Spatz P, Steinmuller SAM, Tutov A, Poeta E, Morilleau A, Carles A, Deventer MH, Hofmann J, Stove CP, Monti B, Maurice T, Decker M (2023) <br />Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model<br /><i>Journal of Medicinal Chemistry</i> <br /><br />Hofmann J, Spatz P, Walther R, Gutmann M, Maurice T, Decker M (2022) <br />Synthesis and Biological Evaluation of Flavonoid-Cinnamic Acid Amide Hybrids with Distinct Activity against Neurodegeneration in Vitro and in Vivo<br /><i>Chemistry</i> <br /><br />Scheiner M, Sink A, Hoffmann M, Vrigneau C, Endres E, Carles A, Sotriffer C, Maurice T, Decker M (2022) <br />Photoswitchable Pseudoirreversible Butyrylcholinesterase Inhibitors Allow Optical Control of Inhibition in Vitro and Enable Restoration of Cognition in an Alzheimer's Disease Mouse Model upon Irradiation<br /><i>Journal of the American Chemical Society</i> <br /><br />Spatz P, Zimmermann T, Steinmuller S, Hofmann J, Maurice T, Decker M (2022) <br />Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model<br /><i>RSC Med Chem</i> <b>13</b>: 944<br /><br />Gentzsch C, Hoffmann M, Ohshima Y, Nose N, Chen X, Higuchi T, Decker M (2021) <br />Synthesis and Initial Characterization of a Selective, Pseudo-irreversible Inhibitor of Human Butyrylcholinesterase as PET Tracer<br /><i>ChemMedChem</i> <br /><br />Gentzsch C, Chen X, Spatz P, Kosak U, Knez D, Nose N, Gobec S, Higuchi T, Decker M (2021) <br />Synthesis and Initial Characterization of a Reversible, Selective (18)F-Labeled Radiotracer for Human Butyrylcholinesterase<br /><i>Mol Imaging Biol</i> <br /><br />Hofmann J, Ginex T, Espargaro A, Scheiner M, Gunesch S, Arago M, Stigloher C, Sabate R, Luque FJ, Decker M (2021) <br />Azobioisosteres of Curcumin with Pronounced Activity against Amyloid Aggregation, Intracellular Oxidative Stress, and Neuroinflammation<br /><i>Chemistry</i> <b>27</b>: 6015<br /><br />Pont C, Ginex T, Grinan-Ferre C, Scheiner M, Mattellone A, Martinez N, Arce EM, Soriano-Fernandez Y, Naldi M, De Simone A, Barenys M, Gomez-Catalan J, Perez B, Sabate R, Andrisano V, Loza MI, Brea J, Bartolini M, Bolognesi ML, Decker M, Pallas M, Luque FJ, Munoz-Torrero D (2021) <br />From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects<br /><i>Eur Journal of Medicinal Chemistry</i> <b>225</b>: 113779<br /><br />Scheiner M, Hoffmann M, He F, Poeta E, Chatonnet A, Monti B, Maurice T, Decker M (2021) <br />Selective Pseudo-irreversible Butyrylcholinesterase Inhibitors Transferring Antioxidant Moieties to the Enzyme Show Pronounced Neuroprotective Efficacy In Vitro and In Vivo in an Alzheimer's Disease Mouse Model<br /><i>Journal of Medicinal Chemistry</i> <b>64(13):</b>: 9302<br /><br />Scheiner M, Sink A, Spatz P, Endres E, Decker M (2021) <br />Photopharmacology on Acetylcholinesterase: Novel Photoswitchable Inhibitors with Improved Pharmacological Profiles<br /><i>ChemPhotoChem</i> <b>5</b>: 149<br /><br />Basagni F, Rosini M, Decker M (2020) <br />Functionalized Cannabinoid Subtype 2 Receptor Ligands: Fluorescent, PET, Photochromic and Covalent Molecular Probes<br /><i>ChemMedChem</i> <b>15</b>: 1374<br /><br />Gunesch S, Hoffmann M, Kiermeier C, Fischer W, Pinto AFM, Maurice T, Maher P, Decker M (2020) <br />7-O-Esters of taxifolin with pronounced and overadditive effects