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selective AChE inhibitors with GSK-3beta inhibitory property for the treatment of Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>229</b>: 114095<br /><br />Nasir F, Bahadur A, Lin X, Gao Y, Tian C (2021) <br />Novel insights into host receptors and receptor-mediated signaling that regulate arbuscular mycorrhizal symbiosis<br /><i>J Exp Bot</i> <b>72</b>: 1546<br /><br />Wu D, Gao D, Yu H, Pi G, Xiong R, Lei H, Wang X, Liu E, Ye J, Gao Y, He T, Jiang T, Sun F, Su J, Song G, Peng W, Yang Y, Wang JZ (2021) <br />Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway<br /><i>Clin Transl Med</i> <b>11</b>: e428<br /><br />Yang Y, Zhao Y, Liu Q, You T, Gao Y, Chen H, Yin P (2021) <br />A highly sensitive acetylcholinesterase electrochemical biosensor based on Au-Tb alloy nanospheres for determining organophosphate pesticides<br /><i>Nanotechnology</i> <br /><br />Zhao J, Liu S, Gao Y, Ma M, Yan X, Cheng D, Wan D, Zeng Z, Yu P, Gong D (2021) <br />Characterization of a novel lipase from Bacillus licheniformis NCU CS-5 for applications in detergent industry and biodegradation of 2,4-D butyl ester<br /><i>Int J Biol Macromol</i> <br /><br />van Haren MJ, Gao Y, Buijs N, Campagna R, Sartini D, Emanuelli M, Mateuszuk L, Kij A, Chlopicki S, Escude Martinez de Castilla P, Schiffelers R, Martin NI (2021) <br />Esterase-Sensitive Prodrugs of a Potent Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT) Display Cellular Activity<br /><i>Biomolecules</i> <b>11</b>: 1357<br /><br />Ding J, Zhou Y, Zhu H, Deng M, Gao Y, Yang Y, Huang Z (2020) <br />Characterization of EstZY: A new acetylesterase with 7-aminocephalosporanic acid deacetylase activity from Alicyclobacillus tengchongensis<br /><i>Int J Biol Macromol</i> <b>148</b>: 333<br /><br />Gao Y, Fang L, Xiang QQ, Wang D, Ding LY, Ding CZ, Chen LQ (2020) <br />Ecological risk assessment of heavy metals in fish from the Dianchi 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Epacromius coerulipes<br /><i>Pest Manag Sci</i> <b>76</b>: 227<br /><br />Li T, Gao Y, Li H, Zhang C, Xing Y, Jiao M, Shi YE, Li W, Zhai Y, Wang Z (2020) <br />Ultrasensitive detection of butyrylcholinesterase activity based on the inner filter effect of MnO(2) nanosheets on sulfur nanodots<br /><i>Analyst</i> <b>145</b>: 5206<br /><br />Liu J, Fernandez D, Gao Y, Pierre S, Dai G (2020) <br />Enzymology, Histological and Ultrastructural Effects of Ar-Turmerone on Culex pipiens pallens Larvae<br /><i>Insects</i> <b>11</b>: <br /><br />Ma W, Bi J, Zhao C, Gao Y, Zhang G (2020) <br />Design, synthesis and biological evaluation of acridone glycosides as selective BChE inhibitors<br /><i>Carbohydr Res</i> <b>491</b>: 107977<br /><br />Man J, Cui K, Fu X, Zhang D, Lu Z, Gao Y, Yu L, Li N, Wang J (2020) <br />Donepezil promotes neurogenesis via Src signaling pathway in a rat model of chronic cerebral hypoperfusion<br /><i>Brain Research</i> <b>1736</b>: 146782<br /><br />Weng S, Fan Z, Qiu 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Butyrylcholinesterase: A BChE-Ghrelin Axis<br /><i>Chemico-Biological Interactions</i> <b>259</b>: 