Basagni F, Ortega JA, Bertozzi SM, Armirotti A, Summa M, Bertorelli R, Bartolini M, Mellor IR, Bedeschi M, Bottegoni G, Lembo V, Minarini A, Cavalli A, Rosini M (2023) <br />Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties<br /><i>Eur Journal of Medicinal Chemistry</i> <b>261</b>: 115803<br /><br />Uliassi E, Bergamini C, Rizzardi N, Naldi M, Cores A, Bartolini M, Carlos Menendez J, Bolognesi ML (2023) <br />Quinolinetrione-tacrine hybrids as multi-target-directed ligands against Alzheimer's disease<br /><i>Bioorganic & Medicinal Chemistry</i> <b>91</b>: 117419<br /><br />Codony S, Pont C, Grinan-Ferre C, Di Pede-Mattatelli A, Calvo-Tusell C, Feixas F, Osuna S, Jarne-Ferrer J, Naldi M, Bartolini M, Loza MI, Brea J, Perez B, Bartra C, Sanfeliu C, Juarez-Jimenez J, Morisseau C, Hammock BD, Pallas M, Vazquez S, Munoz-Torrero D (2022) <br />Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease<br /><i>Journal of Medicinal Chemistry</i> <b>65</b>: 4909<br /><br />Gorecki L, Uliassi E, Bartolini M, Janockova J, Hrabinova M, Hepnarova V, Prchal L, Muckova L, Pejchal J, Karasova JZ, Mezeiova E, Benkova M, Kobrlova T, Soukup O, Petralla S, Monti B, Korabecny J, Bolognesi ML (2021) <br />Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease<br /><i>ACS Chem Neurosci</i> <br /><br />Ismaili L, Monnin J, Etievant A, Arribas RL, Viejo L, Refouvelet B, Soukup O, Janockova J, Hepnarova V, Korabecny J, Kucera T, Jun D, Andrys R, Musilek K, Baguet A, Garcia-Frutos EM, De Simone A, Andrisano V, Bartolini M, de los Rios C, Marco-Contelles J, Haffen E (2021) <br />(+/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease<br /><i>ACS Chem Neurosci</i> <br /><br />Montanari S, Allara M, Scalvini L, Kostrzewa M, Belluti F, Gobbi S, Naldi M, Rivara S, Bartolini M, Ligresti A, Bisi A, Rampa A (2021) <br />New Coumarin Derivatives as Cholinergic and Cannabinoid System Modulators<br /><i>Molecules</i> <b>26</b>: 3254<br /><br />Naldi M, Brusotti G, Massolini G, Andrisano V, Temporini C, Bartolini M (2021) <br />Bio-Guided Fractionation of Stem Bark Extracts from Phyllanthus muellarianus: Identification of Phytocomponents with Anti-Cholinesterase Activity<br /><i>Molecules</i> <b>26</b>: <br /><br />Perone R, Albertini C, Uliassi E, Di Pietri F, de Sena Murteira Pinheiro P, Petralla S, Rizzardi N, Fato R, Pulkrabkova L, Soukup O, Tramarin A, Bartolini M, Bolognesi ML (2021) <br />Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy<br /><i>ChemMedChem</i> <b>16</b>: 187<br /><br />Pont C, Ginex T, Grinan-Ferre C, Scheiner M, Mattellone A, Martinez N, Arce EM, Soriano-Fernandez Y, Naldi M, De Simone A, Barenys M, Gomez-Catalan J, Perez B, Sabate R, Andrisano V, Loza MI, Brea J, Bartolini M, Bolognesi ML, Decker M, Pallas M, Luque FJ, Munoz-Torrero D (2021) <br />From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects<br /><i>Eur Journal of Medicinal Chemistry</i> <b>225</b>: 113779<br /><br />Rossi M, Freschi M, de Camargo Nascente L, Salerno A, de Melo Viana Teixeira S, Nachon F, Chantegreil F, Soukup O, Prchal L, Malaguti M, Bergamini C, Bartolini M, Angeloni C, Hrelia S, Soares Romeiro LA, Bolognesi ML (2021) <br />Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease<br /><i>Journal of Medicinal Chemistry</i> <b>64</b>: 4972<br /><br />Viayna E, Coquelle N, Cieslikiewicz-Bouet M, Cisternas P, Oliva CA, Sanchez-Lopez E, Ettcheto M, Bartolini M, De Simone A, Ricchini M, Rendina M, Pons M, Firuzi O, Perez B, Saso L, Andrisano V, Nachon F, Brazzolotto