Da Silva O, Probst N, Landry C, Hanak AS, Warnault P, Coisne C, Calas AG, Gosselet F, Courageux C, Gastellier AJ, Trancart M, Baati R, Dehouck MP, Jean L, Nachon F, Renard PY, Dias J (2022) <br />A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning<br /><i>Journal of Medicinal Chemistry</i> <br /><br />Viayna E, Coquelle N, Cieslikiewicz-Bouet M, Cisternas P, Oliva CA, Sanchez-Lopez E, Ettcheto M, Bartolini M, De Simone A, Ricchini M, Rendina M, Pons M, Firuzi O, Perez B, Saso L, Andrisano V, Nachon F, Brazzolotto X, Garcia ML, Camins A, Silman I, Jean L, Inestrosa NC, Colletier JP, Renard PY, Munoz-Torrero D (2021) <br />Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice<br /><i>Journal of Medicinal Chemistry</i> <b>64</b>: 812<br /><br />Cieslikiewicz-Bouet M, Naldi M, Bartolini M, Perez B, Servent D, Jean L, Araoz R, Renard PY (2020) <br />Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor<br /><i>Biochemical Pharmacology</i> <br /><br />Zorbaz T, Misetic P, Probst N, Zunec S, Zandona A, Mendas G, Micek V, Macek Hrvat N, Katalinic M, Braiki A, Jean L, Renard PY, Gabelica Markovic V, Kovarik Z (2020) <br />Pharmacokinetic evaluation of brain penetrating morpholine-3-hydroxy-2-pyridine oxime as an antidote for nerve agent poisoning<br /><i>ACS Chem Neurosci</i> <br /><br />Jean L, Brimijoin S, Vaux DJ (2019) <br />In vivo localization of human acetylcholinesterase-derived species in a beta-sheet conformation at the core of senile plaques in Alzheimer's disease<br /><i>Journal of Biological Chemistry</i> <b>294</b>: 6253<br /><br />Oukoloff K, Coquelle N, Bartolini M, Naldi M, Le Guevel R, Bach S, Josselin B, Ruchaud S, Catto M, Pisani L, Denora N, Iacobazzi RM, Silman I, Sussman JL, Buron F, Colletier JP, Jean L, Routier S, Renard PY (2019) <br />Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3<br /><i>Eur Journal of Medicinal Chemistry</i> <b>168</b>: 58<br /><br />Galdeano C, Coquelle N, Cieslikiewicz-Bouet M, Bartolini M, Perez B, Clos MV, Silman I, Jean L, Colletier JP, Renard PY, Munoz-Torrero D (2018) <br />Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis<br /><i>Molecules</i> <b>23</b>: <br /><br />Pashirova TN, Braiki A, Zueva IV, Petrov KA, Babaev VM, Burilova EA, Samarkina DA, Rizvanov IK, Souto EB, Jean L, Renard PY, Masson P, Zakharova LY, Sinyashin OG (2018) <br />Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection<br /><i>J Control Release</i> <b>290</b>: 102<br /><br />Santoni G, de Sousa J, De la Mora E, Dias J, Jean L, Sussman JL, Silman I, Renard PY, Brown RCD, Weik M, Baati R, Nachon F (2018) <br />Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents<br /><i>Journal of Medicinal Chemistry</i> <b>61</b>: 7630<br /><br />Zorbaz T, Braiki A, Marakovic N, Renou J, De la Mora E, Macek Hrvat N, Katalinic M, Silman I, Sussman JL, Mercey G, Gomez C, Mougeot R, Perez B, Baati R, Nachon F, Weik M, Jean L, Kovarik Z, Renard PY (2018) <br />Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration<br /><i>Chemistry</i> <b>24</b>: 9675<br /><br />Calas AG, Dias J, Rousseau C, Arboleas M, Touvrey-Loiodice M, Mercey G, Jean L, Renard PY, Nachon F (2017) <br />An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice<br /><i>Chemico-Biological Interactions</i> <b>267</b>: 11<br /><br />Renard PY, Jean L (2017) <br />Probing the cholinergic system to understand neurodegenerative diseases<br /><i>Future Med Chem</i> <b>9</b>: 131<br /><br />Chao S, Krejci E, Bernard V, Leroy J, Jean L, Renard PY (2016) <br />A selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging<br /><i>Chem Commun (Camb)</i> <b>52</b>: 11599<br /><br />Araoz R, Bouet