Zhao T, Liu S, Hanna NH, Jalal S, Ding X, Wan J, Yan C, Du H (2023)
LAL deficiency induced myeloid-derived suppressor cells as targets and biomarkers for lung cancer
J Immunother Cancer 11:

Gao C, Du H (2022)
The Interaction Between Two Metabolites of Polygala Tenuifolia and Cholinesterases
Protein Pept Lett

Lam P, Ashbrook A, Zygmunt DA, Yan C, Du H, Martin PT (2022)
Therapeutic efficacy of rscAAVrh74.miniCMV.LIPA gene therapy in a mouse model of lysosomal acid lipase deficiency
Mol Ther Methods Clin Dev 26: 413

Shao Z, Shao J, Huo X, Li W, Kong Y, Du H, Li X, Zhang C (2022)
Identification of closely associated SNPs and candidate genes with seed size and shape via deep re-sequencing GWAS in soybean
Theor Appl Genet

Xu Z, Cao Q, Manyande A, Xiong S, Du H (2022)
Analysis of the binding selectivity and inhibiting mechanism of chlorogenic acid isomers and their interaction with grass carp endogenous lipase using multi-spectroscopic, inhibition kinetics and modeling methods
Food Chem 382: 132106

Zhao T, Liu S, Ding X, Johnson EM, Hanna NH, Singh K, Sen CK, Wan J, Du H, Yan C (2022)
Lysosomal acid lipase, CSF1R and PD-L1 determine functions of CD11c+ myeloid-derived suppressor cells
JCI Insight

Ding X, Zhao T, Lee CC, Yan C, Du H (2021)
Lysosomal Acid Lipase Deficiency Controls T- and B-Regulatory Cell Homeostasis in the Lymph Nodes of Mice with Human Cancer Xenotransplants
American Journal of Pathology 191: 353

Du H, Jiang X, Ma M, Xu H, Liu S, Ma F (2020)
Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation
Bioorganic & Medicinal Chemistry Lett

Du H, Hu RW, Zhao HM, Huang HB, Xiang L, Liu BL, Feng NX, Li H, Li YW, Cai QY, Mo CH (2020)
Mechanistic insight into esterase-catalyzed hydrolysis of phthalate esters (PAEs) based on integrated multi-spectroscopic analyses and docking simulation
J Hazard Mater 408: 124901

Nguyen HD, Ticer T, Bastian D, Kuril S, Li H, Du H, Yan C, Yu XZ (2020)
Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease
Cell Rep 33: 108316

Zhao HM, Du H, Huang CQ, Li S, Zeng XH, Huang XJ, Xiang L, Li H, Li YW, Cai QY, Mo CH, He Z (2019)
Bioaugmentation of Exogenous Strain Rhodococcus sp. 2G Can Efficiently Mitigate Di(2-ethylhexyl) Phthalate Contamination to Vegetable Cultivation
Journal of Agricultural and Food Chemistry 67: 6940

Yan X, Chen T, Zhang L, Du H (2018)
Study of the interactions of forsythiaside and rutin with acetylcholinesterase (AChE)
Int J Biol Macromol 119: 1344

Ma F, Du H (2017)
Novel deoxyvasicinone derivatives as potent multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation
Eur Journal of Medicinal Chemistry 140: 118

Tuohetahuntila M, Molenaar MR, Spee B, Brouwers JF, Wubbolts R, Houweling M, Yan C, Du H, VanderVen BC, Vaandrager AB, Helms JB (2017)
Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation
Journal of Biological Chemistry 292: 12436

Xiao Q, Zhou H, Wei H, Du H, Tan W, Zhan Y, Pistolozzi M (2017)
A new method to characterize the kinetics of cholinesterases inhibited by carbamates
J Pharm Biomed Anal 144: 175

Yan X, Chen T, Zhang L, Du H (2017)
Protective effects of Forsythoside A on amyloid beta-induced apoptosis in PC12 cells by downregulating acetylcholinesterase
European Journal of Pharmacology 810: 141

