Author

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Author Report for: Tobin AB

Contact information:

Tobin Andrew B
University of Glasgow, Davidson Building,G12 8QQ Glasgow - Univ of Leicester, Dept Cell Physiology & Pharmacology, Medical Sciences Building, University Rd, Leicester LE1 9HN
United Kingdom
Phone :
Fax :
Send E-Mail to Tobin Andrew B
Visit the web site of Tobin AB at : http://www2.le.ac.uk/departments/molcellbiol/staff/andrew-tobin





    Title: From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease
    Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C and Tobin AB <38 more author(s)>
    Ref: Cell, 184:5886, 2021 : PubMed

            

    Title: Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs
    Bradley SJ, Molloy C, Valuskova P, Dwomoh L, Scarpa M, Rossi M, Finlayson L, Svensson KA, Chernet E and Tobin AB <12 more author(s)>
    Ref: Nat Chemical Biology, 16:240, 2020 : PubMed

            

    Title: M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss
    Bradley SJ, Bourgognon JM, Sanger HE, Verity N, Mogg AJ, White DJ, Butcher AJ, Moreno JA, Molloy C and Tobin AB <11 more author(s)>
    Ref: J Clinical Investigation, 127:487, 2017 : PubMed

            

    Title: Identification of phosphorylation sites in the COOH-terminal tail of the mu-opioid receptor
    Chen YJ, Oldfield S, Butcher AJ, Tobin AB, Saxena K, Gurevich VV, Benovic JL, Henderson G, Kelly E
    Ref: Journal of Neurochemistry, 124:189, 2013 : PubMed

            

    Title: Experimental tools for the study of protein phosphorylation in Plasmodium
    Dorin-Semblat D, Bottrill AR, Solyakov L, Tobin AB, Doerig C
    Ref: Methods Mol Biol, 923:241, 2013 : PubMed

            

    Title: The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism
    Hudson BD, Shimpukade B, Mackenzie AE, Butcher AJ, Pediani JD, Christiansen E, Heathcote H, Tobin AB, Ulven T, Milligan G
    Ref: Molecular Pharmacology, 84:710, 2013 : PubMed

            

    Title: ERK5 Activation by Gq-Coupled Muscarinic Receptors Is Independent of Receptor Internalization and beta-Arrestin Recruitment
    Sanchez-Fernandez G, Cabezudo S, Garcia-Hoz C, Tobin AB, Mayor F, Jr., Ribas C
    Ref: PLoS ONE, 8:e84174, 2013 : PubMed

            

    Title: Physiological role of G-protein coupled receptor phosphorylation
    Butcher AJ, Kong KC, Prihandoko R, Tobin AB
    Ref: Handbook of Experimental Pharmacology, :79, 2012 : PubMed

            

    Title: Stimulus bias provides evidence for conformational constraints in the structure of a G protein-coupled receptor
    Gregory KJ, Sexton PM, Tobin AB, Christopoulos A
    Ref: Journal of Biological Chemistry, 287:37066, 2012 : PubMed

            

    Title: A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development
    Guttery DS, Ferguson DJ, Poulin B, Xu Z, Straschil U, Klop O, Solyakov L, Sandrini SM, Brady D and Tewari R <4 more author(s)>
    Ref: PLoS Pathog, 8:e1002554, 2012 : PubMed

            

    Title: A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion
    Guttery DS, Poulin B, Ferguson DJ, Szoor B, Wickstead B, Carroll PL, Ramakrishnan C, Brady D, Patzewitz EM and Tewari R <6 more author(s)>
    Ref: PLoS Pathog, 8:e1002948, 2012 : PubMed

            

    Title: Spatiotemporal and functional characterisation of the Plasmodium falciparum cGMP-dependent protein kinase
    Hopp CS, Flueck C, Solyakov L, Tobin AB, Baker DA
    Ref: PLoS ONE, 7:e48206, 2012 : PubMed

            

    Title: Insights into the Plasmodium falciparum schizont phospho-proteome
    Lasonder E, Treeck M, Alam M, Tobin AB
    Ref: Microbes Infect, 14:811, 2012 : PubMed

