Report for Trankle C

General

Full name : Trankle Christian

First name : Christian

Mail : Pharmakologie und Toxikologie, Pharmazeutisches Institut, Universitat Bonn, Gerhard-Domagk-Str. 3, 53121 Bonn

Zip Code :

City :

Country : Germany

Email :

Phone :

Fax :

Website :

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References (45)

Title : Beta and gamma carboline derivatives as potential anti-Alzheimer agents: A comparison - Otto_2014_Eur.J.Med.Chem_87C_63
Author(s) : Otto R , Penzis R , Gaube F , Winckler T , Appenroth D , Fleck C , Trankle C , Lehmann J , Enzensperger C
Ref : Eur Journal of Medicinal Chemistry , 87C :63 , 2014
Abstract : Otto_2014_Eur.J.Med.Chem_87C_63
ESTHER : Otto_2014_Eur.J.Med.Chem_87C_63
PubMedSearch : Otto_2014_Eur.J.Med.Chem_87C_63
PubMedID: 25240096

Title : A muscarinic view on Gq -
Author(s) : Mohr K , Trankle C
Ref : Naunyn Schmiedebergs Arch Pharmacol , 386 :935 , 2013
PubMedID: 23779215

Title : The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling - Bock_2012_Nat.Commun_3_1044
Author(s) : Bock A , Merten N , Schrage R , Dallanoce C , Batz J , Klockner J , Schmitz J , Matera C , Simon K , Kebig A , Peters L , Muller A , Schrobang-Ley J , Trankle C , Hoffmann C , De Amici M , Holzgrabe U , Kostenis E , Mohr K
Ref : Nat Commun , 3 :1044 , 2012
Abstract : Bock_2012_Nat.Commun_3_1044
ESTHER : Bock_2012_Nat.Commun_3_1044
PubMedSearch : Bock_2012_Nat.Commun_3_1044
PubMedID: 22948826

Title : A hydrazide linker strategy for heterobivalent compounds as ortho- and allosteric ligands of acetylcholine-binding proteins - Elsinghorst_2011_Curr.Top.Med.Chem_11_2731
Author(s) : Elsinghorst PW , Hartig W , Gundisch D , Mohr K , Trankle C , Gutschow M
Ref : Curr Top Med Chem , 11 :2731 , 2011
Abstract : Elsinghorst_2011_Curr.Top.Med.Chem_11_2731
ESTHER : Elsinghorst_2011_Curr.Top.Med.Chem_11_2731
PubMedSearch : Elsinghorst_2011_Curr.Top.Med.Chem_11_2731
PubMedID: 22039876

Title : Rational design of dualsteric GPCR ligands: quests and promise - Mohr_2010_Br.J.Pharmacol_159_997
Author(s) : Mohr K , Trankle C , Kostenis E , Barocelli E , De Amici M , Holzgrabe U
Ref : British Journal of Pharmacology , 159 :997 , 2010
Abstract : Mohr_2010_Br.J.Pharmacol_159_997
ESTHER : Mohr_2010_Br.J.Pharmacol_159_997
PubMedSearch : Mohr_2010_Br.J.Pharmacol_159_997
PubMedID: 20136835

Title : Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors - Fang_2010_J.Med.Chem_53_2094
Author(s) : Fang L , Jumpertz S , Zhang Y , Appenroth D , Fleck C , Mohr K , Trankle C , Decker M
Ref : Journal of Medicinal Chemistry , 53 :2094 , 2010
Abstract : Fang_2010_J.Med.Chem_53_2094
ESTHER : Fang_2010_J.Med.Chem_53_2094
PubMedSearch : Fang_2010_J.Med.Chem_53_2094
PubMedID: 20158205

Title : Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity - Antony_2009_FASEB.J_23_442
Author(s) : Antony J , Kellershohn K , Mohr-Andra M , Kebig A , Prilla S , Muth M , Heller E , Disingrini T , Dallanoce C , Bertoni S , Schrobang J , Trankle C , Kostenis E , Christopoulos A , Holtje HD , Barocelli E , De Amici M , Holzgrabe U , Mohr K
Ref : FASEB Journal , 23 :442 , 2009
Abstract : Antony_2009_FASEB.J_23_442
ESTHER : Antony_2009_FASEB.J_23_442
PubMedSearch : Antony_2009_FASEB.J_23_442
PubMedID: 18842964

