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| Title : Designing a Small Fluorescent Inhibitor to Investigate Soluble Epoxide Hydrolase Engagement in Living Cells - Brunst_2022_ACS.Med.Chem.Lett_13_1062 |
| Author(s) : Brunst S , Schonfeld J , Breunig P , Burgers LD , DeMeglio M , Ehrler JHM , Lillich FF , Weizel L , Hefendehl JK , Furst R , Proschak E , Hiesinger K |
| Ref : ACS Med Chem Lett , 13 :1062 , 2022 |
| Abstract : Brunst_2022_ACS.Med.Chem.Lett_13_1062 |
| ESTHER : Brunst_2022_ACS.Med.Chem.Lett_13_1062 |
| PubMedSearch : Brunst_2022_ACS.Med.Chem.Lett_13_1062 |
| PubMedID: 35859883 |
| Title : Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH\/PPARgamma Modulator - Hartmann_2021_J.Med.Chem_64_2815 |
| Author(s) : Hartmann M , Bibli SI , Tews D , Ni X , Kircher T , Kramer JS , Kilu W , Heering J , Hernandez-Olmos V , Weizel L , Scriba GKE , Krait S , Knapp S , Chaikuad A , Merk D , Fleming I , Fischer-Posovszky P , Proschak E |
| Ref : Journal of Medicinal Chemistry , 64 :2815 , 2021 |
| Abstract : Hartmann_2021_J.Med.Chem_64_2815 |
| ESTHER : Hartmann_2021_J.Med.Chem_64_2815 |
| PubMedSearch : Hartmann_2021_J.Med.Chem_64_2815 |
| PubMedID: 33620196 |
| Title : Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor gamma Agonists\/Soluble Epoxide Hydrolase Inhibitors - Lillich_2021_J.Med.Chem_64_17259 |
| Author(s) : Lillich FF , Willems S , Ni X , Kilu W , Borkowsky C , Brodsky M , Kramer JS , Brunst S , Hernandez-Olmos V , Heering J , Schierle S , Kestner RI , Mayser FM , Helmstadter M , Gobel T , Weizel L , Namgaladze D , Kaiser A , Steinhilber D , Pfeilschifter W , Kahnt AS , Proschak A , Chaikuad A , Knapp S , Merk D , Proschak E |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : Lillich_2021_J.Med.Chem_64_17259 |
| ESTHER : Lillich_2021_J.Med.Chem_64_17259 |
| PubMedSearch : Lillich_2021_J.Med.Chem_64_17259 |
| PubMedID: 34818007 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Soluble epoxide hydrolase inhibitors with carboranes as non-natural 3-D pharmacophores - Scholz_2020_Eur.J.Med.Chem_185_111766 |
| Author(s) : Scholz MS , Wingen LM , Brunst S , Wittmann SK , Cardoso ILA , Weizel L , Proschak E |
| Ref : Eur Journal of Medicinal Chemistry , 185 :111766 , 2020 |
| Abstract : Scholz_2020_Eur.J.Med.Chem_185_111766 |
| ESTHER : Scholz_2020_Eur.J.Med.Chem_185_111766 |
| PubMedSearch : Scholz_2020_Eur.J.Med.Chem_185_111766 |
| PubMedID: 31677445 |
| Title : Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase - Hiesinger_2020_J.Med.Chem_63_11498 |
| Author(s) : Hiesinger K , Kramer JS , Beyer S , Eckes T , Brunst S , Flauaus C , Wittmann SK , Weizel L , Kaiser A , Kretschmer SBM , George S , Angioni C , Heering J , Geisslinger G , Schubert-Zsilavecz M , Schmidtko A , Pogoryelov D , Pfeilschifter J , Hofmann B , Steinhilber D , Schwalm S , Proschak E |
| Ref : Journal of Medicinal Chemistry , 63 :11498 , 2020 |
| Abstract : Hiesinger_2020_J.Med.Chem_63_11498 |
| ESTHER : Hiesinger_2020_J.Med.Chem_63_11498 |
| PubMedSearch : Hiesinger_2020_J.Med.Chem_63_11498 |
| PubMedID: 33044073 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor gamma - Gobel_2019_Front.Pharmacol_10_263 |
| Author(s) : Gobel T , Diehl O , Heering J , Merk D , Angioni C , Wittmann SK , Buscato E , Kottke R , Weizel L , Schader T , Maier TJ , Geisslinger G , Schubert-Zsilavecz M , Steinhilber D , Proschak E , Kahnt AS |
| Ref : Front Pharmacol , 10 :263 , 2019 |
| Abstract : Gobel_2019_Front.Pharmacol_10_263 |
| ESTHER : Gobel_2019_Front.Pharmacol_10_263 |
| PubMedSearch : Gobel_2019_Front.Pharmacol_10_263 |
| PubMedID: 30949053 |
| Title : Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase - Lukin_2018_Bioorg.Chem_80_655 |
| Author(s) : Lukin A , Kramer J , Hartmann M , Weizel L , Hernandez-Olmos V , Falahati K , Burghardt I , Kalinchenkova N , Bagnyukova D , Zhurilo N , Rautio J , Forsberg M , Ihalainen J , Auriola S , Leppanen J , Konstantinov I , Pogoryelov D , Proschak E , Dar'in D , Krasavin M |
| Ref : Bioorg Chem , 80 :655 , 2018 |
| Abstract : Lukin_2018_Bioorg.Chem_80_655 |
| ESTHER : Lukin_2018_Bioorg.Chem_80_655 |
| PubMedSearch : Lukin_2018_Bioorg.Chem_80_655 |
| PubMedID: 30059891 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis - Schmidt_2017_J.Med.Chem_60_7703 |
| Author(s) : Schmidt J , Rotter M , Weiser T , Wittmann S , Weizel L , Kaiser A , Heering J , Goebel T , Angioni C , Wurglics M , Paulke A , Geisslinger G , Kahnt A , Steinhilber D , Proschak E , Merk D |
| Ref : Journal of Medicinal Chemistry , 60 :7703 , 2017 |
| Abstract : Schmidt_2017_J.Med.Chem_60_7703 |
| ESTHER : Schmidt_2017_J.Med.Chem_60_7703 |
| PubMedSearch : Schmidt_2017_J.Med.Chem_60_7703 |
| PubMedID: 28845983 |
| Title : N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase\/Peroxisome Proliferator-Activated Receptor gamma Modulators - Blocher_2016_J.Med.Chem_59_61 |
| Author(s) : Blocher R , Lamers C , Wittmann SK , Merk D , Hartmann M , Weizel L , Diehl O , Bruggerhoff A , Boss M , Kaiser A , Schader T , Gobel T , Grundmann M , Angioni C , Heering J , Geisslinger G , Wurglics M , Kostenis E , Brune B , Steinhilber D , Schubert-Zsilavecz M , Kahnt AS , Proschak E |
| Ref : Journal of Medicinal Chemistry , 59 :61 , 2016 |
| Abstract : Blocher_2016_J.Med.Chem_59_61 |
| ESTHER : Blocher_2016_J.Med.Chem_59_61 |
| PubMedSearch : Blocher_2016_J.Med.Chem_59_61 |
| PubMedID: 26595749 |