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission
Neuroscience 370: 191

Kuca K, Musilek K, Jun D, Karasova JZ, Nepovimova E, Soukup O, Hrabinova M, Mikler J, Franca TCC, da Cunha EFF, de Castro AA, Valis M, Ramalho TC (2018)
A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase
BMC Pharmacol Toxicol 19: 8

Kuca K, Karasova JZ, Soukup O, Kassa J, Novotna E, Sepsova V, Horova A, Pejchal J, Hrabinova M, Vodakova E, Jun D, Nepovimova E, Valis M, Musilek K (2018)
Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings
Drug Des Devel Ther 12: 505

Kuca K, Jun D, Junova L, Musilek K, Hrabinova M, da Silva JAV, Ramalho TC, Valko M, Wu Q, Nepovimova E, Franca TCC (2018)
Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon
Molecules 23:

Malinak D, Nepovimova E, Jun D, Musilek K, Kuca K (2018)
Novel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking Study
Molecules 23:

Malinak D, Korabecny J, Soukup O, Gorecki L, Nepovimova E, Psotka M, Dolezal R, Nguyen TD, Mezeiova E, Musilek K, Kuca K (2018)
A Review of the Synthesis of Quaternary Acetylcholinesterase Reactivators
Current Organic Chemistry 22": 1619

Mezeiova E, Spilovska K, Nepovimova E, Gorecki L, Soukup O, Dolezal R, Malinak D, Janockova J, Jun D, Kuca K, Korabecny J (2018)
Profiling donepezil template into multipotent hybrids with antioxidant properties
J Enzyme Inhib Med Chem 33: 583

Nepovimova E, Kuca K (2018)
Chemical warfare agent NOVICHOK - mini-review of available data
Food & Chemical Toxicology 121: 343

Soares FV, de Castro AA, Pereira AF, Leal DHS, Mancini DT, Krejcar O, Ramalho TC, da Cunha EFF, Kuca K (2018)
Theoretical Studies Applied to the Evaluation of the DFPase Bioremediation Potential against Chemical Warfare Agents Intoxication
Int J Mol Sci 19:

Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R, Pavek P, Jost P, Kobrlova T, Jankockova J, Gorecki L, Psotka M, Nguyen TD, Box K, Outhwaite B, Ceckova M, Sorf A, Jun D, Kuca K (2018)
In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
Med Chem 14: 281

Karasova JZ, Mzik M, Hroch M, Korabecny J, Nepovimova E, Vorisek V, Palicka V, Kuca K (2018)
The New Acetylcholinesterase Inhibitors PC-37 and PC-48 (7-Methoxytacrine-Donepezil-Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics and In Vivo Formation of the Major Metabolites in Rats
Basic Clin Pharmacol Toxicol 122: 373

Zorbaz T, Malinak D, Marakovic N, Macek Hrvat N, Zandona A, Novotny M, Skarka A, Andrys R, Benkova M, Soukup O, Katalinic M, Kuca K, Kovarik Z, Musilek K (2018)
Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents
Journal of Medicinal Chemistry 61: 10753

de Almeida JSFD, Cavalcante SFA, Dolezal R, Kuca K, Musilek K, Jun D, Franca TCC (2018)
Molecular modeling studies on the interactions of aflatoxin B1 and its metabolites with the peripheral anionic site (PAS) of human acetylcholinesterase
J Biomol Struct Dyn

de Almeida JSFD, Dolezal R, Krejcar O, Kuca K, Musilek K, Jun D, Franca TCC (2018)
Molecular Modeling Studies on the Interactions of Aflatoxin B1 and Its Metabolites with Human Acetylcholinesterase. Part II: Interactions with the Catalytic Anionic Site (CAS)
Toxins (Basel) 10:

de Paula RL, de Almeida JSFD, Cavalcante SFA, Goncalves AS, Simas ABC, Franca TCC, Valis M, Kuca K, Nepovimova E, Granjeiro JM (2018)
Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon
Molecules 23:

Babkova K, Korabecny J, Soukup O, Nepovimova E, Jun D, Kuca K (2017)
Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors
Future Med Chem 9: 1015

Cuya T, Goncalves ADS, da Silva JAV, Ramalho TC, Kuca K, Franca TCC (2017)
The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: A computational study
J Biomol Struct Dyn

Gazova Z, Soukup O, Sepsova V, Siposova K, Drtinova L, Jost P, Spilovska K, Korabecny J, Nepovimova E, Fedunova D, Horak M, Kaniakova M, Wang ZJ, Hamouda AK, Kuca K (2017)
Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment
Biochimica & Biophysica Acta Mol Basis Dis 1863: 607

Gorecki L, Korabecny J, Musilek K, Nepovimova E, Malinak D, Kucera T, Dolezal R, Jun D, Soukup O, Kuca K (2017)
Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016)
Expert Opin Ther Pat 27: 971

Hamulakova S, Janovec L, Soukup O, Jun D, Kuca K (2017)
Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids
Int J Biol Macromol 104: 333

Horak M, Holubova K, Nepovimova E, Krusek J, Kaniakova M, Korabecny J, Vyklicky L, Kuca K, Stuchlik A, Ricny J, Vales K, Soukup O (2017)
The pharmacology of tacrine at N-methyl-d-aspartate receptors
Prog Neuropsychopharmacol Biological Psychiatry 75: 54

Karasova JZ, Kvetina J, Tacheci I, Radochova V, Musilek K, Kuca K, Bures J (2017)
Pharmacokinetic profile of promising acetylcholinesterase reactivators K027 and K203 in experimental pigs
Toxicol Lett 273: 20

Karasova JZ, Maderycova Z, Tumova M, Jun D, Rehacek V, Kuca K, Misik J (2017)
Activity of cholinesterases in a young and healthy middle-European population: Relevance for toxicology, pharmacology and clinical praxis
Toxicol Lett 277: 24

Lorke DE, Nurulain SM, Hasan MY, Kuca K, Petroianu GA (2017)
Optimal Pre-treatment for Acute Exposure to the Organophosphate Dicrotophos
Curr Pharm Des 23: 3432

Mezeiova E, Korabecny J, Sepsova V, Hrabinova M, Jost P, Muckova L, Kucera T, Dolezal R, Misik J, Spilovska K, Pham NL, Pokrievkova L, Roh J, Jun D, Soukup O, Kaping D, Kuca K (2017)
Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy
Molecules 22:

Psotka M, Malinak D, Gorecki L, Nguyen TD, Soukup O, Jun D, Kuca K, Musilek K, Korabecny J (2017)
HLo-7 - A review of acetylcholinesterase reactivator against organophosphorus intoxication
Military Medical Science Letters 86: 70

Soukup O, Winder M, Killi UK, Wsol V, Jun D, Kuca K, Tobin G (2017)
Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment
Curr Neuropharmacol 15: 637

Spilovska K, Korabecny J, Sepsova V, Jun D, Hrabinova M, Jost P, Muckova L, Soukup O, Janockova J, Kucera T, Dolezal R, Mezeiova E, Kaping D, Kuca K (2017)
Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation
Molecules 22:

Spilovska K, Korabecny J, Nepovimova E, Dolezal R, Mezeiova E, Soukup O, Kuca K (2017)
Multitarget Tacrine Hybrids with Neuroprotective Properties to Confront Alzheimer's Disease
Curr Top Med Chem 17: 1006

de Souza FR, Garcia DR, Guizado TC, Kuca K, de Alencastro RB, Franca TCC (2017)
Behavior of uncharged oximes compared to HI6 and 2-PAM in the human AChE-Tabun conjugate: A molecular modeling approach
J Biomol Struct Dyn

Antonijevic E, Musilek K, Kuca K, Djukic-Cosic D, Vucinic S, Antonijevic B (2016)
Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor
Neurotoxicology 55: 33

