Distaso M, Cea-Rama I, Coscolin C, Chernikova TN, Tran H, Ferrer M, Sanz-Aparicio J, Golyshin PN (2023)
The Mobility of the Cap Domain Is Essential for the Substrate Promiscuity of a Family IV Esterase from Sorghum Rhizosphere Microbiome
Applied Environmental Microbiology

Fernandez-Lopez L, Cea-Rama I, Alvarez-Malmagro J, Ressmann AK, Gonzalez-Alfonso JL, Coscolin C, Shahgaldian P, Plou FJ, Modregger J, Pita M, Sanz-Aparicio J, Ferrer M (2023)
Transforming an esterase into an enantioselective catecholase through bioconjugation of a versatile metal-chelating inhibitor
Chem Commun (Camb)

Cea-Rama I, Coscolin C, Gonzalez-Alfonso JL, Raj J, Vasiljevic M, Plou FJ, Ferrer M, Sanz-Aparicio J (2022)
Crystal structure of a family VIII beta-lactamase fold hydrolase reveals the molecular mechanism for its broad substrate scope
Febs J

Cea-Rama I, Coscolin C, Katsonis P, Bargiela R, Golyshin PN, Lichtarge O, Ferrer M, Sanz-Aparicio J (2021)
Structure and evolutionary trace-assisted screening of a residue swapping the substrate ambiguity and chiral specificity in an esterase
Comput Struct Biotechnol J 19: 2307

Alonso S, Santiago G, Cea-Rama I, Fernandez-Lopez L, Coscolin C, Modregger J, Ressmann A, Martinez-Martinez M, Marrero H, Bargiela R, Pita M, Gonzalez-Alfonso JL, Briand M, Rojo D, Barbas C, Plou FJ, Golyshin PN, Shahgaldian P, Sanz-Aparicio J, Guallar V, Ferrer M (2019)
Genetically engineered proteins with two active sites for enhanced biocatalysis and synergistic chemo- and biocatalysis
Nature Catalysis 3: 319

Giunta CI, Cea-Rama I, Alonso S, Briand ML, Bargiela R, Coscolin C, Corvini PF, Ferrer M, Sanz-Aparicio J, Shahgaldian P (2020)
Tuning the Properties of Natural Promiscuous Enzymes by Engineering Their Nano-environment
ACS Nano