            

    Title: Plasmodium kinases as targets for new-generation antimalarials
    Lucet IS, Tobin AB, Drewry D, Wilks AF, Doerig C
    Ref: Future Med Chem, 4:2295, 2012 : PubMed

            

    Title: Influence of the accessory protein SET on M3 muscarinic receptor phosphorylation and G protein coupling
    Simon V, Oner SS, Cohen-Tannoudji J, Tobin AB, Lanier SM
    Ref: Molecular Pharmacology, 82:17, 2012 : PubMed

            

    Title: An evolutionary perspective on the kinome of malaria parasites
    Talevich E, Tobin AB, Kannan N, Doerig C
    Ref: Philos Trans R Soc Lond B Biol Sci, 367:2607, 2012 : PubMed

            

    Title: Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL)
    Alvarez-Curto E, Prihandoko R, Tautermann CS, Zwier JM, Pediani JD, Lohse MJ, Hoffmann C, Tobin AB, Milligan G
    Ref: Molecular Pharmacology, 80:1033, 2011 : PubMed

            

    Title: Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code
    Butcher AJ, Prihandoko R, Kong KC, McWilliams P, Edwards JM, Bottrill A, Mistry S, Tobin AB
    Ref: Journal of Biological Chemistry, 286:11506, 2011 : PubMed

            

    Title: Examining site-specific GPCR phosphorylation
    Butcher AJ, Tobin AB, Kong KC
    Ref: Methods Mol Biol, 746:237, 2011 : PubMed

            

    Title: The role of M(3)-muscarinic receptor signaling in insulin secretion
    Kong KC, Tobin AB
    Ref: Commun Integr Biol, 4:489, 2011 : PubMed

            

    Title: Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum
    Solyakov L, Halbert J, Alam MM, Semblat JP, Dorin-Semblat D, Reininger L, Bottrill AR, Mistry S, Abdi A and Doerig C <15 more author(s)>
    Ref: Nat Commun, 2:565, 2011 : PubMed

            

    Title: Parasite protein kinases: at home and abroad
    Doerig C, Tobin AB
    Ref: Cell Host Microbe, 8:305, 2010 : PubMed

            

    Title: Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias
    Gregory KJ, Hall NE, Tobin AB, Sexton PM, Christopoulos A
    Ref: Journal of Biological Chemistry, 285:7459, 2010 : PubMed

            

    Title: M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1
    Kong KC, Butcher AJ, McWilliams P, Jones D, Wess J, Hamdan FF, Werry T, Rosethorne EM, Charlton SJ and Tobin AB <3 more author(s)>
    Ref: Proc Natl Acad Sci U S A, 107:21181, 2010 : PubMed

            

    Title: The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner
    Poulin B, Butcher A, McWilliams P, Bourgognon JM, Pawlak R, Kong KC, Bottrill A, Mistry S, Wess J and Tobin AB <2 more author(s)>
    Ref: Proc Natl Acad Sci U S A, 107:9440, 2010 : PubMed

            

    Title: N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons
    Butcher AJ, Torrecilla I, Young KW, Kong KC, Mistry SC, Bottrill AR, Tobin AB
    Ref: Journal of Biological Chemistry, 284:17147, 2009 : PubMed

            

    Title: Full and partial agonists of muscarinic M3 receptors reveal single and oscillatory Ca2+ responses by beta 2-adrenoceptors
    Kurian N, Hall CJ, Wilkinson GF, Sullivan M, Tobin AB, Willars GB
    Ref: Journal of Pharmacology & Experimental Therapeutics, 330:502, 2009 : PubMed

            

    Title: Regulation of p53 expression, phosphorylation and subcellular localization by a G-protein-coupled receptor
    Solyakov L, Sayan E, Riley J, Pointon A, Tobin AB
    Ref: Oncogene, 28:3619, 2009 : PubMed

            

    Title: G-protein-coupled receptor structure: what can we learn?
    Tobin AB
    Ref: F1000 Biol Rep, 1:11, 2009 : PubMed

