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| Title : Inhibition of Butyrylcholinesterase with Fluorobenzylcymserine, An Experimental Alzheimer's Drug Candidate: Validation of Enzoinformatics Results by Classical and Innovative Enzyme Kinetic Analyses - Kamal_2017_CNS.Neurol.Disord.Drug.Targets_16_820 |
| Author(s) : Kamal MA , Shakil S , Nawaz MS , Yu QS , Tweedie D , Tan Y , Qu X , Greig NH |
| Ref : CNS Neurol Disord Drug Targets , 16 :820 , 2017 |
| Abstract : Kamal_2017_CNS.Neurol.Disord.Drug.Targets_16_820 |
| ESTHER : Kamal_2017_CNS.Neurol.Disord.Drug.Targets_16_820 |
| PubMedSearch : Kamal_2017_CNS.Neurol.Disord.Drug.Targets_16_820 |
| PubMedID: 28176640 |
| Title : Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms - Tweedie_2016_PLoS.One_11_e0156493 |
| Author(s) : Tweedie D , Fukui K , Li Y , Yu QS , Barak S , Tamargo IA , Rubovitch V , Holloway HW , Lehrmann E , Wood WH, 3rd , Zhang Y , Becker KG , Perez E , Van Praag H , Luo Y , Hoffer BJ , Becker RE , Pick CG , Greig NH |
| Ref : PLoS ONE , 11 :e0156493 , 2016 |
| Abstract : Tweedie_2016_PLoS.One_11_e0156493 |
| ESTHER : Tweedie_2016_PLoS.One_11_e0156493 |
| PubMedSearch : Tweedie_2016_PLoS.One_11_e0156493 |
| PubMedID: 27254111 |
| Title : (-)-phenserine attenuates soman-induced neuropathology - Chen_2014_PLoS.One_9_e99818 |
| Author(s) : Chen J , Pan H , Chen C , Wu W , Iskandar K , He J , Piermartiri T , Jacobowitz DM , Yu QS , McDonough JH , Greig NH , Marini AM |
| Ref : PLoS ONE , 9 :e99818 , 2014 |
| Abstract : Chen_2014_PLoS.One_9_e99818 |
| ESTHER : Chen_2014_PLoS.One_9_e99818 |
| PubMedSearch : Chen_2014_PLoS.One_9_e99818 |
| PubMedID: 24955574 |
| Title : Selective Acetyl- and Butyrylcholinesterase Inhibitors Reduce Amyloid-beta Ex Vivo Activation of Peripheral Chemo-cytokines From Alzheimer's Disease Subjects: Exploring the Cholinergic Anti-inflammatory Pathway - Reale_2014_Curr.Alzheimer.Res_11_608 |
| Author(s) : Reale M , Di Nicola M , Velluto L , D'Angelo C , Costantini E , Lahiri DK , Kamal MA , Yu QS , Greig NH |
| Ref : Curr Alzheimer Res , 11 :608 , 2014 |
| Abstract : Reale_2014_Curr.Alzheimer.Res_11_608 |
| ESTHER : Reale_2014_Curr.Alzheimer.Res_11_608 |
| PubMedSearch : Reale_2014_Curr.Alzheimer.Res_11_608 |
| PubMedID: 24359497 |
| Title : Synthesis of the Alzheimer Drug Posiphen into its Primary Metabolic Products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their Inhibition of Amyloid Precursor Protein, alpha -Synuclein Synthesis, Interleukin-1beta Release, and Cholinergic Action - Yu_2013_Antiinflamm.Antiallergy.Agents.Med.Chem_12_117 |
| Author(s) : Yu QS , Reale M , Kamal MA , Holloway HW , Luo W , Sambamurti K , Ray B , Lahiri DK , Rogers JT , Greig NH |
| Ref : Antiinflamm Antiallergy Agents Med Chem , 12 :117 , 2013 |
| Abstract : Yu_2013_Antiinflamm.Antiallergy.Agents.Med.Chem_12_117 |
| ESTHER : Yu_2013_Antiinflamm.Antiallergy.Agents.Med.Chem_12_117 |
| PubMedSearch : Yu_2013_Antiinflamm.Antiallergy.Agents.Med.Chem_12_117 |
| PubMedID: 23360256 |
| Title : Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group - Bartolucci_2012_Biochem.J_444_269 |
| Author(s) : Bartolucci C , Stojan J , Yu QS , Greig NH , Lamba D |
| Ref : Biochemical Journal , 444 :269 , 2012 |
| Abstract : Bartolucci_2012_Biochem.J_444_269 |
