Schrag JD, Cygler M (2004) <br />Defining substrate characteristics from 3D structure; perspective on EstA structure<br /><i>Structure</i> <b>12</b>: 521<br /><br />Cygler M, Schrag JD (1999) <br />Structure and conformational flexibility of Candida rugosa lipase<br /><i>Biochimica & Biophysica Acta</i> <b>1441</b>: 205<br /><br />Cygler M, Schrag JD (1997) <br />Structure as basis for understanding interfacial properties of lipases<br /><i>Methods Enzymol</i> <b>284</b>: 3<br /><br />Holmquist M, Tessier DC, Cygler M (1997) <br />High-level production of recombinant Geotrichum candidum lipases in yeast Pichia pastoris<br /><i>Protein Expr Purif</i> <b>11</b>: 35<br /><br />Schrag JD, Cygler M (1997) <br />Lipases and alpha/beta hydrolase fold<br /><i>Methods Enzymol</i> <b>284</b>: 85<br /><br />Schrag JD, Li Y, Cygler M, Lang D, Burgdorf T, Hecht HJ, Schmid RD, Schomburg D, Rydel TJ, Oliver JD, Strickland LC, Dunaway CM, Larson SB, Day J, McPherson A (1997) <br />The open conformation of a Pseudomonas lipase<br /><i>Structure</i> <b>5</b>: 187<br /><br />Shilton BH, Thomas DY, Cygler M (1997) <br />Crystal structure of Kex1deltap, a prohormone-processing carboxypeptidase from Saccharomyces cerevisiae<br /><i>Biochemistry</i> <b>36</b>: 9002<br /><br />Gulomova K, Ziomek E, Schrag JD, Davranov K, Cygler M (1996) <br />Purification and characterization of a Penicillium sp. lipase which discriminates against diglycerides<br /><i>Lipids</i> <b>31</b>: 379<br /><br />Shilton BH, Li Y, Tessier D, Thomas DY, Cygler M (1996) <br />Crystallization of a soluble form of the Kex1p serine carboxypeptidase from Saccharomyces cerevisiae<br /><i>Protein Science</i> <b>5</b>: 395<br /><br />Bertolini MC, Schrag JD, Cygler M, Ziomek E, Thomas DY, Vernet T (1995) <br />Expression and characterization of Geotrichum candidum lipase I gene. Comparison of specificity profile with lipase II<br /><i>European Journal of Biochemistry</i> <b>228</b>: 863<br /><br />Cygler M, Grochulski P, Schrag JD (1995) <br />Structural determinants defining common stereoselectivity of lipases toward secondary alcohols<br /><i>Can J Microbiol</i> <b>41 Suppl 1</b>: 289<br /><br />Cygler M, Grochulski P, Schrag JD (1995) <br />Substrate Binding Site and the Role of the FLAP Loop in Candida rugosa Lipase, A Close Relative of Acetylcholinesterase<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 71<br /><br />Schrag JD, Vernet T, Laramee L, Thomas DY, Recktenwald A, Okoniewska M, Ziomek E, Cygler M (1995) <br />Redesigning the active site of Geotrichum candidum lipase<br /><i>Protein Engineering</i> <b>8</b>: 835<br /><br />Bertolini MC, Laramee L, Thomas DY, Cygler M, Schrag JD, Vernet T (1994) <br />Polymorphism in the lipase genes of Geotrichum candidum strains<br /><i>European Journal of Biochemistry</i> <b>219</b>: 119<br /><br />Cygler M, Grochulski P, Kazlauskas RJ, Schrag JD, Bouthillier F, Rubin B, Serreqi AN, Gupta AK (1994) <br />A structural basis for the chiral preferences of lipases<br /><i>Journal of the American Chemical Society</i> <b>116</b>: 3180<br /><br />Grochulski P, Bouthillier F, Kazlauskas RJ, Serreqi AN, Schrag JD, Ziomek E, Cygler M (1994) <br />Analogs of reaction intermediates identify a unique substrate binding site in Candida rugosa lipase<br /><i>Biochemistry</i> <b>33</b>: 3494<br /><br />Grochulski P, Li Y, Schrag JD, Cygler M (1994) <br />Two conformational states of Candida rugosa lipase<br /><i>Protein Science</i> <b>3</b>: 82<br /><br />Cygler M, Schrag JD, Sussman JL, Harel M, Silman I, Gentry MK, Doctor BP (1993) <br />Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins<br /><i>Protein Science</i> <b>2</b>: 366<br /><br />Cygler M (1993) <br />Enzymes. Snapshots along the pathway [news; comment]<br /><i>Nature</i> <b>363</b>: 674<br /><br />Grochulski P, Li Y, Schrag JD, Bouthillier F, Smith P, Harrison D, Rubin B, Cygler M (1993) <br />Insights into interfacial activation from an open structure of Candida rugosa lipase<br /><i>Journal of Biological Chemistry</i> <b>268</b>: 12843<br /><br />Schrag JD, Cygler M (1993) <br />1.8 A refined structure of the lipase from Geotrichum candidum<br /><i>Journal of Molecular Biology</i> <b>230</b>: 575<br /><br />Vernet T, Ziomek E, Recktenwald A, Schrag JD, de Montigny C, Tessier DC, Thomas DY, Cygler M (1993) <br />Cloning and expression of Geotrichum candidum lipase II gene in yeast. Probing of the enzyme active site by site-directed mutagenesis<br /><i>Journal of Biological Chemistry</i> <b>268</b>: 26212<br /><br />Cygler M, Schrag JD, Ergan F (1992) <br />Advances in structural understanding of lipases<br /><i>Biotechnol Genet Eng Rev</i> <b>10</b>: 143<br /><br />Cygler M, Schrag JD (1992) <br />Sequence Alignment of Esterases and Lipases Based on 3-D Structures of Two Members of This Family<br /><i>In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases</i> <b>(Shafferman, A. and Velan, B., Eds) Plenum Press, New York</b>: 109<br /><br />Ollis DL, Cheah E, Cygler M, Dijkstra B, Frolow F, Franken SM, Harel M, Remington SJ, Silman I, Schrag JD, Sussman JL, Verschueren KHG, Goldman A (1992) <br />The alpha/beta hydrolase fold<br /><i>Protein Engineering</i> <b>5</b>: 197<br /><br />Schrag JD, Winkler FK, Cygler M (1992) <br />Pancreatic lipases: evolutionary intermediates in a positional change of catalytic carboxylates?<br /><i>Journal of Biological Chemistry</i> <b>267</b>: 4300<br /><br />Schrag JD, Li YG, Wu S, Cygler M (1991) <br />Ser-His-Glu triad forms the catalytic site of the lipase from Geotrichum candidum<br /><i>Nature</i> <b>351</b>: 761<br /><br />