Despotovic D, Aharon E, Trofimyuk O, Dubovetskyi A, Cherukuri KP, Ashani Y, Eliason O, Sperfeld M, Leader H, Castelli A, Fumagalli L, Savidor A, Levin Y, Longo LM, Segev E, Tawfik DS (2022)
Utilization of diverse organophosphorus pollutants by marine bacteria
Proc Natl Acad Sci U S A 119: e2203604119
Despotovic D, Aharon E, Trofimyuk O, Dubovetskyi A, Cherukuri KP, Ashani Y, Leader H, Castelli A, Fumagalli A, Savidor A, Levin Y, Longo LM, Segev E, Tawfik DS (2020)
Widespread Utilization of Diverse Organophosphate Pollutants by Marine Bacteria
Biorxiv
Silman I, Shnyrov VL, Ashani Y, Roth E, Nicolas A, Sussman JL, Weiner L (2021)
Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif
Protein Science
Despotovic D, Aharon E, Dubovetskyi A, Leader H, Ashani Y, Tawfik DS (2019)
A mixture of three engineered phosphotriesterases enables rapid detoxification of the entire spectrum of known threat nerve agents
Protein Engineering Des Sel 32: 169
Goldsmith M, Ashani Y (2018)
Catalytic bioscavengers as countermeasures against organophosphate nerve agents
Chemico-Biological Interactions 292: 50
Ashani Y, Leader H, Aggarwal N, Silman I, Worek F, Sussman JL, Goldsmith M (2016)
In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications
Chemico-Biological Interactions 259: 252
Dym O, Song W, Felder CE, Roth E, Shnyrov V, Ashani Y, Xu Y, Joosten RP, Weiner L, Sussman JL, Silman I (2016)
The Impact of Crystallization Conditions on Structure-Based Drug Design: A Case Study on the Methylene Blue/Acetylcholinesterase Complex
Protein Science 25: 1096
Goldenzweig A, Goldsmith M, Hill SE, Gertman O, Laurino P, Ashani Y, Dym O, Unger T, Albeck S, Prilusky J, Lieberman RL, Aharoni A, Silman I, Sussman JL, Tawfik DS, Fleishman SJ (2016)
Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability
Mol Cell 63: 337
Goldsmith M, Ashani Y, Margalit R, Nyska A, Mirelman D, Tawfik DS (2016)
A new post-intoxication treatment of paraoxon and parathion poisonings using an evolved PON1 variant and recombinant GOT1
Chemico-Biological Interactions 259: 242
Goldsmith M, Eckstein S, Ashani Y, Greisen P, Jr., Leader H, Sussman JL, Aggarwal N, Ovchinnikov S, Tawfik DS, Baker D, Thiermann H, Worek F (2016)
Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro
Archives of Toxicology 90: 2711
Wille T, Neumaier K, Koller M, Ehinger C, Aggarwal N, Ashani Y, Goldsmith M, Sussman JL, Tawfik DS, Thiermann H, Worek F (2016)
Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection
Toxicol Lett 258: 198
Worek F, Seeger T, Goldsmith M, Ashani Y, Leader H, Sussman JL, Tawfik DS, Thiermann H, Wille T (2014)
Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro
Archives of Toxicology 88: 1257
Worek F, Seeger T, Reiter G, Goldsmith M, Ashani Y, Leader H, Sussman JL, Aggarwal N, Thiermann H, Tawfik DS (2014)
Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: A proof-of-concept study
Toxicol Lett 231: 45
Cherny I, Greisen P, Jr., Ashani Y, Khare SD, Oberdorfer G, Leader H, Baker D, Tawfik DS (2013)
Engineering v-type nerve agents detoxifying enzymes using computationally focused libraries
ACS Chemical Biology 8: 2394
Silman I, Roth E, Paz A, Triquigneaux MM, Ehrenshaft M, Xu Y, Shnyrov VL, Sussman JL, Deterding LJ, Ashani Y, Mason RP, Weiner L (2013)
The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a model system for studying the molecular consequences of photodynamic therapy
Chemico-Biological Interactions 203: 63
Goldsmith M, Ashani Y, Simo Y, Ben-David M, Leader H, Silman I, Sussman JL, Tawfik DS (2012)
Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification
Chemical Biology 19: 456
Khare SD, Kipnis Y, Greisen P, Jr., Takeuchi R, Ashani Y, Goldsmith M, Song Y, Gallaher JL, Silman I, Leader H, Sussman JL, Stoddard BL, Tawfik DS, Baker D (2012)
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis
Nat Chemical Biology 8: 294
Paz A, Roth E, Ashani Y, Xu Y, Shnyrov VL, Sussman JL, Silman I, Weiner L (2012)
Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase
Protein Science 21: 1138
Triquigneaux MM, Ehrenshaft M, Roth E, Silman I, Ashani Y, Mason RP, Weiner L, Deterding LJ (2012)
Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer Methylene Blue
Biochemical Journal 448: 83
Ashani Y, Goldsmith M, Leader H, Silman I, Sussman JL, Tawfik DS (2011)
In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases
Toxicol Lett 206: 24
Gupta RD, Goldsmith M, Ashani Y, Simo Y, Mullokandov G, Bar H, Ben-David M, Leader H, Margalit R, Silman I, Sussman JL, Tawfik DS (2011)
Directed evolution of hydrolases for prevention of G-type nerve agent intoxication
Nat Chemical Biology 7: 120
Ashani Y, Gupta RD, Goldsmith M, Silman I, Sussman JL, Tawfik DS, Leader H (2010)
Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers
Chemico-Biological Interactions 187: 362
Sanson B, Nachon F, Colletier JP, Froment MT, Toker L, Greenblatt HM, Sussman JL, Ashani Y, Masson P, Silman I, Weik M (2009)
Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime
Journal of Medicinal Chemistry 52: 7593
Weiner L, Shnyrov VL, Konstantinovskii L, Roth E, Ashani Y, Silman I (2009)
Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors
Biochemistry 48: 563
Groner E, Ashani Y, Schorer-Apelbaum D, Sterling J, Herzig Y, Weinstock M (2007)
The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates
Molecular Pharmacology 71: 1610
Segev O, Columbus I, Ashani Y, Cohen Y (2005)
Probing the molecular interaction of chymotrypsin with organophosphorus compounds by 31P diffusion NMR in aqueous solutions
J Org Chem 70: 309
Ashani Y, Pistinner S (2004)
Estimation of the upper limit of human butyrylcholinesterase dose required for protection against organophosphates toxicity: a mathematically based toxicokinetic model
Toxicol Sci 77: 358
Ashani Y, Segev O, Balan A (2004)
The effect of fluoride on the scavenging of organophosphates by human butyrylcholinesterase in buffer solutions and human plasma
Toxicol Appl Pharmacol 194: 90
Ashani Y, Balan A (2004)
Poster (34) Interaction of drugs and environmental factors with bioscavengers: does fluoride in human plasma affect the antidotal properties of human butyrylcholinesterase?
In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina: 338
Doctor BP, Saxena A, Ashani Y, Ross M (2004)
Poster (32) Bioscavengers: antidotes for organophosphate chemical warfare agent toxicity.
In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina: 337
Saxena A, Luo C, Bansal R, Sun W, Clark M, Ashani Y, Ross M, Doctor BP (2004)
Human serum butyrylcholinesterase: A future generation antidote for organophosphate chemical warfare agent toxicity .
In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina: 269
Saxena A, Luo C, Bansal R, Sun W, Clark M, Ashani Y, Ross M, Doctor BP (2004)
Poster (36) Human serum butyrylcholinesterase: a future generation antidote for organophosphate chemical warfare agent toxicity
In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina: 339
Ashani Y, Bhattacharjee AK, Leader H, Saxena A, Doctor BP (2003)
Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators
Biochemical Pharmacology 66: 191
Rosenberg YJ, Luo C, Ashani Y, Doctor BP, Fischer R, Wolfe G, Saxena A (2002)
Pharmacokinetics and immunologic consequences of exposing macaques to purified homologous butyrylcholinesterase
Life Sciences 72: 125
Leader H, Vincze A, Manisterski B, Rothschild N, Dosoretz C, Ashani Y (1999)
Characterization of O,O-diethylphosphoryl oximes as inhibitors of cholinesterases and substrates of phosphotriesterases
Biochemical Pharmacology 58: 503
Luo C, Saxena A, Ashani Y, Leader H, Radic Z, Taylor P, Doctor BP (1999)
Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime
Chemico-Biological Interactions 119-120: 129
Allon N, Raveh L, Gilat E, Cohen E, Grunwald J, Ashani Y (1998)
Prophylaxis against soman inhalation toxicity in guinea pigs by pretreatment alone with human serum butyrylcholinesterase
Toxicol Sci 43: 121