Benek O, Soukup O, Pasdiorova M, Hroch L, Sepsova V, Jost P, Hrabinova M, Jun D, Kuca K, Zala D, Ramsay RR, Marco-Contelles J, Musilek K (2016)
Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease
ChemMedChem 11: 1264

Dolezal R, Soukup O, Malinak D, Savedra RML, Marek J, Dolezalova M, Pasdiorova M, Salajkova S, Korabecny J, Honegr J, Ramalho TC, Kuca K (2016)
Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies
Eur Journal of Medicinal Chemistry 121: 699

Gorecki L, Korabecny J, Musilek K, Malinak D, Nepovimova E, Dolezal R, Jun D, Soukup O, Kuca K (2016)
SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides
Archives of Toxicology 90: 2831

Hamulakova S, Poprac P, Jomova K, Brezova V, Lauro P, Drostinova L, Jun D, Sepsova V, Hrabinova M, Soukup O, Kristian P, Gazova Z, Bednarikova Z, Kuca K, Valko M (2016)
Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules
J Inorg Biochem 161: 52

Janockova J, Zilecka E, Kasparkova J, Brabec V, Soukup O, Kuca K, Kozurkova M (2016)
Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity
Mol Biosyst 12: 2910

Jerabek J, Uliassi E, Guidotti L, Korabecny J, Soukup O, Sepsova V, Hrabinova M, Kuca K, Bartolini M, Pena-Altamira LE, Petralla S, Monti B, Roberti M, Bolognesi ML (2016)
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease
Eur Journal of Medicinal Chemistry 127: 250

Karasova JZ, Hroch M, Musilek K, Kuca K (2016)
Small Quaternary Inhibitors K298 and K524: Cholinesterases Inhibition, Absorption, Brain Distribution, and Toxicity
Neurotox Res 29: 267

Kristofikova Z, Ricny J, Soukup O, Korabecny J, Nepovimova E, Kuca K, Ripova D (2016)
Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1
Dementia & Geriatric Cognitive Disorders 43: 45

Musilek K, Hambalek J, Holas O, Dohnal V, Kuca K (2016)
Monooxime Bispyridinium Reactivators Bearing Xylene Linker Synthesis and In Vitro Evaluation on Model of Organophosphate-Inhibited Acetylcholinesterase
Med Chem 12: 362

Mzik M, Korabecny J, Nepovimova E, Vorisek V, Palicka V, Kuca K, Karasova JZ (2016)
An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study
Journal of Chromatography B Analyt Technol Biomed Life Sciences 1020: 85

Nepovimova E, Korabecny J, Dolezal R, Nguyen TD, Jun D, Soukup O, Pasdiorova M, Jost P, Muckova L, Malinak D, Gorecki L, Musilek K, Kuca K (2016)
A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication
Toxicol Res (Camb) 5: 1012

Ojha S, Nurulain SM, Dhanasekaran S, Shafiullah M, Adem A, Sharma C, Kuca K, Kalasz H (2016)
Blood-fetus penetration of pralidoxime
Military Medical Science Letters 85: 63

Ramalho TC, de Castro AA, Silva DR, Silva MC, Franca TCC, Bennion BJ, Kuca K (2016)
Computational Enzymology and Organophosphorus Degrading Enzymes: Promising Approaches Toward Remediation Technologies of Warfare Agents and Pesticides
Curr Med Chem 23: 1041

Sahu AK, Sharma R, Gupta B, Musilek K, Kuca K, Acharya J, Ghosh KK (2016)
Oxime-mediated in vitro reactivation kinetic analysis of organophosphates-inhibited human and electric eel acetylcholinesterase
Toxicol Mech Methods

Spicakova A, Anzenbacher P, Liskova B, Kuca K, Fusek J, Anzenbacherova E (2016)
Evaluation of possible inhibition of human liver drug metabolizing cytochromes P450 by two new acetylcholinesterase oxime-type reactivators
Food & Chemical Toxicology 88: 100

Winter M, Wille T, Musilek K, Kuca K, Thiermann H, Worek F (2016)
Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase
Toxicol Lett 244: 136

Bures J, Jun D, Hrabinova M, Tacheci I, Kvetina J, Pavlik M, Rejchrt S, Douda T, Kunes M, Kuca K, Kopacova M (2015)
Impact of tacrine and 7-methoxytacrine on gastric myoelectrical activity assessed using electrogastrography in experimental pigs
Neuro Endocrinol Lett 36:

Dolezal R, Korabecny J, Malinak D, Honegr J, Musilek K, Kuca K (2015)
Ligand-based 3D QSAR analysis of reactivation potency of mono- and bis-pyridinium aldoximes toward VX-inhibited rat acetylcholinesterase
J Mol Graph Model 56: 113

Giacoppo JO, Franca TCC, Kuca K, da Cunha EFF, Abagyan R, Mancini DT, Ramalho TC (2015)
Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agents
J Biomol Struct Dyn 33: 2048

Horn G, Wille T, Musilek K, Kuca K, Thiermann H, Worek F (2015)
Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase
Archives of Toxicology 89: 405

Korabecny J, Andrs M, Nepovimova E, Dolezal R, Babkova K, Horova A, Malinak D, Mezeiova E, Gorecki L, Sepsova V, Hrabinova M, Soukup O, Jun D, Kuca K (2015)
7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment
Molecules 20: 22084

Kuca K, Hrabinova M, Jun D, Musilek K, Penhaker M, Krejcar O, Soukup O (2015)
Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE
Med Chem 11: 683

Musil K, Florianova V, Bucek P, Dohnal V, Kuca K, Musilek K (2015)
Development and validation of a FIA/UV-vis method for pK determination of oxime based acetylcholinesterase reactivators
J Pharm Biomed Anal 117: 240

Nepovimova E, Korabecny J, Dolezal R, Babkova K, Ondrejicek A, Jun D, Sepsova V, Horova A, Hrabinova M, Soukup O, Bukum N, Jost P, Muckova L, Kassa J, Malinak D, Andrs M, Kuca K (2015)
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity
Journal of Medicinal Chemistry 58: 8985

Petroianu GA, Nurulain SM, Hasan MY, Kuca K, Lorke DE (2015)
Reversible cholinesterase inhibitors as pre-treatment for exposure to organophosphates: assessment using azinphos-methyl
J Appl Toxicol 35: 493

Sepsova V, Karasova JZ, Tobin G, Jun D, Korabecny J, Cabelova P, Janska K, Krusek J, Skrenkova K, Kuca K, Soukup O (2015)
Cholinergic properties of new 7-methoxytacrine-donepezil derivatives
Gen Physiol Biophys 34: 189

Sharma R, Gupta B, Singh N, Acharya JR, Musilek K, Kuca K, Ghosh KK (2015)
Development and Structural Modifications of Cholinesterase Reactivators against Chemical Warfare Agents in Last Decade: A Review
Mini Rev Med Chem 15: 58

Benek O, Musilek K, Horova A, Dohnal V, Dolezal R, Kuca K (2014)
Preparation, in vitro screening and molecular modelling of monoquaternary compounds related to the selective acetylcholinesterase inhibitor BW284c51
Med Chem 11: 21

Giacoppo JO, de Lima WE, Kuca K, da Cunha EFF, Franca TCC, Ramalho TC (2014)
Chemical warfare: perspectives on reactivating the enzyme acetylcholinesterase inhibited by organophosphates
Military Medical Science Letters 83: 165

Gupta B, Sharma R, Singh N, Kuca K, Acharya JR, Ghosh KK (2014)
In vitro reactivation kinetics of paraoxon- and DFP-inhibited electric eel AChE using mono- and bis-pyridinium oximes
Archives of Toxicology 88: 381

Gupta B, Singh N, Sharma R, Foretic B, Musilek K, Kuca K, Acharya J, Satnami ML, Ghosh KK (2014)
Assessment of antidotal efficacy of cholinesterase reactivators against paraoxon: In vitro reactivation kinetics and physicochemical properties
Bioorganic & Medicinal Chemistry Lett 24: 4743

