Da Silva O, Probst N, Landry C, Hanak AS, Warnault P, Coisne C, Calas AG, Gosselet F, Courageux C, Gastellier AJ, Trancart M, Baati R, Dehouck MP, Jean L, Nachon F, Renard PY, Dias J (2022)
A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning
Journal of Medicinal Chemistry

Viayna E, Coquelle N, Cieslikiewicz-Bouet M, Cisternas P, Oliva CA, Sanchez-Lopez E, Ettcheto M, Bartolini M, De Simone A, Ricchini M, Rendina M, Pons M, Firuzi O, Perez B, Saso L, Andrisano V, Nachon F, Brazzolotto X, Garcia ML, Camins A, Silman I, Jean L, Inestrosa NC, Colletier JP, Renard PY, Munoz-Torrero D (2021)
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice
Journal of Medicinal Chemistry 64: 812

Cieslikiewicz-Bouet M, Naldi M, Bartolini M, Perez B, Servent D, Jean L, Araoz R, Renard PY (2020)
Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor
Biochemical Pharmacology

Zorbaz T, Misetic P, Probst N, Zunec S, Zandona A, Mendas G, Micek V, Macek Hrvat N, Katalinic M, Braiki A, Jean L, Renard PY, Gabelica Markovic V, Kovarik Z (2020)
Pharmacokinetic evaluation of brain penetrating morpholine-3-hydroxy-2-pyridine oxime as an antidote for nerve agent poisoning
ACS Chem Neurosci

Jean L, Brimijoin S, Vaux DJ (2019)
In vivo localization of human acetylcholinesterase-derived species in a beta-sheet conformation at the core of senile plaques in Alzheimer's disease
Journal of Biological Chemistry 294: 6253

Oukoloff K, Coquelle N, Bartolini M, Naldi M, Le Guevel R, Bach S, Josselin B, Ruchaud S, Catto M, Pisani L, Denora N, Iacobazzi RM, Silman I, Sussman JL, Buron F, Colletier JP, Jean L, Routier S, Renard PY (2019)
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3
Eur Journal of Medicinal Chemistry 168: 58

Galdeano C, Coquelle N, Cieslikiewicz-Bouet M, Bartolini M, Perez B, Clos MV, Silman I, Jean L, Colletier JP, Renard PY, Munoz-Torrero D (2018)
Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis
Molecules 23:

Pashirova TN, Braiki A, Zueva IV, Petrov KA, Babaev VM, Burilova EA, Samarkina DA, Rizvanov IK, Souto EB, Jean L, Renard PY, Masson P, Zakharova LY, Sinyashin OG (2018)
Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection
J Control Release 290: 102

Santoni G, de Sousa J, De la Mora E, Dias J, Jean L, Sussman JL, Silman I, Renard PY, Brown RCD, Weik M, Baati R, Nachon F (2018)
Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents
Journal of Medicinal Chemistry 61: 7630

Zorbaz T, Braiki A, Marakovic N, Renou J, De la Mora E, Macek Hrvat N, Katalinic M, Silman I, Sussman JL, Mercey G, Gomez C, Mougeot R, Perez B, Baati R, Nachon F, Weik M, Jean L, Kovarik Z, Renard PY (2018)
Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration
Chemistry 24: 9675

Calas AG, Dias J, Rousseau C, Arboleas M, Touvrey-Loiodice M, Mercey G, Jean L, Renard PY, Nachon F (2017)
An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice
Chemico-Biological Interactions 267: 11

Renard PY, Jean L (2017)
Probing the cholinergic system to understand neurodegenerative diseases
Future Med Chem 9: 131

Chao S, Krejci E, Bernard V, Leroy J, Jean L, Renard PY (2016)
A selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging
Chem Commun (Camb) 52: 11599

Araoz R, Bouet m, Bartolini M, Coquelle N, Colletier JP, Servent D, Molgo J, Jean L, Renard PY (2015)
Poster: Multi-target directed ligands: Electrophysiological characterization of an anticholinesterase inhibitor coupled to an agonist of alpha7 nicotinic acetylcholine receptor
Biochemical Pharmacology 97: 621

Kliachyna M, Santoni G, Nussbaum V, Renou J, Sanson B, Colletier JP, Arboleas M, Loiodice M, Weik M, Jean L, Renard PY, Nachon F, Baati R (2014)
Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase
Eur Journal of Medicinal Chemistry 78C: 455

Oueis E, Santoni G, Ronco C, Syzgantseva O, Tognetti V, Joubert L, Romieu A, Weik M, Jean L, Sabot C, Nachon F, Renard PY (2014)
Reaction site-driven regioselective synthesis of AChE inhibitors
Org Biomol Chem 12: 156

Renou J, Loiodice M, Arboleas M, Baati R, Jean L, Nachon F, Renard PY (2014)
Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases
Chem Commun (Camb) 50: 3947

Nachon F, Carletti E, Ronco C, Trovaslet M, Nicolet Y, Jean L, Renard PY (2013)
Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase
Biochemical Journal 453: 393

Renou J, Mercey G, Verdelet T, Paunescu E, Gillon E, Arboleas M, Loiodice M, Kliachyna M, Baati R, Nachon F, Jean L, Renard PY (2013)
Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents
Chemico-Biological Interactions 203: 81

Brazzolotto X, Wandhammer M, Ronco C, Trovaslet M, Jean L, Lockridge O, Renard PY, Nachon F (2012)
Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure
Febs J 279: 2905

Mercey G, Renou J, Verdelet T, Kliachyna M, Baati R, Gillon E, Arboleas M, Loiodice M, Nachon F, Jean L, Renard PY (2012)
Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase
Journal of Medicinal Chemistry 55: 10791

Mercey G, Verdelet T, Renou J, Kliachyna M, Baati R, Nachon F, Jean L, Renard PY (2012)
Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents
Acc Chem Res 45: 756

Ronco C, Carletti E, Colletier JP, Weik M, Nachon F, Jean L, Renard PY (2012)
Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography
ChemMedChem 7: 400

Ziemianin A, Ronco C, Dole R, Jean L, Renard PY, Lange CM (2012)
Screening of new huprines--inhibitors of acetylcholinesterases by electrospray ionization ion trap mass spectrometry
J Pharm Biomed Anal 70: 1

Mercey G, Verdelet T, Saint-Andre G, Gillon E, Wagner A, Baati R, Jean L, Nachon F, Renard PY (2011)
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase
Chem Commun (Camb) 47: 5295

Ronco C, Foucault R, Gillon E, Bohn P, Nachon F, Jean L, Renard PY (2011)
New huprine derivatives functionalized at position 9 as highly potent acetylcholinesterase inhibitors
ChemMedChem 6: 876

Ronco C, Sorin G, Nachon F, Foucault R, Jean L, Romieu A, Renard PY (2009)
Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry 17: 4523

Jean L, Lee CF, Shaw M, Vaux DJ (2008)
Structural elements regulating amyloidogenesis: a cholinesterase model system
PLoS ONE 3: e1834

Jean L, Thomas B, Tahiri-Alaoui A, Shaw M, Vaux DJ (2007)
Heterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease
PLoS ONE 2: e652