Zhao T, Ding X, Yan C, Du H (2017)
Endothelial Rab7 GTPase mediates tumor growth and metastasis in lysosomal acid lipase-deficient mice
Journal of Biological Chemistry 292: 19198

Grumet L, Eichmann TO, Taschler U, Zierler KA, Leopold C, Moustafa T, Radovic B, Romauch M, Yan C, Du H, Haemmerle G, Zechner R, Fickert P, Kratky D, Zimmermann R, Lass A (2016)
Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover
Journal of Biological Chemistry 291: 17977

Luo W, Wen Y, Tu Y, Du H, Li Q, Zhu C, Li Y (2016)
A New Flavonoid Glycoside from Lysionotus pauciflorus
Nat Prod Commun 11: 621

Radovic B, Vujic N, Leopold C, Schlager S, Goeritzer M, Patankar JV, Korbelius M, Kolb D, Reindl J, Wegscheider M, Tomin T, Birner-Gruenberger R, Schittmayer M, Groschner L, Magnes C, Diwoky C, Frank S, Steyrer E, Du H, Graier WF, Madl T, Kratky D (2016)
Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice
Diabetologia 59: 1743

Du H, Zhao T, Ding X, Yan C (2015)
Hepatocyte-Specific Expression of Human Lysosome Acid Lipase Corrects Liver Inflammation and Tumor Metastasis in lal(-/-) Mice
American Journal of Pathology 185: 2379

Pistolozzi M, Du H, Wei H, Tan W (2015)
Stereoselective inhibition of human butyrylcholinesterase by the enantiomers of bambuterol and their intermediates
Drug Metabolism & Disposition: The Biological Fate of Chemicals 43: 344

Tu Y, Zhong Y, Du H, Luo W, Wen Y, Li Q, Zhu C, Li Y (2015)
Anticholinesterases and antioxidant alkamides from Piper nigrum fruits
Nat Prod Res

Wang J, Du H, Mou YR, Niu JY, Zhang WT, Yang HC, Li AW (2015)
Abundance and significance of neuroligin-1 and glutamate in Hirschsprung's disease
World J Gastroenterol 21: 7172

Zeng Z, Chen C, Du H, Wang G, Li M (2015)
High quality draft genomic sequence of Flavobacterium enshiense DK69(T) and comparison among Flavobacterium genomes
Stand Genomic Sci 10: 92

Sun Y, Xu YH, Du H, Quinn B, Liou B, Stanton L, Inskeep V, Ran H, Jakubowitz P, Grilliot N, Grabowski GA (2014)
Reversal of advanced disease in lysosomal acid lipase deficient mice: a model for lysosomal acid lipase deficiency disease
Mol Genet Metab 112: 229

Du H, Kwon IK, Kim J (2013)
Neuregulin-1 impairs the long-term depression of hippocampal inhibitory synapses by facilitating the degradation of endocannabinoid 2-AG
Journal of Neuroscience 33: 15022

Yan C, Ding X, Dasgupta N, Wu L, Du H (2012)
Gene profile of myeloid-derived suppressive cells from the bone marrow of lysosomal acid lipase knock-out mice
PLoS ONE 7: e30701

Bowden KL, Bilbey NJ, Bilawchuk LM, Boadu E, Sidhu R, Ory DS, Du H, Chan T, Francis GA (2011)
Lysosomal acid lipase deficiency impairs regulation of ABCA1 gene and formation of high density lipoproteins in cholesteryl ester storage disease
Journal of Biological Chemistry 286: 30624

