Pang Z, Schafroth MA, Ogasawara D, Wang Y, Nudell V, Lal NK, Yang D, Wang K, Herbst DM, Ha J, Guijas C, Blankman JL, Cravatt BF, Ye L (2022)
In situ identification of cellular drug targets in mammalian tissue
Cell 185: 1793
Cisar JS, Weber OD, Clapper JR, Blankman JL, Henry CL, Simon GM, Alexander JP, Jones TK, Ezekowitz RAB, O'Neill GP, Grice CA (2018)
Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders
Journal of Medicinal Chemistry 61: 9062
Naydenov AV, Horne EA, Cheah CS, Swinney K, Hsu KL, Cao JK, Marrs WR, Blankman JL, Tu S, Cherry AE, Fung S, Wen A, Li W, Saporito MS, Selley DE, Cravatt BF, Oakley JC, Stella N (2014)
ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6/2 Mice
Neuron 83: 361
Blankman JL, Long JZ, Trauger SA, Siuzdak G, Cravatt BF (2013)
ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC
Proc Natl Acad Sci U S A 110: 1500
Blankman JL, Cravatt BF (2013)
Chemical probes of endocannabinoid metabolism
Pharmacol Rev 65: 849
Chen DH, Naydenov A, Blankman JL, Mefford HC, Davis M, Sul Y, Barloon AS, Bonkowski E, Wolff J, Matsushita M, Smith C, Cravatt BF, Mackie K, Raskind WH, Stella N, Bird TD (2013)
Two Novel Mutations in ABHD12: Expansion of the Mutation Spectrum in PHARC and Assessment of Their Functional Effects
Hum Mutat 34: 1672
Thomas G, Betters JL, Lord CC, Brown AL, Marshall S, Ferguson D, Sawyer J, Davis MA, Melchior JT, Blume LC, Howlett AC, Ivanova PT, Milne SB, Myers DS, Mrak I, Leber V, Heier C, Taschler U, Blankman JL, Cravatt BF, Lee RG, Crooke RM, Graham MJ, Zimmermann R, Brown HA, Brown JM (2013)
The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome
Cell Rep 5: 508
Nomura DK, Morrison BE, Blankman JL, Long JZ, Kinsey SG, Marcondes MC, Ward AM, Hahn YK, Lichtman AH, Conti B, Cravatt BF (2011)
Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation
Science 334: 809
Pan B, Wang W, Zhong P, Blankman JL, Cravatt BF, Liu QS (2011)
Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice
Journal of Neuroscience 31: 13420
Straiker A, Wager-Miller J, Hu SS, Blankman JL, Cravatt BF, Mackie K (2011)
COX-2 and fatty acid amide hydrolase can regulate the time course of depolarization-induced suppression of excitation
British Journal of Pharmacology 164: 1672
Zhong P, Pan B, Gao XP, Blankman JL, Cravatt BF, Liu QS (2011)
Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum
Journal de Physiologie 589: 4847
Bachovchin DA, Ji T, Li W, Simon GM, Blankman JL, Adibekian A, Hoover H, Niessen S, Cravatt BF (2010)
Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening
Proc Natl Acad Sci U S A 107: 20941
Lichtman AH, Blankman JL, Cravatt BF (2010)
Endocannabinoid overload
Molecular Pharmacology 78: 993
Marrs WR, Blankman JL, Horne EA, Thomazeau A, Lin YH, Coy J, Bodor AL, Muccioli GG, Hu SS, Woodruff G, Fung S, Lafourcade M, Alexander JP, Long JZ, Li W, Xu C, Moller T, Mackie K, Manzoni OJ, Cravatt BF, Stella N (2010)
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors
Nat Neurosci 13: 951
Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Pan B, Kinsey SG, Nguyen PT, Ramesh D, Booker L, Burston JJ, Thomas EA, Selley DE, Sim-Selley LJ, Liu QS, Lichtman AH, Cravatt BF (2010)
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
Nat Neurosci 13: 1113
Hoover HS, Blankman JL, Niessen S, Cravatt BF (2008)
Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling
Bioorganic & Medicinal Chemistry Lett 18: 5838
Nomura DK, Blankman JL, Simon GM, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE (2008)
Activation of the endocannabinoid system by organophosphorus nerve agents
Nat Chemical Biology 4: 373
Blankman JL, Simon GM, Cravatt BF (2007)
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol
Chemical Biology 14: 1347
Li W, Blankman JL, Cravatt BF (2007)
A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases
Journal of the American Chemical Society 129: 9594