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Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering
Structure
Blumenthal DK, Cheng X, Fajer M, Ho KY, Rohrer J, Gerlits O, Taylor P, Juneja P, Kovalevsky A, Radic Z (2021)
Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects
Journal of Biological Chemistry
Ma C, Guan H, Lin Q, Liu C, Ju Z, Xue Y, Cheng X, Wang C (2021)
Dynamic changes in chemical compositions and anti-acetylcholinesterase activity associated with steaming process of stem-leaf saponins of Panax notoginseng
Biomedical Chromatography
Zhang J, Meng H, Kong X, Cheng X, Ma T, He H, Du W, Yang S, Li S, Zhang L (2021)
Combined effects of polyethylene and organic contaminant on zebrafish (Danio rerio): Accumulation of 9-Nitroanthracene, biomarkers and intestinal microbiota
Environ Pollut 277: 116767
Cheng X, Dong S, Chen D, Rui Q, Guo J, Dayong W, Jiang J (2020)
Potential of esterase DmtH in transforming plastic additive dimethyl terephthalate to less toxic mono-methyl terephthalate
Ecotoxicology & Environmental Safety 187: 109848
Gorecki L, Gerlits O, Kong X, Cheng X, Blumenthal DK, Taylor P, Ballatore C, Kovalevsky A, Radic Z (2020)
Rational design, synthesis and evaluation of uncharged, smart bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase
Journal of Biological Chemistry 295: 4079
Zhou JH, Wu B, Wang WX, Lei F, Cheng X, Qin JJ, Cai JJ, Zhang XJ, Zhou F, Liu YM, Li HM, Zhu LH, She ZG, Zhang X, Yang J, Li HL (2020)
No significant association between dipeptidyl peptidase-4 inhibitors and adverse outcomes of COVID-19
World J Clin Cases 8: 5576
Bai P, Wang K, Zhang P, Shi J, Cheng X, Zhang Q, Zheng C, Cheng Y, Yang J, Lu X, Sang Z (2019)
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease
Eur Journal of Medicinal Chemistry 183: 111737
Deng G, Liu W, Ma C, Rong X, Zhang Y, Wang Y, Wu C, Cao N, Ding W, Guan H, Cheng X, Wang C (2019)
In vivo and in vitro metabolism and pharmacokinetics of cholinesterase inhibitor deoxyvasicine from aerial parts of Peganum harmala Linn in rats via UPLC-ESI-QTOF-MS and UPLC-ESI-MS/MS
J Ethnopharmacol 236: 288
Deng G, Wu C, Rong X, Li S, Ju Z, Wang Y, Ma C, Ding W, Guan H, Cheng X, Liu W, Wang C (2019)
Ameliorative effect of deoxyvasicine on scopolamine-induced cognitive dysfunction by restoration of cholinergic function in mice
Phytomedicine 63: 153007
Gerlits O, Ho KY, Cheng X, Blumenthal D, Taylor P, Kovalevsky A, Radic Z (2019)
A new crystal form of human acetylcholinesterase for exploratory room-temperature crystallography studies
Chemico-Biological Interactions
Gerlits O, Kong X, Cheng X, Wymore T, Blumenthal DK, Taylor P, Radic Z, Kovalevsky A (2019)
Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase
Journal of Biological Chemistry 294: 10607
Jiang B, Meng L, Zou N, Wang H, Li S, Huang L, Cheng X, Wang Z, Chen W, Wang C (2019)
Mechanism-based pharmacokinetics-pharmacodynamics studies of harmine and harmaline on neurotransmitters regulatory effects in healthy rats: Challenge on monoamine oxidase and acetylcholinesterase inhibition
Phytomedicine 62: 152967
Lin R, Zhang X, Xin B, Zou M, Gao Y, Qin F, Hu Q, Xie B, Cheng X (2019)
Genome sequence of Isaria javanica and comparative genome analysis insights into family S53 peptidase evolution in fungal entomopathogens
Applied Microbiology & Biotechnology 103: 7111
Zhang Y, Li S, Wang Y, Deng G, Cao N, Wu C, Ding W, Cheng X, Wang C (2019)
Potential Pharmacokinetic Drug(-)Drug Interaction Between Harmine, a Cholinesterase Inhibitor, and Memantine, a Non-Competitive N-Methyl-d-Aspartate Receptor Antagonist
Molecules 24:
Zhao L, Cheng X, Zhong C (2019)
Implications of Successful Symptomatic Treatment in Parkinson's Disease for Therapeutic Strategies of Alzheimer's Disease
ACS Chem Neurosci 10: 922
Zhou Y, Lu X, Yang H, Chen Y, Wang F, Li J, Tang Z, Cheng X, Yang Y, Xu L, Xia Q (2019)
Discovery of Selective Butyrylcholinesterase (BChE) Inhibitors through a Combination of Computational Studies and Biological Evaluations
Molecules 24:
Chen Q, Yu HL, Cheng X, Xu JH (2018)
Structural investigation of the enantioselectivity and thermostability mechanisms of esterase RhEst1
J Mol Graph Model 85: 182
Zhang Y, Cheng X, Wang Y, Diez-Simon C, Flokova K, Bimbo A, Bouwmeester HJ, Ruyter-Spira C (2018)
The tomato MAX1 homolog, SlMAX1, is involved in the biosynthesis of tomato strigolactones from carlactone
New Phytol 219: 297
Zhu Y, Liu W, Qi S, Wang H, Wang Y, Deng G, Zhang Y, Li S, Ma C, Cheng X, Wang C (2018)
Stereoselective glucuronidation metabolism, pharmacokinetics, anti-amnesic pharmacodynamics, and toxic properties of vasicine enantiomers in vitro and in vivo
Eur J Pharm Sci 123: 459
Chen C, Zheng Y, Wu T, Wu C, Cheng X (2017)
Oral administration of grape seed polyphenol extract restores memory deficits in chronic cerebral hypoperfusion rats
Behav Pharmacol 28: 207
Li S, Cheng X, Wang C (2017)
A review on traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the genus Peganum
J Ethnopharmacol 203: 127
Liu W, Zhu Y, Wang Y, Qi S, Ma C, Li S, Jiang B, Cheng X, Wang Z, Xuan Z, Wang C (2017)
Anti-amnesic effect of extract and alkaloid fraction from aerial parts of Peganum harmala on scopolamine-induced memory deficits in mice
J Ethnopharmacol 204: 95
Peng L, Xu S, Zheng X, Cheng X, Zhang R, Liu J, Liu B, Tong A (2017)
Rational Design of a Red-Emissive Fluorophore with AIE and ESIPT Characteristics and Its Application in Light-Up Sensing of Esterase
Analytical Chemistry 89: 3162
Kovalevsky A, Blumenthal DK, Cheng X, Taylor P, Radic Z (2016)
Limitations in current acetylcholinesterase structure-based design of oxime antidotes for organophosphate poisoning
Annals of the New York Academy of Sciences 1378: 41
Liu YC, Su J, Wu XD, Zhang ZJ, Fan M, Zhu QF, He J, Li XN, Peng LY, Cheng X, Zhao QS (2016)
Five new Lycopodium alkaloids from the aerial parts of Phlegmariurus henryi
Fitoterapia 115: 148
Liu J, Qiao Q, Cheng X, Du G, Deng G, Zhao M, Liu F (2016)
Transcriptome differences between fiber-type and seed-type Cannabis sativa variety exposed to salinity
Physiol Mol Biol Plants 22: 429
Wang Z, Zhao Z, Cheng X, Liu S, Wei Q, Scott IM (2016)
Conifer flavonoid compounds inhibit detoxification enzymes and synergize insecticides
Pestic Biochem Physiol 127: 1
Chen Q, Luan ZJ, Cheng X, Xu JH (2015)
Molecular dynamics investigation of the substrate binding mechanism in carboxylesterase
Biochemistry 54: 1841
Chen Q, Luan ZJ, Yu HL, Cheng X, Xu JH (2015)
Rational design of a carboxylic esterase RhEst1 based on computational analysis of substrate binding
J Mol Graph Model 62: 319
Jiang WW, Su J, Wu XD, He J, Peng LY, Cheng X, Zhao QS (2015)
Geissoschizine methyl ether N-oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla
Nat Prod Res 29: 842
Jiang WW, Liu YC, Zhang ZJ, He J, Su J, Cheng X, Peng LY, Shao LD, Wu XD, Yang JH, Zhao QS (2015)
Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum
Fitoterapia 109: 155
Liu W, Shi X, Yang Y, Cheng X, Liu Q, Han H, Yang B, He C, Wang Y, Jiang B, Wang Z, Wang C (2015)
In vitro and in vivo metabolism and inhibitory activities of vasicine, a potent acetylcholinesterase and butyrylcholinesterase inhibitor
PLoS ONE 10: e0122366
Liu YC, Fan M, Jiang WW, Liu F, Wu XD, He J, Cheng X, Peng LY, Su J, Zhang ZJ, Zhao QS (2015)
Four new fawcettimine-related alkaloids from Phlegmariurus squarrosus
J Asian Nat Prod Res 17: 967
Yang Y, Cheng X, Liu W, Chou G, Wang Z, Wang C (2015)
Potent AChE and BChE inhibitors isolated from seeds of Peganum harmala Linn by a bioassay-guided fractionation
J Ethnopharmacol 168: 279
de Bruijn I, Cheng X, de Jager V, Exposito RG, Watrous J, Patel N, Postma J, Dorrestein PC, Kobayashi D, Raaijmakers JM (2015)
Comparative genomics and metabolic profiling of the genus Lysobacter
BMC Genomics 16: 991
Chang C, Cheng X, Huang XY, Dai SM (2014)
Amino acid substitutions of acetylcholinesterase associated with carbofuran resistance in Chilo suppressalis
Pest Manag Sci 70: 1930
Cheng X, Wu J, Geng M, Xiong J (2014)
The role of synaptic activity in the regulation of amyloid beta levels in Alzheimer's disease
Neurobiology of Aging 35: 1217
Cheng X, Wang X, Qiu T, Yuan M, Sun J, Gao J (2014)
Molecular Cloning and Characterization of a Novel Cold-Adapted Family VIII Esterase from a Biogas Slurry Metagenomic Library
J Microbiol Biotechnol 24: 1484
Hao CN, Shi YQ, Cheng ZE, Cheng X (2014)
Beyond autonomic neuromodulation: Acetylcholinesterase inhibitor against peripheral artery disease
Int J Cardiol 178C: 253
Jiang WW, Liu F, Gao X, He J, Cheng X, Peng LY, Wu XD, Zhao QS (2014)
Huperserines A-E, Lycopodium alkaloids from Huperzia serrata
Fitoterapia 99C: 72
Liu W, Yang Y, Cheng X, Gong C, Li S, He D, Yang L, Wang Z, Wang C (2014)
Rapid and sensitive detection of the inhibitive activities of acetyl- and butyryl-cholinesterases inhibitors by UPLC-ESI-MS/MS
J Pharm Biomed Anal 94: 215
Liu F, Liu YC, Jiang WW, He J, Wu XD, Peng LY, Su J, Cheng X, Zhao QS (2014)
Carinatines A and B, Alkaloids from
Nat Prod Bioprospect 4: 221
Ravindran MS, Rao SP, Cheng X, Shukla A, Cazenave-Gassiot A, Yao SQ, Wenk MR (2014)
Targeting Lipid Esterases in Mycobacteria Grown Under Different Physiological Conditions Using Activity-based Profiling with Tetrahydrolipstatin (THL)
Mol Cell Proteomics 13: 435
Wang HL, Cheng X, Sine SM (2012)
Intramembrane proton binding site linked to activation of bacterial pentameric ion channel
Journal of Biological Chemistry 287: 6482
Wu ZP, Wu XW, Shen T, Li YP, Cheng X, Gu LQ, Huang ZS, An LK (2012)
Synthesis and acetylcholinesterase and butyrylcholinesterase inhibitory activities of 7-alkoxyl substituted indolizinoquinoline-5,12-dione derivatives
Arch Pharm (Weinheim) 345: 175
Zhang Y, Cheng X, Aleksunes L, Klaassen CD (2012)
Transcription factor-mediated regulation of carboxylesterase enzymes in livers of mice
Drug Metabolism & Disposition: The Biological Fate of Chemicals 40: 1191
Cheng X, Ivanov I, Wang H, Sine SM, McCammon JA (2009)
Molecular-dynamics simulations of ELIC-a prokaryotic homologue of the nicotinic acetylcholine receptor
Biophysical Journal 96: 4502
Qian Z, Horton JR, Cheng X, Lutz S (2009)
Structural redesign of lipase B from Candida antarctica by circular permutation and incremental truncation
Journal of Molecular Biology 393: 191
Wang HL, Cheng X, Taylor P, McCammon JA, Sine SM (2008)
Control of cation permeation through the nicotinic receptor channel
PLoS Comput Biol 4: e41
Cheng X, Ivanov I, Wang H, Sine SM, McCammon JA (2007)
Nanosecond-timescale conformational dynamics of the human alpha7 nicotinic acetylcholine receptor
Biophysical Journal 93: 2622
Cheng X, McAsey ME, Li M, Randall S, Cady C, Nathan BP, Struble RG (2007)
Estradiol replacement increases the low-density lipoprotein receptor related protein (LRP) in the mouse brain
Neuroscience Letters 417: 50
Cheng Y, Cheng X, Radic Z, McCammon JA (2007)
Acetylcholinesterase: mechanisms of covalent inhibition of wild-type and H447I mutant determined by computational analyses
Journal of the American Chemical Society 129: 6562
Ivanov I, Cheng X, Sine SM, McCammon JA (2007)
Barriers to ion translocation in cationic and anionic receptors from the Cys-loop family
J Am Chem Soc 129: 8217
Struble RG, Nathan BP, Cady C, Cheng X, McAsey M (2007)
Estradiol regulation of astroglia and apolipoprotein E: an important role in neuronal regeneration
Experimental Gerontology 42: 54
Cheng X, Wang H, Grant B, Sine SM, McCammon JA (2006)
Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors
PLoS Comput Biol 2: e134
Lu B, Cheng X, Huang J, McCammon JA (2006)
Order N algorithm for computation of electrostatic interactions in biomolecular systems
Proc Natl Acad Sci U S A 103: 19314
Dai S, Liu G, Qian Y, Cheng X (2001)
The sorption behavior of complex pollution system composed of aldicarb and surfactant--SDBS
Water Res 35: 2286