Hamulakova S, Imrich J, Janovec L, Kristian P, Danihel I, Holas O, Pohanka M, Bohm S, Kozurkova M, Kuca K (2014)
Novel tacrine/acridine anticholinesterase inhibitors with piperazine and thiourea linkers
Int J Biol Macromol 70C: 435

Hamulakova S, Janovec L, Hrabinova M, Spilovska K, Korabecny J, Kristian P, Kuca K, Imrich J (2014)
Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors
Journal of Medicinal Chemistry 57: 7073

Killi UK, Wsol V, Soukup O, Kuca K, Winder M, Tobin G (2014)
In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat
Clinical & Experimental Pharmacology & Physiology 41: 139

Korabecny J, Dolezal R, Cabelova P, Horova A, Hruba E, Ricny J, Sedlacek L, Nepovimova E, Spilovska K, Andrs M, Musilek K, Opletalova V, Sepsova V, Ripova D, Kuca K (2014)
7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies
Eur Journal of Medicinal Chemistry 82C: 426

Korabecny J, Soukup O, Dolezal R, Spilovska K, Nepovimova E, Andrs M, Nguyen TD, Jun D, Musilek K, Kucerova-Chlupacova M, Kuca K (2014)
From Pyridinium-based to Centrally Active Acetylcholinesterase Reactivators
Mini Rev Med Chem 14: 215

Kunes M, Kvetina J, Bures J, Karasova JZ, Pavlik M, Tacheci I, Musilek K, Kuca K (2014)
HI-6 oxime (an acetylcholinesterase reactivator): blood plasma pharmacokinetics and organ distribution in experimental pigs
Neuro Endocrinol Lett 35: 186

Lorke DE, Nurulain SM, Hasan MY, Kuca K, Petroianu GA (2014)
Prophylactic administration of non-organophosphate cholinesterase inhibitors before acute exposure to organophosphates: assessment using terbufos sulfone
J Appl Toxicol 34: 1096

Nepovimova E, Uliassi E, Korabecny J, Pena-Altamira LE, Samez S, Pesaresi A, Garcia GE, Bartolini M, Andrisano V, Bergamini C, Fato R, Lamba D, Roberti M, Kuca K, Monti B, Bolognesi ML (2014)
Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects
Journal of Medicinal Chemistry 57: 8576

Radulescu M, Kuca K, Musilek K, David V (2014)
Structural modifications of dicationic acetylcholinesterase reactivators studied under ion-pairing mechanism in reversed-phase liquid chromatography
J Sep Sci 37: 3024

Sepsova V, Krusek J, Karasova JZ, Zemek F, Musilek K, Kuca K, Soukup O (2014)
The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor
Physiol Res 63: 771

Wu QH, Wang X, Yang W, Nussler AK, Xiong LY, Kuca K, Dohnal V, Zhang XJ, Yuan ZH (2014)
Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update
Archives of Toxicology 88: 1309

Zemek F, Drtinova L, Nepovimova E, Sepsova V, Korabecny J, Klimes J, Kuca K (2014)
Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine
Expert Opin Drug Safety 13: 759

Zunec S, Kopjar N, Zeljezic D, Kuca K, Musilek K, Lucic Vrdoljak A (2014)
In vivo evaluation of cholinesterase activity, oxidative stress markers, cyto- and genotoxicity of K048 oxime-a promising antidote against organophosphate poisoning
Basic Clin Pharmacol Toxicol 114: 344

Bhattacharjee AK, Musilek K, Kuca K (2013)
In silico pharmacophore modeling on known pyridinium oxime reactivators of cyclosarin (GF) inhibited AChE to Aid discovery of potential, more efficacious novel non-oxime reactivators
Curr Comput Aided Drug Des 9: 402

Bures J, Kvetina J, Pavlik M, Kunes M, Kopacova M, Rejchrt S, Jun D, Hrabinova M, Kuca K, Tacheci I (2013)
Impact of paraoxon followed by acetylcholinesterase reactivator HI-6 on gastric myoelectric activity in experimental pigs
Neuro Endocrinol Lett 34: 79

Cahlikova L, Hrabinova M, Kulhankova A, Benesova N, Chlebek J, Jun D, Novak Z, Macakova K, Kunes J, Kuca K, Opletal L (2013)
Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities
Nat Prod Commun 8: 1541

Dohnal V, Dohnalova L, Jun D, Kuca K (2013)
selective monitoring of enzymatic activity of acetylcholinesterase by flow injection analysis with mass spectrometric detection
Military Medical Science Letters 82: 120

Janockova J, Gulasova Z, Musilek K, Kuca K, Kozurkova M (2013)
Novel cholinesterase modulators and their ability to interact with DNA
Spectrochim Acta A Mol Biomol Spectrosc 115C: 364

Janockova J, Gulasova Z, Plsikova J, Musilek K, Kuca K, Mikes J, Culka L, Fedorocko P, Kozurkova M (2013)
Interaction of cholinesterase modulators with DNA and their cytotoxic activity
Int J Biol Macromol 64C: 53

Karasova JZ, Zemek F, Kunes M, Kvetina J, Chladek J, Jun D, Bures J, Tacheci I, Kuca K (2013)
Intravenous application of HI-6 salts (dichloride and dimethansulphonate) in pigs: comparison with pharmacokinetics profile after intramuscular administration
Neuro Endocrinol Lett 34: 74

Karasova JZ, Chladek J, Hroch M, Josef F, Hnidkova D, Kuca K (2013)
Pharmacokinetic study of two acetylcholinesterase reactivators, trimedoxime and newly synthesized oxime K027, in rat plasma
J Appl Toxicol 33: 18

Komloova M, Horova A, Hrabinova M, Jun D, Dolezal M, Vinsova J, Kuca K, Musilek K (2013)
Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors
Bioorganic & Medicinal Chemistry Lett 23: 6663

Kuca K, Musilek K, Jun D, Karasova J, Soukup O, Pejchal J, Hrabinova M (2013)
Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX
Med Chem 9: 689

Kuca K, Jun D, Musilek K, Pohanka M, Karasova JZ, Soukup O (2013)
Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides
Mini Rev Med Chem 13: 2102

Petroianu GA, Nurulain SM, Shafiullah M, Hasan MY, Kuca K, Lorke DE (2013)
Usefulness of administration of non-organophosphate cholinesterase inhibitors before acute exposure to organophosphates: assessment using paraoxon
Journal of Applied Toxicology 33: 894

Sepsova V, Karasova JZ, Korabecny J, Dolezal R, Zemek F, Bennion BJ, Kuca K (2013)
Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study
Int J Mol Sci 14: 16882

Singh N, Karpichev Y, Gupta B, Satnami ML, Marek J, Kuca K, Ghosh KK (2013)
Physicochemical properties and supernucleophilicity of oxime-functionalized surfactants: hydrolytic catalysts toward dephosphorylation of di- and triphosphate esters
J Phys Chem B 117: 3806

Soukup O, Jun D, Tobin G, Kuca K (2013)
The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors
Archives of Toxicology 87: 711

Soukup O, Jun D, Karasova JZ, Patocka J, Musilek K, Korabecny J, Krusek J, Kaniakova M, Sepsova V, Mandikova J, Trejtnar F, Pohanka M, Drtinova L, Pavlik M, Tobin G, Kuca K (2013)
A Resurrection of 7-MEOTA: A Comparison with Tacrine
Curr Alzheimer Res 10: 893

Spilovska K, Korabecny J, Kral J, Horova A, Musilek K, Soukup O, Drtinova L, Gazova Z, Siposova K, Kuca K (2013)
7-methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in alzheimer's disease treatment, synthesis, biological evaluation and molecular modeling studies
Molecules 18: 2397

