Fernandes F, Barroso MF, De Simone A, Emrikova E, Dias-Teixeira M, Pereira JP, Chlebek J, Fernandes VC, Rodrigues F, Andrisano V, Delerue-Matos C, Grosso C (2022) <br />Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease<br /><i>J Ethnopharmacol</i> <b>290</b>: 115107<br /><br />Ismaili L, Monnin J, Etievant A, Arribas RL, Viejo L, Refouvelet B, Soukup O, Janockova J, Hepnarova V, Korabecny J, Kucera T, Jun D, Andrys R, Musilek K, Baguet A, Garcia-Frutos EM, De Simone A, Andrisano V, Bartolini M, de los Rios C, Marco-Contelles J, Haffen E (2021) <br />(+/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease<br /><i>ACS Chem Neurosci</i> <br /><br />Naldi M, Brusotti G, Massolini G, Andrisano V, Temporini C, Bartolini M (2021) <br />Bio-Guided Fractionation of Stem Bark Extracts from Phyllanthus muellarianus: Identification of Phytocomponents with Anti-Cholinesterase Activity<br /><i>Molecules</i> <b>26</b>: <br /><br />Pont C, Ginex T, Grinan-Ferre C, Scheiner M, Mattellone A, Martinez N, Arce EM, Soriano-Fernandez Y, Naldi M, De Simone A, Barenys M, Gomez-Catalan J, Perez B, Sabate R, Andrisano V, Loza MI, Brea J, Bartolini M, Bolognesi ML, Decker M, Pallas M, Luque FJ, Munoz-Torrero D (2021) <br />From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects<br /><i>Eur Journal of Medicinal Chemistry</i> <b>225</b>: 113779<br /><br />Viayna E, Coquelle N, Cieslikiewicz-Bouet M, Cisternas P, Oliva CA, Sanchez-Lopez E, Ettcheto M, Bartolini M, De Simone A, Ricchini M, Rendina M, Pons M, Firuzi O, Perez B, Saso L, Andrisano V, Nachon F, Brazzolotto X, Garcia ML, Camins A, Silman I, Jean L, Inestrosa NC, Colletier JP, Renard PY, Munoz-Torrero D (2021) <br />Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice<br /><i>Journal of Medicinal Chemistry</i> <b>64</b>: 812<br /><br />Vrabec R, Marikova J, Locarek M, Korabecny J, Hulcova D, Hosalkova A, Kunes J, Chlebek J, Kucera T, Hrabinova M, Jun D, Soukup O, Andrisano V, Jenco J, Safratova M, Novakova L, Opletal L, Cahlikova L (2021) <br />Monoterpene indole alkaloids from Vinca minor L. 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Dutch Master as potential drugs in treatment of Alzheimer's disease<br /><i>Phytochemistry</i> <b>165</b>: 112055<br /><br />Perez-Areales FJ, Turcu AL, Barniol-Xicota M, Pont C, Pivetta D, Espargaro A, Bartolini M, De Simone A, Andrisano V, Perez B, Sabate R, Sureda FX, Vazquez S, Munoz-Torrero D (2019) <br />A novel class of multitarget anti-Alzheimer benzohomoadamantanechlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors<br /><i>Eur Journal of Medicinal Chemistry</i> <b>180</b>: 613<br /><br />Andrisano V, Naldi M, De Simone A, Bartolini M (2018) <br />A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017<br /><i>Expert Opin Ther Pat</i> <b>28</b>: 455<br /><br />Milelli A, De Simone A, Ticchi N, Chen HH, Betari N, Andrisano V, Tumiatti V (2017) <br />Tacrine-based Multifunctional Agents in Alzheimer's Disease: An Old Story in Continuous Development section sign<br /><i>Curr Med Chem</i> <b>24</b>: 3522<br /><br />Pandolfi F, De Vita D, Bortolami M, Coluccia A, Di Santo R, Costi R, Andrisano V, Alabiso F, Bergamini C, Fato R, Bartolini M, Scipione L (2017) <br />New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation<br /><i>Eur Journal of Medicinal Chemistry</i> <b>141</b>: 197<br /><br />Perez-Areales FJ, Betari N, Viayna A, Pont C, Espargaro A, Bartolini M, De Simone A, Rinaldi Alvarenga JF, Perez B, Sabate R, Lamuela-Raventos RM, Andrisano V, Luque FJ, Munoz-Torrero D (2017) <br />Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids<br /><i>Future Med Chem</i> <b>9</b>: 965<br /><br />Seidl C, de Moraes Santos CA, De Simone A, Bartolini