Takada-Takatori Y, Nakagawa S, Kimata R, Nao Y, Mizukawa Y, Urushidani T, Izumi Y, Akaike A, Tsuchida K, Kume T (2019)
Donepezil modulates amyloid precursor protein endocytosis and reduction by up-regulation of SNX33 expression in primary cortical neurons
Sci Rep 9: 11922

Makitani K, Nakagawa S, Izumi Y, Akaike A, Kume T (2017)
Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes
J Pharmacol Sci 134: 37

Akaike A, Takada-Takatori Y, Kume T, Izumi Y (2010)
Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection
Journal of Molecular Neuroscience 40: 211

Shen H, Kihara T, Hongo H, Wu X, Kem WR, Shimohama S, Akaike A, Niidome T, Sugimoto H (2010)
Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors
British Journal of Pharmacology 161: 127

Takada-Takatori Y, Kume T, Izumi Y, Niidome T, Fujii T, Sugimoto H, Akaike A (2010)
Mechanisms of chronic nicotine treatment-induced enhancement of the sensitivity of cortical neurons to the neuroprotective effect of donepezil in cortical neurons
J Pharmacol Sci 112: 265

Takahashi J, Hijikuro I, Kihara T, Murugesh MG, Fuse S, Kunimoto R, Tsumura Y, Akaike A, Niidome T, Okuno Y, Takahashi T, Sugimoto H (2010)
Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry Lett 20: 1718

Takahashi J, Hijikuro I, Kihara T, Murugesh MG, Fuse S, Tsumura Y, Akaike A, Niidome T, Takahashi T, Sugimoto H (2010)
Design, synthesis and evaluation of carbamate-modified (-)-N(1)-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry Lett 20: 1721

Ohnishi M, Katsuki H, Takagi M, Kume T, Akaike A (2009)
Long-term treatment with nicotine suppresses neurotoxicity of, and microglial activation by, thrombin in cortico-striatal slice cultures
European Journal of Pharmacology 602: 288

Takada-Takatori Y, Kume T, Izumi Y, Ohgi Y, Niidome T, Fujii T, Sugimoto H, Akaike A (2009)
Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation
Biol Pharm Bull 32: 318

Takeuchi H, Yanagida T, Inden M, Takata K, Kitamura Y, Yamakawa K, Sawada H, Izumi Y, Yamamoto N, Kihara T, Uemura K, Inoue H, Taniguchi T, Akaike A, Takahashi R, Shimohama S (2009)
Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models
Journal of Neuroscience Research 87: 576

Akasofu S, Sawada K, Kosasa T, Hihara H, Ogura H, Akaike A (2008)
Donepezil attenuates excitotoxic damage induced by membrane depolarization of cortical neurons exposed to veratridine
European Journal of Pharmacology 588: 189

Goto Y, Niidome T, Hongo H, Akaike A, Kihara T, Sugimoto H (2008)
Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's disease
European Journal of Pharmacology 583: 84

Takada-Takatori Y, Kume T, Ohgi Y, Fujii T, Niidome T, Sugimoto H, Akaike A (2008)
Mechanisms of alpha7-nicotinic receptor up-regulation and sensitization to donepezil induced by chronic donepezil treatment
European Journal of Pharmacology 590: 150

Takada-Takatori Y, Kume T, Ohgi Y, Izumi Y, Niidome T, Fujii T, Sugimoto H, Akaike A (2008)
Mechanism of neuroprotection by donepezil pretreatment in rat cortical neurons chronically treated with donepezil
Journal of Neuroscience Research 86: 3575

Oda T, Kume T, Katsuki H, Niidome T, Sugimoto H, Akaike A (2007)
Donepezil potentiates nerve growth factor-induced neurite outgrowth in PC12 cells
J Pharmacol Sci 104: 349

Akaike A (2006)
Preclinical evidence of neuroprotection by cholinesterase inhibitors
Alzheimer Disease & Associated Disorders 20: S8

Takada-Takatori Y, Kume T, Sugimoto M, Katsuki H, Niidome T, Sugimoto H, Fujii T, Okabe S, Akaike A (2006)
Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity
European Journal of Pharmacology 549: 19

Takada-Takatori Y, Kume T, Sugimoto M, Katsuki H, Sugimoto H, Akaike A (2006)
Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade
Neuropharmacology 51: 474

Katsuki H, Shinohara A, Fujimoto S, Kume T, Akaike A (2005)
Tetraethylammonium exacerbates ischemic neuronal injury in rat cerebrocortical slice cultures
European Journal of Pharmacology 508: 85

Kume T, Sugimoto M, Takada Y, Yamaguchi T, Yonezawa A, Katsuki H, Sugimoto H, Akaike A (2005)
Up-regulation of nicotinic acetylcholine receptors by central-type acetylcholinesterase inhibitors in rat cortical neurons
European Journal of Pharmacology 527: 77

Nakamizo T, Kawamata J, Yamashita H, Kanki R, Kihara T, Sawada H, Akaike A, Shimohama S (2005)
Stimulation of nicotinic acetylcholine receptors protects motor neurons
Biochemical & Biophysical Research Communications 330: 1285

Takada Y, Yonezawa A, Kume T, Katsuki H, Kaneko S, Sugimoto H, Akaike A (2003)
Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons
Journal of Pharmacology & Experimental Therapeutics 306: 772

Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A (2001)
alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity
Journal of Biological Chemistry 276: 13541

Kihara T, Shimohama S, Urushitani M, Sawada H, Kimura J, Kume T, Maeda T, Akaike A (1998)
Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity
Brain Research 792: 331

Kaneko S, Maeda T, Kume T, Kochiyama H, Akaike A, Shimohama S, Kimura J (1997)
Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via alpha7-neuronal receptors and neuronal CNS receptors
Brain Research 765: 135

Kihara T, Shimohama S, Sawada H, Kimura J, Kume T, Kochiyama H, Maeda T, Akaike A (1997)
Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity
Annals of Neurology 42: 159

Albuquerque EX, Allen CN, Aracava Y, Akaike A, Shaw KP, Rickett DL (1986)
Activation and Inhibition of the Nicotinic Receptor: Actions of Physostigmine, Pyridostigmine and Meproadifen
Advances in Behavioral Biology 30: 677

Shaw KP, Aracava Y, Akaike A, Daly JW, Rickett DL, Albuquerque EX (1985)
The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex
Molecular Pharmacology 28: 527

Akaike A, Ikeda SR, Brookes N, Pascuzzo GJ, Rickett DL, Albuquerque EX (1984)
The nature of the interactions of pyridostigmine with the nicotinic acetylcholine receptor-ionic channel complex. II. Patch clamp studies
Molecular Pharmacology 25: 102

Albuquerque EX, Akaike A, Shaw KP, Rickett DL (1984)
The interaction of anticholinesterase agents with the acetylcholine receptor-ionic channel complex
Fundamental & Applied Toxicology 4: S27

Allen CN, Akaike A, Albuquerque EX (1984)
The frog interosseal muscle fiber as a new model for patch clamp studies of chemosensitive- and voltage-sensitive ion channels: actions of acetylcholine and batrachotoxin
Journal de Physiologie (Paris) 79: 338

Pascuzzo GJ, Akaike A, Maleque MA, Shaw KP, Aronstam RS, Rickett DL, Albuquerque EX (1984)
The nature of the interactions of pyridostigmine with the nicotinic acetylcholine receptor-ionic channel complex. I. Agonist, desensitizing, and binding properties
Molecular Pharmacology 25: 92