Bhattacharjee AK, Kuca K, Musilek K, Gordon RK (2012)
An in silico stereo-electronic comparison of conventional pyridinium oximes and K-oximes for organophosphate (OP) poisoning
Med Chem 8: 230

Hamulakova S, Janovec L, Hrabinova M, Kristian P, Kuca K, Banasova M, Imrich J (2012)
Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease
Eur Journal of Medicinal Chemistry 55: 23

Holas O, Musilek K, Pohanka M, Kuca K (2012)
The progress in the cholinesterase quantification methods
Expert Opin Drug Discov 7: 1207

Kassa J, Musilek K, Karasova JZ, Kuca K, Bajgar J (2012)
Two possibilities how to increase the efficacy of antidotal treatment of nerve agent poisonings
Mini Rev Med Chem 12: 24

Korabecny J, Spilovska K, Benek O, Musilek K, Soukup O, Kuca K (2012)
[Tacrine and its derivatives in the therapy of Alzheimers disease]
Ceska a Slovenska Farmacie 61: 210

Lorke DE, Hasan MY, Nurulain SM, Shafiullah MS, Kuca K, Petroianu GA (2012)
Acetylcholinesterase Inhibitors as Pretreatment before Acute Exposure to Organophosphates: Assessment Using Methyl-paraoxon
CNS Neurol Disord Drug Targets 11: 1052

Matos KS, da Cunha EFF, da Silva Goncalves A, Wilter A, Kuca K, Franca TCC, Ramalho TC (2012)
First principles calculations of thermodynamics and kinetic parameters and molecular dynamics simulations of acetylcholinesterase reactivators: can mouse data provide new insights into humans?
J Biomol Struct Dyn 30: 546

Misik J, Pavlik M, Novotny L, Pavlikova R, Chilcott RP, Cabal J, Kuca K (2012)
In vivo decontamination of the nerve agent VX using the domestic swine model
Clinical Toxicology (Phila) 50: 807

Soukup O, Kristofikova Z, Jun D, Tambor V, Ripova D, Kuca K (2012)
The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers
Toxicol Lett 212: 315

Worek F, von der Wellen J, Musilek K, Kuca K, Thiermann H (2012)
Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase
Archives of Toxicology 86: 1379

Jun D, Musilova L, Musilek K, Kuca K (2011)
In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase
Int J Mol Sci 12: 2077

Karasova JZ, Zemek F, Bajgar J, Vasatova M, Prochazka P, Novotny L, Kuca K (2011)
Partition of bispyridinium oximes (trimedoxime and K074) administered in therapeutic doses into different parts of the rat brain
J Pharm Biomed Anal 54: 1082

Karasova JZ, Kuca K, Jun D, Bajgar J (2011)
Human serum butyrylcholinesterase as a prophylaxis against russian VX
Military Medical Science Letters 80: 97

Komloova M, Musilek K, Horova A, Holas O, Dohnal V, Gunn-Moore F, Kuca K (2011)
Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment
Bioorganic & Medicinal Chemistry Lett 21: 2505

Korabecny J, Musilek K, Zemek F, Horova A, Holas O, Nepovimova E, Opletalova V, Hroudova J, Fisar Z, Jung YS, Kuca K (2011)
Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties
Bioorganic & Medicinal Chemistry Lett 21: 6563

Kuca K, Musilek K, Karasova J, Jun D, Soukup O, Pohanka M, Ghosh KK, Hrabinova M (2011)
On the universality of oxime Hl-7 - antidote for case of the nerve agent poisoning
Military Medical Science Letters 80: 80

Lorke DE, Hasan MY, Nurulain SM, Shafiullah M, Kuca K, Petroianu GA (2011)
Pretreatment for acute exposure to diisopropylfluorophosphate: in vivo efficacy of various acetylcholinesterase inhibitors
Journal of Applied Toxicology 31: 515

Musilek K, Roder J, Komloova M, Holas O, Hrabinova M, Pohanka M, Dohnal V, Opletalova V, Kuca K, Jung YS (2011)
Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128
Bioorganic & Medicinal Chemistry Lett 21: 150

Musilek K, Komloova M, Holas O, Horova A, Pohanka M, Gunn-Moore F, Dohnal V, Dolezal M, Kuca K (2011)
Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking
Bioorganic & Medicinal Chemistry 19: 754

Musilek K, Komloova M, Holas O, Hrabinova M, Pohanka M, Dohnal V, Nachon F, Dolezal M, Kuca K (2011)
Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment
Eur Journal of Medicinal Chemistry 46: 811

Musilek K, Pavlikova R, Marek J, Komloova M, Holas O, Hrabinova M, Pohanka M, Dohnal V, Dolezal M, Gunn-Moore F, Kuca K (2011)
The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage
J Enzyme Inhib Med Chem 26: 245

Musilek K, Dolezal M, Gunn-Moore F, Kuca K (2011)
Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides
Med Res Rev 31: 548

Patocka J, Gupta RC, Kuca K (2011)
Anatoxin-a(s): natural organophosphorus anticholinesterase agent
Military Medical Science Letters 80: 129

Pohanka M, Hrabinova M, Kuca K, Simonato JP (2011)
Assessment of acetylcholinesterase activity using indoxylacetate and comparison with the standard Ellman's method
Int J Mol Sci 12: 2631

Pohanka M, Pikula J, Kuca K, Kassa J (2011)
Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model
Bratislavske Lekarske Listy 112: 539

Sepsova V, Karasova JZ, Zemek F, Bennion BJ, Kuca K (2011)
Oximes as inhibitors of acetylholinesterase - a structure-activity relationship (SAR) study
Military Medical Science Letters 80: 178

Soukup O, Kumar UK, Proska J, Bratova L, Adem A, Jun D, Fusek J, Kuca K, Tobin G (2011)
The effect of oxime reactivators on muscarinic receptors: functional and binding examinations
Environ Toxicol Pharmacol 31: 364

Soukup O, Krusek J, Kaniakova M, Kumar UK, Oz M, Jun D, Fusek J, Kuca K, Tobin G (2011)
Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors
Physiol Res 60: 679

Zemek F, Karasova JZ, Musilek K, Kuca K (2011)
Method optimization for acetylcholinesterase modulators-albumin interactions
Military Medical Science Letters 80: 58

Dos Santos AA, dos Santos DB, Ribeiro RP, Colle D, Peres KC, Hermes J, Barbosa AM, Dafre AL, de Bem AF, Kuca K, Farina M (2011)
Effects of K074 and pralidoxime on antioxidant and acetylcholinesterase response in malathion-poisoned mice
Neurotoxicology 32: 888

Bajgar J, Hajek P, Karasova JZ, Kassa J, Paseka A, Slizova D, Krs O, Kuca K, Jun D, Fusek J, Capek L (2010)
A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques
J Enzyme Inhib Med Chem 25: 790

Zunec S, Katalinic M, Vrdoljak AL, Kovarik Z, Kuca K, Radic B (2010)
In vivo experimental approach to treatment against tabun poisoning
J Enzyme Inhib Med Chem 25: 531

Zunec S, Radic B, Kuca K, Lucic Vrdoljak A (2010)
The antidotal efficacy of the bispyridinium oximes K027 and TMB-4 against tabun poisoning in mice
Chemico-Biological Interactions 187: 291

Bhattacharjee AK, Kuca K, Musilek K, Gordon RK (2010)
In silico pharmacophore model for tabun-inhibited acetylcholinesterase reactivators: a study of their stereoelectronic properties
Chemical Research in Toxicology 23: 26

Jun D, Stodulka P, Kuca K, Dolezal B (2010)
High-performance liquid chromatography analysis of by-products and intermediates arising during the synthesis of the acetylcholinesterase reactivator HI-6
Journal of Chromatography Sci 48: 694

Karasova JZ, Novotny L, Antos K, Zivna H, Kuca K (2010)
Time-dependent changes in concentration of two clinically used acetylcholinesterase reactivators (HI-6 and obidoxime) in rat plasma determined by HPLC techniques after in vivo administration
Anal Sci 26: 63