X, Garcia ML, Camins A, Silman I, Jean L, Inestrosa NC, Colletier JP, Renard PY, Munoz-Torrero D (2021) <br />Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice<br /><i>Journal of Medicinal Chemistry</i> <b>64</b>: 812<br /><br />de Andrade Ramos G, Souza de Oliveira A, Bartolini M, Naldi M, Liparulo I, Bergamini C, Uliassi E, Wu L, Fraser PE, Abreu M, Kiametis AS, Gargano R, Silveira ER, Brand GD, Prchal L, Soukup O, Korabecny J, Bolognesi ML, Soares Romeiro LA (2021) <br />Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties<br /><i>RSC Med Chem</i> <b>12</b>: 1154<br /><br />Cieslikiewicz-Bouet M, Naldi M, Bartolini M, Perez B, Servent D, Jean L, Araoz R, Renard PY (2020) <br />Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor<br /><i>Biochemical Pharmacology</i> <br /><br />Marques CS, Lopez O, Bagetta D, Carreiro EP, Petralla S, Bartolini M, Hoffmann M, Alcaro S, Monti B, Bolognesi ML, Decker M, Fernandez-Bolanos JG, Burke AJ (2020) <br />N-1,2,3-triazole-isatin derivatives for cholinesterase and beta-amyloid aggregation inhibition: A comprehensive bioassay study<br /><i>Bioorg Chem</i> <b>98</b>: 103753<br /><br />Perez-Areales FJ, Garrido M, Aso E, Bartolini M, De Simone A, Espargaro A, Ginex T, Sabate R, Perez B, Andrisano V, Puigoriol-Illamola D, Pallas M, Luque FJ, Loza MI, Brea J, Ferrer I, Ciruela F, Messeguer A, Munoz-Torrero D (2020) <br />Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6<br /><i>Journal of Medicinal Chemistry</i> <b>63</b>: 9360<br /><br />AlFadly ED, Elzahhar PA, Tramarin A, Elkazaz S, Shaltout H, Abu-Serie MM, Janockova J, Soukup O, Ghareeb DA, El-Yazbi AF, Rafeh RW, Bakkar NZ, Kobeissy F, Iriepa I, Moraleda I, Saudi MNS, Bartolini M, Belal ASF (2019) <br />Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase<br /><i>Eur Journal of Medicinal Chemistry</i> <b>167</b>: 161<br /><br />Bartolini M, Marco-Contelles J (2019) <br />Tacrines as Therapeutic Agents for Alzheimer's Disease. 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The Tacripyrines and Related Annulated Tacrines<br /><i>Chem Rec</i> <b>19</b>: 927<br /><br />Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ, Nachon F, Pejchal J, Jarosova M, Hepnarova V, Jun D, Hrabinova M, Dolezal R, Karasova JZ, Mzik M, Kristofikova Z, Misik J, Muckova L, Jost P, Soukup O, Benkova M, Setnicka V, Habartova L, Chvojkova M, Kleteckova L, Vales K, Mezeiova E, Uliassi E, Valis M, Nepovimova E, Bolognesi ML, Kuca K (2019) <br />Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>168</b>: 491<br /><br />De Simone A, Naldi M, Tedesco D, Bartolini M, Davani L, Andrisano V (2019) <br />Advanced analytical methodologies in Alzheimer's disease drug discovery<br /><i>J Pharm Biomed Anal</i> <b>178</b>: 112899<br /><br />Montanari S, Mahmoud AM, Pruccoli L, Rabbito A, Naldi M, Petralla S, Moraleda I, Bartolini M, Monti B, Iriepa I, Belluti F, Gobbi S, Di Marzo V, Bisi A, Tarozzi A, Ligresti A, Rampa A (2019) <br />Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment<br /><i>Eur Journal of Medicinal Chemistry</i> <b>178</b>: 243<br /><br />Oukoloff K, Coquelle N, Bartolini M, Naldi M, Le Guevel R, Bach S, Josselin B, Ruchaud S, Catto M, Pisani L, Denora N, Iacobazzi RM, Silman I, Sussman JL, Buron F, Colletier JP, Jean L, Routier S, Renard PY (2019) <br />Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3<br /><i>Eur Journal of Medicinal Chemistry</i> <b>168</b>: 58<br /><br />Perez-Areales FJ, Turcu AL, Barniol-Xicota M, Pont C, Pivetta