Hatfield MJ, Chen J, Fratt EM, Chi L, Bollinger JC, Binder RJ, Bowling J, Hyatt JL, Scarborough J, Jeffries C, Potter PM (2017)
Selective Inhibitors of Human Liver Carboxylesterase Based on a beta-Lapachone Scaffold: Novel Reagents for Reaction Profiling
Journal of Medicinal Chemistry 60: 1568

Hatfield MJ, Umans RA, Hyatt JL, Edwards CC, Wierdl M, Tsurkan L, Taylor MR, Potter PM (2016)
Carboxylesterases: General detoxifying enzymes
Chemico-Biological Interactions 259: 327

Hatfield MJ, Tsurkan LG, Hyatt JL, Edwards CC, Lemoff A, Jeffries C, Yan B, Potter PM (2013)
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza (Danshen)
Journal of Natural Products 76: 36

Tsurkan LG, Hatfield MJ, Edwards CC, Hyatt JL, Potter PM (2013)
Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors
Chemico-Biological Interactions 203: 226

Hatfield MJ, Tsurkan L, Garrett M, Shaver TM, Hyatt JL, Edwards CC, Hicks LD, Potter PM (2011)
Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11
Biochemical Pharmacology 81: 24

Parkinson EI, Hatfield MJ, Tsurkan L, Hyatt JL, Edwards CC, Hicks LD, Yan B, Potter PM (2011)
Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones
Bioorganic & Medicinal Chemistry 19: 4635

Hatfield MJ, Tsurkan LG, Hyatt JL, Yu X, Edwards CC, Hicks LD, Wadkins RM, Potter PM (2010)
Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin
British Journal of Pharmacology 160: 1916

Young BM, Hyatt JL, Bouck DC, Chen T, Hanumesh P, Price J, Boyd VA, Potter PM, Webb TR (2010)
Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors
Journal of Medicinal Chemistry 53: 8709

Hicks LD, Hyatt JL, Stoddard S, Tsurkan L, Edwards CC, Wadkins RM, Potter PM (2009)
Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity
Journal of Medicinal Chemistry 52: 3742

Barthel BL, Torres RC, Hyatt JL, Edwards CC, Hatfield MJ, Potter PM, Koch TH (2008)
Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug
Journal of Medicinal Chemistry 51: 298

Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM (2008)
An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11
Cancer Gene Therapy 15: 183

Hicks LD, Hyatt JL, Moak T, Edwards CC, Tsurkan L, Wierdl M, Ferreira AM, Wadkins RM, Potter PM (2007)
Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils
Bioorganic & Medicinal Chemistry 15: 3801

Hyatt JL, Wadkins RM, Tsurkan L, Hicks LD, Hatfield MJ, Edwards CC, Ross CR, 2nd, Cantalupo SA, Crundwell G, Danks MK, Guy RK, Potter PM (2007)
Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1
Journal of Medicinal Chemistry 50: 5727

Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM (2007)
Selective inhibition of carboxylesterases by isatins, indole-2,3-diones
Journal of Medicinal Chemistry 50: 1876

Wadkins RM, Hyatt JL, Edwards CC, Tsurkan L, Redinbo MR, Wheelock CE, Jones PD, Hammock BD, Potter PM (2007)
Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds
Molecular Pharmacology 71: 713

Hyatt JL, Tsurkan L, Wierdl M, Edwards CC, Danks MK, Potter PM (2006)
Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity
Mol Cancer Ther 5: 2281

Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, Redinbo MR (2005)
Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil
Journal of Molecular Biology 352: 165

Harel M, Hyatt JL, Brumshtein B, Morton CL, Yoon KJ, Wadkins RM, Silman I, Sussman JL, Potter PM (2005)
The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action
Molecular Pharmacology 67: 1874

Harel M, Hyatt JL, Brumshtein B, Morton CL, Wadkins RM, Silman I, Sussman JL, Potter PM (2005)
The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase
Chemico-Biological Interactions 157-158: 153

Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM (2005)
Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11
Chemico-Biological Interactions 157-158: 247

Hyatt JL, Stacy V, Wadkins RM, Yoon KJ, Wierdl M, Edwards CC, Zeller M, Hunter AD, Danks MK, Crundwell G, Potter PM (2005)
Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety
Journal of Medicinal Chemistry 48: 5543

Morton CL, Iacono L, Hyatt JL, Taylor KR, Cheshire PJ, Houghton PJ, Danks MK, Stewart CF, Potter PM (2005)
Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice
Cancer Chemother Pharmacol 56: 629

Tyminski E, Leroy S, Terada K, Finkelstein DM, Hyatt JL, Danks MK, Potter PM, Saeki Y, Chiocca EA (2005)
Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan
Cancer Research 65: 6850

Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K, Beroza P, Danks MK, Potter PM (2005)
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases
Journal of Medicinal Chemistry 48: 2906

Wadkins RM, Hyatt JL, Yoon KJ, Morton CL, Lee RE, Damodaran K, Beroza P, Danks MK, Potter PM (2004)
Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity
Molecular Pharmacology 65: 1336

Yoon KJ, Hyatt JL, Morton CL, Lee RE, Potter PM, Danks MK (2004)
Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application
Mol Cancer Ther 3: 903

Bencharit S, Morton CL, Hyatt JL, Kuhn P, Danks MK, Potter PM, Redinbo MR (2003)
Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition
Chemical Biology 10: 341