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| Title : 4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H(3) Receptors and Cholinesterases - Michalska_2024_ACS.Chem.Neurosci__ |
| Author(s) : Michalska B , Dziegielewski M , Godyn J , Werner T , Bajda M , Karcz T , Szczepanska K , Stark H , Wieckowska A , Walczynski K , Staszewski M |
| Ref : ACS Chem Neurosci , : , 2024 |
| Abstract : Michalska_2024_ACS.Chem.Neurosci__ |
| ESTHER : Michalska_2024_ACS.Chem.Neurosci__ |
| PubMedSearch : Michalska_2024_ACS.Chem.Neurosci__ |
| PubMedID: 38440987 |
| Title : Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer's disease - Hafez_2023_J.Enzyme.Inhib.Med.Chem_38_2175821 |
| Author(s) : Hafez DE , Dubiel M , La Spada G , Catto M , Reiner-Link D , Syu YT , Abdel-Halim M , Hwang TL , Stark H , Abadi AH |
| Ref : J Enzyme Inhib Med Chem , 38 :2175821 , 2023 |
| Abstract : Hafez_2023_J.Enzyme.Inhib.Med.Chem_38_2175821 |
| ESTHER : Hafez_2023_J.Enzyme.Inhib.Med.Chem_38_2175821 |
| PubMedSearch : Hafez_2023_J.Enzyme.Inhib.Med.Chem_38_2175821 |
| PubMedID: 36789662 |
| Title : Guanidines: Synthesis of Novel Histamine H(3)R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect - Staszewski_2023_Pharmaceuticals.(Basel)_16_ |
| Author(s) : Staszewski M , Iwan M , Werner T , Bajda M , Godyn J , Latacz G , Korga-Plewko A , Kubik J , Szalaj N , Stark H , Malawska B , Wieckowska A , Walczynski K |
| Ref : Pharmaceuticals (Basel) , 16 : , 2023 |
| Abstract : Staszewski_2023_Pharmaceuticals.(Basel)_16_ |
| ESTHER : Staszewski_2023_Pharmaceuticals.(Basel)_16_ |
| PubMedSearch : Staszewski_2023_Pharmaceuticals.(Basel)_16_ |
| PubMedID: 37242458 |
| Title : Multitargeting Histamine H(3) Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives - Lazewska_2023_Molecules_28_ |
| Author(s) : Lazewska D , Kaleta M , Zareba P , Godyn J , Dubiel M , Honkisz-Orzechowska E , Doroz-Plonka A , Wieckowska A , Stark H , Kiec-Kononowicz K |
| Ref : Molecules , 28 : , 2023 |
| Abstract : Lazewska_2023_Molecules_28_ |
| ESTHER : Lazewska_2023_Molecules_28_ |
| PubMedSearch : Lazewska_2023_Molecules_28_ |
| PubMedID: 36903593 |
| Title : Evaluation of chromane derivatives: Promising privileged scaffolds for lead discovery within Alzheimer's disease - Moutayakine_2022_Bioorg.Med.Chem_68_116807 |
| Author(s) : Moutayakine A , Marques C , Lopez O , Bagetta D , Leitzbach L , Hagenow S , Carreiro EP , Stark H , Alcaro S , Fernandez-Bolanos JG , Burke AJ |
| Ref : Bioorganic & Medicinal Chemistry , 68 :116807 , 2022 |
| Abstract : Moutayakine_2022_Bioorg.Med.Chem_68_116807 |
| ESTHER : Moutayakine_2022_Bioorg.Med.Chem_68_116807 |
| PubMedSearch : Moutayakine_2022_Bioorg.Med.Chem_68_116807 |
| PubMedID: 35653868 |
| Title : Multitargeting approaches to cognitive impairment: Synthesis of aryl-alkylpiperazines and assessment at cholinesterases, histamine H(3) and dopamine D(3) receptors - Aranha_2022_Bioorg.Med.Chem_78_117132 |
| Author(s) : Aranha C , Reiner-Link D , Leitzbach LR , Lopes FB , Stark H , Fernandes JPS |
