Chen H, Wu X, Gu X, Zhou Y, Ye L, Zhang K, Pan H, Wang J, Wei H, Zhu B, Naman CB, Mak SH, Carlier PR, Cui W, Han YF (2018)
Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice
Front Cell Neurosci 12: 396

Huang L, Lin J, Xiang S, Zhao K, Yu J, Zheng J, Xu D, Mak SH, Hu S, Nirasha S, Wang C, Chen X, Zhang J, Xu S, Wei X, Zhang Z, Zhou D, Zhou W, Cui W, Han YF, Hu Z, Wang Q (2016)
Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice
ACS Chem Neurosci 7: 1047

Chang L, Cui W, Yang Y, Xu S, Zhou WH, Fu HJ, Hu SQ, Mak SH, Hu JW, Wang Q, Pui-Yan Ma V, Chung-Lit Choi T, Dik-Lung Ma E, Tao L, Pang YP, Rowan MJ, Anwyl R, Han YF (2015)
Protection against beta-amyloid-induced synaptic and memory impairments via altering beta-amyloid assembly by bis(heptyl)-cognitin
Sci Rep 5: 10256

Hu SQ, Wang R, Cui W, Mak SH, Li G, Hu YJ, Lee MY, Pang YP, Han YF (2015)
Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's beta-Amyloid Neurotoxicity Via the Inhibition of Abeta Fibrils Formation and Disaggregation of Preformed Fibrils
CNS Neurosci Ther 21: 953

Hu SQ, Cui W, Xu DP, Mak SH, Tang J, Choi CL, Pang YP, Han YF (2013)
Substantial Neuroprotection Against K(+) Deprivation-Induced Apoptosis in Primary Cerebellar Granule Neurons by Novel Dimer Bis(propyl)-Cognitin Via the Activation of VEGFR-2 Signaling Pathway
CNS Neurosci Ther 19: 764

Han RW, Zhang RS, Chang M, Peng YL, Wang P, Hu SQ, Choi CL, Yin M, Wang R, Han YF (2012)
Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins
Brain Research 1470: 59

Cui W, Cui GZ, Li W, Zhang Z, Hu S, Mak SH, Zhang H, Carlier PR, Choi CL, Wong YT, Lee SM, Han YF (2011)
Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through alpha7 nAChR
Brain Research 1401: 10

Cui W, Li W, Zhao Y, Mak SH, Gao Y, Luo J, Zhang H, Liu Y, Carlier PR, Rong J, Han YF (2011)
Preventing H(2)O(2)-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone
Brain Research 1394: 14

Pan SY, Guo BF, Zhang Y, Yu Q, Yu ZL, Dong H, Ye Y, Han YF, Ko KM (2011)
Tacrine treatment at high dose suppresses the recognition memory in juvenile and adult mice with attention to hepatotoxicity
Basic Clin Pharmacol Toxicol 108: 421

Zhang H, Mak SH, Cui W, Li W, Han R, Hu S, Ye M, Pi R, Han YF (2011)
Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway
Neurochem Int 59: 981

Zhou L, Liu YW, Peoples RW, Yang M, Tian X, Ai YX, Pang YP, Li ZW, Han YF, Li CY (2009)
Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons
Neuropharmacology 57: 33

Liu YW, Luo JL, Ren H, Peoples RW, Ai YX, Liu LJ, Pang YP, Li ZW, Han YF, Li CY (2008)
Inhibition of NMDA-gated ion channels by bis(7)-tacrine: whole-cell and single-channel studies
Neuropharmacology 54: 1086

Yu H, Li WM, Kan KK, Ho JM, Carlier PR, Pang YP, Gu ZM, Zhong Z, Chan K, Wang YT, Han YF (2008)
The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine
J Pharm Biomed Anal 46: 75

Zhang L, Yu H, Li WM, Cheung MC, Pang YP, Lin G, Wang YT, Zuo Z, Han YF (2008)
Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry
Biomedical Chromatography 22: 414

Li WM, Kan KK, Carlier PR, Pang YP, Han YF (2007)
East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A
Curr Alzheimer Res 4: 386

Xiao XQ, Wu DC, Gao Y, Fu Y, Lee NT, Ho WL, Tsim KWK, Han YF (2004)
Huperzine A, a promising anti-Alzheimer?s agent, reduces staurosporine-induced apoptosis in NG108-15 cells.
Cholinergic Mechanisms, CRC Press

Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL (2003)
Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity
J Am Chem Soc 125: 363

Carlier PR, Du DM, Han YF, Liu J, Perola E, Williams ID, Pang YP (2000)
Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product
Angew Chem Int Ed Engl 39: 1775

Pan SY, Han YF (2000)
Learning deficits induced by 4 belladonna alkaloids are preferentially attenuated by tacrine
Acta Pharmacol Sin 21: 124

Wang LM, Han YF, Tang XC (2000)
Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats
European Journal of Pharmacology 398: 65

Wu DC, Xiao XQ, Ng AK, Chen PM, Chung W, Lee NT, Carlier PR, Pang YP, Yu AC, Han YF (2000)
Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected]
Neuroscience Letters 288: 95

Xiao XQ, Wang R, Han YF, Tang XC (2000)
Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells
Neuroscience Letters 286: 155

Xiao XQ, Lee NT, Carlier PR, Pang Y, Han YF (2000)
Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine
Neuroscience Letters 290: 197

Carlier PR, Han YF, Chow ES, Li CP, Wang H, Lieu TX, Wong HS, Pang YP (1999)
Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis
Bioorganic & Medicinal Chemistry 7: 351

Han YF, Li CP, Chow E, Wang H, Pang YP, Carlier PR (1999)
Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities
Bioorganic & Medicinal Chemistry 7: 2569

Li CY, Wang H, Xue H, Carlier PR, Hui KM, Pang YP, Li ZW, Han YF (1999)
Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist
Neuroreport 10: 795

Wang H, Carlier PR, Ho WL, Wu DC, Lee NT, Li CP, Pang YP, Han YF (1999)
Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE
Neuroreport 10: 789

Wang H, Carlier PR, Ho WL, Lee NT, Pang YP, Han YF (1999)
Attenuation of scopolamine-induced deficits in navigational memory performance in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor
Zhongguo Yao Li Xue Bao 20: 211