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Author Report for: Soukup O

Contact information:

Soukup Ondrej
Department of Toxicology; Faculty of Military Health Science; University of Defense; Trebesska 1575; 500 01 Hradec Kralove
Czech Republic
Phone : +420603351801
Fax :
Send E-Mail to Soukup Ondrej





    Title: Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition
    Misiachna A, Svobodova B, Netolicky J, Chvojkova M, Kleteckova L, Prchal L, Novak M, Hrabinova M, Kucera T and Soukup O <14 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 266:116130, 2024 : PubMed

            

    Title: Sustainable ionic liquids-based molecular platforms for designing acetylcholinesterase reactivators
    Kapitanov IV, Spulak M, Pour M, Soukup O, Marek J, Jun D, Novak M, Diz de Almeida JSF, Costa Franca TC and Karpichev Y <2 more author(s)>
    Ref: Chemico-Biological Interactions, :110735, 2023 : PubMed

            

    Title: UHPLC-Orbitrap study of the first phase tacrine in vitro metabolites and related Alzheimer's drug candidates using human liver microsomes
    Novak M, Svobodova B, Konecny J, Kuratkova A, Nevosadova L, Prchal L, Korabecny J, Lauschke VM, Soukup O, Kucera R
    Ref: J Pharm Biomed Anal, 224:115154, 2023 : PubMed

            

    Title: Tacrine First-Phase Biotransformation and Associated Hepatotoxicity: A Possible Way to Avoid Quinone Methide Formation
    Novak M, Vajrychova M, Koutsilieri S, Sismanoglou DC, Kobrlova T, Prchal L, Svobodova B, Korabecny J, Zarybnicky T and Soukup O <4 more author(s)>
    Ref: ACS Chemical Biology, 18:1993, 2023 : PubMed

            

    Title: A-agents, misleadingly known as Novichoks: a narrative review
    Opravil J, Pejchal J, Finger V, Korabecny J, Rozsypal T, Hrabinova M, Muckova L, Hepnarova V, Konecny J and Jun D <1 more author(s)>
    Ref: Archives of Toxicology, :, 2023 : PubMed

            

    Title: Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation
    Pidany F, Kroustkova J, Al Mamun A, Suchankova D, Brazzolotto X, Nachon F, Chantegreil F, Dolezal R, Pulkrabkova L and Cahlikova L <10 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 252:115301, 2023 : PubMed

            

    Title: Differentiated SH-SY5Y neuroblastoma cells as a model for evaluation of nerve agent-associated neurotoxicity
    Pulkrabkova L, Muckova L, Hrabinova M, Sorf A, Kobrlova T, Jost P, Bezdekova D, Korabecny J, Jun D, Soukup O
    Ref: Archives of Toxicology, :, 2023 : PubMed

            

    Title: Structure-Guided Design of N-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease
    Svobodova B, Pulkrabkova L, Panek D, Misiachna A, Kolcheva M, Andrys R, Handl J, Capek J, Nyvltova P and Korabecny J <10 more author(s)>
    Ref: Int J Mol Sci, 24:, 2023 : PubMed

            

    Title: The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs
    Tsianou CC, Kvetina J, Radochova V, Kohoutova D, Rejchrt S, Valis M, Karasova JZ, Tacheci I, Knoblochova V and Bures J <1 more author(s)>
    Ref: PLoS ONE, 18:e0286386, 2023 : PubMed

            

    Title: N-substituted arylhydroxamic acids as acetylcholinesterase reactivators
    Bondar D, Kapitanov I, Pulkrabkova L, Soukup O, Jun D, Diniz FB, Franca TCC, Kuca K, Karpichev Y
    Ref: Chemico-Biological Interactions, :110078, 2022 : PubMed

            

    Title: Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities
    Chrienova Z, Nepovimova E, Andrys R, Dolezal R, Janockova J, Muckova L, Fabova L, Soukup O, Oleksak P and Kuca K <3 more author(s)>
    Ref: J Enzyme Inhib Med Chem, 37:2605, 2022 : PubMed

            

    Title: Countermeasures in organophosphorus intoxication: pitfalls and prospects
    Gorecki L, Soukup O, Korabecny J
    Ref: Trends in Pharmacological Sciences, :, 2022 : PubMed

            

    Title: Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile
    Makhaeva GF, Kovaleva NV, Boltneva NP, Rudakova EV, Lushchekina SV, Astakhova TY, Serkov IV, Proshin AN, Radchenko EV and Richardson RJ <4 more author(s)>
    Ref: Molecules, 27:, 2022 : PubMed