271<br /><br />Cai C, Gao Y, Liu Y, Zhong N, Liu N (2016) <br />Immobilization of Candida antarctica lipase B onto SBA-15 and their application in glycerolysis for diacylglycerols synthesis<br /><i>Food Chem</i> <b>212</b>: 205<br /><br />Chen VP, Gao Y, Geng L, Stout MB, Jensen MD, Brimijoin S (2016) <br />Butyrylcholinesterase deficiency promotes adipose tissue growth and hepatic lipid accumulation in male mice on high-fat diet<br /><i>Endocrinology</i> <br /><br />Grabner GF, Eichmann TO, Wagner B, Gao Y, Farzi A, Taschler U, Radner FP, Schweiger M, Lass A, Holzer P, Zinser E, Tschop MH, Yi CX, Zimmermann R (2016) <br />Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation<br /><i>Journal of Biological Chemistry</i> <b>291</b>: 913<br /><br />Murthy V, Reyes S, Geng L, Gao Y, Brimijoin S (2016) <br />Cocaine Hydrolase Gene Transfer 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Toxicity of Cocaine Metabolites Generated by Cocaine Hydrolase<br /><i>Cellular Molecular Neurobiology</i> <b>35</b>: 819<br /><br />Sarma BK, Liu X, Wu H, Gao Y, Kodadek T (2015) <br />Solid phase synthesis of 1,3,4-oxadiazin-5 (6R)-one and 1,3,4-oxadiazol-2-one scaffolds from acyl hydrazides<br /><i>Org Biomol Chem</i> <b>13</b>: 59<br /><br />Tuan EW, Horti AG, Olson TT, Gao Y, Stockmeier CA, Al-Muhtasib N, Bowman Dalley C, Lewin AE, Wolfe BB, Sahibzada N, Xiao Y, Kellar KJ (2015) <br />AT-1001 Is a Partial Agonist with High Affinity and Selectivity at Human and Rat alpha3beta4 Nicotinic Cholinergic Receptors<br /><i>Molecular Pharmacology</i> <b>88</b>: 640<br /><br />Wang Y, Sheng Z, Li Q, Gao Y, Dai Y, Liu G, Zhao Y, Li N (2015) <br />Transgenic mouse milk expressing human bile salt-stimulated lipase improves the survival and growth status of premature mice<br /><i>Mol Biotechnol</i> <b>57</b>: 287<br /><br />Wu B, Long Q, Gao Y, Wang Z, Shao T, Liu Y, Li Y, Ding W (2015) <br 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synthesis of 1, 3-diacylglycerols by direct esterification of glycerol with saturated fatty acids<br /><i>Lipids Health Dis</i> <b>12</b>: 65<br /><br />Anker JJ, Brimijoin S, Gao Y, Geng L, Zlebnik NE, Parks RJ, Carroll ME (2012) <br />Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months<br /><i>Biological Psychiatry</i> <b>71</b>: 700<br /><br />Brimijoin S, Gao Y (2012) <br />Cocaine hydrolase gene therapy for cocaine abuse<br /><i>Future Med Chem</i> <b>4</b>: 151<br /><br />Carroll ME, Zlebnik NE, Anker JJ, Kosten TR, Orson FM, Shen X, Kinsey B, Parks RJ, Gao Y, Brimijoin S (2012) <br />Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion<br /><i>PLoS ONE</i> <b>7</b>: e43536<br /><br />Carroll ME, Gao Y, Brimijoin S, Anker JJ (2011) <br />Effects of cocaine hydrolase on cocaine self-administration under a PR schedule and during extended access (escalation) in rats<br /><i>Psychopharmacology (Berl)</i> <b>213</b>: 817<br /><br />Cui W, Li W, Zhao Y, Mak SH, Gao Y, Luo J, Zhang H, Liu Y, Carlier PR, Rong J, Han YF (2011) <br />Preventing H(2)O(2)-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone<br /><i>Brain Research</i> <b>1394</b>: 14<br /><br />Du