Costa LG, Garrick JM, Roque PJ, Pellacani C (2016) <br />Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More<br /><i>Oxid Med Cell Longev</i> <b>2016</b>: 2986796<br /><br />Furlong CE, Marsillach J, Jarvik GP, Costa LG (2016) <br />Paraoxonases-1, -2 and -3: What are their functions?<br /><i>Chemico-Biological Interactions</i> <b>259</b>: 51<br /><br />Garrick JM, Dao K, de Laat R, Elsworth J, Cole TB, Marsillach J, Furlong CE, Costa LG (2016) <br />Developmental expression of paraoxonase 2<br /><i>Chemico-Biological Interactions</i> <b>259</b>: 168<br /><br />Roque PJ, Dao K, Costa LG (2016) <br />Microglia mediate diesel exhaust particle-induced cerebellar neuronal toxicity through neuroinflammatory mechanisms<br /><i>Neurotoxicology</i> <b>56</b>: 204<br /><br />Cole TB, Li WF, Co AL, Hay AM, MacDonald JW, Bammler TK, Farin FM, Costa LG, Furlong CE (2014) <br />Repeated Gestational Exposure of Mice to Chlorpyrifos Oxon Is Associated with Paraoxonase 1 (PON1) Modulated Effects in Maternal and Fetal Tissues<br /><i>Toxicol Sci</i> <b>141</b>: 409<br /><br />Costa LG, de Laat R, Dao K, Pellacani C, Cole TB, Furlong CE (2014) <br />Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection<br /><i>Neurotoxicology</i> <b>43</b>: 3<br /><br />Pizzurro DM, Dao K, Costa LG (2014) <br />Diazinon and diazoxon impair the ability of astrocytes to foster neurite outgrowth in primary hippocampal neurons<br /><i>Toxicol Appl Pharmacol</i> <b>274</b>: 372<br /><br />Pizzurro DM, Dao K, Costa LG (2014) <br />Astrocytes protect against diazinon- and diazoxon-induced inhibition of neurite outgrowth by regulating neuronal glutathione<br /><i>Toxicology</i> <b>318</b>: 59<br /><br />Costa LG, Giordano G, Cole TB, Marsillach J, Furlong CE (2013) <br />Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity<br /><i>Toxicology</i> <b>307</b>: 115<br /><br />Costa LG, Tait L, de Laat R, Dao K, Giordano G, Pellacani C, Cole TB, Furlong CE (2013) <br />Modulation of Paraoxonase 2 (PON2) in Mouse Brain by the Polyphenol Quercetin: A Mechanism of Neuroprotection?<br /><i>Neurochem Res</i> <b>38</b>: 1809<br /><br />Giordano G, Tait L, Furlong CE, Cole TB, Kavanagh TJ, Costa LG (2013) <br />Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression<br /><i>Free Radic Biol Med</i> <b>58</b>: 98<br /><br />Marsillach J, Costa LG, Furlong CE (2013) <br />Protein adducts as biomarkers of exposure to organophosphorus compounds<br /><i>Toxicology</i> <b>307</b>: 46<br /><br />Cole TB, Fisher JC, Burbacher TM, Costa LG, Furlong CE (2012) <br />Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon<br /><i>Neurotoxicology & Teratology</i> <b>34</b>: 311<br /><br />Camps J, Joven J, Mackness B, Mackness MI, Tawfik DS, Draganov DI, Costa LG, Paragh G, Seres I, Horke S, James RW, Hernandez AF, Reddy ST, Shih DM, Navab M, Rochu D, Aviram M (2011) <br />Paraoxonase-1 and clopidogrel efficacy<br /><i>Nat Med</i> <b>17</b>: 1041<br /><br />Cole TB, Beyer RP, Bammler TK, Park SS, Farin FM, Costa LG, Furlong CE (2011) <br />Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression<br /><i>Toxicol Sci</i> <b>123</b>: 155<br /><br />Costa LG, Giordano G, Furlong CE (2011) <br />Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: the hunt goes on<br /><i>Biochemical Pharmacology</i> <b>81</b>: 337<br /><br />Giordano G, Cole TB, Furlong CE, Costa LG (2011) <br />Paraoxonase 2 (PON2) in the mouse central nervous system: a neuroprotective role?<br /><i>Toxicol Appl Pharmacol</i> <b>256</b>: 369<br /><br />Cole TB, Jansen K, Park S, Li WF, Furlong CE, Costa LG (2010) <br />The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status<br /><i>Advances in Experimental Medicine & Biology</i> <b>660</b>: 47<br /><br />Furlong CE, Suzuki SM, Stevens RC, Marsillach J, Richter RJ, Jarvik GP, Checkoway H, Samii A, Costa LG, Griffith A, Roberts JW, Yearout D, Zabetian CP (2010) <br />Human PON1, a biomarker of risk of disease and exposure<br /><i>Chemico-Biological Interactions</i> <b>187</b>: 355<br /><br />Jansen KL, Cole TB, Park SS, Furlong CE, Costa LG (2009) <br />Paraoxonase 