            

    Title: Protein kinases of malaria parasites: an update
    Doerig C, Billker O, Haystead T, Sharma P, Tobin AB, Waters NC
    Ref: Trends Parasitol, 24:570, 2008 : PubMed

            

    Title: G-protein-coupled receptor phosphorylation: where, when and by whom
    Tobin AB
    Ref: British Journal of Pharmacology, 153 Suppl 1:S167, 2008 : PubMed

            

    Title: Location, location, location...site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling
    Tobin AB, Butcher AJ, Kong KC
    Ref: Trends in Pharmacological Sciences, 29:413, 2008 : PubMed

            

    Title: Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits
    Cockerill SL, Tobin AB, Torrecilla I, Willars GB, Standen NB, Mitcheson JS
    Ref: Journal of Physiology, 581:479, 2007 : PubMed

            

    Title: Phosphorylation and regulation of a G protein-coupled receptor by protein kinase CK2
    Torrecilla I, Spragg EJ, Poulin B, McWilliams PJ, Mistry SC, Blaukat A, Tobin AB
    Ref: Journal of Cell Biology, 177:127, 2007 : PubMed

            

    Title: Transient hypoxia induces sequestration of M1 and M2 muscarinic acetylcholine receptors
    Mou L, Gates A, Mosser VA, Tobin AB, Jackson DA
    Ref: Journal of Neurochemistry, 96:510, 2006 : PubMed

            

    Title: The proto-oncogene SET interacts with muscarinic receptors and attenuates receptor signaling
    Simon V, Guidry J, Gettys TW, Tobin AB, Lanier SM
    Ref: Journal of Biological Chemistry, 281:40310, 2006 : PubMed

            

    Title: Co-ordinated covalent modification of G-protein coupled receptors
    Torrecilla I, Tobin AB
    Ref: Curr Pharm Des, 12:1797, 2006 : PubMed

            

    Title: Antimuscarinic antibodies in Sjogren's syndrome: where are we, and where are we going?
    Dawson L, Tobin AB, Smith P, Gordon T
    Ref: Arthritis Rheum, 52:2984, 2005 : PubMed

            

    Title: Signalling of the M3-muscarinic receptor to the anti-apoptotic pathway
    Budd DC, Spragg EJ, Ridd K, Tobin AB
    Ref: Biochemical Journal, 381:43, 2004 : PubMed

            

    Title: Regulation of casein kinase-2 (CK2) activity by inositol phosphates
    Solyakov L, Cain K, Tracey BM, Jukes R, Riley AM, Potter BV, Tobin AB
    Ref: Journal of Biological Chemistry, 279:43403, 2004 : PubMed

            

    Title: G-protein-coupled receptor phosphorylation and palmitoylation
    Tobin AB, Wheatley M
    Ref: Methods Mol Biol, 259:275, 2004 : PubMed

            

    Title: G-protein-coupled receptor regulation of P2X1 receptors does not involve direct channel phosphorylation
    Vial C, Tobin AB, Evans RJ
    Ref: Biochemical Journal, 382:101, 2004 : PubMed

            

    Title: The C-terminal tail of the M3-muscarinic receptor possesses anti-apoptotic properties
    Budd DC, McDonald J, Emsley N, Cain K, Tobin AB
    Ref: Journal of Biological Chemistry, 278:19565, 2003 : PubMed

            

    Title: The anti-apoptotic response of the Gq/11-coupled muscarinic receptor family
    Tobin AB, Budd DC
    Ref: Biochemical Society Transactions, 31:1182, 2003 : PubMed

            

    Title: Are we beta-ARKing up the wrong tree? Casein kinase 1 alpha provides an additional pathway for GPCR phosphorylation
    Tobin AB
    Ref: Trends in Pharmacological Sciences, 23:337, 2002 : PubMed

            

    Title: Phosphorylation of the Gq/11-coupled m3-muscarinic receptor is involved in receptor activation of the ERK-1/2 mitogen-activated protein kinase pathway
    Budd DC, Willars GB, McDonald JE, Tobin AB
    Ref: Journal of Biological Chemistry, 276:4581, 2001 : PubMed

