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| Title : The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease - Serrano_2017_J.Psychiatry.Neurosci_42_59 |
| Author(s) : Serrano MP , Herrero-Labrador R , Futch HS , Serrano J , Romero A , Fernandez AP , Samadi A , Unzeta M , Marco-Contelles J , Martinez-Murillo R |
| Ref : J Psychiatry Neurosci , 42 :59 , 2017 |
| Abstract : Serrano_2017_J.Psychiatry.Neurosci_42_59 |
| ESTHER : Serrano_2017_J.Psychiatry.Neurosci_42_59 |
| PubMedSearch : Serrano_2017_J.Psychiatry.Neurosci_42_59 |
| PubMedID: 27636528 |
| Title : In-vitro and in-vivo evaluation of the modulatory effects of the multitarget compound ASS234 on the monoaminergic system - Esteban_2017_J.Pharm.Pharmacol_69_314 |
| Author(s) : Esteban G , Van Schoors J , Sun P , Van Eeckhaut A , Marco-Contelles J , Smolders I , Unzeta M |
| Ref : J Pharm Pharmacol , 69 :314 , 2017 |
| Abstract : Esteban_2017_J.Pharm.Pharmacol_69_314 |
| ESTHER : Esteban_2017_J.Pharm.Pharmacol_69_314 |
| PubMedSearch : Esteban_2017_J.Pharm.Pharmacol_69_314 |
| PubMedID: 28134992 |
| Title : Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease - Ismaili_2017_Prog.Neurobiol_151_4 |
| Author(s) : Ismaili L , Refouvelet B , Benchekroun M , Brogi S , Brindisi M , Gemma S , Campiani G , Filipic S , Agbaba D , Esteban G , Unzeta M , Nikolic K , Butini S , Marco-Contelles J |
| Ref : Prog Neurobiol , 151 :4 , 2017 |
| Abstract : Ismaili_2017_Prog.Neurobiol_151_4 |
| ESTHER : Ismaili_2017_Prog.Neurobiol_151_4 |
| PubMedSearch : Ismaili_2017_Prog.Neurobiol_151_4 |
| PubMedID: 26797191 |
| Title : Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation - Wu_2016_Eur.J.Med.Chem_121_864 |
| Author(s) : Wu MY , Esteban G , Brogi S , Shionoya M , Wang L , Campiani G , Unzeta M , Inokuchi T , Butini S , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 121 :864 , 2016 |
| Abstract : Wu_2016_Eur.J.Med.Chem_121_864 |
| ESTHER : Wu_2016_Eur.J.Med.Chem_121_864 |
| PubMedSearch : Wu_2016_Eur.J.Med.Chem_121_864 |
| PubMedID: 26471320 |
| Title : Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease - Unzeta_2016_Front.Neurosci_10_205 |
| Author(s) : Unzeta M , Esteban G , Bolea I , Fogel WA , Ramsay RR , Youdim MB , Tipton KF , Marco-Contelles J |
| Ref : Front Neurosci , 10 :205 , 2016 |
| Abstract : Unzeta_2016_Front.Neurosci_10_205 |
| ESTHER : Unzeta_2016_Front.Neurosci_10_205 |
| PubMedSearch : Unzeta_2016_Front.Neurosci_10_205 |
| PubMedID: 27252617 |
| Title : ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy - Marco-Contelles_2016_Front.Neurosci_10_294 |
| Author(s) : Marco-Contelles J , Unzeta M , Bolea I , Esteban G , Ramsay RR , Romero A , Martinez-Murillo R , Carreiras MC , Ismaili L |
| Ref : Front Neurosci , 10 :294 , 2016 |
| Abstract : Marco-Contelles_2016_Front.Neurosci_10_294 |
| ESTHER : Marco-Contelles_2016_Front.Neurosci_10_294 |
| PubMedSearch : Marco-Contelles_2016_Front.Neurosci_10_294 |
| PubMedID: 27445665 |
| Title : Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease - Wang_2014_Eur.J.Med.Chem_80_543 |
| Author(s) : Wang L , Esteban G , Ojima M , Bautista-Aguilera OM , Inokuchi T , Moraleda I , Iriepa I , Samadi A , Youdim MB , Romero A , Soriano E , Herrero R , Fernandez Fernandez AP , Ricardo Martinez M , Marco-Contelles J , Unzeta M |
| Ref : Eur Journal of Medicinal Chemistry , 80 :543 , 2014 |
| Abstract : Wang_2014_Eur.J.Med.Chem_80_543 |
| ESTHER : Wang_2014_Eur.J.Med.Chem_80_543 |
| PubMedSearch : Wang_2014_Eur.J.Med.Chem_80_543 |
| PubMedID: 24813882 |
| Title : Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease - Esteban_2014_Biochim.Biophys.Acta_1844_1104 |
| Author(s) : Esteban G , Allan J , Samadi A , Mattevi A , Unzeta M , Marco-Contelles J , Binda C , Ramsay RR |
| Ref : Biochimica & Biophysica Acta , 1844 :1104 , 2014 |
| Abstract : Esteban_2014_Biochim.Biophys.Acta_1844_1104 |
| ESTHER : Esteban_2014_Biochim.Biophys.Acta_1844_1104 |
| PubMedSearch : Esteban_2014_Biochim.Biophys.Acta_1844_1104 |
| PubMedID: 24642166 |
| Title : Effects of novel monoamine oxidases and cholinesterases targeting compounds on brain neurotransmitters and behavior in rat model of vascular dementia - Stasiak_2014_Curr.Pharm.Des_20_161 |
| Author(s) : Stasiak A , Mussur M , Unzeta M , Samadi A , Marco-Contelles JL , Fogel WA , Marco-Contelles J |