Yan G, Zhang G, Fang X, Zhang Y, Li C, Ling F, Cooper DN, Li Q, Li Y, van Gool AJ, Du H, Chen J, Chen R, Zhang P, Huang Z, Thompson JR, Meng Y, Bai Y, Wang J, Zhuo M, Wang T, Huang Y, Wei L, Li J, Wang Z, Hu H, Yang P, Le L, Stenson PD, Li B, Liu X, Ball EV, An N, Huang Q, Fan W, Zhang X, Wang W, Katze MG, Su B, Nielsen R, Yang H, Wang X (2011)
Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques
Nat Biotechnol 29: 1019

Qu P, Shelley WC, Yoder MC, Wu L, Du H, Yan C (2010)
Critical roles of lysosomal acid lipase in myelopoiesis
American Journal of Pathology 176: 2394

Qu P, Du H, Wilkes DS, Yan C (2009)
Critical roles of lysosomal acid lipase in T cell development and function
American Journal of Pathology 174: 944

Rosenbaum AI, Rujoi M, Huang AY, Du H, Grabowski GA, Maxfield FR (2009)
Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors
Biochimica & Biophysica Acta 1791: 1155

Ye C, Zheng H, Zhang J, Jing H, Wang L, Xiong Y, Wang W, Zhou Z, Sun Q, Luo X, Du H, Gottschalk M, Xu J (2009)
Clinical, experimental, and genomic differences between intermediately pathogenic, highly pathogenic, and epidemic Streptococcus suis
J Infect Dis 199: 97

Du H, Cameron TL, Garger SJ, Pogue GP, Hamm LA, White E, Hanley KM, Grabowski GA (2008)
Wolman disease/cholesteryl ester storage disease: efficacy of plant-produced human lysosomal acid lipase in mice
J Lipid Res 49: 1646

Du H, Li M, Yang P (2008)
Effects of 3-benzidino-6-phenylpyridazine, as an acetylcholinesterase inhibitor, on outward potassium current in acutely isolated rat hippocampal pyramidal neurons
Toxicol Lett 181: 104

Li Y, Qin Y, Li H, Wu R, Yan C, Du H (2007)
Lysosomal acid lipase over-expression disrupts lamellar body genesis and alveolar structure in the lung
International Journal of Experimental Pathology 88: 427

Yan C, Lian X, Dai Y, Wang X, Qu P, White A, Qin Y, Du H (2007)
Gene delivery by the hSP-B promoter to lung alveolar type II epithelial cells in LAL-knockout mice through bone marrow mesenchymal stem cells
Gene Therapy 14: 1461

Yan C, Lian X, Li Y, Dai Y, White A, Qin Y, Li H, Hume DA, Du H (2006)
Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal-/- mice
American Journal of Pathology 169: 916

Du H, Dardzinski BJ, O'Brien KJ, Donnelly LF (2005)
MRI of fat distribution in a mouse model of lysosomal acid lipase deficiency
AJR Am J Roentgenol 184: 658

Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, Van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK (2005)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4
Nature 434: 724

Lian X, Yan C, Qin Y, Knox L, Li T, Du H (2005)
Neutral lipids and peroxisome proliferator-activated receptor-{gamma} control pulmonary gene expression and inflammation-triggered pathogenesis in lysosomal acid lipase knockout mice
American Journal of Pathology 167: 813

Lian X, Yan C, Yang L, Xu Y, Du H (2004)
Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung
American Journal of Physiology Lung Cell Mol Physiol 286: L801

Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK (2003)
The DNA sequence of human chromosome 7
Nature 424: 157

Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC (2003)
The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes
Nature 423: 825

Du H, Heur M, Witte DP, Ameis D, Grabowski GA (2002)
Lysosomal Acid lipase deficiency: correction of lipid storage by adenovirus-mediated gene transfer in mice
Hum Gene Therapy 13: 1361

Du H, Schiavi S, Levine M, Mishra J, Heur M, Grabowski GA (2001)
Enzyme therapy for lysosomal acid lipase deficiency in the mouse
Hum Mol Genet 10: 1639

