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8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease<br /><i>ChemMedChem</i> <b>11</b>: 1284<br /><br />Benchekroun M, Bartolini M, Egea J, Romero A, Soriano E, Pudlo M, Luzet V, Andrisano V, Jimeno ML, Lopez MG, Wehle S, Gharbi T, Refouvelet B, de Andres L, Herrera-Arozamena C, Monti B, Bolognesi ML, Rodriguez-Franco MI, Decker M, Marco-Contelles J, Ismaili L (2015) <br />Novel tacrine-grafted ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic Acid hybrids<br /><i>ChemMedChem</i> <b>10</b>: 523<br /><br />Lemes LF, de Andrade Ramos G, de Oliveira AS, da Silva FM, de Castro Couto G, da Silva Boni M, Guimaraes MJ, Souza IN, Bartolini M, Andrisano V, do Nascimento Nogueira PC, Silveira ER, Brand GD, Soukup O, Korabecny J, Romeiro NC, Castro NG, Bolognesi ML, Romeiro LA (2015) <br />Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>108</b>: 687<br /><br />Nepovimova E, Uliassi E, Korabecny J, Pena-Altamira LE, Samez S, Pesaresi A, Garcia GE, Bartolini M, Andrisano V, Bergamini C, Fato R, Lamba D, Roberti M, Kuca K, Monti B, Bolognesi ML (2014) <br />Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects<br /><i>Journal of Medicinal Chemistry</i> <b>57</b>: 8576<br /><br />Capurro V, Busquet P, Lopes JP, Bertorelli R, Tarozzo G, Bolognesi ML, Piomelli D, Reggiani A, Cavalli A (2013) <br />Pharmacological characterization of memoquin, a multi-target compound for the treatment of Alzheimer's disease<br /><i>PLoS ONE</i> <b>8</b>: e56870<br /><br />Prati F, Bartolini M, Simoni E, De Simone A, Pinto A, Andrisano V, Bolognesi ML (2013) <br />Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>23</b>: 6254<br /><br />Rosini M, Simoni E, Bartolini M, Soriano E, Marco-Contelles J, Andrisano V, Monti B, Windisch M, Hutter-Paier B, McClymont DW, Mellor IR, Bolognesi ML (2013) <br />The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti-Alzheimer Multitarget Profile of Dimebon<br /><i>ChemMedChem</i> <b>8</b>: 1276<br /><br />Minarini A, Milelli A, Tumiatti V, Rosini M, Simoni E, Bolognesi ML, Andrisano V, Bartolini M, Motori E, Angeloni C, Hrelia S (2012) <br />Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment<br /><i>Neuropharmacology</i> <b>62</b>: 997<br /><br />Rosini M, Simoni E, Bartolini M, Tarozzi A, Matera R, Milelli A, Hrelia P, Andrisano V, Bolognesi ML, Melchiorre C (2011) <br />Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>46</b>: 5435<br /><br 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7883<br /><br />Bolognesi ML, Minarini A, Rosini M, Tumiatti V, Melchiorre C (2008) <br />From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease<br /><i>Mini Rev Med Chem</i> <b>8</b>: 960<br /><br />Rosini M, Simoni E, Bartolini M, Cavalli A, Ceccarini L, Pascu N, McClymont DW, Tarozzi A, Bolognesi ML, Minarini A, Tumiatti V, Andrisano V, Mellor IR, Melchiorre C (2008) <br />Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush<br /><i>Journal of Medicinal Chemistry</i> <b>51</b>: 4381<br /><br />Tumiatti V, Milelli A, Minarini A, Rosini M, Bolognesi ML, Micco M, Andrisano V, Bartolini M, Mancini F, Recanatini M, Cavalli A, Melchiorre C (2008) <br />Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer<br /><i>Journal of Medicinal Chemistry</i> <b>51</b>: 7308<br /><br />Bolognesi ML, Cavalli A, Valgimigli L, Bartolini M, Rosini M, Andrisano V, Recanatini M, Melchiorre C (2007) <br />Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease<br /><i>Journal of Medicinal Chemistry</i> <b>50</b>: 6446<br /><br />Bolognesi ML, Andrisano V, Bartolini M, Banzi R, Melchiorre C (2005) <br />Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 24<br /><br />Bolognesi ML, Andrisano V, Bartolini M, Cavalli A, Minarini A, Recanatini M, Rosini M, Tumiatti V, Melchiorre C (2005) <br />Heterocyclic inhibitors of AChE acylation and peripheral sites<br /><i>Farmaco</i> <b>60</b>: 465<br /><br />Rosini M, Andrisano V, Bartolini M, Bolognesi ML, Hrelia P, Minarini A, Tarozzi A, Melchiorre C (2005) <br />Rational approach to discover multipotent anti-Alzheimer drugs<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 360<br /><br />Bolognesi ML, Bartolini M, Cavalli A, Andrisano V, Rosini M, Minarini A, Melchiorre C (2004) <br />Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues<br /><i>Journal of Medicinal Chemistry</i> <b>47</b>: 5945<br /><br />Melchiorre C, Antonello A, Banzi R, Bolognesi ML, Minarini A, Rosini M, Tumiatti V (2003) <br />Polymethylene tetraamine backbone as template for the development of biologically active polyamines<br /><i>Med Res Rev</i> <b>23</b>: 200<br /><br />Bolognesi ML, Bixel MG, Marucci G, Bartolini M, Krauss M, Angeli P, Antonello A, Rosini M, Tumiatti V, Hucho F, Melchiorre C (2002) <br />Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure<br /><i>Journal of Medicinal Chemistry</i> <b>45</b>: 3286<br /><br />Bolognesi ML, Andrisano V, Bartolini M, Minarini A, Rosini M, Tumiatti V, Melchiorre C (2001) <br />Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors<br /><i>Journal of Medicinal Chemistry</i> <b>44</b>: 105<br /><br />D'Agostino G, Bolognesi ML, Lucchelli A, Vicini D, Balestra B, Spelta V, Melchiorre C, Tonini M (2000) <br />Prejunctional muscarinic inhibitory control of acetylcholine release in the human isolated detrusor: involvement of the M4 receptor subtype<br /><i>British Journal of Pharmacology</i> <b>129</b>: 493<br /><br />Tumiatti V, Angeli P, Andrisano V, Bolognesi ML, Cavalli A, Marucci G, Minarini A, Recanatini M, Rosini M, Melchiorre C (2000) <br />[4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]-trimethylammonium (McN-A-343)-related compounds. Effect of the butynyl chain inclusion into an aromatic unit on the potency for muscarinic receptors<br /><i>Bioorganic & Medicinal Chemistry</i> <b>8</b>: 681<br /><br />Rosini M, Budriesi R, Bixel MG, Bolognesi ML, Chiarini A, Hucho F, Krogsgaard-Larsen P, Mellor IR, Minarini A, Tumiatti V, Usherwood PN, Melchiorre C (1999) <br />Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists<br /><i>Journal of Medicinal Chemistry</i> <b>42</b>: 5212<br /><br />Bolognesi ML, Minarini A, Budriesi R, Cacciaguerra S, Chiarini A, Spampinato S, Tumiatti V, Melchiorre C (1998) <br />Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists<br /><i>Journal of Medicinal Chemistry</i> <b>41</b>: 4150<br /><br />Melchiorre C, Andrisano V, Bolognesi ML, Budriesi R, Cavalli A, Cavrini V, Rosini M, Tumiatti V, Recanatini M (1998) <br />Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone for Potential Use against Alzheimer's Disease<br /><i>Journal of Medicinal Chemistry</i> <b>41</b>: 4186<br /><br />Melchiorre C, Romualdi P, Bolognesi ML, Donatini A, Ferri S (1994) <br />Binding profile of benextramine at neuropeptide Y receptor subtypes in rat brain areas<br /><i>European Journal of Pharmacology</i> <b>265</b>: 93<br /><br />