Title : Allosteric small molecules unveil a role of an extracellular E2\/transmembrane helix 7 junction for G protein-coupled receptor activation - Jager_2007_J.Biol.Chem_282_34968
Author(s) : Jager D , Schmalenbach C , Prilla S , Schrobang J , Kebig A , Sennwitz M , Heller E , Trankle C , Holzgrabe U , Holtje HD , Mohr K
Ref : Journal of Biological Chemistry , 282 :34968 , 2007
Abstract : Jager_2007_J.Biol.Chem_282_34968
ESTHER : Jager_2007_J.Biol.Chem_282_34968
PubMedSearch : Jager_2007_J.Biol.Chem_282_34968
PubMedID: 17890226

Title : First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor - Elsinghorst_2007_J.Med.Chem_50_5685
Author(s) : Elsinghorst PW , Cieslik JS , Mohr K , Trankle C , Gutschow M
Ref : Journal of Medicinal Chemistry , 50 :5685 , 2007
Abstract : Elsinghorst_2007_J.Med.Chem_50_5685
ESTHER : Elsinghorst_2007_J.Med.Chem_50_5685
PubMedSearch : Elsinghorst_2007_J.Med.Chem_50_5685
PubMedID: 17944454

Title : Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist - Grossmuller_2006_Naunyn.Schmiedebergs.Arch.Pharmacol_372_267
Author(s) : Grossmuller M , Antony J , Trankle C , Holzgrabe U , Mohr K
Ref : Naunyn Schmiedebergs Arch Pharmacol , 372 :267 , 2006
Abstract : Grossmuller_2006_Naunyn.Schmiedebergs.Arch.Pharmacol_372_267
ESTHER : Grossmuller_2006_Naunyn.Schmiedebergs.Arch.Pharmacol_372_267
PubMedSearch : Grossmuller_2006_Naunyn.Schmiedebergs.Arch.Pharmacol_372_267
PubMedID: 16362429

Title : Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2\/M5 chimeric receptors - Trankle_2005_Mol.Pharmacol_68_1597
Author(s) : Trankle C , Dittmann A , Schulz U , Weyand O , Buller S , Johren K , Heller E , Birdsall NJ , Holzgrabe U , Ellis J , Holtje HD , Mohr K
Ref : Molecular Pharmacology , 68 :1597 , 2005
Abstract : Trankle_2005_Mol.Pharmacol_68_1597
ESTHER : Trankle_2005_Mol.Pharmacol_68_1597
PubMedSearch : Trankle_2005_Mol.Pharmacol_68_1597
PubMedID: 16157694

Title : Structure\/activity relationships of M2 muscarinic allosteric modulators - Mohr_2003_Receptors.Channels_9_229
Author(s) : Mohr K , Trankle C , Holzgrabe U
Ref : Receptors Channels , 9 :229 , 2003
Abstract : Mohr_2003_Receptors.Channels_9_229
ESTHER : Mohr_2003_Receptors.Channels_9_229
PubMedSearch : Mohr_2003_Receptors.Channels_9_229
PubMedID: 12893536

Title : Cooperative interactions at M2 muscarinic acetylcholine receptors: structure\/activity relationships in stepwise shortened bispyridinium- and bis(ammonio)alkane-type allosteric modulators - Gilsbach_2003_Neurochem.Res_28_667
Author(s) : Gilsbach R , Grossmuller M , Alptuzun V , Erciyas E , Trankle C , Holzgrabe U , Mohr K
Ref : Neurochem Res , 28 :667 , 2003
Abstract : Gilsbach_2003_Neurochem.Res_28_667
ESTHER : Gilsbach_2003_Neurochem.Res_28_667
PubMedSearch : Gilsbach_2003_Neurochem.Res_28_667
PubMedID: 12675159

