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Paper(s) concerning Lalistat-alkyne-probe

1 reference(s) found.
Listing paper details in reverse chronological order.
We are grateful to Keith Bradnam for improvment of this script

Title: Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases
Davda D, Martin BR
Ref: Medchemcomm, 7:1797, 2016 : PubMed
Abstract


ESTHER: Lehmann_2016_Medchemcomm_7_1797
PubMedSearch: Lehmann 2016 Medchemcomm 7 1797
Gene_locus related to this paper: myctu-Rv3084
Inhibitor(s) related to this paper: Lalistat-alkyne-probe, Lalistat-1, Lalistat-2

Abstract

Lalistat inhibits growth of Mycobacterium tuberculosis in bacterial culture as well as in infected macrophages. Target identification by quantitative proteomics revealed a cluster of 20 hydrolytic proteins including members of the lipase family. Lipases are essential for M. tuberculosis fatty acid production and energy storage thus representing promising antibiotic targets.