Du H, Heur M, Duanmu M, Grabowski GA, Hui DY, Witte DP, Mishra J (2001)
Lysosomal acid lipase-deficient mice: depletion of white and brown fat, severe hepatosplenomegaly, and shortened life span
J Lipid Res 42: 489

Tietge UJ, Sun G, Czarnecki S, Yu Q, Lohse P, Du H, Grabowski GA, Glick JM, Rader DJ (2001)
Phenotypic correction of lipid storage and growth arrest in wolman disease fibroblasts by gene transfer of lysosomal acid lipase
Hum Gene Therapy 12: 279

Tabata S, Kaneko T, Nakamura Y, Kotani H, Kato T, Asamizu E, Miyajima N, Sasamoto S, Kimura T, Hosouchi T, Kawashima K, Kohara M, Matsumoto M, Matsuno A, Muraki A, Nakayama S, Nakazaki N, Naruo K, Okumura S, Shinpo S, Takeuchi C, Wada T, Watanabe A, Yamada M, Yasuda M, Sato S, de la Bastide M, Huang E, Spiegel L, Gnoj L, O'Shaughnessy A, Preston R, Habermann K, Murray J, Johnson D, Rohlfing T, Nelson J, Stoneking T, Pepin K, Spieth J, Sekhon M, Armstrong J, Becker M, Belter E, Cordum H, Cordes M, Courtney L, Courtney W, Dante M, Du H, Edwards J, Fryman J, Haakensen B, Lamar E, Latreille P, Leonard S, Meyer R, Mulvaney E, Ozersky P, Riley A, Strowmatt C, Wagner-McPherson C, Wollam A, Yoakum M, Bell M, Dedhia N, Parnell L, Shah R, Rodriguez M, See LH, Vil D, Baker J, Kirchoff K, Toth K, King L, Bahret A, Miller B, Marra M, Martienssen R, McCombie WR, Wilson RK, Murphy G, Bancroft I, Volckaert G, Wambutt R, Dusterhoft A, Stiekema W, Pohl T, Entian KD, Terryn N, Hartley N, Bent E, Johnson S, Langham SA, McCullagh B, Robben J, Grymonprez B, Zimmermann W, Ramsperger U, Wedler H, Balke K, Wedler E, Peters S, van Staveren M, Dirkse W, Mooijman P, Lankhorst RK, Weitzenegger T, Bothe G, Rose M, Hauf J, Berneiser S, Hempel S, Feldpausch M, Lamberth S, Villarroel R, Gielen J, Ardiles W, Bents O, Lemcke K, Kolesov G, Mayer K, Rudd S, Schoof H, Schueller C, Zaccaria P, Mewes HW, Bevan M, Fransz P (2000)
Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana
Nature 408: 823

Buton X, Mamdouh Z, Ghosh R, Du H, Kuriakose G, Beatini N, Grabowski GA, Maxfield FR, Tabas I (1999)
Unique cellular events occurring during the initial interaction of macrophages with matrix-retained or methylated aggregated low density lipoprotein (LDL). Prolonged cell-surface contact during which ldl-cholesteryl ester hydrolysis exceeds ldl protein degradation
Journal of Biological Chemistry 274: 32112