1 (PON1) modulates the toxicity of mixed organophosphorus compounds<br /><i>Toxicol Appl Pharmacol</i> <b>236</b>: 142<br /><br />Eaton DL, Daroff RB, Autrup H, Bridges J, Buffler P, Costa LG, Coyle J, McKhann G, Mobley WC, Nadel L, Neubert D, Schulte-Hermann R, Spencer PS (2008) <br />Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment<br /><i>Crit Rev Toxicol</i> <b>38 Suppl 2</b>: 1<br /><br />Costa LG (2006) <br />Current issues in organophosphate toxicology<br /><i>Clinica Chimica Acta</i> <b>366</b>: 1<br /><br />Cole TB, Walter BJ, Shih DM, Tward AD, Lusis AJ, Timchalk C, Richter RJ, Costa LG, Furlong CE (2005) <br />Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism<br /><i>Pharmacogenet Genomics</i> <b>15</b>: 589<br /><br />Costa LG, Cole TB, Furlong CE (2005) <br />Paraoxonase (PON1): from toxicology to cardiovascular medicine<br /><i>Acta Biomed</i> <b>76 Suppl 2</b>: 50<br /><br />Costa LG, Cole TB, Vitalone A, Furlong CE (2005) <br />Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity<br /><i>Clinica Chimica Acta</i> <b>352</b>: 37<br /><br />Costa LG, Vitalone A, Cole TB, Furlong CE (2005) <br />Modulation of paraoxonase (PON1) activity<br /><i>Biochemical Pharmacology</i> <b>69</b>: 541<br /><br />Furlong CE, Cole TB, Walter BJ, Shih DM, Tward A, Lusis AJ, Timchalk C, Richter RJ, Costa LG (2005) <br />Paraoxonase 1 (PON1) status and risk of insecticide exposure<br /><i>J Biochem Mol Toxicol</i> <b>19</b>: 182<br /><br />Furlong CE, Cole TB, Jarvik GP, Pettan-Brewer C, Geiss GK, Richter RJ, Shih DM, Tward AD, Lusis AJ, Costa LG (2005) <br />Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants<br /><i>Neurotoxicology</i> <b>26</b>: 651<br /><br />Zurich MG, Honegger P, Schilter B, Costa LG, Monnet-Tschudi F (2004) <br />Involvement of glial cells in the neurotoxicity of parathion and chlorpyrifos<br /><i>Toxicol Appl Pharmacol</i> <b>201</b>: 97<br /><br />Furlong CE, Li WF, Richter RJ, Shih DM, Lusis AJ, Alleva E, Costa LG (2000) <br />Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1)<br /><i>Neurotoxicology</i> <b>21</b>: 91<br /><br />Li WF, Costa LG, Richter RJ, Hagen T, Shih DM, Tward A, Lusis AJ, Furlong CE (2000) <br />Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds<br /><i>Pharmacogenetics</i> <b>10</b>: 767<br /><br />Monnet-Tschudi F, Zurich MG, Schilter B, Costa LG, Honegger P (2000) <br />Maturation-dependent effects of chlorpyrifos and parathion and their oxygen analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures<br /><i>Toxicol Appl Pharmacol</i> <b>165</b>: 175<br /><br />Costa LG, Li WF, Richter RJ, Shih DM, Lusis A, Furlong CE (1999) <br />The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism<br /><i>Chemico-Biological Interactions</i> <b>119-120</b>: 429<br /><br />Castoldi AF, Barni S, Randine G, Costa LG, Manzo L (1998) <br />Ethanol selectively interferes with the trophic action of NMDA and carbachol on cultured cerebellar granule neurons undergoing apoptosis<br /><i>Brain Research Developmental Brain Research</i> <b>111</b>: 279<br /><br />Furlong CE, Li WF, Costa LG, Richter RJ, Shih DM, Lusis AJ (1998) <br />Genetically determined susceptibility to organophosphorus insecticides and nerve agents: developing a mouse model for the human PON1 polymorphism<br /><i>Neurotoxicology</i> <b>19</b>: 645<br /><br />Shih DM, Gu L, Xia YR, Navab M, Li WF, Hama S, Castellani LW, Furlong CE, Costa LG, Fogelman AM, Lusis AJ (1998) <br />Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis<br /><i>Nature</i> <b>394</b>: 284<br /><br />Li WF, Matthews C, Disteche CM, Costa LG, Furlong CE (1997) <br />Paraoxonase (PON1) gene in mice: sequencing, chromosomal localization and developmental expression<br /><i>Pharmacogenetics</i> <b>7</b>: 137<br /><br />Castoldi AF, Candura SM, Costa Paola, Manzo L, Costa LG (1996) <br />Interaction of mercury compounds with muscarinic receptor subtypes in the rat brain<br /><i>Neurotoxicology</i> <b>17</b>: 735<br /><br />Guizzetti M, Costa Paola, Peters J, Costa LG (1996) <br />Acetylcholine as a mitogen: muscarinic receptor-mediated