Title : Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2\/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-occupied receptors - Voigtlander_2003_Mol.Pharmacol_64_21
Author(s) : Voigtlander U , Johren K , Mohr M , Raasch A , Trankle C , Buller S , Ellis J , Holtje HD , Mohr K
Ref : Molecular Pharmacology , 64 :21 , 2003
Abstract : Voigtlander_2003_Mol.Pharmacol_64_21
ESTHER : Voigtlander_2003_Mol.Pharmacol_64_21
PubMedSearch : Voigtlander_2003_Mol.Pharmacol_64_21
PubMedID: 12815157

Title : Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors - Trankle_2003_Mol.Pharmacol_64_180
Author(s) : Trankle C , Weyand O , Voigtlander U , Mynett A , Lazareno S , Birdsall NJ , Mohr K
Ref : Molecular Pharmacology , 64 :180 , 2003
Abstract : Trankle_2003_Mol.Pharmacol_64_180
ESTHER : Trankle_2003_Mol.Pharmacol_64_180
PubMedSearch : Trankle_2003_Mol.Pharmacol_64_180
PubMedID: 12815174

Title : Systematic development of high affinity bis(ammonio)alkane-type allosteric enhancers of muscarinic ligand binding - Muth_2003_J.Med.Chem_46_1031
Author(s) : Muth M , Bender W , Scharfenstein O , Holzgrabe U , Balatkova E , Trankle C , Mohr K
Ref : Journal of Medicinal Chemistry , 46 :1031 , 2003
Abstract : Muth_2003_J.Med.Chem_46_1031
ESTHER : Muth_2003_J.Med.Chem_46_1031
PubMedSearch : Muth_2003_J.Med.Chem_46_1031
PubMedID: 12620079

Title : Allosteric modulation of muscarinic receptor signaling: alcuronium-induced conversion of pilocarpine from an agonist into an antagonist - Zahn_2002_J.Pharmacol.Exp.Ther_301_720
Author(s) : Zahn K , Eckstein N , Trankle C , Sadee W , Mohr K
Ref : Journal of Pharmacology & Experimental Therapeutics , 301 :720 , 2002
Abstract : Zahn_2002_J.Pharmacol.Exp.Ther_301_720
ESTHER : Zahn_2002_J.Pharmacol.Exp.Ther_301_720
PubMedSearch : Zahn_2002_J.Pharmacol.Exp.Ther_301_720
PubMedID: 11961078

Title : Elevation of ligand binding to muscarinic M(2) acetylcholine receptors by bis(ammonio)alkane-type allosteric modulators - Raasch_2002_J.Med.Chem_45_3809
Author(s) : Raasch A , Scharfenstein O , Trankle C , Holzgrabe U , Mohr K
Ref : Journal of Medicinal Chemistry , 45 :3809 , 2002
Abstract : Raasch_2002_J.Med.Chem_45_3809
ESTHER : Raasch_2002_J.Med.Chem_45_3809
PubMedSearch : Raasch_2002_J.Med.Chem_45_3809
PubMedID: 12166953

Title : Poster: Binding of the radiolabelled allosteric ligand [3H]dimethyl-W84 to M4 muscarinic receptors -
Author(s) : Trankle C , Weyand O , Lazareno S , Birdsall NJ , Mohr K
Ref : Life Sciences , 68 :2619 , 2001
PubMedID:

Title : Poster: Modulation of partial agonist efficacy in M2-receptors by structurally diverse muscarinic allosteric agents -
Author(s) : Mohr K , Zahn K , Trankle C
Ref : Life Sciences , 68 :2620 , 2001
PubMedID:

Title : Poster: Ligand for the common allosteric site of M2-receptors of subnanomolar potency -
Author(s) : Holzgrabe U , Bender W , Balatkova E , Trankle C , Mohr K
Ref : Life Sciences , 68 :2620 , 2001
PubMedID:

Title : Poster: Effects of atypical allosteric agents on the binding of [3H]dimethyl-w84 to M2 receptors -
Author(s) : Weyand O , Lazareno S , Birdsall NJ , Mohr K , Trankle C
Ref : Life Sciences , 68 :2621 , 2001
PubMedID:

Title : Muscarinic allosteric modulation: M2\/M3 subtype selectivity of gallamine is independent of G-protein coupling specificity - Trankle_2001_Naunyn.Schmiedebergs.Arch.Pharmacol_364_172
Author(s) : Trankle C , Kostenis E , Mohr K
Ref : Naunyn Schmiedebergs Arch Pharmacol , 364 :172 , 2001
Abstract : Trankle_2001_Naunyn.Schmiedebergs.Arch.Pharmacol_364_172
ESTHER : Trankle_2001_Naunyn.Schmiedebergs.Arch.Pharmacol_364_172
PubMedSearch : Trankle_2001_Naunyn.Schmiedebergs.Arch.Pharmacol_364_172
PubMedID: 11534857

Title : Probing the size of a hydrophobic binding pocket within the allosteric site of muscarinic acetylcholine M2-receptors - Bender_2000_Life.Sci_66_1675
Author(s) : Bender W , Staudt M , Trankle C , Mohr K , Holzgrabe U
Ref : Life Sciences , 66 :1675 , 2000
Abstract : Bender_2000_Life.Sci_66_1675
ESTHER : Bender_2000_Life.Sci_66_1675
PubMedSearch : Bender_2000_Life.Sci_66_1675
PubMedID: 10809164

Title : Testing the specificity of allosteric modulators of muscarinic receptors in phylogenetically closely related histamine H1-receptors - Franken_2000_Naunyn.Schmiedebergs.Arch.Pharmacol_361_107
Author(s) : Franken C , Trankle C , Mohr K
Ref : Naunyn Schmiedebergs Arch Pharmacol , 361 :107 , 2000
Abstract : Franken_2000_Naunyn.Schmiedebergs.Arch.Pharmacol_361_107
ESTHER : Franken_2000_Naunyn.Schmiedebergs.Arch.Pharmacol_361_107
PubMedSearch : Franken_2000_Naunyn.Schmiedebergs.Arch.Pharmacol_361_107
PubMedID: 10685864

Title : Ligands for the common allosteric site of acetylcholine M2-receptors: development and application - Holzgrabe_2000_Pharm.Acta.Helv_74_149
Author(s) : Holzgrabe U , Bender W , Cid HM , Staudt M , Pick R , Pfletschinger C , Balatkova E , Trankle C , Mohr K
Ref : Pharm Acta Helv , 74 :149 , 2000
Abstract : Holzgrabe_2000_Pharm.Acta.Helv_74_149
ESTHER : Holzgrabe_2000_Pharm.Acta.Helv_74_149
PubMedSearch : Holzgrabe_2000_Pharm.Acta.Helv_74_149
PubMedID: 10812952

Title : Probing the selectivity of allosteric modulators of muscarinic receptors at other G-protein-coupled receptors - Pfaffendorf_2000_J.Auton.Pharmacol_20_55
Author(s) : Pfaffendorf M , Batink HD , Trankle C , Mohr K , van Zwieten PA
Ref : J Auton Pharmacol , 20 :55 , 2000
Abstract : Pfaffendorf_2000_J.Auton.Pharmacol_20_55
ESTHER : Pfaffendorf_2000_J.Auton.Pharmacol_20_55
PubMedSearch : Pfaffendorf_2000_J.Auton.Pharmacol_20_55
PubMedID: 11048962

Title : Structure-activity relationships in a series of bisquaternary bisphthalimidine derivatives modulating the muscarinic M(2)-receptor allosterically - Botero Cid_2000_J.Med.Chem_43_2155
Author(s) : Botero Cid HM , Trankle C , Baumann K , Pick R , Mies-Klomfass E , Kostenis E , Mohr K , Holzgrabe U
Ref : Journal of Medicinal Chemistry , 43 :2155 , 2000
Abstract : Botero Cid_2000_J.Med.Chem_43_2155
ESTHER : Botero Cid_2000_J.Med.Chem_43_2155
PubMedSearch : Botero Cid_2000_J.Med.Chem_43_2155
PubMedID: 10841794