Ashani Y, Grauer E, Grunwald J, Allon N, Raveh L (1998)
Current Capabilities in Extrapolating from Animal to Human the Capacity of Human Butyrylcholinesterase to Detoxify Organophosphates
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 255
Ashani Y, Leader H, Rothschild N, Dosoretz C (1998)
Combined effect of organophosphorus hydrolase and oxime on the reactivation rate of diethylphosphoryl-acetylcholinesterase conjugates
Biochemical Pharmacology 55: 159
Leader H, Vincze A, Rothschild N, Dosoretz C, Ashani Y (1998)
Sequestration of Toxic Phosphorylated Oximes by Stoichiometric and Catalytic Scavengers
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 305
Luo C, Ashani Y, Doctor BP (1998)
Acceleration of oxime-induced reactivation of acetylcholinesterase-organophosphate conjugate and 31P NMR detection of phosporyl oxime from the conjugate
Journal de Physiologie (Paris) 92: 461
Luo C, Ashani Y, Saxena A, Leader H, Maxwell DM, Taylor P, Doctor BP (1998)
Acceleration of Oxime-Induced Reactivation of Organophosphate-Inhibited Acetylcholinesterase by Quaternary Ligands
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 215
Luo C, Ashani Y, Doctor BP (1998)
Acceleration of Oxime-Induced Reactivation of Organophosphate-Inhibited Fetal Bovine Serum Acetylcholinesterase by Monoquaternary and Bisquaternary Ligands
Molecular Pharmacology 53: 718
Saxena A, Ashani Y, Raveh L, Doctor BP (1998)
The Role of Oligosaccharides in the Pharmacokinetics of Cholinesterases
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 283
Saxena A, Ashani Y, Raveh L, Stevenson D, Patel T, Doctor BP (1998)
Role of oligosaccharides in the pharmacokinetics of tissue-derived and genetically engineered cholinesterases
Molecular Pharmacology 53: 112
Grunwald J, Marcus D, Papier Y, Raveh L, Pittel Z, Ashani Y (1997)
Large-scale purification and long-term stability of human butyrylcholinesterase: a potential bioscavenger drug
Journal of Biochemical & Biophysical Methods 34: 123
Raveh L, Grauer E, Grunwald J, Cohen E, Ashani Y (1997)
The stoichiometry of protection against soman and VX toxicity in monkeys pretreated with human butyrylcholinesterase
Toxicol Appl Pharmacol 145: 43
Saxena A, Raveh L, Ashani Y, Doctor BP (1997)
Structure of glycan moieties responsible for the extended circulatory life time of fetal bovine serum acetylcholinesterase and equine serum butyrylcholinesterase
Biochemistry 36: 7481
Allon N, Raveh L, Gilat E, Grunwald J, Manistersky E, Cohen E, Ashani Y (1995)
Protection of Guinea Pigs against Soman Inhalation by Pretreatment Alone with Human Butyrylcholinesterase
In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.: 398
Ashani Y, Radic Z, Tsigelny I, Vellom DC, Pickering NA, Quinn DM, Doctor BP, Taylor P (1995)
Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes
Journal of Biological Chemistry 270: 6370
Ashani Y, Radic Z, Tsigelny I, Vellom DC, Pickering NA, Quinn DM, Doctor BP, Taylor P (1995)
Amino Acid Residues that Control Mono- and Bisquaternary Oxime-Induced Reactivation of O-Ethyl Methylphosphonylated Cholinesterases
In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.: 133
Doctor BP, Gentry MK, Saxena A, Ashani Y (1995)
Modulation of Catalysis and Inhibition of Fetal Bovine Serum Acetylcholinesterase by Monoclonal Antibodies
In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.: 141
Gentry MK, Moorad DR, Hur RS, Saxena A, Ashani Y, Doctor BP (1995)
Characterization of monoclonal antibodies that inhibit the catalytic activity of acetylcholinesterases
Journal of Neurochemistry 64: 842
Grauer E, Raveh L, Kapon J, Grunwald J, Cohen E, Ashani Y (1995)
Human Butyrylcholinesterase as Prophylaxis Treatment against Soman
In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.: 400
Kadar T, Raveh L, Brandeis R, Grunwald J, Cohen E, Ashani Y (1995)
Prevention of Brain Damage and Behavioral Performance Changes following an IV Injection of Soman and VX in Rats Pretreated with Human Butyrylcholinesterase