| ESTHER : Bartolucci_2012_Biochem.J_444_269 |
| PubMedSearch : Bartolucci_2012_Biochem.J_444_269 |
| PubMedID: 22390827 |
| Gene_locus related to this paper: torma-ACHE |
| Title : Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-beta peptide in mice - Furukawa-Hibi_2011_Behav.Brain.Res_225_222 |
| Author(s) : Furukawa-Hibi Y , Alkam T , Nitta A , Matsuyama A , Mizoguchi H , Suzuki K , Moussaoui S , Yu QS , Greig NH , Nagai T , Yamada K |
| Ref : Behavioural Brain Research , 225 :222 , 2011 |
| Abstract : Furukawa-Hibi_2011_Behav.Brain.Res_225_222 |
| ESTHER : Furukawa-Hibi_2011_Behav.Brain.Res_225_222 |
| PubMedSearch : Furukawa-Hibi_2011_Behav.Brain.Res_225_222 |
| PubMedID: 21820013 |
| Title : Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine - Yu_2010_Bioorg.Med.Chem_18_4687 |
| Author(s) : Yu QS , Holloway HW , Luo W , Lahiri DK , Brossi A , Greig NH |
| Ref : Bioorganic & Medicinal Chemistry , 18 :4687 , 2010 |
| Abstract : Yu_2010_Bioorg.Med.Chem_18_4687 |
| ESTHER : Yu_2010_Bioorg.Med.Chem_18_4687 |
| PubMedSearch : Yu_2010_Bioorg.Med.Chem_18_4687 |
| PubMedID: 20627738 |
| Title : Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions - Barak_2009_Biochem.J_417_213 |
| Author(s) : Barak D , Ordentlich A , Stein D , Yu QS , Greig NH , Shafferman A |
| Ref : Biochemical Journal , 417 :213 , 2009 |
| Abstract : Barak_2009_Biochem.J_417_213 |
| ESTHER : Barak_2009_Biochem.J_417_213 |
| PubMedSearch : Barak_2009_Biochem.J_417_213 |
| PubMedID: 18729824 |
| Title : Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices - Wang_2009_Neurobiol.Aging_30_1061 |
| Author(s) : Wang Y , Greig NH , Yu QS , Mattson MP |
| Ref : Neurobiology of Aging , 30 :1061 , 2009 |
| Abstract : Wang_2009_Neurobiol.Aging_30_1061 |
| ESTHER : Wang_2009_Neurobiol.Aging_30_1061 |
| PubMedSearch : Wang_2009_Neurobiol.Aging_30_1061 |
| PubMedID: 18068871 |
| Title : Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease - Bartolini_2009_J.Chromatogr.A_1216_2730 |
| Author(s) : Bartolini M , Greig NH , Yu QS , Andrisano V |
| Ref : Journal of Chromatography A , 1216 :2730 , 2009 |
| Abstract : Bartolini_2009_J.Chromatogr.A_1216_2730 |
| ESTHER : Bartolini_2009_J.Chromatogr.A_1216_2730 |
| PubMedSearch : Bartolini_2009_J.Chromatogr.A_1216_2730 |
| PubMedID: 18950780 |
| Title : Tetrahydrofurobenzofuran cymserine, a potent butyrylcholinesterase inhibitor and experimental Alzheimer drug candidate, enzyme kinetic analysis - Kamal_2008_J.Neural.Transm.(Vienna)_115_889 |
| Author(s) : Kamal MA , Qu X , Yu QS , Tweedie D , Holloway HW , Li Y , Tan Y , Greig NH |
| Ref : J Neural Transm (Vienna) , 115 :889 , 2008 |
| Abstract : Kamal_2008_J.Neural.Transm.(Vienna)_115_889 |
| ESTHER : Kamal_2008_J.Neural.Transm.(Vienna)_115_889 |
| PubMedSearch : Kamal_2008_J.Neural.Transm.(Vienna)_115_889 |
| PubMedID: 18235987 |
| Title : Preclinical investigation of the topical administration of phenserine: transdermal flux, cholinesterase inhibition, and cognitive efficacy - Utsuki_2007_J.Pharmacol.Exp.Ther_321_353 |
| Author(s) : Utsuki T , Uchimura N , Irikura M , Moriuchi H , Holloway HW , Yu QS , Spangler EL , Mamczarz J , Ingram DK , Irie T , Greig NH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 321 :353 , 2007 |
| Abstract : Utsuki_2007_J.Pharmacol.Exp.Ther_321_353 |