| Ref : Bioorganic & Medicinal Chemistry , 78 :117132 , 2022 |
| Abstract : Aranha_2022_Bioorg.Med.Chem_78_117132 |
| ESTHER : Aranha_2022_Bioorg.Med.Chem_78_117132 |
| PubMedSearch : Aranha_2022_Bioorg.Med.Chem_78_117132 |
| PubMedID: 36542960 |
| Title : Benzophenone Derivatives with Histamine H(3) Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease - Godyn_2022_Molecules_28_ |
| Author(s) : Godyn J , Zareba P , Stary D , Kaleta M , Kuder KJ , Latacz G , Mogilski S , Reiner-Link D , Frank A , Doroz-Plonka A , Olejarz-Maciej A , Sudol-Talaj S , Nolte T , Handzlik J , Stark H , Wieckowska A , Malawska B , Kiec-Kononowicz K , Lazewska D , Bajda M |
| Ref : Molecules , 28 : , 2022 |
| Abstract : Godyn_2022_Molecules_28_ |
| ESTHER : Godyn_2022_Molecules_28_ |
| PubMedSearch : Godyn_2022_Molecules_28_ |
| PubMedID: 36615435 |
| Title : Fatty Acid Synthase: Structure, Function, and Regulation - Gunenc_2022_Subcell.Biochem_99_1 |
| Author(s) : Gunenc AN , Graf B , Stark H , Chari A |
| Ref : Subcell Biochem , 99 :1 , 2022 |
| Abstract : Gunenc_2022_Subcell.Biochem_99_1 |
| ESTHER : Gunenc_2022_Subcell.Biochem_99_1 |
| PubMedSearch : Gunenc_2022_Subcell.Biochem_99_1 |
| PubMedID: 36151372 |
| Title : Repurposing of 8-Hydroxyquinoline-based Butyrylcholinesterase and Cathepsin B Ligands as Potent Non-peptidic Deoxyribonuclease I Inhibitors - Gajic_2022_ChemMedChem__ |
| Author(s) : Gajic M , Knez D , Sosic I , Mravljak J , Meden A , Kosak U , Leitzbach L , George S , Hofmann B , Zivkovic A , Steinhilber D , Stark H , Gobec S , Smelcerovic A , Anderluh M |
| Ref : ChemMedChem , : , 2022 |
| Abstract : Gajic_2022_ChemMedChem__ |
| ESTHER : Gajic_2022_ChemMedChem__ |
| PubMedSearch : Gajic_2022_ChemMedChem__ |
| PubMedID: 34994078 |
| Title : Biphenylalkoxyamine Derivatives-Histamine H(3) Receptor Ligands with Butyrylcholinesterase Inhibitory Activity - Lazewska_2021_Molecules_26_ |
| Author(s) : Lazewska D , Zareba P , Godyn J , Doroz-Plonka A , Frank A , Reiner-Link D , Bajda M , Stary D , Mogilski S , Olejarz-Maciej A , Kaleta M , Stark H , Malawska B , Kiec-Kononowicz K |
| Ref : Molecules , 26 : , 2021 |
| Abstract : Lazewska_2021_Molecules_26_ |
| ESTHER : Lazewska_2021_Molecules_26_ |
| PubMedSearch : Lazewska_2021_Molecules_26_ |
| PubMedID: 34208297 |
| Title : Ugi Reaction Synthesis of Oxindole-Lactam Hybrids as Selective Butyrylcholinesterase Inhibitors - Brandao_2021_ACS.Med.Chem.Lett_12_1718 |
| Author(s) : Brandao P , Lopez O , Leitzbach L , Stark H , Fernandez-Bolanos JG , Burke AJ , Pineiro M |
| Ref : ACS Med Chem Lett , 12 :1718 , 2021 |
| Abstract : Brandao_2021_ACS.Med.Chem.Lett_12_1718 |
| ESTHER : Brandao_2021_ACS.Med.Chem.Lett_12_1718 |
| PubMedSearch : Brandao_2021_ACS.Med.Chem.Lett_12_1718 |
| PubMedID: 34795859 |
| Title : Cyanobiphenyls: Novel H(3) receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer's disease - Godyn_2021_Bioorg.Chem_114_105129 |