m, Bartolini M, Coquelle N, Colletier JP, Servent D, Molgo J, Jean L, Renard PY (2015) <br />Poster: Multi-target directed ligands: Electrophysiological characterization of an anticholinesterase inhibitor coupled to an agonist of alpha7 nicotinic acetylcholine receptor<br /><i>Biochemical Pharmacology</i> <b>97</b>: 621<br /><br />Kliachyna M, Santoni G, Nussbaum V, Renou J, Sanson B, Colletier JP, Arboleas M, Loiodice M, Weik M, Jean L, Renard PY, Nachon F, Baati R (2014) <br />Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase<br /><i>Eur Journal of Medicinal Chemistry</i> <b>78C</b>: 455<br /><br />Oueis E, Santoni G, Ronco C, Syzgantseva O, Tognetti V, Joubert L, Romieu A, Weik M, Jean L, Sabot C, Nachon F, Renard PY (2014) <br />Reaction site-driven regioselective synthesis of AChE inhibitors<br /><i>Org Biomol Chem</i> <b>12</b>: 156<br /><br />Renou J, Loiodice M, Arboleas M, Baati R, Jean L, Nachon F, Renard PY (2014) <br />Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases<br /><i>Chem Commun (Camb)</i> <b>50</b>: 3947<br /><br />Nachon F, Carletti E, Ronco C, Trovaslet M, Nicolet Y, Jean L, Renard PY (2013) <br />Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase<br /><i>Biochemical Journal</i> <b>453</b>: 393<br /><br />Renou J, Mercey G, Verdelet T, Paunescu E, Gillon E, Arboleas M, Loiodice M, Kliachyna M, Baati R, Nachon F, Jean L, Renard PY (2013) <br />Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents<br /><i>Chemico-Biological Interactions</i> <b>203</b>: 81<br /><br />Brazzolotto X, Wandhammer M, Ronco C, Trovaslet M, Jean L, Lockridge O, Renard PY, Nachon F (2012) <br />Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure<br /><i>Febs J</i> <b>279</b>: 2905<br /><br />Mercey G, Renou J, Verdelet T, Kliachyna M, Baati R, Gillon E, Arboleas M, Loiodice M, Nachon F, Jean L, Renard PY (2012) <br />Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase<br /><i>Journal of Medicinal Chemistry</i> <b>55</b>: 10791<br /><br />Mercey G, Verdelet T, Renou J, Kliachyna M, Baati R, Nachon F, Jean L, Renard PY (2012) <br />Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents<br /><i>Acc Chem Res</i> <b>45</b>: 756<br /><br />Ronco C, Carletti E, Colletier JP, Weik M, Nachon F, Jean L, Renard PY (2012) <br />Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography<br /><i>ChemMedChem</i> <b>7</b>: 400<br /><br />Ziemianin A, Ronco C, Dole R, Jean L, Renard PY, Lange CM (2012) <br />Screening of new huprines--inhibitors of acetylcholinesterases by electrospray ionization ion trap mass spectrometry<br /><i>J Pharm Biomed Anal</i> <b>70</b>: 1<br /><br />Mercey G, Verdelet T, Saint-Andre G, Gillon E, Wagner A, Baati R, Jean L, Nachon F, Renard PY (2011) <br />First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase<br /><i>Chem Commun (Camb)</i> <b>47</b>: 5295<br /><br />Ronco C, Foucault R, Gillon E, Bohn P, Nachon F, Jean L, Renard PY (2011) <br />New huprine derivatives functionalized at position 9 as highly potent acetylcholinesterase inhibitors<br /><i>ChemMedChem</i> <b>6</b>: 876<br /><br />Ronco C, Sorin G, Nachon F, Foucault R, Jean L, Romieu A, Renard PY (2009) <br />Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors<br /><i>Bioorganic & Medicinal Chemistry</i> <b>17</b>: 4523<br /><br />Jean L, Lee CF, Shaw M, Vaux DJ (2008) <br />Structural elements regulating amyloidogenesis: a cholinesterase model system<br /><i>PLoS ONE</i> <b>3</b>: e1834<br /><br />Jean L, Thomas B, Tahiri-Alaoui A, Shaw M, Vaux DJ (2007) <br />Heterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease<br /><i>PLoS ONE</i> <b>2</b>: e652<br /><br />