D, Espargaro A, Bartolini M, De Simone A, Andrisano V, Perez B, Sabate R, Sureda FX, Vazquez S, Munoz-Torrero D (2019) <br />A novel class of multitarget anti-Alzheimer benzohomoadamantanechlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors<br /><i>Eur Journal of Medicinal Chemistry</i> <b>180</b>: 613<br /><br />Ramos E, Palomino-Antolin A, Bartolini M, Iriepa I, Moraleda I, Diez-Iriepa D, Samadi A, Cortina CV, Chioua M, Egea J, Romero A, Marco-Contelles J (2019) <br />QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy<br /><i>Molecules</i> <b>24</b>: <br /><br />Scheiner M, Dolles D, Gunesch S, Hoffmann M, Nabissi M, Marinelli O, Naldi M, Bartolini M, Petralla S, Poeta E, Monti B, Falkeis C, Vieth M, Hubner H, Gmeiner P, Maitra R, Maurice T, Decker M (2019) <br />Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo<br /><i>Journal of Medicinal Chemistry</i> <b>62</b>: 9078<br /><br />Andrisano V, Naldi M, De Simone A, Bartolini M (2018) <br />A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017<br /><i>Expert Opin Ther Pat</i> <b>28</b>: 455<br /><br />Chioua M, Buzzi E, Moraleda I, Iriepa I, Maj M, Wnorowski A, Giovannini C, Tramarin A, Portali F, Ismaili L, Lopez-Alvarado P, Bolognesi ML, Jozwiak K, Menendez JC, Marco-Contelles J, Bartolini M (2018) <br />Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>155</b>: 839<br /><br />Fabini E, Tramarin A, Bartolini M (2018) <br />Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening<br /><i>J Pharm Biomed Anal</i> <b>155</b>: 177<br /><br />Galdeano C, Coquelle N, Cieslikiewicz-Bouet M, Bartolini M, Perez B, Clos MV, Silman I, Jean L, Colletier JP, Renard PY, Munoz-Torrero D (2018) <br />Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis<br /><i>Molecules</i> <b>23</b>: <br /><br />Rampa A, Bartolini M, Pruccoli L, Naldi M, Iriepa I, Moraleda I, Belluti F, Gobbi S, Tarozzi A, Bisi A (2018) <br />Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer's Disease<br /><i>Molecules</i> <b>23</b>: <br /><br />Pandolfi F, De Vita D, Bortolami M, Coluccia A, Di Santo R, Costi R, Andrisano V, Alabiso F, Bergamini C, Fato R, Bartolini M, Scipione L (2017) <br />New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation<br /><i>Eur Journal of Medicinal Chemistry</i> <b>141</b>: 197<br /><br />Perez-Areales FJ, Betari N, Viayna A, Pont C, Espargaro A, Bartolini M, De Simone A, Rinaldi Alvarenga JF, Perez B, Sabate R, Lamuela-Raventos RM, Andrisano V, Luque FJ, Munoz-Torrero D (2017) <br />Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids<br /><i>Future Med Chem</i> <b>9</b>: 965<br /><br />Rampa A, Montanari S, Pruccoli L, Bartolini M, Falchi F, Feoli A, Cavalli A, Belluti F, Gobbi S, Tarozzi A, Bisi A (2017) <br />Chalcone-based carbamates for Alzheimer's disease treatment<br /><i>Future Med Chem</i> <b>9</b>: 749<br /><br />Seidl C, de Moraes Santos CA, De Simone A, Bartolini M, Weffort-Santos AM, Andrisano V (2017) <br />Uleine Disrupts Key Enzymatic and Non-Enzymatic Biomarkers that Leads to Alzheimer's Disease<br /><i>Curr Alzheimer Res</i> <b>14</b>: 317<br /><br />Simoni E, Bartolini M, Abu IF, Blockley A, Gotti C, Bottegoni G, Caporaso R, Bergamini C, Andrisano V, Cavalli A, Mellor IR, Minarini A, Rosini M (2017) <br />Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation<br /><i>Future Med Chem</i> <b>9</b>: 953<br /><br />Boulebd H, Ismaili L, Bartolini M, Bouraiou A, Andrisano V, Martin H, Bonet A, Moraleda I, Iriepa I, Chioua M, Belfaitah