| Author(s) : Godyn J , Zareba P , aewska D , Stary D , Reiner-Link D , Frank A , Latacz G , Mogilski S , Kaleta M , Doroz-Plonka A , Lubelska A , Honkisz-Orzechowska E , Olejarz-Maciej A , Handzlik J , Stark H , Kiec-Kononowicz K , Malawska B , Bajda M |
| Ref : Bioorg Chem , 114 :105129 , 2021 |
| Abstract : Godyn_2021_Bioorg.Chem_114_105129 |
| ESTHER : Godyn_2021_Bioorg.Chem_114_105129 |
| PubMedSearch : Godyn_2021_Bioorg.Chem_114_105129 |
| PubMedID: 34217977 |
| Title : Simultaneous Blockade of Histamine H(3) Receptors and Inhibition of Acetylcholine Esterase Alleviate Autistic-Like Behaviors in BTBR T+ tf\/J Mouse Model of Autism - Eissa_2020_Biomolecules_10_ |
| Author(s) : Eissa N , Jayaprakash P , Stark H , Lazewska D , Kiec-Kononowicz K , Sadek B |
| Ref : Biomolecules , 10 : , 2020 |
| Abstract : Eissa_2020_Biomolecules_10_ |
| ESTHER : Eissa_2020_Biomolecules_10_ |
| PubMedSearch : Eissa_2020_Biomolecules_10_ |
| PubMedID: 32872194 |
| Title : The Dual-Active Histamine H3 Receptor Antagonist and Acetylcholine Esterase Inhibitor E100 Alleviates Autistic-Like Behaviors and Oxidative Stress in Valproic Acid Induced Autism in Mice - Eissa_2020_Int.J.Mol.Sci_21_ |
| Author(s) : Eissa N , Azimullah S , Jayaprakash P , Jayaraj RL , Reiner D , Ojha SK , Beiram R , Stark H , Lazewska D , Kiec-Kononowicz K , Sadek B |
| Ref : Int J Mol Sci , 21 : , 2020 |
| Abstract : Eissa_2020_Int.J.Mol.Sci_21_ |
| ESTHER : Eissa_2020_Int.J.Mol.Sci_21_ |
| PubMedSearch : Eissa_2020_Int.J.Mol.Sci_21_ |
| PubMedID: 32503208 |
| Title : In silico and in vitro studies of two non-imidazole multiple targeting agents at histamine H3 receptors and cholinesterase enzymes - Ghamari_2020_Chem.Biol.Drug.Des_95_279 |
| Author(s) : Ghamari N , Dastmalchi S , Zarei O , Arias-Montano JA , Reiner D , Ustun-Alkan F , Stark H , Hamzeh-Mivehroud M |
| Ref : Chemical Biology Drug Des , 95 :279 , 2020 |
| Abstract : Ghamari_2020_Chem.Biol.Drug.Des_95_279 |
| ESTHER : Ghamari_2020_Chem.Biol.Drug.Des_95_279 |
| PubMedSearch : Ghamari_2020_Chem.Biol.Drug.Des_95_279 |
| PubMedID: 31661597 |
| Title : Isoquinoline alkaloids from the roots of Zanthoxylum rigidum as multi-target inhibitors of cholinesterase, monoamine oxidase A and Abeta1-42 aggregation - Gonzalez_2020_Bioorg.Chem_98_103722 |
| Author(s) : Gonzalez EP , Hagenow S , Murillo MA , Stark H , Suarez LC |
| Ref : Bioorg Chem , 98 :103722 , 2020 |
| Abstract : Gonzalez_2020_Bioorg.Chem_98_103722 |
| ESTHER : Gonzalez_2020_Bioorg.Chem_98_103722 |
| PubMedSearch : Gonzalez_2020_Bioorg.Chem_98_103722 |
| PubMedID: 32155491 |
| Title : The dual-active histamine H3 receptor antagonist and acetylcholine esterase inhibitor E100 ameliorates stereotyped repetitive behavior and neuroinflammation in sodium valproate induced autism in mice - Eissa_2019_Chem.Biol.Interact__108775 |
| Author(s) : Eissa N , Azimullah S , Jayaprakash P , Jayaraj RL , Reiner D , Ojha SK , Beiram R , Stark H , Lazewska D , Kiec-Kononowicz K , Sadek B |
