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Paper(s) concerning LIR

1 reference(s) found.
Listing paper details in reverse chronological order.
We are grateful to Keith Bradnam for improvment of this script

Title: Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors
Kurukulasuriya R, Rohde JJ, Szczepankiewicz BG, Basha F, Lai C, Jae HS, Winn M, Stewart KD, Longenecker KL and von Geldern TW <3 more author(s)> Kurukulasuriya R, Rohde JJ, Szczepankiewicz BG, Basha F, Lai C, Jae HS, Winn M, Stewart KD, Longenecker KL, Lubben TW, Ballaron SJ, Sham HL, von Geldern TW (- 3)
Ref: Bioorganic & Medicinal Chemistry Lett, 16:6226, 2006 : PubMed
Abstract


ESTHER: Kurukulasuriya_2006_Bioorg.Med.Chem.Lett_16_6226
PubMedSearch: Kurukulasuriya 2006 Bioorg.Med.Chem.Lett 16 6226
PubMedID: 17010607
Gene_locus related to this paper: ratno-dpp4
Inhibitor(s) related to this paper: LIR

Abstract

A series of xanthine mimetics containing 5,5 and 5,6 heterocycle fused imidazoles were synthesized as dipeptidyl peptidase IV inhibitors. Compound 7 is potent (h-DPPIV K(i)=2nM) and exhibits excellent selectivity and no species specificity against rat and human enzymes. The X-ray structure confirms that the binding mode of 7 to rat DPPIV is similar to the parent xanthines.