A, Marco-Contelles J (2016) <br />Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy<br /><i>Molecules</i> <b>21</b>: <br /><br />Jerabek J, Uliassi E, Guidotti L, Korabecny J, Soukup O, Sepsova V, Hrabinova M, Kuca K, Bartolini M, Pena-Altamira LE, Petralla S, Monti B, Roberti M, Bolognesi ML (2016) <br />Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>127</b>: 250<br /><br />Montanari S, Bartolini M, Neviani P, Belluti F, Gobbi S, Pruccoli L, Tarozzi A, Falchi F, Andrisano V, Miszta P, Cavalli A, Filipek S, Bisi A, Rampa A (2016) <br />Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives<br /><i>ChemMedChem</i> <b>11</b>: 1296<br /><br />Montanari S, Scalvini L, Bartolini M, Belluti F, Gobbi S, Andrisano V, Ligresti A, Di Marzo V, Rivara S, Mor M, Bisi A, Rampa A (2016) <br />Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents<br /><i>Journal of Medicinal Chemistry</i> <b>59</b>: 6387<br /><br />Prati F, Bergamini C, Fato R, Soukup O, Korabecny J, Andrisano V, Bartolini M, Bolognesi ML (2016) <br />Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease<br /><i>ChemMedChem</i> <b>11</b>: 1284<br /><br />Zha X, Lamba D, Zhang L, Lou Y, Xu C, Kang D, Chen L, Xu Y, De Simone A, Samez S, Pesaresi A, Stojan J, Lopez MG, Egea J, Andrisano V, Bartolini M (2016) <br />Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography<br /><i>Journal of Medicinal Chemistry</i> <b>59</b>: 114<br /><br />Araoz R, Bouet m, Bartolini M, Coquelle N, Colletier JP, Servent D, Molgo J, Jean L, Renard PY (2015) <br />Poster: Multi-target directed ligands: Electrophysiological characterization of an anticholinesterase inhibitor coupled to an agonist of alpha7 nicotinic acetylcholine receptor<br /><i>Biochemical Pharmacology</i> <b>97</b>: 621<br /><br />Benchekroun M, Bartolini M, Egea J, Romero A, Soriano E, Pudlo M, Luzet V, Andrisano V, Jimeno ML, Lopez MG, Wehle S, Gharbi T, Refouvelet B, de Andres L, Herrera-Arozamena C, Monti B, Bolognesi ML, Rodriguez-Franco MI, Decker M, Marco-Contelles J, Ismaili L (2015) <br />Novel tacrine-grafted ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic Acid hybrids<br /><i>ChemMedChem</i> <b>10</b>: 523<br /><br />Lemes LF, de Andrade Ramos G, de Oliveira AS, da Silva FM, de Castro Couto G, da Silva Boni M, Guimaraes MJ, Souza IN, Bartolini M, Andrisano V, do Nascimento Nogueira PC, Silveira ER, Brand GD, Soukup O, Korabecny J, Romeiro NC, Castro NG, Bolognesi ML, Romeiro LA (2015) <br />Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>108</b>: 687<br /><br />Belluti F, De Simone A, Tarozzi A, Bartolini M, Djemil A, Bisi A, Gobbi S, Montanari S, Cavalli A, Andrisano V, Bottegoni G, Rampa A (2014) <br />Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>78C</b>: 157<br /><br />Brogi S, Butini S, Maramai S, Colombo R, Verga L, Lanni C, De Lorenzi E, Lamponi S, Andreassi M, Bartolini M, Andrisano V, Novellino E, Campiani G, Brindisi M, Gemma S (2014) <br />Disease-Modifying Anti-Alzheimer's Drugs: Inhibitors of Human Cholinesterases Interfering with beta-Amyloid Aggregation<br /><i>CNS Neurosci Ther</i> <b>20</b>: 624<br /><br />Nepovimova E, Uliassi E, Korabecny J, Pena-Altamira LE, Samez S, Pesaresi A, Garcia GE, Bartolini M, Andrisano V, Bergamini C, Fato R, Lamba D, Roberti M, Kuca K, Monti B, Bolognesi ML (2014) <br />Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects<br /><i>Journal of Medicinal Chemistry</i> <b>57</b>: 8576<br /><br />Tarozzi A, Bartolini M, Piazzi L, Valgimigli L, Amorati