M, Weffort-Santos AM, Andrisano V (2017) <br />Uleine Disrupts Key Enzymatic and Non-Enzymatic Biomarkers that Leads to Alzheimer's Disease<br /><i>Curr Alzheimer Res</i> <b>14</b>: 317<br /><br />Simoni E, Bartolini M, Abu IF, Blockley A, Gotti C, Bottegoni G, Caporaso R, Bergamini C, Andrisano V, Cavalli A, Mellor IR, Minarini A, Rosini M (2017) <br />Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation<br /><i>Future Med Chem</i> <b>9</b>: 953<br /><br />Boulebd H, Ismaili L, Bartolini M, Bouraiou A, Andrisano V, Martin H, Bonet A, Moraleda I, Iriepa I, Chioua M, Belfaitah A, Marco-Contelles J (2016) <br />Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy<br /><i>Molecules</i> <b>21</b>: <br /><br />Chlebek J, De Simone A, Hostalkova A, Opletal L, Perez C, Perez DI, Havlikova L, Cahlikova L, Andrisano V (2016) <br />Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets<br /><i>Fitoterapia</i> <b>109</b>: 241<br /><br />Montanari S, Bartolini M, Neviani P, Belluti F, Gobbi S, Pruccoli L, Tarozzi A, Falchi F, Andrisano V, Miszta P, Cavalli A, Filipek S, Bisi A, Rampa A (2016) <br />Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives<br /><i>ChemMedChem</i> <b>11</b>: 1296<br /><br />Montanari S, Scalvini L, Bartolini M, Belluti F, Gobbi S, Andrisano V, Ligresti A, Di Marzo V, Rivara S, Mor M, Bisi A, Rampa A (2016) <br />Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents<br /><i>Journal of Medicinal Chemistry</i> <b>59</b>: 6387<br /><br />Prati F, Bergamini C, Fato R, Soukup O, Korabecny J, Andrisano V, Bartolini M, Bolognesi ML (2016) <br />Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease<br /><i>ChemMedChem</i> <b>11</b>: 1284<br /><br />Zha X, Lamba D, Zhang L, Lou Y, Xu C, Kang D, Chen L, Xu Y, De Simone A, Samez S, Pesaresi A, Stojan J, Lopez MG, Egea J, Andrisano V, Bartolini M (2016) <br />Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography<br /><i>Journal of Medicinal Chemistry</i> <b>59</b>: 114<br /><br />Benchekroun M, Bartolini M, Egea J, Romero A, Soriano E, Pudlo M, Luzet V, Andrisano V, Jimeno ML, Lopez MG, Wehle S, Gharbi T, Refouvelet B, de Andres L, Herrera-Arozamena C, Monti B, Bolognesi ML, Rodriguez-Franco MI, Decker M, Marco-Contelles J, Ismaili L (2015) <br />Novel tacrine-grafted ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic Acid hybrids<br /><i>ChemMedChem</i> <b>10</b>: 523<br /><br />Lemes LF, de Andrade Ramos G, de Oliveira AS, da Silva FM, de Castro Couto G, da Silva Boni M, Guimaraes MJ, Souza IN, Bartolini M, Andrisano V, do Nascimento Nogueira PC, Silveira ER, Brand GD, Soukup O, Korabecny J, Romeiro NC, Castro NG, Bolognesi ML, Romeiro LA (2015) <br />Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>108</b>: 687<br /><br />Belluti F, De Simone A, Tarozzi A, Bartolini M, Djemil A, Bisi A, Gobbi S, Montanari S, Cavalli A, Andrisano V, Bottegoni G, Rampa A (2014) <br />Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>78C</b>: 157<br /><br />Brogi S, Butini S, Maramai S, Colombo R, Verga L, Lanni C, De Lorenzi E, Lamponi S, Andreassi M, Bartolini M, Andrisano V, Novellino E, Campiani G, Brindisi M, Gemma S (2014) <br />Disease-Modifying Anti-Alzheimer's Drugs: Inhibitors of Human Cholinesterases Interfering with beta-Amyloid Aggregation<br /><i>CNS Neurosci Ther</i> <b>20</b>: 624<br /><br />Nepovimova E, Uliassi E, Korabecny J, Pena-Altamira LE, Samez S, Pesaresi A, Garcia GE, Bartolini M, Andrisano V, Bergamini C, Fato R, Lamba D, Roberti M, Kuca K, Monti B, Bolognesi ML (2014) <br />Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects<br /><i>Journal of Medicinal Chemistry</i> <b>57</b>: 8576<br /><br />Tarozzi A, Bartolini M, Piazzi L, Valgimigli