Mayer K, Schuller C, Wambutt R, Murphy G, Volckaert G, Pohl T, Dusterhoft A, Stiekema W, Entian KD, Terryn N, Harris B, Ansorge W, Brandt P, Grivell L, Rieger M, Weichselgartner M, de Simone V, Obermaier B, Mache R, Muller M, Kreis M, Delseny M, Puigdomenech P, Watson M, Schmidtheini T, Reichert B, Portatelle D, Perez-Alonso M, Boutry M, Bancroft I, Vos P, Hoheisel J, Zimmermann W, Wedler H, Ridley P, Langham SA, McCullagh B, Bilham L, Robben J, Van der Schueren J, Grymonprez B, Chuang YJ, Vandenbussche F, Braeken M, Weltjens I, Voet M, Bastiaens I, Aert R, Defoor E, Weitzenegger T, Bothe G, Ramsperger U, Hilbert H, Braun M, Holzer E, Brandt A, Peters S, van Staveren M, Dirske W, Mooijman P, Klein Lankhorst R, Rose M, Hauf J, Kotter P, Berneiser S, Hempel S, Feldpausch M, Lamberth S, Van den Daele H, De Keyser A, Buysshaert C, Gielen J, Villarroel R, De Clercq R, van Montagu M, Rogers J, Cronin A, Quail M, Bray-Allen S, Clark L, Doggett J, Hall S, Kay M, Lennard N, McLay K, Mayes R, Pettett A, Rajandream MA, Lyne M, Benes V, Rechmann S, Borkova D, Blocker H, Scharfe M, Grimm M, Lohnert TH, Dose S, de Haan M, Maarse A, Schafer M, Muller-Auer S, Gabel C, Fuchs M, Fartmann B, Granderath K, Dauner D, Herzl A, Neumann S, Argiriou A, Vitale D, Liguori R, Piravandi E, Massenet O, Quigley F, Clabauld G, Mundlein A, Felber R, Schnabl S, Hiller R, Schmidt W, Lecharny A, Aubourg S, Chefdor F, Cooke R, Berger C, Montfort A, Casacuberta E, Gibbons T, Weber N, Vandenbol M, Bargues M, Terol J, Torres A, Perez-Perez A, Purnelle B, Bent E, Johnson S, Tacon D, Jesse T, Heijnen L, Schwarz S, Scholler P, Heber S, Francs P, Bielke C, Frishman D, Haase D, Lemcke K, Mewes HW, Stocker S, Zaccaria P, Bevan M, Wilson RK, de la Bastide M, Habermann K, Parnell L, Dedhia N, Gnoj L, Schutz K, Huang E, Spiegel L, Sehkon M, Murray J, Sheet P, Cordes M, Abu-Threideh J, Stoneking T, Kalicki J, Graves T, Harmon G, Edwards J, Latreille P, Courtney L, Cloud J, Abbott A, Scott K, Johnson D, Minx P, Bentley D, Fulton B, Miller N, Greco T, Kemp K, Kramer J, Fulton L, Mardis E, Dante M, Pepin K, Hillier L, Nelson J, Spieth J, Ryan E, Andrews S, Geisel C, Layman D, Du H, Ali J, Berghoff A, Jones K, Drone K, Cotton M, Joshu C, Antonoiu B, Zidanic M, Strong C, Sun H, Lamar B, Yordan C, Ma P, Zhong J, Preston R, Vil D, Shekher M, Matero A, Shah R, Swaby IK, O'Shaughnessy A, Rodriguez M, Hoffmann J, Till S, Granat S, Shohdy N, Hasegawa A, Hameed A, Lodhi M, Johnson A, Chen E, Marra M, Martienssen R, McCombie WR (1999)
Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana
Nature 402: 769

Du H, Duanmu M, Rosa LR (1998)
Mouse lysosomal acid lipase: characterization of the gene and analysis of promoter activity
Gene 208: 285

Du H, Sheriff S, Bezerra J, Leonova T, Grabowski GA (1998)
Molecular and enzymatic analyses of lysosomal acid lipase in cholesteryl ester storage disease
Mol Genet Metab 64: 126

Du H, Duanmu M, Witte D, Grabowski GA (1998)
Targeted disruption of the mouse lysosomal acid lipase gene: long-term survival with massive cholesteryl ester and triglyceride storage
Hum Mol Genet 7: 1347

Du H, Witte DP, Grabowski GA (1996)
Tissue and cellular specific expression of murine lysosomal acid lipase mRNA and protein
J Lipid Res 37: 937

Sheriff S, Du H, Grabowski GA (1995)
Characterization of lysosomal acid lipase by site-directed mutagenesis and heterologous expression
Journal of Biological Chemistry 270: 27766