in neuroprotection, anti-neuroinflammation, and amelioration of short-term memory impairment in vivo<br /><i>Redox Biol</i> <b>29</b>: 101378<br /><br />Hofmann J, Fayez S, Scheiner M, Hoffmann M, Oerter S, Appelt-Menzel A, Maher P, Maurice T, Bringmann G, Decker M (2020) <br />Sterubin: Enantioresolution and Configurational Stability, Enantiomeric Purity in Nature, and Neuroprotective Activity in Vitro and in Vivo<br /><i>Chemistry</i> <b>26</b>: 7299<br /><br />Marques CS, Lopez O, Bagetta D, Carreiro EP, Petralla S, Bartolini M, Hoffmann M, Alcaro S, Monti B, Bolognesi ML, Decker M, Fernandez-Bolanos JG, Burke AJ (2020) <br />N-1,2,3-triazole-isatin derivatives for cholinesterase and beta-amyloid aggregation inhibition: A comprehensive bioassay study<br /><i>Bioorg Chem</i> <b>98</b>: 103753<br /><br />Hoffmann M, Stiller C, Endres E, Scheiner M, Gunesch S, Sotriffer C, Maurice T, Decker M (2019) <br />Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model<br /><i>Journal of Medicinal Chemistry</i> <b>62</b>: 9116<br /><br />Rodriguez-Soacha DA, Scheiner M, Decker M (2019) <br />Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands<br /><i>Eur Journal of Medicinal Chemistry</i> <b>180</b>: 690<br /><br />Scheiner M, Dolles D, Gunesch S, Hoffmann M, Nabissi M, Marinelli O, Naldi M, Bartolini M, Petralla S, Poeta E, Monti B, Falkeis C, Vieth M, Hubner H, Gmeiner P, Maitra R, Maurice T, Decker M (2019) <br />Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo<br /><i>Journal of Medicinal Chemistry</i> <b>62</b>: 9078<br /><br />Dolles D, Hoffmann M, Gunesch S, Marinelli O, Moller J, Santoni G, Chatonnet A, Lohse MJ, Wittmann HJ, Strasser A, Nabissi M, Maurice T, Decker M (2018) <br />Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles<br /><i>Journal of Medicinal Chemistry</i> <b>61</b>: 1646<br /><br />Holzgrabe U, Decker M (2017) <br />Bitopic muscarinic agonists and antagonists and uses thereof: a patent evaluation of US20160136145A1<br /><i>Expert Opin Ther Pat</i> <b>27</b>: 121<br /><br />Decker M, Munoz-Torrero D (2016) <br />Special Issue: Molecules against Alzheimer<br /><i>Molecules</i> <b>21</b>: <br /><br />Dgachi Y, Ismaili L, Knez D, Benchekroun M, Martin H, Szalaj N, Wehle S, Bautista-Aguilera OM, Luzet V, Bonnet A, Malawska B, Gobec S, Chioua M, Decker M, Chabchoub F, Marco-Contelles J (2016) <br />Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Abeta1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy<br /><i>ChemMedChem</i> <b>11</b>: 1318<br /><br />Dolles D, Nimczick M, Scheiner M, Ramler J, Stadtmuller P, Sawatzky E, Drakopoulos A, Sotriffer C, Wittmann HJ, Strasser A, Decker M (2016) <br />Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB2 R Ligands To Combat Neurodegenerative Disorders<br /><i>ChemMedChem</i> <b>11</b>: 1270<br /><br />Sadek B, Khan N, Darras FH, Pockes S, Decker M (2016) <br />The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats<br /><i>Physiol Behav</i> <b>165</b>: 383<br /><br />Sawatzky E, Wehle S, Kling B, Wendrich J, Bringmann G, Sotriffer CA, Heilmann J, Decker M (2016) <br />Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode<br /><i>Journal of Medicinal Chemistry</i> <b>59</b>: 2067<br /><br />Sawatzky E, Al-Momani E, Kobayashi R, Higuchi T, Samnick