proliferation of rat astrocytes and human astrocytoma cells<br /><i>European Journal of Pharmacology</i> <b>297</b>: 265<br /><br />Yagle K, Costa LG (1996) <br />Effects of organophosphate exposure on muscarinic acetylcholine receptor subtype mRNA levels in the adult rat<br /><i>Neurotoxicology</i> <b>17</b>: 523<br /><br />Costa Paola, Traver DJ, Auger CB, Costa LG (1995) <br />Poster: Identification of m3, m4, m5 subtypes of muscarinic receptor mRNA in human blood mononuclear cells<br /><i>Life Sciences</i> <b>56(11-12)</b>: 1019<br /><br />Costa LG, Guizzetti M (1995) <br />Poster: Activation of muscarinic receptors induces proliferation of rat cortical astrocytes and human astrocytoma cells: Role of protein kinase C<br /><i>Life Sciences</i> <b>56(11-12)</b>: 1026<br /><br />Costa Paola, Auger CB, Traver DJ, Costa LG (1995) <br />Identification of m3, m4 and m5 subtypes of muscarinic receptor mRNA in human blood mononuclear cells<br /><i>Journal of Neuroimmunology</i> <b>60</b>: 45<br /><br />Li WF, Furlong CE, Costa LG (1995) <br />Paraoxonase protects against chlorpyrifos toxicity in mice<br /><i>Toxicology Letters</i> <b>76</b>: 219<br /><br />Costa Paola, Castoldi AF, Traver DJ, Costa LG (1994) <br />Lack of m2 muscarinic acetylcholine receptor mRNA in rat lymphocytes<br /><i>Journal of Neuroimmunology</i> <b>49</b>: 115<br /><br />Costa Paola, Traver DJ, Auger CB, Costa LG (1994) <br />Expression of cholinergic muscarinic receptor subtypes mRNA in rat blood mononuclear cells<br /><i>Immunopharmacology</i> <b>28</b>: 113<br /><br />Ehrich M, Intropido L, Costa LG (1994) <br />Interaction of organophosphorus compounds with muscarinic receptors in SH-SY5Y human neuroblastoma cells<br /><i>J Toxicol Environ Health</i> <b>43</b>: 51<br /><br />Castoldi AF, Manzo L, Costa LG (1993) <br />Cyclic GMP formation induced by muscarinic receptors is mediated by nitric oxide synthesis in rat cortical primary cultures<br /><i>Brain Research</i> <b>610</b>: 57<br /><br />Fitzgerald BB, Costa LG (1993) <br />Modulation of muscarinic receptors and acetylcholinesterase activity in lymphocytes and in brain areas following repeated organophosphate exposure in rats<br /><i>Fundamental & Applied Toxicology</i> <b>20</b>: 210<br /><br />Furlong CE, Costa LG, Hassett C, Richter RJ, Sundstrom JA, Adler DA, Disteche CM, Omiecinski CJ, Chapline C, Crabb JW, et al. (1993) <br />Human and rabbit paraoxonases: purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification<br /><i>Chemico-Biological Interactions</i> <b>87</b>: 35<br /><br />Li WF, Costa LG, Furlong CE (1993) <br />Serum paraoxonase status: a major factor in determining resistance to organophosphates<br /><i>Journal of Toxicology & Environmental Health</i> <b>40</b>: 337<br /><br />Tan XX, Castoldi AF, Manzo L, Costa LG (1993) <br />Interaction of ethanol with muscarinic receptor-stimulated phosphoinositide metabolism during the brain growth spurt in the rat: role of acetaldehyde<br /><i>Neuroscience Letters</i> <b>156</b>: 13<br /><br />Tang C, Castoldi AF, Costa LG (1993) <br />Effects of the muscarinic agonist oxotremorine on membrane fluidity in rat lymphocytes<br /><i>Biochemistry & Molecular Biology International</i> <b>29</b>: 1047<br /><br />Candura SM, Castoldi AF, Manzo L, Costa LG (1991) <br />Interaction of aluminum ions with phosphoinositide metabolism in rat cerebral cortical membranes<br /><i>Life Sciences</i> <b>49</b>: 1245<br /><br />Castoldi AF, Fitzgerald B, Manzo L, Tonini M, Costa LG (1991) <br />Muscarinic M2 receptors in rat brain labeled with [3H] AF-DX 384<br /><i>Res Commun Chem Pathol Pharmacol</i> <b>74</b>: 371<br /><br />Costa LG, McDonald BE, Murphy SD, Omenn GS, Richter RJ, Motulsky AG, Furlong CE (1990) <br />Serum paraoxonase and its influence on paraoxon and chlorpyrifos-oxon toxicity in rats<br /><i>Toxicol Appl Pharmacol</i> <b>103</b>: 66<br /><br />McDonald BE, Costa LG, Murphy SD (1988) <br />Spatial memory impairment and central muscarinic receptor loss following prolonged treatment with organophosphates<br /><i>Toxicol Lett</i> <b>40</b>: 42<br /><br />