In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.: 404
Raveh L, Grunwald J, Cohen E, Ashani Y (1995)
Efficacy of Prophylaxis with Human Butyrylcholinesterase against Soman and VX Poisoning
In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.: 402
Ashani Y, Grunwald J, Kronman C, Velan B, Shafferman A (1994)
Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase
Molecular Pharmacology 45: 555
Caranto GR, Waibel KH, Asher JM, Larrison RW, Brecht KM, Schutz MB, Raveh L, Ashani Y, Wolfe AD, Maxwell DM, Doctor BP (1994)
Amplification of the effectiveness of acetylcholinesterase for detoxification of organophosphorus compounds by bis-quaternary oximes
Biochemical Pharmacology 47: 347
Grunwald J, Raveh L, Doctor BP, Ashani Y (1994)
Huperzine A as a pretreatment candidate drug against nerve agent toxicity
Life Sciences 54: 991
Brandeis R, Raveh L, Grunwald J, Cohen E, Ashani Y (1993)
Prevention of soman-induced cognitive deficits by pretreatment with human butyrylcholinesterase in rats
Pharmacol Biochem Behav 46: 889
Gentry MK, Saxena A, Ashani Y, Doctor BP (1993)
Immunochemical characterization of anti-acetylcholinesterase inhibitory monoclonal antibodies
Chemico-Biological Interactions 87: 227
Raveh L, Grunwald J, Marcus D, Papier Y, Cohen E, Ashani Y (1993)
Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity. In vitro and in vivo quantitative characterization
Biochemical Pharmacology 45: 2465
Segall Y, Waysbort D, Barak D, Ariel N, Doctor BP, Grunwald J, Ashani Y (1993)
Direct observation and elucidation of the structures of aged and nonaged phosphorylated cholinesterases by 31P NMR spectroscopy
Biochemistry 32: 13441
Ashani Y, Peggins JOd, Doctor BP (1992)
Mechanism of inhibition of cholinesterases by huperzine A
Biochemical & Biophysical Research Communications 184: 719
Raveh L, Segall Y, Leader H, Rothschild N, Levanon D, Henis Y, Ashani Y (1992)
Protection against tabun toxicity in mice by prophylaxis with an enzyme hydrolyzing organophosphate esters
Biochemical Pharmacology 44: 397
Ashani Y, Bromberg A, Levy D, Gentry MK, Brady DR, Doctor BP (1991)
Changes in the Catalytic Activity of Acetylcholinesterase upon Complexation with Monoclonal Antibodies
In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC: 235
Ashani Y, Rothschild N, Segall Y, Levanon D, Raveh L (1991)
Prophylaxis against organophosphate poisoning by an enzyme hydrolysing organophosphorus compounds in mice
Life Sciences 49: 367
Ashani Y, Shapira S, Levy D, Wolfe AD, Doctor BP, Raveh L (1991)
Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice
Biochemical Pharmacology 41: 37
Doctor BP, Raveh L, Wolfe AD, Maxwell DM, Ashani Y (1991)
Enzymes as pretreatment drugs for organophosphate toxicity
Neurosci Biobehav Rev 15: 123
Doctor BP, Gentry MK, Wu SJ, Ashani Y, De La Hoz DM (1991)
Fetal Bovine Serum Acetylcholinesterase: Structure-Function Correlation
In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC: 37
Harel M, Su CT, Frolow F, Ashani Y, Silman I, Sussman JL (1991)
Refined crystal structures of aged and non-aged organophosphoryl conjugates of gamma-chymotrypsin
Journal of Molecular Biology 221: 909
Maxwell DM, Wolfe AD, Ashani Y, Doctor BP (1991)
Cholinesterase and Carboxyl esterase as Scavengers for Organophosphorus Agents
In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC: 206
Su CT, Steinberg N, Silman I, Harel M, Sussman JL, Grunwald J, Ashani Y (1991)
Poster: Physicochemical and crystallographic studies on the stability and structure of aged and nonaged organophosphoryl conjugates of chymotrypsin
In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC: 274
Wolfe AD, Ashani Y, Doctor BP, Maxwell DM (1991)
Poster: Esterases as organophosphate scavengers
In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC: 306
Ashani Y, Gentry MK, Doctor BP (1990)
Differences in conformational stability between native and phosphorylated acetylcholinesterase as evidenced by a monoclonal antibody
Biochemistry 29: 2456
Doctor BP, Smyth KK, Gentry MK, Ashani Y, Christner CE, De La Hoz DM, Ogert RA, Smith SW (1989)
Structural and immunochemical properties of fetal bovine serum acetylcholinesterase
Progress in Clinical & Biological Research 289: 305
Raveh L, Ashani Y, Levy D, De La Hoz DM, Wolfe AD, Doctor BP (1989)
Acetylcholinesterase prophylaxis against organophosphate poisoning. Quantitative correlation between protection and blood-enzyme level in mice
Biochemical Pharmacology 38: 529
Steinberg N, Grunwald J, Roth E, August R, Haas E, Ashani Y, Silman I (1989)
Conformational differences between aged and non-aged organophosphoryl conjugates of chymotrypsin
Prog Clin Biol Res 289: 293
Steinberg N, van der Drift AC, Grunwald J, Segall Y, Shirin E, Haas E, Ashani Y, Silman I (1989)
Conformational differences between aged and nonaged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin as detected by optical spectroscopy
Biochemistry 28: 1248
Balan A, Barness I, Simon G, Levy D, Ashani Y (1988)
Tritium labeling of a powerful methylphosphonate inhibitor of cholinesterase: synthesis and biological applications
Analytical Biochemistry 169: 95
Levy D, Ashani Y (1986)
Synthesis and in vitro properties of a powerful quaternary methylphosphonate inhibitor of acetylcholinesterase. A new marker in blood-brain barrier research
Biochemical Pharmacology 35: 1079
Ashani Y, Leader H, Raveh L, Bruckstein R, Spiegelstein M (1983)
In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide
Journal of Medicinal Chemistry 26: 145
Amitai G, Ashani Y, Gafni A, Silman I (1982)
Novel pyrene-containing organophosphates as fluorescent probes for studying aging-induced conformational changes in organophosphate-inhibited acetylcholinesterase
Biochemistry 21: 2060
Amitai G, Ashani Y, Gafni A, Silman I (1980)
New fluorescent organophosphates as probes for studying aging-induced conformational changes in inhibited acetylcholinesterase
Neurochem Int 2C: 199
Amitai G, Ashani Y, Shahar A, Gafni A, Silman I (1980)
Fluorescent organophosphates: novel probes for studying aging-induced conformational changes in inhibited acetylcholinesterase and for localization of cholinesterase in nervous tissue
Monographs in Neural Sciences 7: 70
Rachaman ES, Ashani Y, Leader H, Granoth I, Edery H, Porath G (1979)
Sugar-oximes, new potential antidotes against organophosphorus poisoning
Arzneimittelforschung 29: 875
Voss HF, Ashani Y, Wilson IB (1974)
Purification of acetylcholinesterase by covalent affinity chromatography
Advances in Experimental Medicine & Biology 42: 75
Voss HF, Ashani Y, Wilson IB (1974)
A covalent affinity technique for the purification of all forms of acetylcholinesterase
Methods Enzymol 34: 581
Ashani Y, Snyder SL, Wilson IB (1973)
Linear free energy relationships in the hydrolysis of some inhibitors of acetylcholinesterase
Journal of Medicinal Chemistry 16: 446
Ashani Y, Wilson IB (1972)
A covalent affinity column for the purification of acetylcholinesterase
Biochimica & Biophysica Acta 276: 317
Ashani Y, Snyder SL, Wilson IB (1972)
Inhibition of cholinesterase by 1,3,2-dioxaphosphorinane 2-oxide derivatives
Biochemistry 11: 3518
Ashani Y, Wins P, Wilson IB (1972)
The inhibition of cholinesterase by diethyl phosphorochloridate
Biochimica & Biophysica Acta 284: 427
Ashani Y, Cohen S (1968)
A kinetic study of the reaction between 1,1'-trimethylenebis (4-hydroximinomethylpyridinium) dibromide and diisopropyl phosphorofluoridate
Journal of Medicinal Chemistry 11: 967
Ashani Y, Cohen S (1967)
Reactivators of inhibited acetylcholinesterase. II. The preparation and properties of some new 4-hydroxyin-nomethyl-l-(N-aminoalkyl)-pyridinium salts
Israel Journal of Chemistry 5: 59
Ashani Y, Ederey H, Zahavy J, Kunberg W, Cohen S (1965)
Reactivators of the inhibited acetylcholinesterase. 1. The preparation and properties of 4-hydroximino-methyl-1-methyl-pyridinium iodide
Israel Journal of Chemistry 3: 133