Mortensen UH, Stennicke HR, Breddam K (1998) <br />Reversed-flow affinity elution applied to the purification of carboxypeptidase Y<br /><i>Analytical Biochemistry</i> <b>258</b>: 236<br /><br />Olesen K, Breddam K (1997) <br />Substrates with charged P1 residues are efficiently hydrolyzed by serine carboxypeptidases when S3-P1 interactions are facilitated<br /><i>Biochemistry</i> <b>36</b>: 12235<br /><br />Sorensen SB, Breddam K (1997) <br />The specificity of carboxypeptidase Y may be altered by changing the hydrophobicity of the S'1 binding pocket<br /><i>Protein Science</i> <b>6</b>: 2227<br /><br />Stennicke HR, Olesen K, Sorensen SB, Breddam K (1997) <br />C-terminal incorporation of fluorogenic and affinity labels using wild-type and mutagenized carboxypeptidase Y<br /><i>Analytical Biochemistry</i> <b>248</b>: 141<br /><br />Bullock TL, Breddam K, Remington SJ (1996) <br />Peptide aldehyde complexes with wheat serine carboxypeptidase II: implications for the catalytic mechanism and substrate specificity<br /><i>Journal of Molecular Biology</i> <b>255</b>: 714<br /><br />Stennicke HR, Mortensen UH, Breddam K (1996) <br />Studies on the hydrolytic properties of (serine) carboxypeptidase Y<br /><i>Biochemistry</i> <b>35</b>: 7131<br /><br />Olesen K, Breddam K (1995) <br />Increase of the P1 Lys/Leu substrate preference of carboxypeptidase Y by rational design based on known primary and tertiary structures of serine carboxypeptidases<br /><i>Biochemistry</i> <b>34</b>: 15689<br /><br />Sorensen SB, Raaschou-Nielsen M, Mortensen UH, Remington SJ, Breddam K (1995) <br />Site-Directed Mutagenesis on (Serine) Carboxypeptidase Y from Yeast. The Significance of Thr60 and Met398 in Hydrolysis and Aminolysis Reactions<br /><i>Journal of the American Chemical Society</i> <b>117</b>: 5944<br /><br />Endrizzi JA, Breddam K, Remington SJ (1994) <br />2.8-A structure of yeast serine carboxypeptidase<br /><i>Biochemistry</i> <b>33</b>: 11106<br /><br />Mortensen UH, Breddam K (1994) <br />A conserved glutamic acid bridge in serine carboxypeptidases, belonging to the alpha/beta hydrolase fold, acts as a pH-dependent protein-stabilizing element<br /><i>Protein Science</i> <b>3</b>: 838<br /><br />Mortensen UH, Raaschou-Nielsen M, Breddam K (1994) <br />Recognition of C-terminal amide groups by (serine) carboxypeptidase Y investigated by site-directed mutagenesis<br /><i>Journal of Biological Chemistry</i> <b>269</b>: 15528<br /><br />Mortensen UH, Remington SJ, Breddam K (1994) <br />Site-directed mutagenesis on (serine) carboxypeptidase Y. A hydrogen bond network stabilizes the transition state by interaction with the C-terminal carboxylate group of the substrate<br /><i>Biochemistry</i> <b>33</b>: 508<br /><br />Olesen K, Mortensen UH, Aasmul-Olsen S, Kielland-Brandt MC, Remington SJ, Breddam K (1994) <br />The activity of carboxypeptidase Y toward substrates with basic P1 amino acid residues is drastically increased by mutational replacement of leucine 178<br /><i>Biochemistry</i> <b>33</b>: 11121<br /><br />Raaschou-Nielsen M, Mortensen UH, Olesen K, Breddam K (1994) <br />Improvement of the applicability of carboxypeptidase Y in peptide synthesis by protein engineering<br /><i>Pept Res</i> <b>7</b>: 132<br /><br />Stennicke HR, Mortensen UH, Christensen U, Remington SJ, Breddam K (1994) <br />Effects of introduced aspartic and glutamic acid residues on the P'1 substrate specificity, pH dependence and stability of carboxypeptidase Y<br /><i>Protein Engineering</i> <b>7</b>: 911<br /><br />Kanstrup A, Breddam K, Buchardt O (1993) <br />Application of quantitative structure-activity relationship modeling to the evaluation of the changes in enzymatic activity of carboxypeptidase Y upon chemical modifications<br /><i>Archives of Biochemistry & Biophysics</i> <b>304</b>: 332<br /><br />Svendsen I, Hofmann T, Endrizzi J, Remington SJ, Breddam K (1993) <br />The primary structure of carboxypeptidase S1 from Penicillium janthinellum<br /><i>FEBS Letters</i> <b>333</b>: 39<br /><br />Dal Degan F, Ribadeau-Dumas B, Breddam K (1992) <br />Purification and characterization of two serine carboxypeptidases from Aspergillus niger and their use in C-terminal sequencing of proteins and peptide synthesis<br /><i>Applied Environmental Microbiology</i> <b>58</b>: 2144<br /><br />Henriksen DB, Rolland M, Jakobsen MH, Buchardt O, Breddam K (1992) <br />C-terminal amidation of calcitonin by carboxypeptidase Y catalyzed transpeptidation with a photocleavable nucleophile<br /><i>Pept Res</i> <b>5</b>: 321<br /><br />Liao DI, Breddam K, Sweet RM, Bullock T, Remington SJ (1992) <br />Refined atomic model of wheat serine carboxypeptidase II at 2.2-A resolution<br /><i>Biochemistry</i> <b>31</b>: 9796<br /><br />Wilson KP, Liao DI, Bullock T, Remington SJ, Breddam K (1990) <br />Crystallization of serine carboxypeptidases<br /><i>Journal of Molecular Biology</i> <b>211</b>: 301<br /><br />Bech LM, Breddam K (1989) <br />Inactivation of carboxypeptidase Y by mutational removal of the putative essential histidyl residue<br /><i>Carlsberg Res Commun</i> <b>54</b>: 165<br /><br />Sorensen SB, Svendsen I, Breddam K (1989) <br />Primary structure of carboxypeptidase III from malted barley<br /><i>Carlsberg Res Commun</i> <b>54</b>: 193<br /><br />Bech LM, Breddam K (1988) <br />Chemical modifications of a cysteinyl residue introduced in the binding site of carboxypeptidase Y by site-directed mutagenesis<br /><i>Carlsberg Res Commun</i> <b>53</b>: 381<br /><br />Sorensen SB, Svensen I, Breddam K (1987) <br />Primary structure of carboxypeptidase II from malted barley.<br /><i>Carlsberg Res Commun</i> <b>52</b>: 285<br /><br />Sorensen SB, Breddam K, Svensen I (1986) <br />Primary structure of carboxypeptidase I from malted barley<br /><i>Carlsberg Res Commun</i> <b>51</b>: 475<br /><br />