Liu P, Ewis HE, Tai PC, Lu CD, Weber IT (2007)
Crystal structure of the Geobacillus stearothermophilus carboxylesterase Est55 and its activation of prodrug CPT-11
Journal of Molecular Biology 367: 212

Harel M, Hyatt JL, Brumshtein B, Morton CL, Yoon KJ, Wadkins RM, Silman I, Sussman JL, Potter PM (2005)
The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action
Molecular Pharmacology 67: 1874

Harel M, Hyatt JL, Brumshtein B, Morton CL, Wadkins RM, Silman I, Sussman JL, Potter PM (2005)
The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase
Chemico-Biological Interactions 157-158: 153

Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM (2005)
Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11
Chemico-Biological Interactions 157-158: 247

Ma MK, McLeod HL (2003)
Lessons learned from the irinotecan metabolic pathway
Curr Med Chem 10: 41

Ohtsuka K, Inoue S, Kameyama M, Kanetoshi A, Fujimoto T, Takaoka K, Araya Y, Shida A (2003)
Intracellular conversion of irinotecan to its active form, SN-38, by native carboxylesterase in human non-small cell lung cancer
Lung Cancer 41: 187

Tobin PJ, Dodds HM, Clarke S, Schnitzler M, Rivory LP (2003)
The relative contributions of carboxylesterase and beta-glucuronidase in the formation of SN-38 in human colorectal tumours
Oncol Rep 10: 1977

Sai K, Kaniwa N, Ozawa S, Sawada JI (2001)
A new metabolite of irinotecan in which formation is mediated by human hepatic cytochrome P-450 3A4
Drug Metabolism & Disposition: The Biological Fate of Chemicals 29: 1505

Santos A, Zanetta S, Cresteil T, Deroussent A, Pein F, Raymond E, Vernillet L, Risse ML, Boige V, Gouyette A, Vassal G (2000)
Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans
Clin Cancer Research 6: 2012

Wierdl M, Morton CL, Danks MK, Potter PM (2000)
Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation
Biochemical Pharmacology 59: 773

Dodds HM, Rivory LP (1999)
The mechanism for the inhibition of acetylcholinesterases by irinotecan (CPT-11)
Molecular Pharmacology 56: 1346

Morton CL, Wadkins RM, Danks MK, Potter PM (1999)
The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase
Cancer Research 59: 1458

Wadkins RM, Potter PM, Vladu B, Marty J, Mangold G, Weitman S, Manikumar G, Wani MC, Wall ME, Von Hoff DD (1999)
Water soluble 20(S)-glycinate esters of 10,11-methylenedioxycamptothecins are highly active against human breast cancer xenografts
Cancer Research 59: 3424

Danks MK, Morton CL, Pawlik CA, Potter PM (1998)
Overexpression of a rabbit liver carboxylesterase sensitizes human tumor cells to CPT-11
Cancer Research 58: 20

Guichard SM, Morton CL, Krull EJ, Stewart CF, Danks MK, Potter PM (1998)
Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver carboxylesterase
Clin Cancer Research 4: 3089

Hecht JR (1998)
Gastrointestinal toxicity or irinotecan
Oncology 12: 72

Kuhn JG (1998)
Pharmacology of irinotecan
Oncology 12: 39

Potter PM, Pawlik CA, Morton CL, Naeve CW, Danks MK (1998)
Isolation and partial characterization of a cDNA encoding a rabbit liver carboxylesterase that activates the prodrug irinotecan (CPT-11)
Cancer Research 58: 2646

Potter PM, Wolverton JS, Morton CL, Wierdl M, Danks MK (1998)
Cellular localization domains of a rabbit and a human carboxylesterase: influence on irinotecan (CPT-11) metabolism by the rabbit enzyme
Cancer Research 58: 3627

Haaz MC, Rivory LP, Riche C, Robert J (1997)
The transformation of irinotecan (CPT-11) to its active metabolite SN-38 by human liver microsomes. Differential hydrolysis for the lactone and carboxylate forms
Naunyn Schmiedebergs Arch Pharmacol 356: 257

Jansen WJ, Zwart B, Hulscher ST, Giaccone G, Pinedo HM, Boven E (1997)
CPT-11 in human colon-cancer cell lines and xenografts: characterization of cellular sensitivity determinants
International Journal of Cancer 70: 335

Slatter JG, Su P, Sams JP, Schaaf LJ, Wienkers LC (1997)
Bioactivation of the anticancer agent CPT-11 to SN-38 by human hepatic microsomal carboxylesterases and the in vitro assessment of potential drug interactions
Drug Metabolism & Disposition: The Biological Fate of Chemicals 25: 1157

Rivory LP, Riou JF, Haaz MC, Sable S, Vuilhorgne M, Commercon A, Pond SM, Robert J (1996)
Identification and properties of a major plasma metabolite of irinotecan (CPT-11) isolated from the plasma of patients
Cancer Research 56: 3689

Rivory LP, Bowles MR, Robert J, Pond SM (1996)
Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by human liver carboxylesterase
Biochemical Pharmacology 52: 1103