Hayes TR, Chao CK, Blecha JE, Huynh TL, Zinn KR, Thompson CM, Gerdes JM, VanBrocklin HF (2021)
Biological Distribution and Metabolic Profiles of Carbon-11 and Fluorine-18 Tracers of VX- and Sarin-Analogs in Sprague-Dawley Rats
Chemical Research in Toxicology 34: 63
Hayes TR, Blecha JE, Chao CK, Huynh TL, VanBrocklin HD, Zinn KR, Taylor P, Gerdes JM, Thompson CM (2020)
Positron emission tomography evaluation of oxime countermeasures in live rats using the tracer O-(2-[(18) F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate [(18) F]-VXS
Annals of the New York Academy of Sciences
Thompson CM, Gerdes JM, VanBrocklin HF (2020)
Positron emission tomography studies of organophosphate chemical threats and oxime countermeasures
Neurobiol Dis 133: 104455
Hayes TR, Blecha JE, Thompson CM, Gerdes JM, VanBrocklin HF (2019)
Divergent synthesis of organophosphate [(11)C]VX- and [(11)C]Sarin-surrogates from a common set of starting materials
Appl Radiat Isot 151: 182
Chao CK, Balasubramanian N, Gerdes JM, Thompson CM (2018)
The inhibition, reactivation and mechanism of VX-, sarin-, fluoro-VX and fluoro-sarin surrogates following their interaction with HuAChE and HuBuChE
Chemico-Biological Interactions 291: 220
Hayes TR, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF (2018)
Radiosynthesis of O-(1-[(18) F]fluoropropan-2-yl)-O-(4-nitrophenyl)methylphosphonate: A novel PET tracer surrogate of sarin
J Labelled Comp Radiopharm 61: 1089
Neumann KD, Blecha JE, Hayes TR, Huynh T, Chao CK, Guilloteau N, Zinn KR, VanBrocklin HF, Thompson CM, Gerdes JM (2018)
Radiosynthesis, ex Vivo Biodistribution, and in Vivo Positron Emission Tomography Imaging Evaluations of [(11)C]2-Pyridinealdoxime Methiodide ([(11)C]2-PAM): A First-In-Class Antidote Tracer for Organophosphate Intoxication
ACS Chem Neurosci 9: 3007
Neumann KD, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF (2017)
An improved radiosynthesis of O-(2-[18 F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate: A first-in-class cholinesterase PET tracer
J Labelled Comp Radiopharm 60: 337
Chao CK, Ahmed SK, Gerdes JM, Thompson CM (2016)
Novel Organophosphate Ligand O-(2-Fluoroethyl)-O-(p-Nitrophenyl)Methylphosphonate: Synthesis, Hydrolytic Stability and Analysis of the Inhibition and Reactivation of Cholinesterases
Chemical Research in Toxicology 29: 1810
James SL, Ahmed SK, Murphy S, Braden MR, Belabassi Y, VanBrocklin HF, Thompson CM, Gerdes JM (2014)
A Novel Fluorine-18 beta-Fluoroethoxy Organophosphate Positron Emission Tomography Imaging Tracer Targeted to Central Nervous System Acetylcholinesterase
ACS Chem Neurosci 5: 519
Kaleem Ahmed S, Belabassi Y, Sankaranarayanan L, Chao CK, Gerdes JM, Thompson CM (2013)
Synthesis and anti-acetylcholinesterase properties of novel beta- and gamma-substituted alkoxy organophosphonates
Bioorganic & Medicinal Chemistry Lett 23: 2048
Guo L, Suarez AI, Braden MR, Gerdes JM, Thompson CM (2010)
Inhibition of acetylcholinesterase by chromophore-linked fluorophosphonates
Bioorganic & Medicinal Chemistry Lett 20: 1194