S, Decker M (2016) <br />A Novel Way To Radiolabel Human Butyrylcholinesterase for Positron Emission Tomography through Irreversible Transfer of the Radiolabeled Moiety<br /><i>ChemMedChem</i> <b>11</b>: 1540<br /><br />Sawatzky E, Drakopoulos A, Rolz M, Sotriffer C, Engels B, Decker M (2016) <br />Experimental and theoretical investigations into the stability of cyclic aminals<br /><i>Beilstein J Org Chem</i> <b>12</b>: 2280<br /><br />Benchekroun M, Bartolini M, Egea J, Romero A, Soriano E, Pudlo M, Luzet V, Andrisano V, Jimeno ML, Lopez MG, Wehle S, Gharbi T, Refouvelet B, de Andres L, Herrera-Arozamena C, Monti B, Bolognesi ML, Rodriguez-Franco MI, Decker M, Marco-Contelles J, Ismaili L (2015) <br />Novel tacrine-grafted ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic Acid hybrids<br /><i>ChemMedChem</i> <b>10</b>: 523<br /><br />Khan N, Saad A, Nurulain SM, Darras FH, Decker M, Sadek B (2015) <br />The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats<br /><i>Behavioural Brain Research</i> <b>297</b>: 155<br /><br />Chen X, Wehle S, Kuzmanovic N, Merget B, Holzgrabe U, Konig B, Sotriffer CA, Decker M (2014) <br />Acetylcholinesterase inhibitors with photoswitchable inhibition of beta-amyloid aggregation<br /><i>ACS Chem Neurosci</i> <b>5</b>: 377<br /><br />Darras FH, Pockes S, Huang G, Wehle S, Strasser A, Wittmann HJ, Nimczick M, Sotriffer CA, Decker M (2014) <br />Synthesis, Biological Evaluation, and Computational Studies of Tri- and Tetracyclic Nitrogen-Bridgehead Compounds as Potent Dual-Acting AChE Inhibitors and hH3 Receptor Antagonists<br /><i>ACS Chem Neurosci</i> <b>5</b>: 225<br /><br />Darras FH, Kling B, Sawatzky E, Heilmann J, Decker M (2014) <br />Cyclic acyl guanidines bearing carbamate moieties allow potent and dirigible cholinesterase inhibition of either acetyl- or butyrylcholinesterase<br /><i>Bioorganic & Medicinal Chemistry</i> <b>22</b>: 5020<br /><br />Darras FH, Wehle S, Huang G, Sotriffer CA, Decker M (2014) <br />Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with 'inverted' binding mode<br /><i>Bioorganic & Medicinal Chemistry</i> <b>22</b>: 4867<br /><br />Huang G, Kling B, Darras FH, Heilmann J, Decker M (2014) <br />Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine<br /><i>Eur Journal of Medicinal Chemistry</i> <b>81C</b>: 15<br /><br />Chen X, Zenger K, Lupp A, Kling B, Heilmann J, Fleck C, Kraus B, Decker M (2012) <br />Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo<br /><i>Journal of Medicinal Chemistry</i> <b>55</b>: 5231<br /><br />Darras FH, Kling B, Heilmann J, Decker M (2012) <br />Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer<br /><i>ACS Med Chem Lett</i> <b>3</b>: 914<br /><br />Decker M, Adamska M, Cronin A, Di Giallonardo F, Burgener J, Marowsky A, Falck JR, Morisseau C, Hammock BD, Gruzdev A, Zeldin DC, Arand M (2012) <br />EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides<br /><i>J Lipid Res</i> <b>53</b>: 2038<br /><br />Chen X, Tikhonova IG, Decker M (2011) <br />Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors<br /><i>Bioorganic & Medicinal Chemistry</i> <b>19</b>: 1222<br /><br />Cronin A, Decker M, Arand M (2011) <br />Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase<br /><i>J Lipid Res</i> <b>52</b>: 712<br /><br />Macabeo