Fernandes F, Barroso MF, De Simone A, Emrikova E, Dias-Teixeira M, Pereira JP, Chlebek J, Fernandes VC, Rodrigues F, Andrisano V, Delerue-Matos C, Grosso C (2022) <br />Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease<br /><i>J Ethnopharmacol</i> <b>290</b>: 115107<br /><br />Ismaili L, Monnin J, Etievant A, Arribas RL, Viejo L, Refouvelet B, Soukup O, Janockova J, Hepnarova V, Korabecny J, Kucera T, Jun D, Andrys R, Musilek K, Baguet A, Garcia-Frutos EM, De Simone A, Andrisano V, Bartolini M, de los Rios C, Marco-Contelles J, Haffen E (2021) <br />(+/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease<br /><i>ACS Chem Neurosci</i> <br /><br />Pont C, Ginex T, Grinan-Ferre C, Scheiner M, Mattellone A, Martinez N, Arce EM, Soriano-Fernandez Y, Naldi M, De Simone A, Barenys M, Gomez-Catalan J, Perez B, Sabate R, Andrisano V, Loza MI, Brea J, Bartolini M, Bolognesi ML, Decker M, Pallas M, Luque FJ, Munoz-Torrero D (2021) <br />From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects<br /><i>Eur Journal of Medicinal Chemistry</i> <b>225</b>: 113779<br /><br />Viayna E, Coquelle N, Cieslikiewicz-Bouet M, Cisternas P, Oliva CA, Sanchez-Lopez E, Ettcheto M, Bartolini M, De Simone A, Ricchini M, Rendina M, Pons M, Firuzi O, Perez B, Saso L, Andrisano V, Nachon F, Brazzolotto X, Garcia ML, Camins A, Silman I, Jean L, Inestrosa NC, Colletier JP, Renard PY, Munoz-Torrero D (2021) <br />Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice<br /><i>Journal of Medicinal Chemistry</i> <b>64</b>: 812<br /><br />Perez-Areales FJ, Garrido M, Aso E, Bartolini M, De Simone A, Espargaro A, Ginex T, Sabate R, Perez B, Andrisano V, Puigoriol-Illamola D, Pallas M, Luque FJ, Loza MI, Brea J, Ferrer I, Ciruela F, Messeguer A, Munoz-Torrero D (2020) <br />Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6<br /><i>Journal of Medicinal Chemistry</i> <b>63</b>: 9360<br /><br />Perinova R, Maafi N, Korabecny J, Kohelova E, De Simone A, Al Mamun A, Hulcova D, Markova J, Kucera T, Jun D, Safratova M, Marikova J, Andrisano V, Jenco J, Kunes J, Martinez A, Novakova L, Cahlikova L (2020) <br />Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer's disease<br /><i>Bioorg Chem</i> <b>100</b>: 103928<br /><br />De Simone A, Naldi M, Tedesco D, Bartolini M, Davani L, Andrisano V (2019) <br />Advanced analytical methodologies in Alzheimer's disease drug discovery<br /><i>J Pharm Biomed Anal</i> <b>178</b>: 112899<br /><br />Hulcova D, Marikova J, Korabecny J, Hostalkova A, Jun D, Kunes J, Chlebek J, Opletal L, De Simone A, Novakova L, Andrisano V, Ruzicka A, Cahlikova L (2019) <br />Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease<br /><i>Phytochemistry</i> <b>165</b>: 112055<br /><br />Kohelova E, Perinova R, Maafi N, Korabecny J, Hulcova D, Marikova J, Kucera T, Martinez Gonzalez L, Hrabinova M, Vorcakova K, Novakova L, De Simone A, Havelek R, Cahlikova L (2019) <br />Derivatives of the beta-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer's Disease<br /><i>Molecules</i> <b>24</b>: <br /><br />Perez-Areales FJ, Turcu AL, Barniol-Xicota M, Pont C, Pivetta D, Espargaro A, Bartolini M, De Simone A, Andrisano V, Perez B, Sabate R, Sureda FX, Vazquez S, Munoz-Torrero D (2019) <br />A novel class of multitarget anti-Alzheimer benzohomoadamantanechlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors<br /><i>Eur Journal of Medicinal Chemistry</i> <b>180</b>: 613<br /><br />Andrisano V, Naldi M, De Simone A, Bartolini M (2018) <br />A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017<br /><i>Expert Opin Ther Pat</i> <b>28</b>: 455<br /><br />Milelli A, De Simone A, Ticchi N, Chen HH, Betari N, Andrisano V, Tumiatti V (2017) <br />Tacrine-based Multifunctional Agents in Alzheimer's Disease: An Old Story in Continuous Development section sign<br /><i>Curr Med Chem</i> <b>24</b>: 3522<br /><br />Perez-Areales FJ, Betari N, Viayna A, Pont C, Espargaro A, Bartolini M, De Simone A, Rinaldi Alvarenga JF, Perez B, Sabate R, Lamuela-Raventos RM, Andrisano V, Luque FJ, Munoz-Torrero D (2017) <br />Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids<br /><i>Future Med Chem</i> <b>9</b>: 965<br /><br />Seidl C, de Moraes Santos CA, De Simone A, Bartolini M, Weffort-Santos AM, Andrisano V (2017) <br />Uleine Disrupts Key Enzymatic and Non-Enzymatic Biomarkers that Leads to Alzheimer's Disease<br /><i>Curr Alzheimer Res</i> <b>14</b>: 317<br /><br />Chlebek J, De Simone A, Hostalkova A, Opletal L, Perez C, Perez DI, Havlikova L, Cahlikova L, Andrisano V (2016) <br />Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets<br /><i>Fitoterapia</i> <b>109</b>: 241<br /><br />Zha X, Lamba D, Zhang L, Lou Y, Xu C, Kang D, Chen L, Xu Y, De Simone A, Samez S, Pesaresi A, Stojan J, Lopez MG, Egea J, Andrisano V, Bartolini M (2016) <br />Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography<br /><i>Journal of Medicinal Chemistry</i> <b>59</b>: 114<br /><br />Belluti F, De Simone A, Tarozzi A, Bartolini M, Djemil A, Bisi A, Gobbi S, Montanari S, Cavalli A, Andrisano V, Bottegoni G, Rampa A (2014) <br />Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>78C</b>: 157<br /><br />Viayna E, Sola I, Bartolini M, De Simone A, Tapia-Rojas C, Serrano FG, Sabate R, Juarez-Jimenez J, Perez B, Luque FJ, Andrisano V, Clos MV, Inestrosa NC, Munoz-Torrero D (2014) <br />Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents<br /><i>Journal of Medicinal Chemistry</i> <b>57</b>: 2549<br /><br />Prati F, Bartolini M, Simoni E, De Simone A, Pinto A, Andrisano V, Bolognesi ML (2013) <br />Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>23</b>: 6254<br /><br />Bertucci C, De Simone A, Pistolozzi M, Rosini M (2011) <br />Reversible human serum albumin binding of lipocrine: a circular dichroism study<br /><i>Chirality</i> <b>23</b>: 827<br /><br />