Galdeano C, Coquelle N, Cieslikiewicz-Bouet M, Bartolini M, Perez B, Clos MV, Silman I, Jean L, Colletier JP, Renard PY, Munoz-Torrero D (2018) <br />Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis<br /><i>Molecules</i> <b>23</b>: <br /><br />Relat J, Come J, Perez B, Camps P, Munoz-Torrero D, Badia A, Gimenez-Llort L, Clos MV (2018) <br />Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice<br /><i>Int J Mol Sci</i> <b>19</b>: <br /><br />Gimenez-Llort L, Ratia M, Perez B, Camps P, Munoz-Torrero D, Badia A, Clos MV (2017) <br />Behavioural effects of novel multitarget anticholinesterasic derivatives in Alzheimer's disease<br /><i>Behav Pharmacol</i> <b>28</b>: 124<br /><br />Di Pietro O, Vicente-Garcia E, Taylor MC, Berenguer D, Viayna E, Lanzoni A, Sola I, Sayago H, Riera C, Fisa R, Clos MV, Perez B, Kelly JM, Lavilla R, Munoz-Torrero D (2015) <br />Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity<br /><i>Eur Journal of Medicinal Chemistry</i> <b>105</b>: 120<br /><br />Gimenez-Llort L, Ratia M, Perez B, Camps P, Munoz-Torrero D, Badia A, Clos MV (2015) <br />AVCRI104P3, a novel multitarget compound with cognition-enhancing and anxiolytic activities: Studies in cognitively poor middle-aged mice<br /><i>Behavioural Brain Research</i> <b>286</b>: 97<br /><br />Sola I, Aso E, Frattini D, Lopez-Gonzalez I, Espargaro A, Sabate R, Di Pietro O, Luque FJ, Clos MV, Ferrer I, Munoz-Torrero D (2015) <br />Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies<br /><i>Journal of Medicinal Chemistry</i> <b>58</b>: 6018<br /><br />Sola I, Castella S, Viayna E, Galdeano C, Taylor MC, Gbedema SY, Perez B, Clos MV, Jones DC, Fairlamb AH, Wright CW, Kelly JM, Munoz-Torrero D (2015) <br />Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity<br /><i>Bioorganic & Medicinal Chemistry</i> <b>23</b>: 5156<br /><br />Di Pietro O, Perez-Areales FJ, Juarez-Jimenez J, Espargaro A, Clos MV, Perez B, Lavilla R, Sabate R, Luque FJ, Munoz-Torrero D (2014) <br />Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting beta-amyloid, tau, and cholinesterase pathologies<br /><i>Eur Journal of Medicinal Chemistry</i> <b>84C</b>: 107<br /><br />Perez-Areales FJ, Di Pietro O, Espargaro A, Vallverdu-Queralt A, Galdeano C, Ragusa IM, Viayna E, Guillou C, Clos MV, Perez B, Sabate R, Lamuela-Raventos RM, Luque FJ, Munoz-Torrero D (2014) <br />Shogaol-huprine hybrids: Dual antioxidant and anticholinesterase agents with beta-amyloid and tau anti-aggregating properties<br /><i>Bioorganic & Medicinal Chemistry</i> <b>22</b>: 5298<br /><br />Sola I, Artigas A, Taylor MC, Gbedema SY, Perez B, Clos MV, Wright CW, Kelly JM, Munoz-Torrero D (2014) <br />Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>24</b>: 5435<br /><br />Viayna E, Sola I, Bartolini M, De Simone A, Tapia-Rojas C, Serrano FG, Sabate R, Juarez-Jimenez J, Perez B, Luque FJ, Andrisano V, Clos MV, Inestrosa NC, Munoz-Torrero D (2014) <br />Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents<br /><i>Journal of Medicinal Chemistry</i> <b>57</b>: 2549<br /><br />Di Pietro O, Viayna E, Vicente-Garcia E, Bartolini M, Ramon R, Juarez-Jimenez J, Clos MV, Perez B, Andrisano V, Luque FJ, Lavilla R, Munoz-Torrero D (2013) <br />1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies<br /><i>Eur Journal of Medicinal Chemistry</i> <b>73C</b>: 141<br /><br />Ratia M, Gimenez-Llort L, Camps P, Munoz-Torrero D, Perez B, Clos MV, Badia A (2013) <br />Huprine X and Huperzine A Improve Cognition and Regulate Some Neurochemical Processes Related with Alzheimer's Disease in Triple Transgenic Mice (3xTg-AD)<br /><i>Neurodegener Dis</i> <b>11</b>: 129<br /><br />Galdeano C, Viayna E, Sola I, Formosa X, Camps P, Badia A, Clos MV, Relat J, Ratia M, Bartolini M, Mancini F, Andrisano V, Salmona M, Minguillon C, Gonzalez-Munoz GC, Rodriguez-Franco MI, Bidon-Chanal A, Luque FJ, Munoz-Torrero D (2012) <br />Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases<br /><i>Journal of Medicinal Chemistry</i> <b>55</b>: 661<br /><br />Munoz-Torrero D, Pera M, Relat J, Ratia M, Galdeano C, Viayna E, Sola I, Formosa X, Camps P, Badia A, Clos MV (2012) <br />Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents<br /><i>Neurodegener Dis</i> <b>10</b>: 96<br /><br />Camps P, Formosa X, Galdeano