R, Bolondi C, Djemil A, Mancini F, Andrisano V, Rampa A (2014) <br />From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer's disease<br /><i>Pharmacol Res Perspect</i> <b>2</b>: e00023<br /><br />Viayna E, Sola I, Bartolini M, De Simone A, Tapia-Rojas C, Serrano FG, Sabate R, Juarez-Jimenez J, Perez B, Luque FJ, Andrisano V, Clos MV, Inestrosa NC, Munoz-Torrero D (2014) <br />Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents<br /><i>Journal of Medicinal Chemistry</i> <b>57</b>: 2549<br /><br />Bartolini M, Naldi M, Nicolau DV, van Delft FC, van Zijl J, Snijder J, van den Heuvel EF, Naburgh EP, Calonghi N, Andrisano V (2013) <br />Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase<br /><i>Anal Bioanal Chem</i> <b>405</b>: 795<br /><br />Butini S, Brindisi M, Brogi S, Maramai S, Guarino E, Panico A, Saxena A, Chauhan V, Colombo R, Verga L, De Lorenzi E, Bartolini M, Andrisano V, Novellino E, Campiani G, Gemma S (2013) <br />Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation<br /><i>ACS Med Chem Lett</i> <b>4</b>: 1178<br /><br />Di Pietro O, Viayna E, Vicente-Garcia E, Bartolini M, Ramon R, Juarez-Jimenez J, Clos MV, Perez B, Andrisano V, Luque FJ, Lavilla R, Munoz-Torrero D (2013) <br />1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies<br /><i>Eur Journal of Medicinal Chemistry</i> <b>73C</b>: 141<br /><br />Prati F, Bartolini M, Simoni E, De Simone A, Pinto A, Andrisano V, Bolognesi ML (2013) <br />Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>23</b>: 6254<br /><br />Rosini M, Simoni E, Bartolini M, Soriano E, Marco-Contelles J, Andrisano V, Monti B, Windisch M, Hutter-Paier B, McClymont DW, Mellor IR, Bolognesi ML (2013) <br />The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti-Alzheimer Multitarget Profile of Dimebon<br /><i>ChemMedChem</i> <b>8</b>: 1276<br /><br />Galdeano C, Viayna E, Sola I, Formosa X, Camps P, Badia A, Clos MV, Relat J, Ratia M, Bartolini M, Mancini F, Andrisano V, Salmona M, Minguillon C, Gonzalez-Munoz GC, Rodriguez-Franco MI, Bidon-Chanal A, Luque FJ, Munoz-Torrero D (2012) <br />Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases<br /><i>Journal of Medicinal Chemistry</i> <b>55</b>: 661<br /><br />Minarini A, Milelli A, Tumiatti V, Rosini M, Simoni E, Bolognesi ML, Andrisano V, Bartolini M, Motori E, Angeloni C, Hrelia S (2012) <br />Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment<br /><i>Neuropharmacology</i> <b>62</b>: 997<br /><br />Rampa A, Bartolini M, Bisi A, Belluti F, Gobbi S, Andrisano V, Ligresti A, Di Marzo V (2012) <br />The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?<br /><i>ACS Med Chem Lett</i> <b>3</b>: 182<br /><br />Samadi A, de los Rios C, Bolea I, Chioua M, Iriepa I, Moraleda I, Bartolini M, Andrisano V, Galvez E, Valderas C, Unzeta M, Marco-Contelles J (2012) <br />Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine<br /><i>Eur Journal of Medicinal Chemistry</i> <b>52</b>: 251<br /><br />Belluti F, Bartolini M, Bottegoni G, Bisi A, Cavalli A, Andrisano V, Rampa A (2011) <br />Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation<br /><i>Eur Journal of Medicinal Chemistry</i> <b>46</b>: 1682<br /><br />Martins C, Carreiras MC, Leon R, de los Rios C, Bartolini M, Andrisano V, Iriepa I, Moraleda I, Galvez E, Garcia M, Egea J, Samadi A, Chioua M, Marco-Contelles J (2011) <br />Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues<br /><i>Eur Journal of Medicinal Chemistry</i> <b>46</b>: 6119<br /><br />Rizzo S, Bisi