Schrag JD, Cygler M (2004)
Defining substrate characteristics from 3D structure; perspective on EstA structure
Structure 12: 521

Cygler M, Schrag JD (1999)
Structure and conformational flexibility of Candida rugosa lipase
Biochimica & Biophysica Acta 1441: 205

Cygler M, Schrag JD (1997)
Structure as basis for understanding interfacial properties of lipases
Methods Enzymol 284: 3

Holmquist M, Tessier DC, Cygler M (1997)
High-level production of recombinant Geotrichum candidum lipases in yeast Pichia pastoris
Protein Expr Purif 11: 35

Schrag JD, Cygler M (1997)
Lipases and alpha/beta hydrolase fold
Methods Enzymol 284: 85

Schrag JD, Li Y, Cygler M, Lang D, Burgdorf T, Hecht HJ, Schmid RD, Schomburg D, Rydel TJ, Oliver JD, Strickland LC, Dunaway CM, Larson SB, Day J, McPherson A (1997)
The open conformation of a Pseudomonas lipase
Structure 5: 187

Shilton BH, Thomas DY, Cygler M (1997)
Crystal structure of Kex1deltap, a prohormone-processing carboxypeptidase from Saccharomyces cerevisiae
Biochemistry 36: 9002

Gulomova K, Ziomek E, Schrag JD, Davranov K, Cygler M (1996)
Purification and characterization of a Penicillium sp. lipase which discriminates against diglycerides
Lipids 31: 379

Shilton BH, Li Y, Tessier D, Thomas DY, Cygler M (1996)
Crystallization of a soluble form of the Kex1p serine carboxypeptidase from Saccharomyces cerevisiae
Protein Science 5: 395

Bertolini MC, Schrag JD, Cygler M, Ziomek E, Thomas DY, Vernet T (1995)
Expression and characterization of Geotrichum candidum lipase I gene. Comparison of specificity profile with lipase II
European Journal of Biochemistry 228: 863

Cygler M, Grochulski P, Schrag JD (1995)
Structural determinants defining common stereoselectivity of lipases toward secondary alcohols
Can J Microbiol 41 Suppl 1: 289

Cygler M, Grochulski P, Schrag JD (1995)
Substrate Binding Site and the Role of the FLAP Loop in Candida rugosa Lipase, A Close Relative of Acetylcholinesterase
In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.: 71

Schrag JD, Vernet T, Laramee L, Thomas DY, Recktenwald A, Okoniewska M, Ziomek E, Cygler M (1995)
Redesigning the active site of Geotrichum candidum lipase
Protein Engineering 8: 835

Bertolini MC, Laramee L, Thomas DY, Cygler M, Schrag JD, Vernet T (1994)
Polymorphism in the lipase genes of Geotrichum candidum strains
European Journal of Biochemistry 219: 119

Cygler M, Grochulski P, Kazlauskas RJ, Schrag JD, Bouthillier F, Rubin B, Serreqi AN, Gupta AK (1994)
A structural basis for the chiral preferences of lipases
Journal of the American Chemical Society 116: 3180

Grochulski P, Bouthillier F, Kazlauskas RJ, Serreqi AN, Schrag JD, Ziomek E, Cygler M (1994)
Analogs of reaction intermediates identify a unique substrate binding site in Candida rugosa lipase
Biochemistry 33: 3494

Grochulski P, Li Y, Schrag JD, Cygler M (1994)
Two conformational states of Candida rugosa lipase
Protein Science 3: 82

Cygler M, Schrag JD, Sussman JL, Harel M, Silman I, Gentry MK, Doctor BP (1993)
Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins
Protein Science 2: 366

Cygler M (1993)
Enzymes. Snapshots along the pathway [news; comment]
Nature 363: 674

Grochulski P, Li Y, Schrag JD, Bouthillier F, Smith P, Harrison D, Rubin B, Cygler M (1993)
Insights into interfacial activation from an open structure of Candida rugosa lipase
Journal of Biological Chemistry 268: 12843

Schrag JD, Cygler M (1993)
1.8 A refined structure of the lipase from Geotrichum candidum
Journal of Molecular Biology 230: 575

Vernet T, Ziomek E, Recktenwald A, Schrag JD, de Montigny C, Tessier DC, Thomas DY, Cygler M (1993)
Cloning and expression of Geotrichum candidum lipase II gene in yeast. Probing of the enzyme active site by site-directed mutagenesis
Journal of Biological Chemistry 268: 26212

Cygler M, Schrag JD, Ergan F (1992)
Advances in structural understanding of lipases
Biotechnol Genet Eng Rev 10: 143

Cygler M, Schrag JD (1992)
Sequence Alignment of Esterases and Lipases Based on 3-D Structures of Two Members of This Family
In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases (Shafferman, A. and Velan, B., Eds) Plenum Press, New York: 109

Ollis DL, Cheah E, Cygler M, Dijkstra B, Frolow F, Franken SM, Harel M, Remington SJ, Silman I, Schrag JD, Sussman JL, Verschueren KHG, Goldman A (1992)
The alpha/beta hydrolase fold
Protein Engineering 5: 197

Schrag JD, Winkler FK, Cygler M (1992)
Pancreatic lipases: evolutionary intermediates in a positional change of catalytic carboxylates?
Journal of Biological Chemistry 267: 4300

Schrag JD, Li YG, Wu S, Cygler M (1991)
Ser-His-Glu triad forms the catalytic site of the lipase from Geotrichum candidum
Nature 351: 761