J, Fan Z, Ma X, Gao Y, Wu Y, Liu S, Shen Y, Fan M, Wang S (2011) <br />Expression of Dpp6 in mouse embryonic craniofacial development<br /><i>Acta Histochemica</i> <b>113</b>: 636<br /><br />Gao Y, Lu Y, Teng KL, Chen ML, Zheng HJ, Zhu YQ, Zhong J (2011) <br />Complete genome sequence of Lactococcus lactis subsp. lactis CV56, a probiotic strain isolated from the vaginas of healthy women<br /><i>Journal of Bacteriology</i> <b>193</b>: 2886<br /><br />Mao Z, Wheeler JJ, Townsend R, Gao Y, Kshirsagar S, Keirns JJ (2011) <br />Population pharmacokinetic-pharmacodynamic analysis of vernakalant hydrochloride injection (RSD1235) in atrial fibrillation or atrial flutter<br /><i>J Pharmacokinet Pharmacodyn</i> <b>38</b>: 541<br /><br />Wang F, Hu S, Gao Y, Qiao Z, Liu W, Bu Z (2011) <br />Complete genome sequences of Brucella melitensis strains M28 and M5-90, with different virulence backgrounds<br /><i>Journal of Bacteriology</i> <b>193</b>: 2904<br /><br />Chanda PK, Gao Y, Mark L, Btesh J, Strassle BW, Lu P, Piesla MJ, Zhang MY, Bingham B, Uveges A, Kowal D, Garbe D, Kouranova EV, Ring RH, Bates B, Pangalos MN, Kennedy JD, Whiteside GT, Samad TA (2010) <br />Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system<br /><i>Molecular Pharmacology</i> <b>78</b>: 996<br /><br />Gao Y, Vasilyev DV, Goncalves MB, Howell FV, Hobbs C, Reisenberg M, Shen R, Zhang MY, Strassle BW, Lu P, Mark L, Piesla MJ, Deng K, Kouranova EV, Ring RH, Whiteside GT, Bates B, Walsh FS, Williams G, Pangalos MN, Samad TA, Doherty P (2010) <br />Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice<br /><i>Journal of Neuroscience</i> <b>30</b>: 2017<br /><br />Gao Y, Orson FM, Kinsey B, Kosten T, Brimijoin S (2010) <br />The concept of pharmacologic cocaine interception as a treatment for drug abuse<br /><i>Chemico-Biological Interactions</i> <b>187</b>: 421<br /><br />Wang Q, Shao Z, Wang X, Gao Y, Li M, Xu L, Xu J, Wang L (2010) <br />Genetic study of capsular switching between Neisseria meningitidis sequence type 7 serogroup A and C strains<br /><i>Infect Immun</i> <b>78</b>: 3883<br /><br />Gao Y, Brimijoin S (2009) <br />Lasting reduction of cocaine action in neostriatum--a hydrolase gene therapy approach<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>330</b>: 449<br /><br />Pang YP, Singh SK, Gao Y, Lassiter TL, Mishra RK, Zhu KY, Brimijoin S (2009) <br />Selective and irreversible inhibitors of aphid acetylcholinesterases: steps toward human-safe insecticides<br /><i>PLoS ONE</i> <b>4</b>: e4349<br /><br />Pang YP, Ekstrom F, Polsinelli GA, Gao Y, Rana S, Hua DH, Andersson B, Andersson PO, Peng L, Singh SK, Mishra RK, Zhu KY, Fallon AM, Ragsdale DW, Brimijoin S (2009) <br />Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases<br /><i>PLoS ONE</i> <b>4</b>: e6851<br /><br />Ray A, Liu J, Karanth S, Gao Y, Brimijoin S, Pope C (2009) <br />Cholinesterase inhibition and acetylcholine accumulation following intracerebral administration of paraoxon in rats<br /><i>Toxicol Appl Pharmacol</i> <b>236</b>: 341<br /><br />Brimijoin S, Gao Y, Anker JJ, Gliddon LA, Lafleur D, Shah R, Zhao Q, Singh M, Carroll ME (2008) <br />A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats<br /><i>Neuropsychopharmacology</i> <b>33</b>: 2715<br /><br />Gao Y, Kuwabara H, Spivak CE, Xiao Y, Kellar K, Ravert HT, Kumar A, Alexander M, Hilton J, Wong DF, Dannals RF, Horti AG (2008) <br />Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2 .1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging properties<br /><i>Journal of Medicinal Chemistry</i> <b>51</b>: 4751<br /><br />Gao Y, Lafleur D, Shah R, Zhao Q, Singh M, Brimijoin S (2008) <br />An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties<br /><i>Chemico-Biological Interactions</i> <b>175</b>: 83<br /><br />Hu WJ, Tan TW, Wang F, Gao Y (2007) <br />[Immobilization of lipase by chemical modification of chitosan]<br /><i>Sheng Wu Gong Cheng Xue Bao</i> <b>23</b>: 667<br /><br />Gao Y, Brimijoin S (2006) <br />Viral transduction of cocaine hydrolase in brain reward centers<br /><i>Cellular Molecular Neurobiology</i> <b>26</b>: 357<br /><br />Gao Y, Atanasova E, Sui N, Pancook JD, Watkins JD, Brimijoin S (2005) <br />Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats<br /><i>Molecular Pharmacology</i> <b>67</b>: 204<br /><br />Gao Y, Brimijoin S (2005) <br />Visualizing viral transduction of a cocaine-hydrolyzing, human butyrylcholinesterase in rats<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 97<br /><br />Zhu X, Yang J, Su Q, Cai J, Gao Y (2005) <br />Molecularly imprinted polymer for monocrotophos and its binding characteristics for organophosphorus pesticides<br /><i>Ann Chim</i> <b>95</b>: 877<br /><br />Gao Y, Brimijoin S (2004) <br />An engineered cocaine hydrolase blunts and reverses cardiovascular responses to cocaine in rats<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>310</b>: 1046<br /><br />Gong W, Shen YP, Ma LG, Pan Y, Du YL, Wang DH, Yang JY, Hu LD, Liu XF, Dong CX, Ma L, Chen YH, Yang XY, Gao Y, Zhu D, Tan X, Mu JY, Zhang DB, Liu YL, Dinesh-Kumar SP, Li Y, Wang XP, Gu HY, Qu LJ, Bai SN, Lu YT, Li JY, Zhao JD, Zuo J, Huang H, Deng XW, Zhu YX (2004) <br />Genome-wide ORFeome cloning and analysis of Arabidopsis transcription factor genes<br /><i>Plant Physiol</i> <b>135</b>: 773<br /><br />Xiao XQ, Wu DC, Gao Y, Fu Y, Lee NT, Ho WL, Tsim KWK, Han YF (2004) <br />Huperzine A, a promising anti-Alzheimer?s agent, reduces staurosporine-induced apoptosis in NG108-15 cells.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Zhou S, Koh HL, Gao Y, Gong ZY, Lee EJ (2004) <br />Herbal bioactivation: the good, the bad and the ugly<br /><i>Life Sciences</i> <b>74</b>: 935<br /><br />Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J, Yang F, Zhang X, Zhang J, Yang G, Wu H, Qu D, Dong J, Sun L, Xue Y, Zhao A, Gao Y, Zhu J, Kan B, Ding K, Chen S, Cheng H, Yao Z, He B, Chen R, Ma D, Qiang B, Wen Y, Hou Y, Yu J (2002) <br />Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157<br /><i>Nucleic Acids Research</i> <b>30</b>: 4432<br /><br />Gao Y, Li Y, Lin J, Li L, Wan X (1998) <br />[Neurotoxicity of antibody against motoneuron on cultured rat cortical neurons]<br /><i>Zhongguo Yi Xue Ke Xue Yuan Xue Bao</i> <b>20</b>: 296<br /><br />