Karasova JZ, Pohanka M, Musilek K, Zemek F, Kuca K (2010)
Passive diffusion of acetylcholinesterase oxime reactivators through the blood-brain barrier: influence of molecular structure
Toxicol In Vitro 24: 1838

Karasova JZ, Kassa J, Musilek K, Jung Y, Kuca K (2010)
Is Oxime Fluorination the Proper Way to Increase Penetration of These Compounds in the Central Nervous System?
Military Medical Science Letters 79: 23

Kassa J, Karasova JZ, Tesarova S, Musilek K, Kuca K, Jung YS (2010)
A Comparison of Neuroprotective Efficacy of the Oxime K203 and its Fluorinated Analogue (KR-22836) with Obidoxime in Tabun-Poisoned Rats
Basic Clin Pharmacol Toxicol 107: 861

Kassa J, Karasova JZ, Caisberger F, Musilek K, Kuca K, Jung YS (2010)
A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice
J Enzyme Inhib Med Chem 25: 480

Kassa J, Karasova JZ, Kuca K, Musilek K (2010)
A comparison of the reactivating and therapeutic efficacy of newly developed oximes (K347, K628) with commonly used oximes (obidoxime, HI-6) against tabun in rats and mice
Drug & Chemical Toxicology 33: 227

Komloova M, Musilek K, Dolezal M, Gunn-Moore F, Kuca K (2010)
Structure-activity relationship of quaternary acetylcholinesterase inhibitors - outlook for early myasthenia gravis treatment
Curr Med Chem 17: 1810

Korabecny J, Musilek K, Holas O, Binder J, Zemek F, Marek J, Pohanka M, Opletalova V, Dohnal V, Kuca K (2010)
Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease
Bioorganic & Medicinal Chemistry Lett 20: 6093

Korabecny J, Musilek K, Holas O, Nepovimova E, Jun D, Zemek F, Opletalova V, Patocka J, Dohnal V, Nachon F, Hroudova J, Fisar Z, Kuca K (2010)
Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment
Molecules 15: 8804

Kovarik Z, Katalinic M, Sinko G, Binder J, Holas O, Jung YS, Musilova L, Jun D, Kuca K (2010)
Pseudo-catalytic scavenging: searching for a suitable reactivator of phosphorylated butyrylcholinesterase
Chemico-Biological Interactions 187: 167

Kuca K, Musilek K, Jun D, Pohanka M, Ghosh KK, Hrabinova M (2010)
Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase
J Enzyme Inhib Med Chem 25: 509

Kuca K, Hrabinova M, Soukup O, Tobin G, Karasova J, Pohanka M (2010)
Pralidoxime--the gold standard of acetylcholinesterase reactivators--reactivation in vitro efficacy
Bratislavske Lekarske Listy 111: 502

Musilek K, Holas O, Misik J, Pohanka M, Novotny L, Dohnal V, Opletalova V, Kuca K (2010)
Monooxime-monocarbamoyl Bispyridinium Xylene-Linked Reactivators of Acetylcholinesterase-Synthesis, In vitro and Toxicity Evaluation, and Docking Studies
ChemMedChem 5: 247

Musilek K, Komloova M, Zavadova V, Holas O, Hrabinova M, Pohanka M, Dohnal V, Nachon F, Dolezal M, Kuca K, Jung YS (2010)
Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications
Bioorganic & Medicinal Chemistry Lett 20: 1763

Pavlikova R, Marek J, Musilek K, Fusek J, Kuca K, Karasova JZ (2010)
New Bisquaternary Inhibitors of Acetylcholinesterase Used as a Prophylactics in Organophosphorus Poisoning
Military Medical Science Letters 79: 46

Pohanka M, Karasova JZ, Kuca K, Pikula J, Holas O, Korabecny J, Cabal J (2010)
Colorimetric dipstick for assay of organophosphate pesticides and nerve agents represented by paraoxon, sarin and VX
Talanta 81: 621

Pohanka M, Musilek K, Kuca K (2010)
Evaluation of aflatoxin B1--acetylcholinesterase dissociation kinetic using the amperometric biosensor technology: prospect for toxicity mechanism
Protein Pept Lett 17: 340

Pohanka M, Pejchal J, Horackova S, Kuca K, Bandouchova H, Damkova V, Pikula J (2010)
Modulation of ionising radiation generated oxidative stress by HI-6 (asoxime) in a laboratory rat model
Neuro Endocrinol Lett 31 Suppl 2: 62

Pohanka M, Vlcek V, Karasova JZ, Kuca K, Cabal J (2010)
Colorimetric Detectors Based on Acetylcholinesterase and Its Construction
Military Medical Science Letters 79: 9

Pohanka M, Drobik O, Krenkova Z, Karasova JZ, Cabal J, Kuca K (2010)
Immobilization of Acetylcholinesterase and a Construction of Biochemical Biosensor for Identification of Toxic Organophosphates.
Military Medical Science Letters 79: 105

Pohanka M, Hrabinova M, Karasova JZ, Holas O, Kuca K, Cabal J (2010)
Testing of a Referential Method Based on Indoxylacetate as a Acetylcholinesterase Substrate for Identification of Reactivation Efficacy.
Military Medical Science Letters 79: 111

Ramalho TC, Franca TCC, Renno MN, Guimaraes AP, da Cunha EFF, Kuca K (2010)
Development of new acetylcholinesterase reactivators: molecular modeling versus in vitro data
Chemico-Biological Interactions 185: 73

Soukup O, Kristofikova Z, Proska J, Tobin G, Patocka J, Marek J, Jun D, Fusek J, Ripova D, Kuca K (2010)
Novel acetylcholinesterase reactivator K112 and its cholinergic properties
Biomed Pharmacother 64: 541

Soukup O, Tobin G, Kumar UK, Binder J, Proska J, Jun D, Fusek J, Kuca K (2010)
Interaction of nerve agent antidotes with cholinergic systems
Curr Med Chem 17: 1708

Soukup O, Tobin G, Kumar UK, Jun D, Fusek J, Kuca K (2010)
Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder
Toxicol Mech Methods 20: 428

Wiesner J, Kriz Z, Kuca K, Jun D, Koca J (2010)
Why acetylcholinesterase reactivators do not work in butyrylcholinesterase
J Enzyme Inhib Med Chem 25: 318

Wiesner J, Kriz Z, Kuca K, Jun D, Koca J (2010)
Influence of the acetylcholinesterase active site protonation on omega loop and active site dynamics
J Biomol Struct Dyn 28: 393

Dos Santos AA, dos Santos DB, Dafre AL, de Bem AF, Souza DO, da Rocha JB, Kuca K, Farina M (2010)
In vitro reactivating effects of standard and newly developed oximes on malaoxon-inhibited mouse brain acetylcholinesterase
Basic Clin Pharmacol Toxicol 107: 768

Bajgar J, Fusek J, Kassa J, Kuca K, Jun D (2009)
Chemical aspects of pharmacological prophylaxis against nerve agent poisoning
Curr Med Chem 16: 2977

Hajek P, Bajgar J, Slizova D, Krs O, Kuca K, Capek L, Fusek J (2009)
Different inhibition of acetylcholinesterase in selected parts of the rat brain following intoxication with VX and Russian VX
Drug & Chemical Toxicology 32: 1

Jeong HC, Park NJ, Chae CH, Musilek K, Kassa J, Kuca K, Jung YS (2009)
Fluorinated pyridinium oximes as potential reactivators for acetylcholinesterases inhibited by paraoxon organophosphorus agent
Bioorganic & Medicinal Chemistry 17: 6213

Karasova JZ, Bajgar J, Jun D, Pavlikova R, Kuca K (2009)
Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX
Neurotox Res 16: 356

Karasova JZ, Kassa J, Musilek K, Pohanka M, Novotny L, Kuca K (2009)
Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats
Int J Mol Sci 10: 3065

Kassa J, Karasova J, Musilek K, Kuca K, Bajgar J (2009)
An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice
Clinical Toxicology (Phila) 47: 72

Kassa J, Karasova JZ, Musilek K, Kuca K (2009)
A comparison of reactivating and therapeutic efficacy of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice
Toxicol Mech Methods 19: 346

Kassa J, Karasova JZ, Musilek K, Kuca K, Jung AY (2009)
A comparison of the neuroprotective efficacy of newly developed oximes (K117, K127) and currently available oxime (obidoxime) in tabun-poisoned rats
Toxicol Mech Methods 19: 232

Kuca K, Cabal J, Jung YS, Musilek K, Soukup O, Jun D, Pohanka M, Musilova L, Karasova J, Novotny L, Hrabinova M (2009)
Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127
Basic Clin Pharmacol Toxicol 105: 207

Kuca K, Musilova L, Palecek J, Cirkva V, Paar M, Musilek K, Hrabinova M, Pohanka M, Karasova JZ, Jun D (2009)
Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon
Molecules 14: 4915

Lorke DE, Hasan MY, Nurulain SM, Kuca K, Schmitt A, Petroianu GA (2009)
Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6
Toxicol Mech Methods 19: 327

Nurulain SM, Lorke DE, Hasan MY, Shafiullah M, Kuca K, Musilek K, Petroianu GA (2009)
Efficacy of eight experimental bispyridinium oximes against paraoxon-induced mortality: comparison with the conventional oximes pralidoxime and obidoxime
Neurotox Res 16: 60

Pohanka M, Karasova JZ, Musilek K, Kuca K, Kassa J (2009)
Effect of five acetylcholinesterase reactivators on tabun-intoxicated rats: induction of oxidative stress versus reactivation efficacy
J Appl Toxicol 29: 483

Pohanka M, Musilek K, Kuca K (2009)
Progress of biosensors based on cholinesterase inhibition
Curr Med Chem 16: 1790

Pohanka M, Jun D, Kuca K (2009)
In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048
J Enzyme Inhib Med Chem 24: 680

Veinlichova A, Jancova P, Siller M, Anzenbacher P, Kuca K, Jun D, Fusek J, Anzenbacherova E (2009)
Effect of acetylcholinesterase oxime-type reactivators K-48 and HI-6 on human liver microsomal cytochromes P450 in vitro
Chemico-Biological Interactions 180: 449

Vrdoljak AL, Zunec S, Zeljezic D, Piljac-Zegarac J, Plestina S, Kuca K, Radic B, Mladinic M, Kopjar N (2009)
Irinotecan side effects relieved by the use of HI-6 oxime: in vivo experimental approach
Basic Clin Pharmacol Toxicol 105: 401

Bajgar J, Fusek J, Kassa J, Jun D, Kuca K, Hajek P (2008)
An attempt to assess functionally minimal acetylcholinesterase activity necessary for survival of rats intoxicated with nerve agents
Chemico-Biological Interactions 175: 281

Zunec S, Vrdoljak AL, Radic B, Kuca K (2008)
New bispyridinium oximes: in vitro and in vivo evaluation of their biological efficiency in soman and tabun poisoning
Chemico-Biological Interactions 175: 413

Calic M, Bosak A, Kuca K, Kovarik Z (2008)
Interactions of butane, but-2-ene or xylene-like linked bispyridinium para-aldoximes with native and tabun-inhibited human cholinesterases
Chemico-Biological Interactions 175: 305

Csermely T, Kalasz H, Petroianu GA, Kuca K, Darvas F, Ludanyi K, Mudhafar AA, Tekes K (2008)
Analysis of pyridinium aldoximes - a chromatographic approach
Curr Med Chem 15: 2401

Jun D, Kuca K, Picha J, Koleckar V, Marek J (2008)
Potency of novel oximes to reactivate sarin inhibited human cholinesterases
Drug & Chemical Toxicology 31: 1

Jun D, Stodulka P, Kuca K, Koleckar V, Dolezal B, Simon P, Veverka M (2008)
TLC analysis of intermediates arising during the preparation of oxime HI-6 dimethanesulfonate
Journal of Chromatography Sci 46: 316

Jun D, Musilova L, Kuca K, Kassa J, Bajgar J (2008)
Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro
Chemico-Biological Interactions 175: 421

Karasova JZ, Kassa J, Jung YS, Musilek K, Pohanka M, Kuca K (2008)
Effect of several new and currently available oxime cholinesterase reactivators on tabun-intoxicated rats
Int J Mol Sci 9: 2243

Kassa J, Karasova J, Musilek K, Kuca K (2008)
An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice
Toxicology 243: 311

Kassa J, Jun D, Karasova J, Bajgar J, Kuca K (2008)
A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats
Chemico-Biological Interactions 175: 425

Kassa J, Karasova J, Musilek K, Kuca K, Jung YS (2008)
A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice
Drug & Chemical Toxicology 31: 371

Kassa J, Kuca K, Karasova J, Musilek K (2008)
The development of new oximes and the evaluation of their reactivating, therapeutic and neuroprotective efficacy against tabun
Mini Rev Med Chem 8: 1134

Kassa J, Karasova J, Bajgar J, Kuca K, Musilek K (2008)
A comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice
J Enzyme Inhib Med Chem 23: 776

Lorke DE, Hasan MY, Arafat K, Kuca K, Musilek K, Schmitt A, Petroianu GA (2008)
In vitro oxime protection of human red blood cell acetylcholinesterase inhibited by diisopropyl-fluorophosphate
J Appl Toxicol 28: 422

Lorke DE, Nurulain SM, Hasan MY, Kuca K, Musilek K, Petroianu GA (2008)
Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: in vivo efficacy to protect from diisopropylfluorophosphate toxicity
J Appl Toxicol 28: 920

Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Opletalova V, Dolezal M (2008)
Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase
J Enzyme Inhib Med Chem 23: 70

Musilek K, Jampilek J, Dohnal J, Jun D, Gunn-Moore F, Dolezal M, Kuca K (2008)
RP-HPLC determination of the lipophilicity of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker
Anal Bioanal Chem 391: 367

Musilek K, Kucera J, Jun D, Dohnal V, Opletalova V, Kuca K (2008)
Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase
Bioorganic & Medicinal Chemistry 16: 8218

Oh KA, Park NJ, Park NS, Kuca K, Jun D, Jung YS (2008)
Reactivation of DFP- and paraoxon-inhibited acetylcholinesterases by pyridinium oximes
Chemico-Biological Interactions 175: 365

Patocka J, Jun D, Kuca K (2008)
Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease
Curr Drug Metab 9: 332

Pohanka M, Hrabinova M, Kuca K (2008)
Diagnosis of Intoxication by the Organophosphate VX: Comparison Between an Electrochemical Sensor and Ellman s Photometric Method
Sensors (Basel) 8: 5229

Pohanka M, Jun D, Kuca K (2008)
Amperometric Biosensors for Real Time Assays of Organophosphates
Sensors (Basel) 8: 5303

Pohanka M, Jun D, Kalasz H, Kuca K (2008)
Cholinesterase biosensor construction - a review
Protein Pept Lett 15: 795

Pohanka M, Kuca K, Kassa J (2008)
New performance of biosensor technology for Alzheimer's disease drugs: in vitro comparison of tacrine and 7-methoxytacrine
Neuro Endocrinol Lett 29: 755

Pohanka M, Jun D, Kuca K (2008)
Photometric microplate assay for estimation of the efficacy of paraoxon-inhibited acetylcholinesterase reactivation
J Enzyme Inhib Med Chem 23: 781

