Grabner GF, Guttenberger N, Mayer N, Migglautsch-Sulzer AK, Lembacher-Fadum C, Fawzy N, Bulfon D, Hofer P, Zullig T, Hartig L, Kulminskaya N, Chalhoub G, Schratter M, Radner FPW, Preiss-Landl K, Masser S, Lass A, Zechner R, Gruber K, Oberer M, Breinbauer R, Zimmermann R (2022) <br />Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes<br /><i>Journal of the American Chemical Society</i> <br /><br />Grininger C, Leypold M, Aschauer P, Pavkov-Keller T, Riegler-Berket L, Breinbauer R, Oberer M (2021) <br />Structural Changes in the Cap of Rv0183/mtbMGL Modulate the Shape of the Binding Pocket<br /><i>Biomolecules</i> <b>11</b>: 1299<br /><br />Mayer N, Schweiger M, Fuchs E, Migglautsch AK, Doler C, Grabner GF, Romauch M, Melcher MC, Zechner R, Zimmermann R, Breinbauer R (2020) <br />Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL)<br /><i>Bioorganic & Medicinal Chemistry</i> <b>28</b>: 115610<br /><br />Grabner GF, Fawzy N, Pribasnig MA, Trieb M, Taschler U, Holzer M, Schweiger M, Wolinski H, Kolb D, Horvath A, Breinbauer R, Rulicke T, Rabl R, Lass A, Stadlbauer V, Hutter-Paier B, Stauber RE, Fickert P, Zechner R, Marsche G, Eichmann TO, Zimmermann R (2019) <br />Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans<br /><i>J Lipid Res</i> <b>60</b>: 1020<br /><br />Aschauer P, Zimmermann R, Breinbauer R, Pavkov-Keller T, Oberer M (2018) <br />The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition<br /><i>Sci Rep</i> <b>8</b>: 8948<br /><br />Schweiger M, Romauch M, Schreiber R, Grabner GF, Hutter S, Kotzbeck P, Benedikt P, Eichmann TO, Yamada S, Knittelfelder O, Diwoky C, Doler C, Mayer N, De Cecco W, Breinbauer R, Zimmermann R, Zechner R (2017) <br />Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice<br /><i>Nat Commun</i> <b>8</b>: 14859<br /><br />Aschauer P, Rengachari S, Lichtenegger J, Schittmayer M, Das KM, Mayer N, Breinbauer R, Birner-Gruenberger R, Gruber CC, Zimmermann R, Gruber K, Oberer M (2016) <br />Crystal structure of the Saccharomyces cerevisiae monoglyceride lipase Yju3p<br /><i>Biochimica & Biophysica Acta</i> <b>1861</b>: 462<br /><br />Pellis A, Haernvall K, Pichler CM, Ghazaryan G, Breinbauer R, Guebitz GM (2016) <br />Enzymatic hydrolysis of poly(ethylene furanoate)<br /><i>J Biotechnol</i> <b>235</b>: 47<br /><br />Birner-Gruenberger R, Breinbauer R (2015) <br />Weighing the proteasome for covalent modifications<br /><i>Chemical Biology</i> <b>22</b>: 315<br /><br />Hofer P, Boeszoermenyi A, Jaeger D, Feiler U, Arthanari H, Mayer N, Zehender F, Rechberger G, Oberer M, Zimmermann R, Lass A, Haemmerle G, Breinbauer R, Zechner R, Preiss-Landl K (2015) <br />Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling<br /><i>Journal of Biological Chemistry</i> <b>290</b>: 18438<br /><br />Leypold M, Wallace PW, Kljajic M, Schittmayer M, Pletz J, Illaszewicz-Trattner C, Guebitz GM, Birner-Gruenberger R, Breinbauer R (2015) <br />A robust and simple protocol for the synthesis of arylfluorophosphonates<br /><i>Tetrahedron Letters</i> <b>56</b>: 5619<br /><br />Mayer N, Schweiger M, Melcher MC, Fledelius C, Zechner R, Zimmermann R, Breinbauer R (2015) <br />Structure-activity studies in the development of a hydrazone based inhibitor of adipose-triglyceride lipase (ATGL)<br /><i>Bioorganic & Medicinal Chemistry</i> <b>23</b>: 2904<br /><br />Pellis A, Herrero Acero E, Weber H, Obersriebnig M, Breinbauer R, Srebotnik E, Guebitz GM (2015) <br />Biocatalyzed approach for the surface functionalization of poly(L-lactic acid) films using hydrolytic enzymes<br /><i>Biotechnol J</i> <b>10</b>: 1739<br /><br />Pribasnig MA, Mrak I, Grabner GF, Taschler U, Knittelfelder O, Scherz B, Eichmann TO, Heier C, Grumet L, Kowaliuk J, Romauch M, Holler S, Anderl F, Wolinski H, Lass A, Breinbauer R, Marsche G, Brown JM, Zimmermann R (2015) <br />alpha/beta Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate<br /><i>Journal of Biological Chemistry</i> <b>290</b>: 29869<br /><br />Taschler U, Schreiber R, Chitraju C, Grabner GF, Romauch M, Wolinski H, Haemmerle G, Breinbauer R, Zechner R, Lass A, Zimmermann R (2015) <br />Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells<br /><i>Biochimica & Biophysica Acta</i> <b>1851</b>: 937<br /><br />Mayer N, Schweiger M, Romauch M, Grabner GF, Eichmann TO, Fuchs E, Ivkovic J, Heier C, Mrak I, Lass A, Hofler G, Fledelius C, Zechner R, Zimmermann R, Breinbauer R (2013) <br />Development of small-molecule inhibitors targeting adipose triglyceride lipase<br /><i>Nat Chemical Biology</i> <b>9</b>: 785<br /><br />Rengachari S, Aschauer P, Schittmayer M, Mayer N, Gruber K, Breinbauer R, Birner-Gruenberger R, Dreveny I, Oberer M (2013) <br />Conformational plasticity and ligand binding of bacterial monoacylglycerol lipase<br /><i>Journal of Biological Chemistry</i> <b>288</b>: 31093<br /><br />Koch MA, Breinbauer R, Waldmann H (2003) <br />Protein structure similarity as guiding principle for combinatorial library design<br /><i>Biol Chem</i> <b>384</b>: 1265<br /><br />