A, Bartolini M, Mancini F, Belluti F, Gobbi S, Andrisano V, Rampa A (2011) <br />Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers<br /><i>Eur Journal of Medicinal Chemistry</i> <b>46</b>: 4336<br /><br />Rosini M, Simoni E, Bartolini M, Tarozzi A, Matera R, Milelli A, Hrelia P, Andrisano V, Bolognesi ML, Melchiorre C (2011) <br />Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>46</b>: 5435<br /><br />Camps P, Formosa X, Galdeano C, Gomez T, Munoz-Torrero D, Ramirez L, Viayna E, Gomez E, Isambert N, Lavilla R, Badia A, Clos MV, Bartolini M, Mancini F, Andrisano V, Bidon-Chanal A, Huertas O, Dafni T, Luque FJ (2010) <br />Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates<br /><i>Chemico-Biological Interactions</i> <b>187</b>: 411<br /><br />Viayna E, Gomez T, Galdeano C, Ramirez L, Ratia M, Badia A, Clos MV, Verdaguer E, Junyent F, Camins A, Pallas M, Bartolini M, Mancini F, Andrisano V, Arce MP, Rodriguez-Franco MI, Bidon-Chanal A, Luque FJ, Camps P, Munoz-Torrero D (2010) <br />Novel huprine derivatives with inhibitory activity toward beta-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates<br /><i>ChemMedChem</i> <b>5</b>: 1855<br /><br />Bartolini M, Greig NH, Yu QS, Andrisano V (2009) <br />Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease<br /><i>Journal of Chromatography A</i> <b>1216</b>: 2730<br /><br />Belluti F, Piazzi L, Bisi A, Gobbi S, Bartolini M, Cavalli A, Valenti P, Rampa A (2009) <br />Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors<br /><i>Eur Journal of Medicinal Chemistry</i> <b>44</b>: 1341<br /><br />Bolognesi ML, Rosini M, Andrisano V, Bartolini M, Minarini A, Tumiatti V, Melchiorre C (2009) <br />MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond<br /><i>Curr Pharm Des</i> <b>15</b>: 601<br /><br />Bolognesi ML, Bartolini M, Rosini M, Andrisano V, Melchiorre C (2009) <br />Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>19</b>: 4312<br /><br />Bolognesi ML, Cavalli A, Bergamini C, Fato R, Lenaz G, Rosini M, Bartolini M, Andrisano V, Melchiorre C (2009) <br />Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks<br /><i>Journal of Medicinal Chemistry</i> <b>52</b>: 7883<br /><br />Camps P, Formosa X, Galdeano C, Munoz-Torrero D, Ramirez L, Gomez E, Isambert N, Lavilla R, Badia A, Clos MV, Bartolini M, Mancini F, Andrisano V, Arce MP, Rodriguez-Franco MI, Huertas O, Dafni T, Luque FJ (2009) <br />Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds<br /><i>Journal of Medicinal Chemistry</i> <b>52</b>: 5365<br /><br />Rizzo S, Cavalli A, Ceccarini L, Bartolini M, Belluti F, Bisi A, Andrisano V, Recanatini M, Rampa A (2009) <br />Structure-activity relationships and binding mode in the human acetylcholinesterase active site of pseudo-irreversible inhibitors related to xanthostigmine<br /><i>ChemMedChem</i> <b>4</b>: 670<br /><br />Camps P, Formosa X, Galdeano C, Gomez T, Munoz-Torrero D, Scarpellini M, Viayna E, Badia A, Clos MV, Camins A, Pallas M, Bartolini M, Mancini F, Andrisano V, Estelrich J, Lizondo M, Bidon-Chanal A, Luque FJ (2008) <br />Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation<br /><i>Journal of Medicinal Chemistry</i> <b>51</b>: 3588<br /><br />Ferretti G, Bacchetti T, Masciangelo S, Nanetti L, Mazzanti L, Silvestrini M, Bartolini M, Provinciali L (2008) <br />Lipid peroxidation in stroke patients<br /><i>Clinical Chemistry & Laboratory Medicine</i> <b>46</b>: 113<br /><br />Petraglio G, Bartolini M, Branduardi D, Andrisano V, Recanatini