L, Amorati R, Bolondi C, Djemil A, Mancini F, Andrisano V, Rampa A (2014) <br />From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer's disease<br /><i>Pharmacol Res Perspect</i> <b>2</b>: e00023<br /><br />Viayna E, Sola I, Bartolini M, De Simone A, Tapia-Rojas C, Serrano FG, Sabate R, Juarez-Jimenez J, Perez B, Luque FJ, Andrisano V, Clos MV, Inestrosa NC, Munoz-Torrero D (2014) <br />Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents<br /><i>Journal of Medicinal Chemistry</i> <b>57</b>: 2549<br /><br />Bartolini M, Naldi M, Nicolau DV, van Delft FC, van Zijl J, Snijder J, van den Heuvel EF, Naburgh EP, Calonghi N, Andrisano V (2013) <br />Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase<br /><i>Anal Bioanal Chem</i> <b>405</b>: 795<br /><br />Butini S, Brindisi M, Brogi S, Maramai S, Guarino E, Panico A, Saxena A, Chauhan V, Colombo R, Verga L, De Lorenzi E, Bartolini M, Andrisano V, Novellino E, Campiani G, Gemma S (2013) <br />Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation<br /><i>ACS Med Chem Lett</i> <b>4</b>: 1178<br /><br />Di Pietro O, Viayna E, Vicente-Garcia E, Bartolini M, Ramon R, Juarez-Jimenez J, Clos MV, Perez B, Andrisano V, Luque FJ, Lavilla R, Munoz-Torrero D (2013) <br />1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies<br /><i>Eur Journal of Medicinal Chemistry</i> <b>73C</b>: 141<br /><br />Prati F, Bartolini M, Simoni E, De Simone A, Pinto A, Andrisano V, Bolognesi ML (2013) <br />Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>23</b>: 6254<br /><br />Rosini M, Simoni E, Bartolini M, Soriano E, Marco-Contelles J, Andrisano V, Monti B, Windisch M, Hutter-Paier B, McClymont DW, Mellor IR, Bolognesi ML (2013) <br />The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti-Alzheimer Multitarget Profile of Dimebon<br /><i>ChemMedChem</i> <b>8</b>: 1276<br /><br />Galdeano C, Viayna E, Sola I, Formosa X, Camps P, Badia A, Clos MV, Relat J, Ratia M, Bartolini M, Mancini F, Andrisano V, Salmona M, Minguillon C, Gonzalez-Munoz GC, Rodriguez-Franco MI, Bidon-Chanal A, Luque FJ, Munoz-Torrero D (2012) <br />Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases<br /><i>Journal of Medicinal Chemistry</i> <b>55</b>: 661<br /><br />Minarini A, Milelli A, Tumiatti V, Rosini M, Simoni E, Bolognesi ML, Andrisano V, Bartolini M, Motori E, Angeloni C, Hrelia S (2012) <br />Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment<br /><i>Neuropharmacology</i> <b>62</b>: 997<br /><br />Rampa A, Bartolini M, Bisi A, Belluti F, Gobbi S, Andrisano V, Ligresti A, Di Marzo V (2012) <br />The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?<br /><i>ACS Med Chem Lett</i> <b>3</b>: 182<br /><br />Samadi A, de los Rios C, Bolea I, Chioua M, Iriepa I, Moraleda I, Bartolini M, Andrisano V, Galvez E, Valderas C, Unzeta M, Marco-Contelles J (2012) <br />Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine<br /><i>Eur Journal of Medicinal Chemistry</i> <b>52</b>: 251<br /><br />Belluti F, Bartolini M, Bottegoni G, Bisi A, Cavalli A, Andrisano V, Rampa A (2011) <br />Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation<br /><i>Eur Journal of Medicinal Chemistry</i> <b>46</b>: 1682<br /><br />Martins C, Carreiras MC, Leon R, de los Rios C, Bartolini M, Andrisano V, Iriepa I, Moraleda I, Galvez E, Garcia M, Egea J, Samadi A, Chioua M, Marco-Contelles J (2011) <br />Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues<br /><i>Eur Journal of Medicinal Chemistry</i> <b>46</b>: 6119<br /><br />Rizzo S, Bisi A, Bartolini M, Mancini F, Belluti F, Gobbi S, Andrisano V, Rampa A (2011) <br />Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers<br /><i>Eur Journal of Medicinal Chemistry</i> <b>46</b>: 