            

    Title: Palmitoylation of the vasopressin V1a receptor reveals different conformational requirements for signaling, agonist-induced receptor phosphorylation, and sequestration
    Hawtin SR, Tobin AB, Patel S, Wheatley M
    Ref: Journal of Biological Chemistry, 276:38139, 2001 : PubMed

            

    Title: Phosphorylation of a synaptic vesicle-associated protein by an inositol hexakisphosphate-regulated protein kinase
    Hilton JM, Plomann M, Ritter B, Modregger J, Freeman HN, Falck JR, Krishna UM, Tobin AB
    Ref: Journal of Biological Chemistry, 276:16341, 2001 : PubMed

            

    Title: Phosphorylation and regulation of a Gq/11-coupled receptor by casein kinase 1alpha
    Budd DC, McDonald JE, Tobin AB
    Ref: Journal of Biological Chemistry, 275:19667, 2000 : PubMed

            

    Title: Cross talk between m3-muscarinic and beta(2)-adrenergic receptors at the level of receptor phosphorylation and desensitization
    Budd DC, Challiss RA, Young KW, Tobin AB
    Ref: Molecular Pharmacology, 56:813, 1999 : PubMed

            

    Title: Activation of the mitogen-activated protein kinase pathway by a Gq/11-coupled muscarinic receptor is independent of receptor internalization
    Budd DC, Rae A, Tobin AB
    Ref: Journal of Biological Chemistry, 274:12355, 1999 : PubMed

            

    Title: Differential regulation of muscarinic M1 and M3 receptors by a putative phosphorylation domain
    Shockley MS, Tolbert LM, Tobin AB, Nahorski SR, Sadee W, Lameh J
    Ref: European Journal of Pharmacology, 377:137, 1999 : PubMed

            

    Title: Agonist-induced desensitization and phosphorylation of m1-muscarinic receptors
    Waugh MG, Challiss RA, Berstein G, Nahorski SR, Tobin AB
    Ref: Biochemical Journal, 338 ( Pt 1):175, 1999 : PubMed

            

    Title: Receptor-mediated endocytosis of albumin by kidney proximal tubule cells is regulated by phosphatidylinositide 3-kinase
    Brunskill NJ, Stuart J, Tobin AB, Walls J, Nahorski SR
    Ref: J Clinical Investigation, 101:2140, 1998 : PubMed

            

    Title: Muscarinic M3 receptor coupling and regulation
    Nahorski SR, Tobin AB, Willars GB
    Ref: Life Sciences, 60:1039, 1997 : PubMed

            

    Title: Phosphorylation of phospholipase C-coupled receptors
    Tobin AB
    Ref: Pharmacol Ther, 75:135, 1997 : PubMed

            

    Title: Protocols employed in the investigation of G protein-coupled receptor phosphorylation
    Tobin AB
    Ref: Methods Mol Biol, 83:227, 1997 : PubMed

            

    Title: Stimulus-dependent phosphorylation of G-protein-coupled receptors by casein kinase 1alpha
    Tobin AB, Totty NF, Sterlin AE, Nahorski SR
    Ref: Journal of Biological Chemistry, 272:20844, 1997 : PubMed

            

    Title: Poster: Characterisation of the muscarinic receptor kinase MRK
    Tobin AB, Nahorski SR
    Ref: Life Sciences, 60:1186, 1997 : PubMed

            

    Title: Identification of a novel receptor kinase that phosphorylates a phospholipase C-linked muscarinic receptor
    Tobin AB, Keys B, Nahorski SR
    Ref: Journal of Biological Chemistry, 271:3907, 1996 : PubMed

            

    Title: Coupling of muscarinic m1, m2 and m3 acetylcholine receptors, expressed in Chinese hamster ovary cells, to pertussis toxin-sensitive/insensitive guanine nucleotide-binding proteins
    Burford NT, Tobin AB, Nahorski SR
    Ref: European Journal of Pharmacology, 289:343, 1995 : PubMed