C, Gomez T, Munoz-Torrero D, Ramirez L, Viayna E, Gomez E, Isambert N, Lavilla R, Badia A, Clos MV, Bartolini M, Mancini F, Andrisano V, Bidon-Chanal A, Huertas O, Dafni T, Luque FJ (2010) <br />Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates<br /><i>Chemico-Biological Interactions</i> <b>187</b>: 411<br /><br />Hedberg MM, Clos MV, Ratia M, Gonzalez D, Lithner CU, Camps P, Munoz-Torrero D, Badia A, Gimenez-Llort L, Nordberg A (2010) <br />Effect of huprine X on beta-amyloid, synaptophysin and alpha7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice<br /><i>Neurodegener Dis</i> <b>7</b>: 379<br /><br />Viayna E, Gomez T, Galdeano C, Ramirez L, Ratia M, Badia A, Clos MV, Verdaguer E, Junyent F, Camins A, Pallas M, Bartolini M, Mancini F, Andrisano V, Arce MP, Rodriguez-Franco MI, Bidon-Chanal A, Luque FJ, Camps P, Munoz-Torrero D (2010) <br />Novel huprine derivatives with inhibitory activity toward beta-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates<br /><i>ChemMedChem</i> <b>5</b>: 1855<br /><br />Camps P, Formosa X, Galdeano C, Munoz-Torrero D, Ramirez L, Gomez E, Isambert N, Lavilla R, Badia A, Clos MV, Bartolini M, Mancini F, Andrisano V, Arce MP, Rodriguez-Franco MI, Huertas O, Dafni T, Luque FJ (2009) <br />Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds<br /><i>Journal of Medicinal Chemistry</i> <b>52</b>: 5365<br /><br />Pera M, Martinez-Otero A, Colombo L, Salmona M, Ruiz-Molina D, Badia A, Clos MV (2009) <br />Acetylcholinesterase as an amyloid enhancing factor in PrP82-146 aggregation process<br /><i>Molecular & Cellular Neurosciences</i> <b>40</b>: 217<br /><br />Camps P, Formosa X, Galdeano C, Gomez T, Munoz-Torrero D, Scarpellini M, Viayna E, Badia A, Clos MV, Camins A, Pallas M, Bartolini M, Mancini F, Andrisano V, Estelrich J, Lizondo M, Bidon-Chanal A, Luque FJ (2008) <br />Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation<br /><i>Journal of Medicinal Chemistry</i> <b>51</b>: 3588<br /><br />Camps P, Gomez E, Munoz-Torrero D, Badia A, Clos MV, Curutchet C, Munoz-Muriedas J, Luque FJ (2006) <br />Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole<br /><i>Journal of Medicinal Chemistry</i> <b>49</b>: 6833<br /><br />Clos MV, Pera M, Ratia M, Roman S, Camps P, Munoz-Torrero D, Colombo L, Salmona M, Badia A (2006) <br />Effect of acetylcholinesterase inhibitors on AChE-induced PrP106-126 aggregation<br /><i>Journal of Molecular Neuroscience</i> <b>30</b>: 89<br /><br />Pera M, Roman S, Ratia M, Camps P, Munoz-Torrero D, Colombo L, Manzoni C, Salmona M, Badia A, Clos MV (2006) <br />Acetylcholinesterase triggers the aggregation of PrP 106-126<br /><i>Biochemical & Biophysical Research Communications</i> <b>346</b>: 89<br /><br />Camps P, Formosa X, Munoz-Torrero D, Petrignet J, Badia A, Clos MV (2005) <br />Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 1701<br /><br />Roman S, Badia A, Camps P, Munoz-Torrero D, Clos MV (2005) <br />Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors<br /><i>Brain Research</i> <b>1061</b>: 73<br /><br />Roman S, Badia A, Camps P, Clos MV (2004) <br />Potentiation effects of (+/-)huprine X, a new acetylcholinesterase inhibitor, on nicotinic receptors in rat cortical synaptosomes<br /><i>Neuropharmacology</i> <b>46</b>: 95<br /><br />Roman S, Vivas NM, Badia A, Clos MV (2002) <br />Interaction of a new potent anticholinesterasic compound (+/-)huprine X with muscarinic receptors in rat brain<br /><i>Neuroscience Letters</i> <b>325</b>: 103<br /><br />Sanz AG, Badia A, Clos MV (2000) <br />Role of calcium on the modulation of spontaneous acetylcholine efflux by the D2 dopamine receptor subtype in rat striatal synaptosomes<br /><i>Brain Research</i> <b>854</b>: 42<br /><br />Dierssen M, Marmol F, Vivas NM, Clos MV, Badia A (1992) <br />Post-train administration of 9-amino-1,2,3,4-tetrahydroacridine enhances passive avoidance retention and decreases beta-adrenoceptor-linked cyclic AMP formation in middle-aged rats<br /><i>Brain Research</i> <b>586</b>: 117<br /><br />Dierssen M, Marmol F, Vivas NM, Clos MV, Gascon S, Badia A (1991) <br />Acute effects of tetrahydroaminoacridine on beta-adrenoceptor-linked cyclic AMP accumulation in brain of young and middle-aged rats<br /><i>Neuroscience Letters</i> <b>132</b>: 51<br /><br />