4336<br /><br />Rosini M, Simoni E, Bartolini M, Tarozzi A, Matera R, Milelli A, Hrelia P, Andrisano V, Bolognesi ML, Melchiorre C (2011) <br />Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>46</b>: 5435<br /><br />Camps P, Formosa X, Galdeano C, Gomez T, Munoz-Torrero D, Ramirez L, Viayna E, Gomez E, Isambert N, Lavilla R, Badia A, Clos MV, Bartolini M, Mancini F, Andrisano V, Bidon-Chanal A, Huertas O, Dafni T, Luque FJ (2010) <br />Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates<br /><i>Chemico-Biological Interactions</i> <b>187</b>: 411<br /><br />Viayna E, Gomez T, Galdeano C, Ramirez L, Ratia M, Badia A, Clos MV, Verdaguer E, Junyent F, Camins A, Pallas M, Bartolini M, Mancini F, Andrisano V, Arce MP, Rodriguez-Franco MI, Bidon-Chanal A, Luque FJ, Camps P, Munoz-Torrero D (2010) <br />Novel huprine derivatives with inhibitory activity toward beta-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates<br /><i>ChemMedChem</i> <b>5</b>: 1855<br /><br />Bartolini M, Greig NH, Yu QS, Andrisano V (2009) <br />Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease<br /><i>Journal of Chromatography A</i> <b>1216</b>: 2730<br /><br />Bolognesi ML, Rosini M, Andrisano V, Bartolini M, Minarini A, Tumiatti V, Melchiorre C (2009) <br />MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond<br /><i>Curr Pharm Des</i> <b>15</b>: 601<br /><br />Bolognesi ML, Bartolini M, Rosini M, Andrisano V, Melchiorre C (2009) <br />Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>19</b>: 4312<br /><br />Bolognesi ML, Cavalli A, Bergamini C, Fato R, Lenaz G, Rosini M, Bartolini M, Andrisano V, Melchiorre C (2009) <br />Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks<br /><i>Journal of Medicinal Chemistry</i> <b>52</b>: 7883<br /><br />Camps P, Formosa X, Galdeano C, Munoz-Torrero D, Ramirez L, Gomez E, Isambert N, Lavilla R, Badia A, Clos MV, Bartolini M, Mancini F, Andrisano V, Arce MP, Rodriguez-Franco MI, Huertas O, Dafni T, Luque FJ (2009) <br />Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds<br /><i>Journal of Medicinal Chemistry</i> <b>52</b>: 5365<br /><br />Rizzo S, Cavalli A, Ceccarini L, Bartolini M, Belluti F, Bisi A, Andrisano V, Recanatini M, Rampa A (2009) <br />Structure-activity relationships and binding mode in the human acetylcholinesterase active site of pseudo-irreversible inhibitors related to xanthostigmine<br /><i>ChemMedChem</i> <b>4</b>: 670<br /><br />Camps P, Formosa X, Galdeano C, Gomez T, Munoz-Torrero D, Scarpellini M, Viayna E, Badia A, Clos MV, Camins A, Pallas M, Bartolini M, Mancini F, Andrisano V, Estelrich J, Lizondo M, Bidon-Chanal A, Luque FJ (2008) <br />Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation<br /><i>Journal of Medicinal Chemistry</i> <b>51</b>: 3588<br /><br />Petraglio G, Bartolini M, Branduardi D, Andrisano V, Recanatini M, Gervasio FL, Cavalli A, Parrinello M (2008) <br />The role of Li+, Na+, and K+ in the ligand binding inside the human acetylcholinesterase gorge<br /><i>Proteins</i> <b>70</b>: 779<br /><br />Piazzi L, Cavalli A, Colizzi F, Belluti F, Bartolini M, Mancini F, Recanatini M, Andrisano V, Rampa A (2008) <br />Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>18</b>: 423<br /><br />Rizzo S, Riviere C, Piazzi L, Bisi A, Gobbi S, Bartolini M, Andrisano V, Morroni F, Tarozzi A, Monti JP, Rampa A (2008) <br />Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity<br /><i>Journal of Medicinal Chemistry</i> <b>51</b>: 2883<br /><br />Rosini M, Simoni E, Bartolini M, Cavalli A, Ceccarini L, Pascu N, McClymont DW, Tarozzi A, Bolognesi ML, Minarini A, Tumiatti V, Andrisano V, Mellor IR, Melchiorre C (2008) <br />Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush<br /><i>Journal of Medicinal Chemistry</i> <b>51</b>: 4381<br /><br />Tumiatti V, Milelli A, Minarini A, Rosini M, Bolognesi ML, Micco M, Andrisano V, Bartolini M, Mancini F, Recanatini M, Cavalli A, Melchiorre C (2008) <br />Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer<br /><i>Journal of Medicinal Chemistry</i> <b>51</b>: 7308<br /><br />Bartolini M, Cavrini V, Andrisano V (2007) <br />Characterization of reversible and pseudo-irreversible acetylcholinesterase inhibitors by means of an immobilized enzyme reactor<br /><i>Journal of Chromatography A</i> <b>1144</b>: 102<br /><br />Bolognesi ML, Cavalli A, Valgimigli L, Bartolini M, Rosini M, Andrisano V, Recanatini M, Melchiorre C (2007) <br />Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease<br /><i>Journal of Medicinal Chemistry</i> <b>50</b>: 6446<br /><br />Mancini F, Naldi M, Cavrini V, Andrisano V (2007) <br />Multiwell fluorometric and colorimetric microassays for the evaluation of beta-secretase (BACE-1) inhibitors<br /><i>Anal Bioanal Chem</i> <b>388</b>: 1175<br /><br />Piazzi L, Belluti F, Bisi A, Gobbi S, Rizzo S, Bartolini M, Andrisano V, Recanatini M, Rampa A (2007) <br />Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones<br /><i>Bioorganic & Medicinal Chemistry</i> <b>15</b>: 575<br /><br />Piazzi L, Cavalli A, Belluti F, Bisi A, Gobbi S, Rizzo S, Bartolini M, Andrisano V, Recanatini M, Rampa A (2007) <br />Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives<br /><i>Journal of Medicinal Chemistry</i> <b>50</b>: 4250<br /><br />Bartolini M, Cavrini V, Andrisano V (2005) <br />Batchwise covalent immobilization of human acetylcholinesterase: Kinetic and inhibition spectrophotometric studies<br /><i>Analytical Biochemistry</i> <b>342</b>: 163<br /><br />Bartolini M, Cavrini V, Andrisano V (2005) <br />Choosing the right chromatographic support in making a new acetylcholinesterase-micro-immobilised enzyme reactor for drug discovery<br /><i>Journal of Chromatography A</i> <b>1065</b>: 135<br /><br />Belluti F, Rampa A, Piazzi L, Bisi A, Gobbi S, Bartolini M, Andrisano V, Cavalli A, Recanatini M, Valenti P (2005) <br />Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 4444<br /><br />Bolognesi ML, Andrisano V, Bartolini M, Banzi R, Melchiorre C (2005) <br />Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 24<br /><br />Bolognesi ML, Andrisano V, Bartolini M, Cavalli A, Minarini A, Recanatini M, Rosini M, Tumiatti V, Melchiorre C (2005) <br />Heterocyclic inhibitors of AChE acylation and peripheral sites<br /><i>Farmaco</i> <b>60</b>: 465<br /><br />Munoz-Ruiz P, Rubio L, Garcia-Palomero E, Dorronsoro I, del Monte-Millan M, Valenzuela R, Usan P, de Austria C, Bartolini M, Andrisano V, Bidon-Chanal A, Orozco M, Luque FJ, Medina M, Martinez A (2005) <br />Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 7223<br /><br />Rosini M, Andrisano V, Bartolini M, Bolognesi ML, Hrelia P, Minarini A, Tarozzi A, Melchiorre C (2005) <br />Rational approach to discover multipotent anti-Alzheimer drugs<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 360<br /><br />Bartolini M, Cavrini V, Andrisano V (2004) <br />Monolithic micro-immobilized-enzyme reactor with human recombinant acetylcholinesterase for on-line inhibition studies<br /><i>Journal of Chromatography A</i> <b>1031</b>: 27<br /><br />Bolognesi ML, Bartolini M, Cavalli A, Andrisano V, Rosini M, Minarini A, Melchiorre C (2004) <br />Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues<br /><i>Journal of Medicinal Chemistry</i> <b>47</b>: 5945<br /><br />Tumiatti V, Andrisano V, Banzi R, Bartolini M, Minarini A, Rosini M, Melchiorre C (2004) <br />Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties<br /><i>Journal of Medicinal Chemistry</i> <b>47</b>: 6490<br /><br />Bartolini M, Bertucci C, Cavrini V, Andrisano V (2003) <br />beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies<br /><i>Biochemical Pharmacology</i> <b>65</b>: 407<br /><br />Gotti R, Bertucci C, Andrisano V, Pomponio R, Cavrini V (2003) <br />Study of donepezil binding to serum albumin by capillary electrophoresis and circular dichroism<br /><i>Anal Bioanal Chem</i> <b>377</b>: 875<br /><br />Piazzi L, Rampa A, Bisi A, Gobbi S, Belluti F, Cavalli A, Bartolini M, Andrisano V, Valenti P, Recanatini M (2003) <br />3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy<br /><i>Journal of Medicinal Chemistry</i> <b>46</b>: 2279<br /><br />Tumiatti V, Rosini M, Bartolini M, Cavalli A, Marucci G, Andrisano V, Angeli P, Banzi R, Minarini A, Recanatini M, Melchiorre C (2003) <br />Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine<br /><i>Journal of Medicinal Chemistry</i> <b>46</b>: 954<br /><br />Bartolini M, Bertucci C, Gotti R, Tumiatti V, Cavalli A, Recanatini M, Andrisano V (2002) <br />Determination of the dissociation constants (pKa) of basic acetylcholinesterase inhibitors by reversed-phase liquid chromatography<br /><i>Journal of Chromatography A</i> <b>958</b>: 59<br /><br />Andrisano V, Bartolini M, Gotti R, Cavrini V, Felix G (2001) <br />Determination of inhibitors' potency (IC50) by a direct high-performance liquid chromatographic method on an immobilised acetylcholinesterase column<br /><i>Journal of Chromatography B Biomed Sci Appl</i> <b>753</b>: 375<br /><br />Bolognesi ML, Andrisano V, Bartolini M, Minarini A, Rosini M, Tumiatti V, Melchiorre C (2001) <br />Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors<br /><i>Journal of Medicinal Chemistry</i> <b>44</b>: 105<br /><br />Rampa A, Piazzi L, Belluti F, Gobbi S, Bisi A, Bartolini M, Andrisano V, Cavrini V, Cavalli A, Recanatini M, Valenti P (2001) <br />Acetylcholinesterase Inhibitors: SAR and Kinetic Studies on omega-[N-Methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl Derivatives<br /><i>Journal of Medicinal Chemistry</i> <b>44</b>: 3810<br /><br />Rampa A, Bisi A, Belluti F, Gobbi S, Valenti P, Andrisano V, Cavrini V, Cavalli A, Recanatini M (2000) <br />Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives<br /><i>Bioorganic & Medicinal Chemistry</i> <b>8</b>: 497<br /><br />Recanatini M, Cavalli A, Belluti F, Piazzi L, Rampa A, Bisi A, Gobbi S, Valenti P, Andrisano V, Bartolini M, Cavrini V (2000) <br />SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues<br /><i>Journal of Medicinal Chemistry</i> <b>43</b>: 2007<br /><br />Tumiatti V, Angeli P, Andrisano V, Bolognesi ML, Cavalli A, Marucci G, Minarini A, Recanatini M, Rosini M, Melchiorre C (2000) <br />[4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]-trimethylammonium (McN-A-343)-related compounds. Effect of the butynyl chain inclusion into an aromatic unit on the potency for muscarinic receptors<br /><i>Bioorganic & Medicinal Chemistry</i> <b>8</b>: 681<br /><br />Melchiorre C, Andrisano V, Bolognesi ML, Budriesi R, Cavalli A, Cavrini V, Rosini M, Tumiatti V, Recanatini M (1998) <br />Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone for Potential Use against Alzheimer's Disease<br /><i>Journal of Medicinal Chemistry</i> <b>41</b>: 4186<br /><br />Rampa A, Bisi A, Valenti P, Recanatini M, Cavalli A, Andrisano V, Cavrini V, Fin L, Buriani A, Giusti P (1998) <br />Acetylcholinesterase Inhibitors: Synthesis and Structure-Activity Relationships of omega-[N-Methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkoxyheteroaryl Derivatives<br /><i>Journal of Medicinal Chemistry</i> <b>41</b>: 3976<br /><br />