            

    Title: Differential coupling of m1, m2 and m3 muscarinic receptor subtypes to inositol 1,4,5-trisphosphate and adenosine 3',5'-cyclic monophosphate accumulation in Chinese hamster ovary cells
    Burford NT, Tobin AB, Nahorski SR
    Ref: Journal of Pharmacology & Experimental Therapeutics, 274:134, 1995 : PubMed

            

    Title: Relationship between agonist binding, phosphorylation and immunoprecipitation of the m3-muscarinic receptor, and second messenger responses
    Tobin AB, Willars GB, Burford NT, Nahorski SR
    Ref: British Journal of Pharmacology, 116:1723, 1995 : PubMed

            

    Title: Poster: Isolation of two novel g-protein-linked receptor kinases, MRK-1 and MRK-2 that phosphorylate the m3-muscarinic receptor
    Tobin AB, Nahorski SR
    Ref: Life Sciences, 56(11-12):1029, 1995 : PubMed

            

    Title: Poster: Agonist induced phosphorylation of M1 muscarinic receptors
    Waugh MG, Nahorski SR, Tobin AB
    Ref: Life Sciences, 56(11-12):1026, 1995 : PubMed

            

    Title: Muscarinic receptor-mediated inositol 1,4,5-trisphosphate formation in SH-SY5Y neuroblastoma cells is regulated acutely by cytosolic Ca2+ and by rapid desensitization
    Wojcikiewicz RJ, Tobin AB, Nahorski SR
    Ref: Journal of Neurochemistry, 63:177, 1994 : PubMed

            

    Title: Rapid agonist-mediated phosphorylation of m3-muscarinic receptors revealed by immunoprecipitation
    Tobin AB, Nahorski SR
    Ref: Journal of Biological Chemistry, 268:9817, 1993 : PubMed

            

    Title: Phosphorylation of a phosphoinositidase C-linked muscarinic receptor by a novel kinase distinct from beta-adrenergic receptor kinase
    Tobin AB, Keys B, Nahorski SR
    Ref: FEBS Letters, 335:353, 1993 : PubMed

            

    Title: Poster: m3-muscarinic receptor specific antisera for use in studies of muscarinic receptor desensitisation
    Tobin AB, Nahorski SR
    Ref: Life Sciences, 52(5-6):585, 1993 : PubMed

            

    Title: Desensitization of cell signalling mediated by phosphoinositidase C
    Wojcikiewicz RJ, Tobin AB, Nahorski SR
    Ref: Trends in Pharmacological Sciences, 14:279, 1993 : PubMed

            

    Title: Rapid desensitization of muscarinic m3 receptor-stimulated polyphosphoinositide responses
    Tobin AB, Lambert DG, Nahorski SR
    Ref: Molecular Pharmacology, 42:1042, 1992 : PubMed

            

    Title: Evidence for the presence of serotonin receptors negatively coupled to adenylate cyclase in the rabbit iris-ciliary body
    Tobin AB, Osborne NN
    Ref: Journal of Neurochemistry, 53:686, 1989 : PubMed

            

    Title: Role of inositol trisphosphate as a second messenger in signal transduction processes: an essay
    Osborne NN, Tobin AB, Ghazi H
    Ref: Neurochem Res, 13:177, 1988 : PubMed

            

    Title: Evidence for the presence of cholinergic muscarinic receptors negatively linked to adenylate cyclase in the iris-ciliary body
    Tobin AB, Osborne NN
    Ref: Neurochem Int, 13:517, 1988 : PubMed

            

    Title: Evidence for the presence of serotonergic nerves and receptors in the iris-ciliary body complex of the rabbit
    Tobin AB, Unger W, Osborne NN
    Ref: Journal of Neuroscience, 8:3713, 1988 : PubMed

            

    Title: Serotonin-accumulating cells in the iris-ciliary body and cornea of various species
    Osborne NN, Tobin AB
    Ref: Experimental Eye Research, 44:731, 1987 : PubMed

            


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer