Zhang HK, Eaton JB, Fedolak A, Gunosewoyo H, Onajole OK, Brunner D, Lukas RJ, Yu LF, Kozikowski AP (2016)
Synthesis and biological evaluation of novel hybrids of highly potent and selective alpha4beta2-Nicotinic acetylcholine receptor (nAChR) partial agonists
Eur Journal of Medicinal Chemistry 124: 689

Gunosewoyo H, Tipparaju SK, Pieroni M, Wang Y, Doctor BP, Nambiar MP, Kozikowski AP (2013)
Structural analogs of huperzine A improve survival in guinea pigs exposed to soman
Bioorganic & Medicinal Chemistry Lett 23: 1544

Zhang H, Tuckmantel W, Eaton JB, Yuen PW, Yu LF, Bajjuri KM, Fedolak A, Wang D, Ghavami A, Caldarone B, Paterson NE, Lowe DA, Brunner D, Lukas RJ, Kozikowski AP (2012)
Chemistry and behavioral studies identify chiral cyclopropanes as selective alpha4beta2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile
Journal of Medicinal Chemistry 55: 717

Caldarone BJ, Wang D, Paterson NE, Manzano M, Fedolak A, Cavino K, Kwan M, Hanania T, Chellappan SK, Kozikowski AP, Olivier B, Picciotto MR, Ghavami A (2011)
Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380
Psychopharmacology (Berl) 217: 199

Liu J, Yu LF, Eaton JB, Caldarone B, Cavino K, Ruiz C, Terry M, Fedolak A, Wang D, Ghavami A, Lowe DA, Brunner D, Lukas RJ, Kozikowski AP (2011)
Discovery of isoxazole analogues of sazetidine-A as selective alpha4beta2-nicotinic acetylcholine receptor partial agonists for the treatment of depression
Journal of Medicinal Chemistry 54: 7280

Malkova L, Kozikowski AP, Gale K (2011)
The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques
Neuropharmacology 60: 1262

Hackett A, Caldarone B, Kozikowski AP, Ghavami A, Olivier B, Hanania T, Paterson NE (2009)
Poster: The nAChR agonist AMOP-H-OH (sazetidine-A) exhibits reinforcing, but not withdrawal-alleviating, properties in rats
Biochemical Pharmacology 78: 919

Valette H, Xiao Y, Peyronneau MA, Damont A, Kozikowski AP, Wei ZL, Kassiou M, Kellar KJ, Dolle F, Bottlaender M (2009)
18F-ZW-104: a new radioligand for imaging neuronal nicotinic acetylcholine receptors--in vitro binding properties and PET studies in baboons
J Nucl Med 50: 1349

Pibiri F, Kozikowski AP, Pinna G, Auta J, Kadriu B, Costa E, Guidotti A (2008)
The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice
Proc Natl Acad Sci U S A 105: 14169

Kozikowski AP, Chellappan SK, Henderson D, Fulton R, Giboureau N, Xiao Y, Wei ZL, Guilloteau D, Emond P, Dolle F, Kellar KJ, Kassiou M (2007)
Acetylenic pyridines for use in PET imaging of nicotinic receptors
ChemMedChem 2: 54

Kozikowski AP, Chellappan SK, Xiao Y, Bajjuri KM, Yuan H, Kellar KJ, Petukhov PA (2007)
Chemical medicine: novel 10-substituted cytisine derivatives with increased selectivity for alpha4beta2 nicotinic acetylcholine receptors
ChemMedChem 2: 1157

Chellappan SK, Xiao Y, Tueckmantel W, Kellar KJ, Kozikowski AP (2006)
Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity
Journal of Medicinal Chemistry 49: 2673

Xiao Y, Fan H, Musachio JL, Wei ZL, Chellappan SK, Kozikowski AP, Kellar KJ (2006)
Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them
Molecular Pharmacology 70: 1454

Wei ZL, Xiao Y, Yuan H, Baydyuk M, Petukhov PA, Musachio JL, Kellar KJ, Kozikowski AP (2005)
Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits
Journal of Medicinal Chemistry 48: 1721

Wei ZL, Xiao Y, Kellar KJ, Kozikowski AP (2004)
Synthesis and pharmacological characterization of bivalent ligands of epibatidine at neuronal nicotinic acetylcholine receptors
Bioorganic & Medicinal Chemistry Lett 14: 1855

Wei ZL, Petukhov PA, Xiao Y, Tuckmantel W, George C, Kellar KJ, Kozikowski AP (2003)
Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues
Journal of Medicinal Chemistry 46: 921

Wei ZL, Xiao Y, George C, Kellar KJ, Kozikowski AP (2003)
Functionalization of the alicyclic skeleton of epibatidine: synthesis and nicotinic acetylcholine receptor binding affinities of epibatidine analogues
Org Biomol Chem 1: 3878

Rajendran V, Saxena A, Doctor BP, Kozikowski AP (2002)
Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B
Bioorganic & Medicinal Chemistry Lett 12: 1521

Campiani G, Kozikowski AP, Wang S, Ming L, Nacci V, Saxena A, Doctor BP (1998)
Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring
Bioorganic & Medicinal Chemistry Lett 8: 1413

Raves ML, Harel M, Pang YP, Silman I, Kozikowski AP, Sussman JL (1997)
Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A
Nat Struct Biol 4: 57

Pang YP, Kozikowski AP (1994)
Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies
J Comput Aided Mol Des 8: 669

Pang YP, Kozikowski AP (1994)
Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program
J Comput Aided Mol Des 8: 683

Saxena A, Qian N, Kovach IM, Kozikowski AP, Pang YP, Vellom DC, Radic Z, Quinn DM, Taylor P, Doctor BP (1994)
Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases
Protein Science 3: 1770

Tang XC, Kindel GH, Kozikowski AP, Hanin I (1994)
Comparison of the effects of natural and synthetic huperzine-A on rat brain cholinergic function in vitro and in vivo
J Ethnopharmacol 44: 147

Hanin I, Tang XC, Kindel GL, Kozikowski AP (1993)
Natural and synthetic Huperzine A: effect on cholinergic function in vitro and in vivo
Annals of the New York Academy of Sciences 695: 304

Geib SJ, Tuckmantel W, Kozikowski AP (1991)
Huperzine A--a potent acetylcholinesterase inhibitor of use in the treatment of Alzheimer's disease
Acta Crystallographica C47 pt4: 824

Mistry JS, Abraham DJ, Kozikowski AP, Hanin I (1991)
Neurochemistry of aging. 2. Design, synthesis, and biological evaluation of halomethyl analogues of choline with high affinity choline transport inhibitory activity
Journal of Medicinal Chemistry 34: 2031