| ESTHER : Utsuki_2007_J.Pharmacol.Exp.Ther_321_353 |
| PubMedSearch : Utsuki_2007_J.Pharmacol.Exp.Ther_321_353 |
| PubMedID: 17255466 |
| Title : The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice - Lahiri_2007_J.Pharmacol.Exp.Ther_320_386 |
| Author(s) : Lahiri DK , Chen D , Maloney B , Holloway HW , Yu QS , Utsuki T , Giordano T , Sambamurti K , Greig NH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 320 :386 , 2007 |
| Abstract : Lahiri_2007_J.Pharmacol.Exp.Ther_320_386 |
| ESTHER : Lahiri_2007_J.Pharmacol.Exp.Ther_320_386 |
| PubMedSearch : Lahiri_2007_J.Pharmacol.Exp.Ther_320_386 |
| PubMedID: 17003227 |
| Title : Kinetic analysis of the inhibition of human butyrylcholinesterase with cymserine - Kamal_2006_Biochim.Biophys.Acta_1760_200 |
| Author(s) : Kamal MA , Al-Jafari AA , Yu QS , Greig NH |
| Ref : Biochimica & Biophysica Acta , 1760 :200 , 2006 |
| Abstract : Kamal_2006_Biochim.Biophys.Acta_1760_200 |
| ESTHER : Kamal_2006_Biochim.Biophys.Acta_1760_200 |
| PubMedSearch : Kamal_2006_Biochim.Biophys.Acta_1760_200 |
| PubMedID: 16309845 |
| Title : Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic, bisnorcymserine - Kamal_2006_J.Alzheimers.Dis_10_43 |
| Author(s) : Kamal MA , Klein P , Yu QS , Tweedie D , Li Y , Holloway HW , Greig NH |
| Ref : J Alzheimers Dis , 10 :43 , 2006 |
| Abstract : Kamal_2006_J.Alzheimers.Dis_10_43 |
| ESTHER : Kamal_2006_J.Alzheimers.Dis_10_43 |
| PubMedSearch : Kamal_2006_J.Alzheimers.Dis_10_43 |
| PubMedID: 16988481 |
| Title : Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide - Utsuki_2006_J.Pharmacol.Exp.Ther_318_855 |
| Author(s) : Utsuki T , Yu QS , Davidson D , Chen D , Holloway HW , Brossi A , Sambamurti K , Lahiri DK , Greig NH , Giordano T |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 318 :855 , 2006 |
| Abstract : Utsuki_2006_J.Pharmacol.Exp.Ther_318_855 |
| ESTHER : Utsuki_2006_J.Pharmacol.Exp.Ther_318_855 |
| PubMedSearch : Utsuki_2006_J.Pharmacol.Exp.Ther_318_855 |
| PubMedID: 16690718 |
| Title : Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine - Luo_2006_J.Med.Chem_49_2174 |
| Author(s) : Luo W , Yu QS , Kulkarni SS , Parrish DA , Holloway HW , Tweedie D , Shafferman A , Lahiri DK , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 49 :2174 , 2006 |
| Abstract : Luo_2006_J.Med.Chem_49_2174 |
| ESTHER : Luo_2006_J.Med.Chem_49_2174 |
| PubMedSearch : Luo_2006_J.Med.Chem_49_2174 |
| PubMedID: 16570913 |
| Title : Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent - Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| Author(s) : Greig NH , Utsuki T , Ingram DK , Wang Y , Pepeu G , Scali C , Yu QS , Mamczarz J , Holloway HW , Giordano T , Chen D , Furukawa K , Sambamurti K , Brossi A , Lahiri DK |
| Ref : Proc Natl Acad Sci U S A , 102 :17213 , 2005 |
| Abstract : Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| ESTHER : Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| PubMedSearch : Greig_2005_Proc.Natl.Acad.Sci.U.S.A_102_17213 |
| PubMedID: 16275899 |
| Title : Syntheses of tetrahydrofurobenzofurans and dihydromethanobenzodioxepines from 5-hydroxy-3-methyl-3H-benzofuran-2-one. Rearrangement and ring expansion under reductive conditions on treatment with hydrides - Luo_2005_J.Org.Chem_70_6171 |
| Author(s) : Luo W , Yu QS , Holloway HW , Parrish D , Greig NH , Brossi A |
| Ref : J Org Chem , 70 :6171 , 2005 |
| Abstract : Luo_2005_J.Org.Chem_70_6171 |
| ESTHER : Luo_2005_J.Org.Chem_70_6171 |
| PubMedSearch : Luo_2005_J.Org.Chem_70_6171 |
| PubMedID: 16050674 |
| Title : Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine - Luo_2005_J.Med.Chem_48_986 |
| Author(s) : Luo W , Yu QS , Zhan M , Parrish D , Deschamps JR , Kulkarni SS , Holloway HW , Alley GM , Lahiri DK , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 48 :986 , 2005 |
| Abstract : Luo_2005_J.Med.Chem_48_986 |
| ESTHER : Luo_2005_J.Med.Chem_48_986 |
| PubMedSearch : Luo_2005_J.Med.Chem_48_986 |
| PubMedID: 15715468 |
| Title : In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger - Cerasoli_2005_Chem.Biol.Interact_157-158_363 |
| Author(s) : Cerasoli DM , Griffiths EM , Doctor BP , Saxena A , Fedorko JM , Greig NH , Yu QS , Huang Y , Wilgus H , Karatzas CN , Koplovitz I , Lenz DE |
| Ref : Chemico-Biological Interactions , 157-158 :363 , 2005 |
| Abstract : Cerasoli_2005_Chem.Biol.Interact_157-158_363 |
| ESTHER : Cerasoli_2005_Chem.Biol.Interact_157-158_363 |
| PubMedSearch : Cerasoli_2005_Chem.Biol.Interact_157-158_363 |
| PubMedID: 16429486 |
| Title : An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease - Greig_2005_Curr.Alzheimer.Res_2_281 |
| Author(s) : Greig NH , Sambamurti K , Yu QS , Brossi A , Bruinsma GB , Lahiri DK |
| Ref : Curr Alzheimer Res , 2 :281 , 2005 |
| Abstract : Greig_2005_Curr.Alzheimer.Res_2_281 |
| ESTHER : Greig_2005_Curr.Alzheimer.Res_2_281 |
| PubMedSearch : Greig_2005_Curr.Alzheimer.Res_2_281 |
| PubMedID: 15974893 |
| Title : The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats - Janas_2005_Life.Sci_76_1073 |
| Author(s) : Janas AM , Cunningham SC , Duffy KB , Devan BD , Greig NH , Holloway HW , Yu QS , Markowska AL , Ingram DK , Spangler EL |
| Ref : Life Sciences , 76 :1073 , 2005 |
| Abstract : Janas_2005_Life.Sci_76_1073 |
| ESTHER : Janas_2005_Life.Sci_76_1073 |
| PubMedSearch : Janas_2005_Life.Sci_76_1073 |
| PubMedID: 15620572 |
| Title : Poster (43) BChE inhibition as a treatment strategy for alzheimer's disease. - |
| Author(s) : Greig NH , Ingram DK , Yu QS , Holloway HW , Utsuki T , Brossi A , Sambamurti K , Lahiri DK |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :343 , 2004 |
| PubMedID: |
| Title : Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines - Yu_2002_J.Med.Chem_45_3684 |
| Author(s) : Yu QS , Zhu X , Holloway HW , Whittaker NF , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 45 :3684 , 2002 |
| Abstract : Yu_2002_J.Med.Chem_45_3684 |
| ESTHER : Yu_2002_J.Med.Chem_45_3684 |
| PubMedSearch : Yu_2002_J.Med.Chem_45_3684 |
| PubMedID: 12166941 |
| Title : Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development - Shaw_2001_Proc.Natl.Acad.Sci.U.S.A_98_7605 |
| Author(s) : Shaw KT , Utsuki T , Rogers J , Yu QS , Sambamurti K , Brossi A , Ge YW , Lahiri DK , Greig NH |
| Ref : Proc Natl Acad Sci U S A , 98 :7605 , 2001 |
| Abstract : Shaw_2001_Proc.Natl.Acad.Sci.U.S.A_98_7605 |
| ESTHER : Shaw_2001_Proc.Natl.Acad.Sci.U.S.A_98_7605 |
| PubMedSearch : Shaw_2001_Proc.Natl.Acad.Sci.U.S.A_98_7605 |
| PubMedID: 11404470 |
| Title : Butyrylcholinesterase accelerates cocaine metabolism: in vitro and in vivo effects in nonhuman primates and humans - Carmona_2000_Drug.Metab.Dispos_28_367 |