Soukup O, Pohanka M, Tobin G, Jun D, Fusek J, Musilek K, Marek J, Kassa J, Kuca K (2008)
The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder
Neuro Endocrinol Lett 29: 759

da Silva AP, Farina M, Franco JL, Dafre AL, Kassa J, Kuca K (2008)
Temporal effects of newly developed oximes (K027, K048) on malathion-induced acetylcholinesterase inhibition and lipid peroxidation in mouse prefrontal cortex
Neurotoxicology 29: 184

Bajgar J, Hajek P, Slizova D, Krs O, Fusek J, Kuca K, Jun D, Bartosova L, Blaha V (2007)
Changes of acetylcholinesterase activity in different rat brain areas following intoxication with nerve agents: biochemical and histochemical study
Chemico-Biological Interactions 165: 14

Bajgar J, Bartosova L, Kuca K, Jun D, Fusek J (2007)
Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase
Drug & Chemical Toxicology 30: 351

Bajgar J, Kuca K, Jun D, Bartosova L, Fusek J (2007)
Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents
Curr Drug Metab 8: 803

Bajgar J, Fusek J, Kuca K, Bartosova L, Jun D (2007)
Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction
Mini Rev Med Chem 7: 461

Bajgar J, Kuca K, Fusek J, Karasova J, Kassa J, Cabal J, Jun D, Blaha V (2007)
Inhibition of blood cholinesterases following intoxication with VX and its derivatives
J Appl Toxicol 27: 458

Gyenge M, Kalasz H, Petroianu GA, Laufer R, Kuca K, Tekes K (2007)
Measurement of K-27, an oxime-type cholinesterase reactivator by high-performance liquid chromatography with electrochemical detection from different biological samples
Journal of Chromatography A 1161: 146

Kassa J, Jun D, Kuca K, Bajgar J (2007)
Comparison of reactivating and therapeutic efficacy of two salts of the oxime HI-6 against tabun, soman and cyclosarin in rats
Basic Clin Pharmacol Toxicol 101: 328

Kassa J, Jun D, Kuca K (2007)
A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats
J Enzyme Inhib Med Chem 22: 297

Kuca K, Jun D, Bajgar J (2007)
Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications
Curr Pharm Des 13: 3445

Kuca K, Musilek K, Paar M, Jun D, Stodulka P, Hrabinova M, Marek J (2007)
Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide--a new nerve agent reactivator
Molecules 12: 1964

Kuca K, Cabal J, Jun D, Hrabinova M (2007)
Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin
Clinical Toxicology (Phila) 45: 512

Kuca K, Cabal J, Jun D, Musilek K (2007)
In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases
Neurotox Res 11: 101

Kuca K, Jun D, Bajgar J (2007)
Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro
Drug & Chemical Toxicology 30: 31

Musilek K, Holas O, Jun D, Dohnal V, Gunn-Moore F, Opletalova V, Dolezal M, Kuca K (2007)
Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase
Bioorganic & Medicinal Chemistry 15: 6733

Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Dolezal M (2007)
Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
J Enzyme Inhib Med Chem 22: 425

Musilek K, Jun D, Cabal J, Kassa J, Gunn-Moore F, Kuca K (2007)
Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203)
Journal of Medicinal Chemistry 50: 5514

Musilek K, Kuca K, Dohnal V, Jun D, Marek J, Koleckar V (2007)
Two step synthesis of a non-symmetric acetylcholinesterase reactivator
Molecules 12: 1755

Musilek K, Kuca K, Jun D (2007)
Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX)
Acta Medica (Hradec Kralove) 50: 203

Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Opletalova V, Dolezal M (2007)
Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker--synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
Bioorganic & Medicinal Chemistry Lett 17: 3172

Petroianu GA, Arafat K, Nurulain SM, Kuca K, Kassa J (2007)
In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon
J Appl Toxicol 27: 168

Petroianu GA, Nurulain SM, Nagelkerke N, Shafiullah M, Kassa J, Kuca K (2007)
Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon
J Appl Toxicol 27: 453

Pohanka M, Kuca K, Jun D (2007)
Amperometric biosensor for pesticide methamidophos assay
Acta Medica (Hradec Kralove) 50: 239

Wiesner J, Kriz Z, Kuca K, Jun D, Koca J (2007)
Acetylcholinesterases--the structural similarities and differences
J Enzyme Inhib Med Chem 22: 417

Bajgar J, Fusek J, Bartosova L, Jun D, Kuca K (2006)
Evaluation of reactivation test in anaesthetized dogs with experimental intoxication with nerve agents
J Appl Toxicol 26: 439

Bajgar J, Bartosova L, Fusek J, Jun D, Kuca K (2006)
Equine butyrylcholinesterase protects rats against inhalation exposure to sublethal sarin concentrations
Arh Hig Rada Toksikol 57: 391

Bartosova L, Kuca K, Kunesova G, Jun D (2006)
The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure
Neurotox Res 9: 291

Calic M, Vrdoljak AL, Radic B, Jelic D, Jun D, Kuca K, Kovarik Z (2006)
In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity
Toxicology 219: 85

Hrabinova M, Musilek K, Jun D, Kuca K (2006)
New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin
J Enzyme Inhib Med Chem 21: 515

Jun D, Kuca K, Hronek M, Opletal L (2006)
Effect of some acetylcholinesterase reactivators on human platelet aggregation in vitro
J Appl Toxicol 26: 258

Kassa J, Jun D, Kuca K (2006)
The Reactivating and Therapeutic Efficacy of Oximes to Counteract Russian VX Poisonings
Int J Toxicol 25: 397

Kassa J, Kuca K, Cabal J, Paar M (2006)
A comparison of the efficacy of new asymmetric bispyridinium oximes (K027, K048) with currently available oximes against tabun by in vivo methods
J Toxicol Environ Health A 69: 1875

Kuca K, Cabal J, Jun D, Hrabinova M (2006)
In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings
Drug & Chemical Toxicology 29: 443

Kuca K, Jun D, Musilek K (2006)
Structural requirements of acetylcholinesterase reactivators
Mini Rev Med Chem 6: 269

Kuca K, Jun D, Cabal J, Hrabinova M, Bartosova L, Opletalova V (2006)
Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent
Basic Clin Pharmacol Toxicol 98: 389

Kuca K, Cabal J, Kassa J, Jun D, Hrabinova M (2006)
In vitro potency of H oximes (HI-6, HLo-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase
J Toxicol Environ Health A 69: 1431

Kuca K, Jun D (2006)
Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes
J Med Toxicol 2: 141

Kuca K, Cabal J, Jun D, Bajgar J, Hrabinova M (2006)
Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases
J Enzyme Inhib Med Chem 21: 663

Kuca K, Picha J, Jun D (2006)
Reactivation potency of new group of acetylcholinesterase reactivators and their comparison with currently available oximes
Acta Medica (Hradec Kralove) 49: 233

Kuca K, Jun D, Musilek K (2006)
Influence of Length and Shape of the Connecting Chain of Bisquaternary Acetylcholinesterase Reactivators on Their Potency to Reactivate Enzyme Inhibited by Sarin
Military Medical Science Letters 75: 37

Lucic Vrdoljak A, Calic M, Radic B, Zunec S, Jun D, Kuca K, Kovarik Z (2006)
Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning
Toxicology 228: 41

Musilek K, Kuca K, Jun D, Dohnal V, Kim TH, Jung YS, Dolezal M (2006)
[Synthesis of reactivators of phosphorylated acetylcholinesterase of bis-pyridiniumdialdoxime type with a 3-oxapentane connecting chain and their testing in vitro on a model of the enzyme inhibited by chlorpyrifos and methylchlorpyrifos]
Ceska a Slovenska Farmacie 55: 115

Musilek K, Kuca K, Jun D, Dohnal V, Dolezal M (2006)
Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase
Bioorganic & Medicinal Chemistry Lett 16: 622

Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Dolezal M (2006)
Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
Bioorganic & Medicinal Chemistry Lett 16: 5673

