Chen H, Wu X, Gu X, Zhou Y, Ye L, Zhang K, Pan H, Wang J, Wei H, Zhu B, Naman CB, Mak SH, Carlier PR, Cui W, Han YF (2018) <br />Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice<br /><i>Front Cell Neurosci</i> <b>12</b>: 396<br /><br />Huang L, Lin J, Xiang S, Zhao K, Yu J, Zheng J, Xu D, Mak SH, Hu S, Nirasha S, Wang C, Chen X, Zhang J, Xu S, Wei X, Zhang Z, Zhou D, Zhou W, Cui W, Han YF, Hu Z, Wang Q (2016) <br />Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice<br /><i>ACS Chem Neurosci</i> <b>7</b>: 1047<br /><br />Chang L, Cui W, Yang Y, Xu S, Zhou WH, Fu HJ, Hu SQ, Mak SH, Hu JW, Wang Q, Pui-Yan Ma V, Chung-Lit Choi T, Dik-Lung Ma E, Tao L, Pang YP, Rowan MJ, Anwyl R, Han YF (2015) <br />Protection against beta-amyloid-induced synaptic and memory impairments via altering beta-amyloid assembly by bis(heptyl)-cognitin<br /><i>Sci Rep</i> <b>5</b>: 10256<br /><br />Hu SQ, Wang R, Cui W, Mak SH, Li G, Hu YJ, Lee MY, Pang YP, Han YF (2015) <br />Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's beta-Amyloid Neurotoxicity Via the Inhibition of Abeta Fibrils Formation and Disaggregation of Preformed Fibrils<br /><i>CNS Neurosci Ther</i> <b>21</b>: 953<br /><br />Hu SQ, Cui W, Xu DP, Mak SH, Tang J, Choi CL, Pang YP, Han YF (2013) <br />Substantial Neuroprotection Against K(+) Deprivation-Induced Apoptosis in Primary Cerebellar Granule Neurons by Novel Dimer Bis(propyl)-Cognitin Via the Activation of VEGFR-2 Signaling Pathway<br /><i>CNS Neurosci Ther</i> <b>19</b>: 764<br /><br />Han RW, Zhang RS, Chang M, Peng YL, Wang P, Hu SQ, Choi CL, Yin M, Wang R, Han YF (2012) <br />Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins<br /><i>Brain Research</i> <b>1470</b>: 59<br /><br />Cui W, Cui GZ, Li W, Zhang Z, Hu S, Mak SH, Zhang H, Carlier PR, Choi CL, Wong YT, Lee SM, Han YF (2011) <br />Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through alpha7 nAChR<br /><i>Brain Research</i> <b>1401</b>: 10<br /><br />Cui W, Li W, Zhao Y, Mak SH, Gao Y, Luo J, Zhang H, Liu Y, Carlier PR, Rong J, Han YF (2011) <br />Preventing H(2)O(2)-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone<br /><i>Brain Research</i> <b>1394</b>: 14<br /><br />Pan SY, Guo BF, Zhang Y, Yu Q, Yu ZL, Dong H, Ye Y, Han YF, Ko KM (2011) <br />Tacrine treatment at high dose suppresses the recognition memory in juvenile and adult mice with attention to hepatotoxicity<br /><i>Basic Clin Pharmacol Toxicol</i> <b>108</b>: 421<br /><br />Zhang H, Mak SH, Cui W, Li W, Han R, Hu S, Ye M, Pi R, Han YF (2011) <br />Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway<br /><i>Neurochem Int</i> <b>59</b>: 981<br /><br />Zhou L, Liu YW, Peoples RW, Yang M, Tian X, Ai YX, Pang YP, Li ZW, Han YF, Li CY (2009) <br />Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons<br /><i>Neuropharmacology</i> <b>57</b>: 33<br /><br />Liu YW, Luo JL, Ren H, Peoples RW, Ai YX, Liu LJ, Pang YP, Li ZW, Han YF, Li CY (2008) <br />Inhibition of NMDA-gated ion channels by bis(7)-tacrine: whole-cell and single-channel studies<br /><i>Neuropharmacology</i> <b>54</b>: 1086<br /><br />Yu H, Li WM, Kan KK, Ho JM, Carlier PR, Pang YP, Gu ZM, Zhong Z, Chan K, Wang YT, Han YF (2008) <br />The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine<br /><i>J Pharm Biomed Anal</i> <b>46</b>: 75<br /><br />Zhang L, Yu H, Li WM, Cheung MC, Pang YP, Lin G, Wang YT, Zuo Z, Han YF (2008) <br />Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry<br /><i>Biomedical Chromatography</i> <b>22</b>: 414<br /><br />Li WM, Kan KK, Carlier PR, Pang YP, Han YF (2007) <br />East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A<br /><i>Curr Alzheimer Res</i> <b>4</b>: 386<br /><br />Xiao XQ, Wu DC, Gao Y, Fu Y, Lee NT, Ho WL, Tsim KWK, Han YF (2004) <br />Huperzine A, a promising anti-Alzheimer?s agent, reduces staurosporine-induced apoptosis in NG108-15 cells.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL (2003) <br />Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity<br /><i>J Am Chem Soc</i> <b>125</b>: 363<br /><br />Carlier PR, Du DM, Han YF, Liu J, Perola E, Williams ID, Pang YP (2000) <br />Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product<br /><i>Angew Chem Int Ed Engl</i> <b>39</b>: 1775<br /><br />Pan SY, Han YF (2000) <br />Learning deficits induced by 4 belladonna alkaloids are preferentially attenuated by tacrine<br /><i>Acta Pharmacol Sin</i> <b>21</b>: 124<br /><br />Wang LM, Han YF, Tang XC (2000) <br />Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats<br /><i>European Journal of Pharmacology</i> <b>398</b>: 65<br /><br />Wu DC, Xiao XQ, Ng AK, Chen PM, Chung W, Lee NT, Carlier PR, Pang YP, Yu AC, Han YF (2000) <br />Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected]<br /><i>Neuroscience Letters</i> <b>288</b>: 95<br /><br />Xiao XQ, Wang R, Han YF, Tang XC (2000) <br />Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells<br /><i>Neuroscience Letters</i> <b>286</b>: 155<br /><br />Xiao XQ, Lee NT, Carlier PR, Pang Y, Han YF (2000) <br />Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine<br /><i>Neuroscience Letters</i> <b>290</b>: 197<br /><br />Carlier PR, Han YF, Chow ES, Li CP, Wang H, Lieu TX, Wong HS, Pang YP (1999) <br />Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis<br /><i>Bioorganic & Medicinal Chemistry</i> <b>7</b>: 351<br /><br />Han YF, Li CP, Chow E, Wang H, Pang YP, Carlier PR (1999) <br />Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities<br /><i>Bioorganic & Medicinal Chemistry</i> <b>7</b>: 2569<br /><br />Li CY, Wang H, Xue H, Carlier PR, Hui KM, Pang YP, Li ZW, Han YF (1999) <br />Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist<br /><i>Neuroreport</i> <b>10</b>: 795<br /><br />Wang H, Carlier PR, Ho WL, Wu DC, Lee NT, Li CP, Pang YP, Han YF (1999) <br />Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE<br /><i>Neuroreport</i> <b>10</b>: 789<br /><br />Wang H, Carlier PR, Ho WL, Lee NT, Pang YP, Han YF (1999) <br />Attenuation of scopolamine-induced deficits in navigational memory performance in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor<br /><i>Zhongguo Yao Li Xue Bao</i> <b>20</b>: 211<br /><br />