| Ref : Chemico-Biological Interactions , :108775 , 2019 |
| Abstract : Eissa_2019_Chem.Biol.Interact__108775 |
| ESTHER : Eissa_2019_Chem.Biol.Interact__108775 |
| PubMedSearch : Eissa_2019_Chem.Biol.Interact__108775 |
| PubMedID: 31369746 |
| Title : Search for new multi-target compounds against Alzheimer's disease among histamine H3 receptor ligands - Bajda_2019_Eur.J.Med.Chem_185_111785 |
| Author(s) : Bajda M , Lazewska D , Godyn J , Zareba P , Kuder K , Hagenow S , Latka K , Stawarska E , Stark H , Kiec-Kononowicz K , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 185 :111785 , 2019 |
| Abstract : Bajda_2019_Eur.J.Med.Chem_185_111785 |
| ESTHER : Bajda_2019_Eur.J.Med.Chem_185_111785 |
| PubMedSearch : Bajda_2019_Eur.J.Med.Chem_185_111785 |
| PubMedID: 31669851 |
| Title : Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases - Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| Author(s) : Bautista-Aguilera OM , Hagenow S , Palomino-Antolin A , Farre-Alins V , Ismaili L , Joffrin PL , Jimeno ML , Soukup O , Janockova J , Kalinowsky L , Proschak E , Iriepa I , Moraleda I , Schwed JS , Romero Martinez A , Lopez-Munoz F , Chioua M , Egea J , Ramsay RR , Marco-Contelles J , Stark H |
| Ref : Angew Chem Int Ed Engl , 56 :12765 , 2017 |
| Abstract : Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| ESTHER : Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| PubMedSearch : Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| PubMedID: 28861918 |
| Title : Predicting targets of compounds against neurological diseases using cheminformatic methodology - Nikolic_2015_J.Comput.Aided.Mol.Des_29_183 |
| Author(s) : Nikolic K , Mavridis L , Bautista-Aguilera OM , Marco-Contelles J , Stark H , do Carmo Carreiras M , Rossi I , Massarelli P , Agbaba D , Ramsay RR , Mitchell JB |
| Ref : J Comput Aided Mol Des , 29 :183 , 2015 |
| Abstract : Nikolic_2015_J.Comput.Aided.Mol.Des_29_183 |
| ESTHER : Nikolic_2015_J.Comput.Aided.Mol.Des_29_183 |
| PubMedSearch : Nikolic_2015_J.Comput.Aided.Mol.Des_29_183 |
| PubMedID: 25425329 |
| Title : Exploring the chemical space of multitarget ligands using aligned self-organizing maps - Achenbach_2013_ACS.Med.Chem.Lett_4_1169 |
| Author(s) : Achenbach J , Klingler FM , Blocher R , Moser D , Hafner AK , Rodl CB , Kretschmer S , Kruger B , Lohr F , Stark H , Hofmann B , Steinhilber D , Proschak E |
| Ref : ACS Med Chem Lett , 4 :1169 , 2013 |
| Abstract : Achenbach_2013_ACS.Med.Chem.Lett_4_1169 |
| ESTHER : Achenbach_2013_ACS.Med.Chem.Lett_4_1169 |
| PubMedSearch : Achenbach_2013_ACS.Med.Chem.Lett_4_1169 |
| PubMedID: 24900624 |
| Title : Multiple enzyme inhibitions by histamine H3 receptor antagonists as potential procognitive agents - Petroianu_2006_Pharmazie_61_179 |
| Author(s) : Petroianu GA , Arafat K , Sasse BC , Stark H |
| Ref : Pharmazie , 61 :179 , 2006 |
| Abstract : Petroianu_2006_Pharmazie_61_179 |
| ESTHER : Petroianu_2006_Pharmazie_61_179 |
| PubMedSearch : Petroianu_2006_Pharmazie_61_179 |
| PubMedID: 16599255 |