AP, Vidar WS, Chen X, Decker M, Heilmann J, Wan B, Franzblau SG, Galvez EV, Aguinaldo MA, Cordell GA (2011) <br />Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa<br /><i>Eur Journal of Medicinal Chemistry</i> <b>46</b>: 3118<br /><br />Fang L, Jumpertz S, Zhang Y, Appenroth D, Fleck C, Mohr K, Trankle C, Decker M (2010) <br />Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors<br /><i>Journal of Medicinal Chemistry</i> <b>53</b>: 2094<br /><br />Schulze M, Siol O, Decker M, Lehmann J (2010) <br />Bivalent 5,8,9,13b-tetrahydro-6H-isoquino[1,2-a]isoquinolines and -isoquinolinium salts: novel heterocyclic templates for butyrylcholinesterase inhibitors<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>20</b>: 2946<br /><br />Decker M, Arand M, Cronin A (2009) <br />Mammalian epoxide hydrolases in xenobiotic metabolism and signalling<br /><i>Archives of Toxicology</i> <b>83</b>: 297<br /><br />Elenes S, Decker M, Cymes GD, Grosman C (2009) <br />Decremental response to high-frequency trains of acetylcholine pulses but unaltered fractional Ca2+ currents in a panel of slow-channel syndrome nicotinic receptor mutants<br /><i>Journal of General Physiology</i> <b>133</b>: 151<br /><br />Decker M, Kraus B, Heilmann J (2008) <br />Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties<br /><i>Bioorganic & Medicinal Chemistry</i> <b>16</b>: 4252<br /><br />Fang L, Appenroth D, Decker M, Kiehntopf M, Lupp A, Peng S, Fleck C, Zhang Y, Lehmann J (2008) <br />NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity<br /><i>Journal of Medicinal Chemistry</i> <b>51</b>: 7666<br /><br />Fang L, Appenroth D, Decker M, Kiehntopf M, Roegler C, Deufel T, Fleck C, Peng S, Zhang Y, Lehmann J (2008) <br />Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates<br /><i>Journal of Medicinal Chemistry</i> <b>51</b>: 713<br /><br />Fang L, Kraus B, Lehmann J, Heilmann J, Zhang Y, Decker M (2008) <br />Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>18</b>: 2905<br /><br />Fleck C, Appenroth D, Decker M, Lehmann J (2008) <br />A new way of data interpretation for cognition tests in rats used to characterise six choline esterase inhibitors with heterocyclic nitrogen bridgehead structure. Application in Alzheimer therapy<br /><i>Arzneimittelforschung</i> <b>58</b>: 543<br /><br />Decker M (2007) <br />Recent advances in the development of hybrid molecules/designed multiple compounds with antiamnesic properties<br /><i>Mini Rev Med Chem</i> <b>7</b>: 221<br /><br />Decker M, Krauth F, Lehmann J (2006) <br />Novel tricyclic quinazolinimines and related tetracyclic nitrogen bridgehead compounds as cholinesterase inhibitors with selectivity towards butyrylcholinesterase<br /><i>Bioorganic & Medicinal Chemistry</i> <b>14</b>: 1966<br /><br />Decker M (2006) <br />Homobivalent quinazolinimines as novel nanomolar inhibitors of cholinesterases with dirigible selectivity toward butyrylcholinesterase<br /><i>Journal of Medicinal Chemistry</i> <b>49</b>: 5411<br /><br />Schott Y, Decker M, Rommelspacher H, Lehmann J (2006) <br />6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>16</b>: 5840<br /><br />Decker M (2005) <br />Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpine<br /><i>Eur Journal of Medicinal Chemistry</i> <b>40</b>: 305<br /><br />