| Author(s) : Carmona GN , Jufer RA , Goldberg SR , Gorelick DA , Greig NH , Yu QS , Cone EJ , Schindler CW |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 28 :367 , 2000 |
| Abstract : Carmona_2000_Drug.Metab.Dispos_28_367 |
| ESTHER : Carmona_2000_Drug.Metab.Dispos_28_367 |
| PubMedSearch : Carmona_2000_Drug.Metab.Dispos_28_367 |
| PubMedID: 10681384 |
| Title : The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics - Greig_2000_Acta.Neurol.Scand.Suppl_176_74 |
| Author(s) : Greig NH , De Micheli E , Holloway HW , Yu QS , Utsuki T , Perry TA , Brossi A , Ingram DK , Deutsch J , Lahiri DK , Soncrant TT |
| Ref : Acta Neurologica Scandinavica Supplementum , 176 :74 , 2000 |
| Abstract : Greig_2000_Acta.Neurol.Scand.Suppl_176_74 |
| ESTHER : Greig_2000_Acta.Neurol.Scand.Suppl_176_74 |
| PubMedSearch : Greig_2000_Acta.Neurol.Scand.Suppl_176_74 |
| PubMedID: 11261809 |
| Title : Attenuation of cocaine-induced locomotor activity by butyrylcholinesterase - Carmona_1998_Exp.Clin.Psychopharmacol_6_274 |
| Author(s) : Carmona GN , Schindler CW , Shoaib M , Jufer R , Cone EJ , Goldberg SR , Greig NH , Yu QS , Gorelick DA |
| Ref : Experimental & Clinical Psychopharmacology , 6 :274 , 1998 |
| Abstract : Carmona_1998_Exp.Clin.Psychopharmacol_6_274 |
| ESTHER : Carmona_1998_Exp.Clin.Psychopharmacol_6_274 |
| PubMedSearch : Carmona_1998_Exp.Clin.Psychopharmacol_6_274 |
| PubMedID: 9725111 |
| Title : Phenserine, a novel acetylcholinesterase inhibitor, attenuates impaired learning of rats in a 14-unit T-maze induced by blockade of the N- methyl-D-aspartate receptor - Patel_1998_Neuroreport_9_171 |
| Author(s) : Patel N , Spangler EL , Greig NH , Yu QS , Ingram DK , Meyer RC |
| Ref : Neuroreport , 9 :171 , 1998 |
| Abstract : Patel_1998_Neuroreport_9_171 |
| ESTHER : Patel_1998_Neuroreport_9_171 |
| PubMedSearch : Patel_1998_Neuroreport_9_171 |
| PubMedID: 9592071 |
| Title : Total syntheses and anticholinesterase activities of (3aS)-N(8)- norphysostigmine, (3aS)-N(8)-norphenserine, their antipodal isomers, and other N(8)-substituted analogues - Yu_1997_J.Med.Chem_40_2895 |
| Author(s) : Yu QS , Pei XF , Holloway HW , Greig NH , Brossi A |
| Ref : Journal of Medicinal Chemistry , 40 :2895 , 1997 |
| Abstract : Yu_1997_J.Med.Chem_40_2895 |
| ESTHER : Yu_1997_J.Med.Chem_40_2895 |
| PubMedSearch : Yu_1997_J.Med.Chem_40_2895 |
| PubMedID: 9288171 |
| Title : Comparative inhibitory effects of various physostigmine analogs against acetyl- and butyrylcholinesterases - Atack_1989_J.Pharmacol.Exp.Ther_249_194 |
| Author(s) : Atack JR , Yu QS , Soncrant TT , Brossi A , Rapoport SI |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 249 :194 , 1989 |
| Abstract : Atack_1989_J.Pharmacol.Exp.Ther_249_194 |
| ESTHER : Atack_1989_J.Pharmacol.Exp.Ther_249_194 |
| PubMedSearch : Atack_1989_J.Pharmacol.Exp.Ther_249_194 |
| PubMedID: 2709330 |
| Title : Carbamate analogues of (-)-physostigmine: in vitro inhibition of acetyl- and butyrylcholinesterase - Yu_1988_FEBS.Lett_234_127 |
| Author(s) : Yu QS , Atack JR , Rapoport SI , Brossi A |
| Ref : FEBS Letters , 234 :127 , 1988 |
| Abstract : Yu_1988_FEBS.Lett_234_127 |
| ESTHER : Yu_1988_FEBS.Lett_234_127 |
| PubMedSearch : Yu_1988_FEBS.Lett_234_127 |
| PubMedID: 3391264 |