Petroianu GA, Arafat K, Kuca K, Kassa J (2006)
Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxon
J Appl Toxicol 26: 64

Petroianu GA, Nurulain SM, Nagelkerke N, Al-Sultan MA, Kuca K, Kassa J (2006)
Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon
J Appl Toxicol 26: 262

Racakova V, Hrabinova M, Jun D, Kuca K (2006)
Substituted monoquaternary oximes as reactivators of cyclosarin--and chlorpyrifos--inhibited acetylcholinesterase
Arh Hig Rada Toksikol 57: 387

Tekes K, Hasan MY, Sheen R, Kuca K, Petroianu GA, Ludanyi K, Kalasz H (2006)
High-performance liquid chromatographic determination of the plasma concentration of K-27, a novel oxime-type cholinesterase reactivator
Journal of Chromatography A 1122: 84

Vesela S, Ondruska V, Kuca K, Patocka J (2006)
Tests with Daphnia magna: a new approach to prescreen toxicity of newly synthesized acetylcholinesterase reactivators
J Enzyme Inhib Med Chem 21: 427

Bartosova L, Kuca K, Jun D, Kunesova G (2005)
Bispyridinium oximes as antidotal treatment of cyclosarin poisoning-in vitro and in vivo testing
Int J Toxicol 24: 399

Bartosova L, Kuca K, Kunesova G (2005)
Effectivity of new acetylcholinesterase reactivators in treatment of cyclosarin poisoning in mice and rats
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 149: 425

Cabal J, Kuca K, Jun D, Bajgar J, Hrabinova M (2005)
[A comparison of the efficacy of the reactivators of acetylcholinesterase inhibited with tabun]
Ceska a Slovenska Farmacie 54: 192

Jun D, Kuca K, Cabal J, Bartosova L, Kunesova G, Kassa J (2005)
Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species
Chemico-Biological Interactions 157-158: 385

Kassa J, Kuca K, Cabal J (2005)
A comparison of the potency of trimedoxime and other currently available oximes to reactivate tabun-inhibited acetylcholinesterase and eliminate acute toxic effects of tabun
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 149: 419

Kim TH, Kuca K, Jun D, Jung YS (2005)
Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents
Bioorganic & Medicinal Chemistry Lett 15: 2914

Krejcova-Kunesova G, Bartosova L, Kuca K (2005)
Signs of cyclosarin-induced neurotoxicity and its pharmacological treatment with quaternary pyridinium-oximes reactivators
Toxicology 216: 32

Kuca K, Cabal J, Kassa J (2005)
A comparison of the potency of newly developed oximes (K005, K027, K033, K048) and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited rat brain acetylcholinesterase by in vitro methods
J Toxicol Environ Health A 68: 677

Kuca K, Cabal J, Jun D, Kassa J, Bartosova L, Kunesova G (2005)
In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions
J Appl Toxicol 25: 296

Kuca K, Cabal J, Kassa J, Jun D, Hrabinova M (2005)
Comparison of in vitro potency of oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain
J Appl Toxicol 25: 271

Kuca K, Cabal J, Musilek K, Jun D, Bajgar J (2005)
Effective bisquaternary reactivators of tabun-inhibited AChE
J Appl Toxicol 25: 491

Kuca K, Bartosova L, Jun D, Patocka J, Cabal J, Kassa J, Kunesova G (2005)
New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 149: 75

Kuca K, Cabal J, Kassa J (2005)
In vitro reactivation of sarin-inhibited brain acetylcholinesterase from different species by various oximes
J Enzyme Inhib Med Chem 20: 227

Kuca K, Cabal J, Kassa J, Jun D, Hrabinova M (2005)
A comparison of the potency of the oxime HLo-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods
Acta Medica (Hradec Kralove) 48: 81

Kuca K, Bartosova L, Kassa J, Cabal J, Bajgar J, Kunesova G, Jun D (2005)
Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivo
Chemico-Biological Interactions 157-158: 367

Kuca K, Cabal J, Jun D, Kassa J, Bartosova L, Kunesova G, Dohnal V (2005)
Strategy for the development of new acetylcholinesterase reactivators - antidotes used for treatment of nerve agent poisonings
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 149: 429

Kuca K, Cabal J (2005)
Evaluation of newly synthesized reactivators of the brain cholinesterase inhibited by sarin nerve agent
Toxicol Mech Methods 15: 247

Musilek K, Kuca K, Jun D, Dohnal V, Dolezal M (2005)
Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase
J Enzyme Inhib Med Chem 20: 409

Patocka J, Jun D, Kuca K (2005)
In vitro inactivation of rat brain acetylcholinesterase by DSP-4 and its derivatives OS-21 and OS-23 and protective activity of tacrine (9-amino-1,2,3,4-tetrahydroacridine)
Acta Medica (Hradec Kralove) 48: 145

Picha J, Kuca K, Kivala M, Kohout M, Cabal J, Liska F (2005)
A new group of monoquaternary reactivators of acetylcholinesterase inhibited by nerve agents
J Enzyme Inhib Med Chem 20: 233

Sevelova L, Kuca K, Krejcova-Kunesova G (2005)
Antidotal treatment of GF-agent intoxication in mice with bispyridinium oximes
Toxicology 207: 1

Wiesner J, Kriz Z, Kuca K, Jun D, Koca J (2005)
Computer Modeling and Simulation - New Technologies in Development of Means against Combat Chemical Substances
Military Medical Science Letters 74: 165

Bartosova L, Kunesova G, Kuca K, Vachek J (2004)
Therapeutic efficacy of different antidotal mixtures against poisoning with GF-agent in mice
Acta Medica (Hradec Kralove) 47: 249

Cabal J, Kuca K, Kassa J (2004)
Specification of the structure of oximes able to reactivate tabun-inhibited acetylcholinesterase
Basic Clin Pharmacol Toxicol 95: 81

Cabal J, Kuca K, Sevelova-Bartosova L, Dohnal V (2004)
Cyclodextrines as functional agents for decontamination of the skin contaminated by nerve agents
Acta Medica (Hradec Kralove) 47: 115

Kassa J, Kunesova G, Vachek J, Kuca K, Cabal J (2004)
Pharmacological Prophylaxis and Antidotal Treatment of Acute Tabun Poisoning
Military Medical Science Letters 73: 107

Kuca K, Kassa J (2004)
In vitro reactivation of acetylcholinesterase using the oxime K027
Vet Hum Toxicol 46: 15

Kuca K, Cabal J (2004)
In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes--K027, K005, K033 and K048
Central European Journal of Public Health 12 Suppl: S59

Kuca K, Kassa J (2004)
Oximes-induced reactivation of rat brain acetylcholinesterase inhibited by VX agent
Hum Exp Toxicol 23: 167

Kuca K, Patocka J (2004)
Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium--oximes
J Enzyme Inhib Med Chem 19: 39

Kuca K, Cabal J, Kassa J (2004)
A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods
Pharmazie 59: 795

Kuca K, Dohnal V (2004)
1,3-Bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents
Acta Medica (Hradec Kralove) 47: 167

Kuca K, Patocka J, Cabal J, Jun D (2004)
Reactivation of organophosphate-inhibited acetylcholinesterase by quaternary pyridinium aldoximes
Neurotox Res 6: 565

Kuca K, Sevelova-Bartosova L, Krejcova-Kunesova G (2004)
In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 AND K048
Acta Medica (Hradec Kralove) 47: 107

Patocka J, Kuca K, Jun D (2004)
Acetylcholinesterase and butyrylcholinesterase--important enzymes of human body
Acta Medica (Hradec Kralove) 47: 215

Kuca K, Bielavsky J, Cabal J, Kassa J (2003)
Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase
Bioorganic & Medicinal Chemistry Lett 13: 3545

Kuca K, Kassa J (2003)
A comparison of the ability of a new bispyridinium oxime--1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods
J Enzyme Inhib Med Chem 18: 529