| Ref : Curr Pharm Des , 20 :161 , 2014 |
| Abstract : Stasiak_2014_Curr.Pharm.Des_20_161 |
| ESTHER : Stasiak_2014_Curr.Pharm.Des_20_161 |
| PubMedSearch : Stasiak_2014_Curr.Pharm.Des_20_161 |
| PubMedID: 23701539 |
| Title : Multipotent cholinesterase\/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids - Bautista-Aguilera_2014_Drug.Des.Devel.Ther_8_1893 |
| Author(s) : Bautista-Aguilera OM , Esteban G , Chioua M , Nikolic K , Agbaba D , Moraleda I , Iriepa I , Soriano E , Samadi A , Unzeta M , Marco-Contelles J |
| Ref : Drug Des Devel Ther , 8 :1893 , 2014 |
| Abstract : Bautista-Aguilera_2014_Drug.Des.Devel.Ther_8_1893 |
| ESTHER : Bautista-Aguilera_2014_Drug.Des.Devel.Ther_8_1893 |
| PubMedSearch : Bautista-Aguilera_2014_Drug.Des.Devel.Ther_8_1893 |
| PubMedID: 25378907 |
| Title : Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase\/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease - Bautista-Aguilera_2014_Eur.J.Med.Chem_75C_82 |
| Author(s) : Bautista-Aguilera OM , Esteban G , Bolea I , Nikolic K , Agbaba D , Moraleda I , Iriepa I , Samadi A , Soriano E , Unzeta M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 75C :82 , 2014 |
| Abstract : Bautista-Aguilera_2014_Eur.J.Med.Chem_75C_82 |
| ESTHER : Bautista-Aguilera_2014_Eur.J.Med.Chem_75C_82 |
| PubMedSearch : Bautista-Aguilera_2014_Eur.J.Med.Chem_75C_82 |
| PubMedID: 24530494 |
| Title : Multipotent, permeable drug ASS234 inhibits Abeta aggregation, possesses antioxidant properties and protects from Abeta-induced apoptosis in vitro - Bolea_2013_Curr.Alzheimer.Res_10_797 |
| Author(s) : Bolea I , Gella A , Monjas L , Perez C , Rodriguez-Franco MI , Marco-Contelles J , Samadi A , Unzeta M |
| Ref : Curr Alzheimer Res , 10 :797 , 2013 |
| Abstract : Bolea_2013_Curr.Alzheimer.Res_10_797 |
| ESTHER : Bolea_2013_Curr.Alzheimer.Res_10_797 |
| PubMedSearch : Bolea_2013_Curr.Alzheimer.Res_10_797 |
| PubMedID: 23919774 |
| Title : Propargylamine-derived multitarget-directed ligands: fighting Alzheimer's disease with monoamine oxidase inhibitors - Bolea_2013_J.Neural.Transm_120_893 |
| Author(s) : Bolea I , Gella A , Unzeta M |
| Ref : J Neural Transm , 120 :893 , 2013 |
| Abstract : Bolea_2013_J.Neural.Transm_120_893 |
| ESTHER : Bolea_2013_J.Neural.Transm_120_893 |
| PubMedSearch : Bolea_2013_J.Neural.Transm_120_893 |
| PubMedID: 23238976 |
| Title : A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BCHE - Esteban_2013_J.Neural.Transm_120_911 |
| Author(s) : Esteban G , Bolea I , Sun P , Sole M , Samadi A , Marco-Contelles J , Unzeta M |
| Ref : J Neural Transm , 120 :911 , 2013 |
| Abstract : Esteban_2013_J.Neural.Transm_120_911 |
| ESTHER : Esteban_2013_J.Neural.Transm_120_911 |
| PubMedSearch : Esteban_2013_J.Neural.Transm_120_911 |
| PubMedID: 23263540 |
| Title : Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine - Samadi_2012_Eur.J.Med.Chem_52_251 |
| Author(s) : Samadi A , de los Rios C , Bolea I , Chioua M , Iriepa I , Moraleda I , Bartolini M , Andrisano V , Galvez E , Valderas C , Unzeta M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 52 :251 , 2012 |
| Abstract : Samadi_2012_Eur.J.Med.Chem_52_251 |
| ESTHER : Samadi_2012_Eur.J.Med.Chem_52_251 |
| PubMedSearch : Samadi_2012_Eur.J.Med.Chem_52_251 |
| PubMedID: 22503231 |
| Title : Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase\/monoamine oxidase inhibitors for the treatment of Alzheimer's disease - Bolea_2011_J.Med.Chem_54_8251 |
| Author(s) : Bolea I , Juarez-Jimenez J , de los Rios C , Chioua M , Pouplana R , Luque FJ , Unzeta M , Marco-Contelles J , Samadi A |
| Ref : Journal of Medicinal Chemistry , 54 :8251 , 2011 |
| Abstract : Bolea_2011_J.Med.Chem_54_8251 |
| ESTHER : Bolea_2011_J.Med.Chem_54_8251 |
| PubMedSearch : Bolea_2011_J.Med.Chem_54_8251 |
| PubMedID: 22023459 |
| Title : Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease - Samadi_2011_Eur.J.Med.Chem_46_4665 |
| Author(s) : Samadi A , Chioua M , Bolea I , de los Rios C , Iriepa I , Moraleda I , Bastida A , Esteban G , Unzeta M , Galvez E , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 46 :4665 , 2011 |
| Abstract : Samadi_2011_Eur.J.Med.Chem_46_4665 |
| ESTHER : Samadi_2011_Eur.J.Med.Chem_46_4665 |
| PubMedSearch : Samadi_2011_Eur.J.Med.Chem_46_4665 |
| PubMedID: 21669479 |