M, Gervasio FL, Cavalli A, Parrinello M (2008) <br />The role of Li+, Na+, and K+ in the ligand binding inside the human acetylcholinesterase gorge<br /><i>Proteins</i> <b>70</b>: 779<br /><br />Piazzi L, Cavalli A, Colizzi F, Belluti F, Bartolini M, Mancini F, Recanatini M, Andrisano V, Rampa A (2008) <br />Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>18</b>: 423<br /><br />Rizzo S, Riviere C, Piazzi L, Bisi A, Gobbi S, Bartolini M, Andrisano V, Morroni F, Tarozzi A, Monti JP, Rampa A (2008) <br />Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity<br /><i>Journal of Medicinal Chemistry</i> <b>51</b>: 2883<br /><br />Rosini M, Simoni E, Bartolini M, Cavalli A, Ceccarini L, Pascu N, McClymont DW, Tarozzi A, Bolognesi ML, Minarini A, Tumiatti V, Andrisano V, Mellor IR, Melchiorre C (2008) <br />Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush<br /><i>Journal of Medicinal Chemistry</i> <b>51</b>: 4381<br /><br />Tumiatti V, Milelli A, Minarini A, Rosini M, Bolognesi ML, Micco M, Andrisano V, Bartolini M, Mancini F, Recanatini M, Cavalli A, Melchiorre C (2008) <br />Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer<br /><i>Journal of Medicinal Chemistry</i> <b>51</b>: 7308<br /><br />Bartolini M, Cavrini V, Andrisano V (2007) <br />Characterization of reversible and pseudo-irreversible acetylcholinesterase inhibitors by means of an immobilized enzyme reactor<br /><i>Journal of Chromatography A</i> <b>1144</b>: 102<br /><br />Bolognesi ML, Cavalli A, Valgimigli L, Bartolini M, Rosini M, Andrisano V, Recanatini M, Melchiorre C (2007) <br />Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease<br /><i>Journal of Medicinal Chemistry</i> <b>50</b>: 6446<br /><br />Piazzi L, Belluti F, Bisi A, Gobbi S, Rizzo S, Bartolini M, Andrisano V, Recanatini M, Rampa A (2007) <br />Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones<br /><i>Bioorganic & Medicinal Chemistry</i> <b>15</b>: 575<br /><br />Piazzi L, Cavalli A, Belluti F, Bisi A, Gobbi S, Rizzo S, Bartolini M, Andrisano V, Recanatini M, Rampa A (2007) <br />Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives<br /><i>Journal of Medicinal Chemistry</i> <b>50</b>: 4250<br /><br />Gotti R, Fiori J, Bartolini M, Cavrini V (2006) <br />Analysis of Amaryllidaceae alkaloids from Narcissus by GC-MS and capillary electrophoresis<br /><i>J Pharm Biomed Anal</i> <b>42</b>: 17<br /><br />Bartolini M, Cavrini V, Andrisano V (2005) <br />Batchwise covalent immobilization of human acetylcholinesterase: Kinetic and inhibition spectrophotometric studies<br /><i>Analytical Biochemistry</i> <b>342</b>: 163<br /><br />Bartolini M, Cavrini V, Andrisano V (2005) <br />Choosing the right chromatographic support in making a new acetylcholinesterase-micro-immobilised enzyme reactor for drug discovery<br /><i>Journal of Chromatography A</i> <b>1065</b>: 135<br /><br />Belluti F, Rampa A, Piazzi L, Bisi A, Gobbi S, Bartolini M, Andrisano V, Cavalli A, Recanatini M, Valenti P (2005) <br />Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 4444<br /><br />Bolognesi ML, Andrisano V, Bartolini M, Banzi R, Melchiorre C (2005) <br />Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 24<br /><br />Bolognesi ML, Andrisano V, Bartolini M, Cavalli A, Minarini A, Recanatini M, Rosini M, Tumiatti V, Melchiorre C (2005) <br />Heterocyclic inhibitors of AChE acylation and peripheral sites<br /><i>Farmaco</i> <b>60</b>: 465<br /><br />Munoz-Ruiz P, Rubio L, Garcia-Palomero E, Dorronsoro I, del Monte-Millan