Title : Bisquaternary ligands of the common allosteric site of M2 acetylcholine receptors: search for the minimum essential distances between the pharmacophoric elements - Nassif-Makki_1999_J.Med.Chem_42_849
Author(s) : Nassif-Makki T , Trankle C , Zlotos D , Bejeuhr G , Cambareri A , Pfletschinger C , Kostenis E , Mohr K , Holzgrabe U
Ref : Journal of Medicinal Chemistry , 42 :849 , 1999
Abstract : Nassif-Makki_1999_J.Med.Chem_42_849
ESTHER : Nassif-Makki_1999_J.Med.Chem_42_849
PubMedSearch : Nassif-Makki_1999_J.Med.Chem_42_849
PubMedID: 10072682

Title : Poster: Modes of allosteric interactions with muscarinic M2 receptors as deduced from buffer-dependent potency shifts -
Author(s) : Schroter A , Trankle C , Mohr K
Ref : Life Sciences , 64 :560 , 1999
PubMedID:

Title : Poster: Assessment of cooperativity factors by the use of a [3H]ligand for the allosteric site of muscarinic M2 receptors -
Author(s) : Trankle C , Weyand O , Schroter A , Mohr K
Ref : Life Sciences , 64 :559 , 1999
PubMedID:

Title : Using a radioalloster to test predictions of the cooperativity model for gallamine binding to the allosteric site of muscarinic acetylcholine M(2) receptors - Trankle_1999_Mol.Pharmacol_56_962
Author(s) : Trankle C , Weyand O , Schroter A , Mohr K
Ref : Molecular Pharmacology , 56 :962 , 1999
Abstract : Trankle_1999_Mol.Pharmacol_56_962
ESTHER : Trankle_1999_Mol.Pharmacol_56_962
PubMedSearch : Trankle_1999_Mol.Pharmacol_56_962
PubMedID: 10531401

Title : Interaction of Mg2+ with the allosteric site of muscarinic M2 receptors - Burgmer_1998_Naunyn.Schmiedebergs.Arch.Pharmacol_357_363
Author(s) : Burgmer U , Schulz U , Trankle C , Mohr K
Ref : Naunyn Schmiedebergs Arch Pharmacol , 357 :363 , 1998
Abstract : Burgmer_1998_Naunyn.Schmiedebergs.Arch.Pharmacol_357_363
ESTHER : Burgmer_1998_Naunyn.Schmiedebergs.Arch.Pharmacol_357_363
PubMedSearch : Burgmer_1998_Naunyn.Schmiedebergs.Arch.Pharmacol_357_363
PubMedID: 9606020

Title : M2 receptor binding of the selective antagonist AF-DX 384: possible involvement of the common allosteric site - Trankle_1998_Mol.Pharmacol_53_304
Author(s) : Trankle C , Andresen I , Lambrecht G , Mohr K
Ref : Molecular Pharmacology , 53 :304 , 1998
Abstract : Trankle_1998_Mol.Pharmacol_53_304
ESTHER : Trankle_1998_Mol.Pharmacol_53_304
PubMedSearch : Trankle_1998_Mol.Pharmacol_53_304
PubMedID: 9463489

Title : Identification of a [3H]Ligand for the common allosteric site of muscarinic acetylcholine M2 receptors - Trankle_1998_Mol.Pharmacol_54_139
Author(s) : Trankle C , Mies-Klomfass E , Botero Cid HM , Holzgrabe U , Mohr K
Ref : Molecular Pharmacology , 54 :139 , 1998
Abstract : Trankle_1998_Mol.Pharmacol_54_139
ESTHER : Trankle_1998_Mol.Pharmacol_54_139
PubMedSearch : Trankle_1998_Mol.Pharmacol_54_139
PubMedID: 9658199

Title : Poster: Structurally closely related bisquaternary allosteric modulators may bind to different recognition sites on the M2-receptor protein -
Author(s) : Trankle C , Mohr K
Ref : Life Sciences , 60 :1171 , 1997
PubMedID:

Title : Poster: Influence of the lateral substituents of bispyridinium compounds on the mode of allosteric action on muscarinic M2-receptors -
Author(s) : Schulz U , Trankle C , Botero Cid HM , Holzgrabe U , Mohr K
Ref : Life Sciences , 60 :1172 , 1997
PubMedID:

Title : Poster: Influence of allosteric modulators of muscarinic receptors on the dissociation characteristics of radioligands of A1-adenosine-, alpha 1 - and beta-adrenergic receptors -
Author(s) : Pfaffendorf M , Batink HD , Trankle C , Mohr K , van Zwieten PA
Ref : Life Sciences , 60 :1172 , 1997
PubMedID:

Title : Molecular rigidity and potency of bispyridinium type allosteric modulators at muscarinic M2-receptors - Trankle_1997_Life.Sci_60_1995
Author(s) : Trankle C , Elis K , Wiese M , Mohr K
Ref : Life Sciences , 60 :1995 , 1997
Abstract : Trankle_1997_Life.Sci_60_1995
ESTHER : Trankle_1997_Life.Sci_60_1995
PubMedSearch : Trankle_1997_Life.Sci_60_1995
PubMedID: 9180353

Title : Divergent modes of action among cationic allosteric modulators of muscarinic M2 receptors - Trankle_1997_Mol.Pharmacol_51_674
Author(s) : Trankle C , Mohr K
Ref : Molecular Pharmacology , 51 :674 , 1997
Abstract : Trankle_1997_Mol.Pharmacol_51_674
ESTHER : Trankle_1997_Mol.Pharmacol_51_674
PubMedSearch : Trankle_1997_Mol.Pharmacol_51_674
PubMedID: 9106634

Title : Search for lead structures to develop new allosteric modulators of muscarinic receptors - Trankle_1996_J.Pharmacol.Exp.Ther_279_926
Author(s) : Trankle C , Kostenis E , Burgmer U , Mohr K
Ref : Journal of Pharmacology & Experimental Therapeutics , 279 :926 , 1996
Abstract : Trankle_1996_J.Pharmacol.Exp.Ther_279_926
ESTHER : Trankle_1996_J.Pharmacol.Exp.Ther_279_926
PubMedSearch : Trankle_1996_J.Pharmacol.Exp.Ther_279_926
PubMedID: 8930201

Title : Poster: Hexamethonium and obidoxime antagonize the allosteric actions of alcuronium, W84, WDUO3, and gallamine at cardiac M2-receptors -
Author(s) : Trankle C , Mohr K
Ref : Life Sciences , 56(11-12) :1010 , 1995
PubMedID:

Title : Allosteric effects of the alkane-bis-ammonium compound W84 and of tacrine on [3H]pirenzepine binding at M1-receptors in rat cerebral cortex - Mohr_1994_Pharmacol.Toxicol_75_391
Author(s) : Mohr K , Trankle C
Ref : Pharmacol Toxicol , 75 :391 , 1994
Abstract : Mohr_1994_Pharmacol.Toxicol_75_391
ESTHER : Mohr_1994_Pharmacol.Toxicol_75_391
PubMedSearch : Mohr_1994_Pharmacol.Toxicol_75_391
PubMedID: 7899262

Title : Search for the pharmacophore of bispyridinium-type allosteric modulators of muscarinic receptors - Botero Cid_1994_J.Med.Chem_37_1439
Author(s) : Botero Cid HM , Holzgrabe U , Kostenis E , Mohr K , Trankle C
Ref : Journal of Medicinal Chemistry , 37 :1439 , 1994
Abstract : Botero Cid_1994_J.Med.Chem_37_1439
ESTHER : Botero Cid_1994_J.Med.Chem_37_1439
PubMedSearch : Botero Cid_1994_J.Med.Chem_37_1439
PubMedID: 8182702

Title : Poster: On the over-additive antimuscarinic action with atropine of potent allosteric stabilizers of antagonist binding to M2-receptors -
Author(s) : Mohr K , Holzgrabe U , Luss H , Trankle C
Ref : Life Sciences , 52(5-6) :564 , 1993
PubMedID: