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| Title : Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer's disease - Macedo_2022_Bioorg.Med.Chem_71_116952 |
| Author(s) : Macedo Vaz S , de Freitas Silva M , Dos Reis Rosa Franco G , Jorge RGM , Motta RdSF , Goncalves Castro N , Alvim Guedes I , Dardenne LE , Amaral Alves M , Garrett da Costa R , Beserra Pinheiro G , Germino Veras L , Renata Mortari M , Pruccoli L , Tarozzi A , Viegas C, Jr. |
| Ref : Bioorganic & Medicinal Chemistry , 71 :116952 , 2022 |
| Abstract : Macedo_2022_Bioorg.Med.Chem_71_116952 |
| ESTHER : Macedo_2022_Bioorg.Med.Chem_71_116952 |
| PubMedSearch : Macedo_2022_Bioorg.Med.Chem_71_116952 |
| PubMedID: 35930852 |
| Title : Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation - Cristancho_2022_RSC.Med.Chem_13_568 |
| Author(s) : Cristancho Ortiz CJ , de Freitas Silva M , Pruccoli L , Fonseca Nadur N , de Azevedo LL , Kummerle AE , Guedes IA , Dardenne LE , Leomil Coelho LF , Guimaraes MJ , da Silva FMR , Castro N , Gontijo VS , Rojas VCT , de Oliveira MK , Vilela FC , Giusti-Paiva A , Barbosa G , Lima LM , Pinheiro GB , Veras LG , Mortari MR , Tarozzi A , Viegas C, Jr. |
| Ref : RSC Med Chem , 13 :568 , 2022 |
| Abstract : Cristancho_2022_RSC.Med.Chem_13_568 |
| ESTHER : Cristancho_2022_RSC.Med.Chem_13_568 |
| PubMedSearch : Cristancho_2022_RSC.Med.Chem_13_568 |
| PubMedID: 35694691 |
| Title : New multifunctional AChE inhibitor drug prototypes protect against Abeta-induced memory deficit - Bellozi_2020_Neurol.Sci_41_451 |
| Author(s) : Bellozi PMQ , Campos AC , Viegas FPD , Silva MF , Machado RP , Vaz SM , Riquiel MM , Carneiro-Junior WO , Lima IVA , Saliba SW , Vaz GN , Viegas C, Jr. , de Oliveira ACP |
| Ref : Neurol Sci , 41 :451 , 2020 |
| Abstract : Bellozi_2020_Neurol.Sci_41_451 |
| ESTHER : Bellozi_2020_Neurol.Sci_41_451 |
| PubMedSearch : Bellozi_2020_Neurol.Sci_41_451 |
| PubMedID: 31506829 |
| Title : PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's Disease - Morroni_2019_Front.Pharmacol_10_658 |
| Author(s) : Morroni F , Sita G , Graziosi A , Ravegnini G , Molteni R , Paladini MS , Dias KST , Dos Santos AF , Viegas C, Jr. , Camps I , Pruccoli L , Tarozzi A , Hrelia P |
| Ref : Front Pharmacol , 10 :658 , 2019 |
| Abstract : Morroni_2019_Front.Pharmacol_10_658 |
| ESTHER : Morroni_2019_Front.Pharmacol_10_658 |
| PubMedSearch : Morroni_2019_Front.Pharmacol_10_658 |
| PubMedID: 31244664 |
| Title : Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease - Dias_2017_Eur.J.Med.Chem_130_440 |
| Author(s) : Dias KS , de Paula CT , Dos Santos T , Souza IN , Boni MS , Guimaraes MJ , da Silva FM , Castro NG , Neves GA , Veloso CC , Coelho MM , de Melo IS , Giusti FC , Giusti-Paiva A , da Silva ML , Dardenne LE , Guedes IA , Pruccoli L , Morroni F , Tarozzi A , Viegas C, Jr. |
| Ref : Eur Journal of Medicinal Chemistry , 130 :440 , 2017 |
| Abstract : Dias_2017_Eur.J.Med.Chem_130_440 |
| ESTHER : Dias_2017_Eur.J.Med.Chem_130_440 |
| PubMedSearch : Dias_2017_Eur.J.Med.Chem_130_440 |
| PubMedID: 28282613 |
| Title : Donepezil: an important prototype to the design of new drug candidates for Alzheimer's disease - Rodrigues_2014_Mini.Rev.Med.Chem_14_2 |
| Author(s) : Rodrigues Simoes MC , Dias Viegas FP , Moreira MS , Freitas Silva M , Riquiel MM , da Rosa PM , Castelli MR , Dos Santos MH , Soares MG , Viegas C , de Freitas Silva M , Viegas C, Jr. |
| Ref : Mini Rev Med Chem , 14 :2 , 2014 |
| Abstract : Rodrigues_2014_Mini.Rev.Med.Chem_14_2 |
| ESTHER : Rodrigues_2014_Mini.Rev.Med.Chem_14_2 |
| PubMedSearch : Rodrigues_2014_Mini.Rev.Med.Chem_14_2 |
| PubMedID: 24251806 |
| Title : Anticholinesterasic, nematostatic and anthelmintic activities of pyridinic and pyrazinic compounds - Valli_2011_Curr.Med.Chem_18_3423 |
| Author(s) : Valli M , Danuello A , Pivatto M , Saldana JC , Heinzen H , Dominguez L , Campos VP , Marqui SR , Young MC , Viegas C, Jr. , Silva DH , Bolzani VS |
| Ref : Curr Med Chem , 18 :3423 , 2011 |
| Abstract : Valli_2011_Curr.Med.Chem_18_3423 |
| ESTHER : Valli_2011_Curr.Med.Chem_18_3423 |
| PubMedSearch : Valli_2011_Curr.Med.Chem_18_3423 |
| PubMedID: 21728957 |
| Title : CNS-selective noncompetitive cholinesterase inhibitors derived from the natural piperidine alkaloid (-)-spectaline - Castro_2008_Eur.J.Pharmacol_580_339 |
| Author(s) : Castro NG , Costa RS , Pimentel LS , Danuello A , Romeiro NC , Viegas C, Jr. , Barreiro EJ , Fraga CA , Bolzani VS , Rocha MS |
| Ref : European Journal of Pharmacology , 580 :339 , 2008 |
| Abstract : Castro_2008_Eur.J.Pharmacol_580_339 |
| ESTHER : Castro_2008_Eur.J.Pharmacol_580_339 |
| PubMedSearch : Castro_2008_Eur.J.Pharmacol_580_339 |
| PubMedID: 18096154 |
| Title : New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids - Viegas_2005_Bioorg.Med.Chem_13_4184 |
| Author(s) : Viegas C, Jr. , Bolzani VS , Pimentel LS , Castro NG , Cabral RF , Costa RS , Floyd C , Rocha MS , Young MC , Barreiro EJ , Fraga CA |
| Ref : Bioorganic & Medicinal Chemistry , 13 :4184 , 2005 |
| Abstract : Viegas_2005_Bioorg.Med.Chem_13_4184 |
| ESTHER : Viegas_2005_Bioorg.Med.Chem_13_4184 |
| PubMedSearch : Viegas_2005_Bioorg.Med.Chem_13_4184 |
| PubMedID: 15878668 |
| Title : New anti-Alzheimer drugs from biodiversity: the role of the natural acetylcholinesterase inhibitors - Viegas_2005_Mini.Rev.Med.Chem_5_915 |
| Author(s) : Viegas C, Jr. , Bolzani Vda S , Barreiro EJ , Fraga CA |
| Ref : Mini Rev Med Chem , 5 :915 , 2005 |
| Abstract : Viegas_2005_Mini.Rev.Med.Chem_5_915 |
| ESTHER : Viegas_2005_Mini.Rev.Med.Chem_5_915 |
| PubMedSearch : Viegas_2005_Mini.Rev.Med.Chem_5_915 |
| PubMedID: 16250834 |
| Title : Further bioactive piperidine alkaloids from the flowers and green fruits of Cassia spectabilis - Viegas_2004_J.Nat.Prod_67_908 |
| Author(s) : Viegas C, Jr. , da SBV , Furlan M , Barreiro EJ , Young MC , Tomazela D , Eberlin MN |
| Ref : Journal of Natural Products , 67 :908 , 2004 |
| Abstract : Viegas_2004_J.Nat.Prod_67_908 |
| ESTHER : Viegas_2004_J.Nat.Prod_67_908 |
| PubMedSearch : Viegas_2004_J.Nat.Prod_67_908 |
| PubMedID: 15165164 |