M, Valenzuela R, Usan P, de Austria C, Bartolini M, Andrisano V, Bidon-Chanal A, Orozco M, Luque FJ, Medina M, Martinez A (2005) <br />Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 7223<br /><br />Rosini M, Andrisano V, Bartolini M, Bolognesi ML, Hrelia P, Minarini A, Tarozzi A, Melchiorre C (2005) <br />Rational approach to discover multipotent anti-Alzheimer drugs<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 360<br /><br />Bartolini M, Cavrini V, Andrisano V (2004) <br />Monolithic micro-immobilized-enzyme reactor with human recombinant acetylcholinesterase for on-line inhibition studies<br /><i>Journal of Chromatography A</i> <b>1031</b>: 27<br /><br />Bolognesi ML, Bartolini M, Cavalli A, Andrisano V, Rosini M, Minarini A, Melchiorre C (2004) <br />Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues<br /><i>Journal of Medicinal Chemistry</i> <b>47</b>: 5945<br /><br />Tumiatti V, Andrisano V, Banzi R, Bartolini M, Minarini A, Rosini M, Melchiorre C (2004) <br />Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties<br /><i>Journal of Medicinal Chemistry</i> <b>47</b>: 6490<br /><br />Bartolini M, Bertucci C, Cavrini V, Andrisano V (2003) <br />beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies<br /><i>Biochemical Pharmacology</i> <b>65</b>: 407<br /><br />Piazzi L, Rampa A, Bisi A, Gobbi S, Belluti F, Cavalli A, Bartolini M, Andrisano V, Valenti P, Recanatini M (2003) <br />3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy<br /><i>Journal of Medicinal Chemistry</i> <b>46</b>: 2279<br /><br />Tumiatti V, Rosini M, Bartolini M, Cavalli A, Marucci G, Andrisano V, Angeli P, Banzi R, Minarini A, Recanatini M, Melchiorre C (2003) <br />Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine<br /><i>Journal of Medicinal Chemistry</i> <b>46</b>: 954<br /><br />Bartolini M, Bertucci C, Gotti R, Tumiatti V, Cavalli A, Recanatini M, Andrisano V (2002) <br />Determination of the dissociation constants (pKa) of basic acetylcholinesterase inhibitors by reversed-phase liquid chromatography<br /><i>Journal of Chromatography A</i> <b>958</b>: 59<br /><br />Bolognesi ML, Bixel MG, Marucci G, Bartolini M, Krauss M, Angeli P, Antonello A, Rosini M, Tumiatti V, Hucho F, Melchiorre C (2002) <br />Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure<br /><i>Journal of Medicinal Chemistry</i> <b>45</b>: 3286<br /><br />Andrisano V, Bartolini M, Gotti R, Cavrini V, Felix G (2001) <br />Determination of inhibitors' potency (IC50) by a direct high-performance liquid chromatographic method on an immobilised acetylcholinesterase column<br /><i>Journal of Chromatography B Biomed Sci Appl</i> <b>753</b>: 375<br /><br />Bolognesi ML, Andrisano V, Bartolini M, Minarini A, Rosini M, Tumiatti V, Melchiorre C (2001) <br />Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors<br /><i>Journal of Medicinal Chemistry</i> <b>44</b>: 105<br /><br />Rampa A, Piazzi L, Belluti F, Gobbi S, Bisi A, Bartolini M, Andrisano V, Cavrini V, Cavalli A, Recanatini M, Valenti P (2001) <br />Acetylcholinesterase Inhibitors: SAR and Kinetic Studies on omega-[N-Methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl Derivatives<br /><i>Journal of Medicinal Chemistry</i> <b>44</b>: 3810<br /><br />Recanatini M, Cavalli A, Belluti F, Piazzi L, Rampa A, Bisi A, Gobbi S, Valenti P, Andrisano V, Bartolini M, Cavrini V (2000) <br />SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues<br /><i>Journal of Medicinal Chemistry</i> <b>43</b>: 2007<br /><br />