            

    Title: Neurotoxicity evoked by organophosphates and available countermeasures
    Pulkrabkova L, Svobodova B, Konecny J, Kobrlova T, Muckova L, Janousek J, Pejchal J, Korabecny J, Soukup O
    Ref: Archives of Toxicology, :, 2022 : PubMed

            

    Title: Development of versatile and potent monoquaternary reactivators of acetylcholinesterase
    Gorecki L, Hepnarova V, Karasova JZ, Hrabinova M, Courageux C, Dias J, Kucera T, Kobrlova T, Muckova L and Korabecny J <7 more author(s)>
    Ref: Archives of Toxicology, :, 2021 : PubMed

            

    Title: Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease
    Gorecki L, Uliassi E, Bartolini M, Janockova J, Hrabinova M, Hepnarova V, Prchal L, Muckova L, Pejchal J and Bolognesi ML <8 more author(s)>
    Ref: ACS Chem Neurosci, :, 2021 : PubMed

            

    Title: Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors
    Gorecki L, Misiachna A, Damborsky J, Dolezal R, Korabecny J, Cejkova L, Hakenova K, Chvojkova M, Karasova JZ and Soukup O <6 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 219:113434, 2021 : PubMed

            

    Title: Design and synthesis of novel tacrine-indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease
    Hamulakova S, Kudlickova Z, Janovec L, Mezencev R, Deckner ZJ, Chernoff YO, Janockova J, Ihnatova V, Bzonek P and Kuca K <6 more author(s)>
    Ref: Future Med Chem, :, 2021 : PubMed

            

    Title: Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells
    Hudacova M, Hamuakova S, Konkoova E, Jendzelovsky R, Vargova J, Sevc J, Fedorocko P, Soukup O, Janockova J and Kozurkova M <8 more author(s)>
    Ref: Int J Mol Sci, 22:, 2021 : PubMed

            

    Title: (+/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease
    Ismaili L, Monnin J, Etievant A, Arribas RL, Viejo L, Refouvelet B, Soukup O, Janockova J, Hepnarova V and Haffen E <12 more author(s)>
    Ref: ACS Chem Neurosci, :, 2021 : PubMed

            

    Title: 7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo
    Kaniakova M, Korabecny J, Holubova K, Kleteckova L, Chvojkova M, Hakenova K, Prchal L, Novak M, Dolezal R and Soukup O <7 more author(s)>
    Ref: Biochemical Pharmacology, :114460, 2021 : PubMed

            

    Title: Cholinesterase Research
    Korabecny J, Soukup O
    Ref: Biomolecules, 11:, 2021 : PubMed

            

    Title: Amiridine-piperazine hybrids as cholinesterase inhibitors and potential multitarget agents for Alzheimer's disease treatment
    Makhaeva GF, Lushchekina SV, Kovaleva NV, Yu Astakhova T, Boltneva NP, Rudakova EV, Serebryakova OG, Proshin AN, Serkov IV and Richardson RJ <7 more author(s)>
    Ref: Bioorg Chem, 112:104974, 2021 : PubMed

            

    Title: Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies
    Mamun AA, Pidany F, Hulcova D, Marikova J, Kucera T, Schmidt M, Catapano MC, Hrabinova M, Jun D and Cahlikova L <9 more author(s)>
    Ref: Int J Mol Sci, 22:, 2021 : PubMed

            

    Title: Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts
    Markova A, Hympanova M, Matula M, Prchal L, Sleha R, Benkova M, Pulkrabkova L, Soukup O, Krocova Z and Marek J <1 more author(s)>
    Ref: Toxics, 9:, 2021 : PubMed

            

    Title: Huprine Y - tryptophan heterodimers with potential implication to Alzheimer's disease treatment
    Mezeiova E, Hrabinova M, Hepnarova V, Jun D, Janockova J, Muckova L, Prchal L, Kristofikova Z, Kucera T and Korabecny J <5 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, :128100, 2021 : PubMed

            

    Title: Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy
    Perone R, Albertini C, Uliassi E, Di Pietri F, de Sena Murteira Pinheiro P, Petralla S, Rizzardi N, Fato R, Pulkrabkova L and Bolognesi ML <3 more author(s)>
    Ref: ChemMedChem, 16:187, 2021 : PubMed

            

    Title: Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease
    Rossi M, Freschi M, de Camargo Nascente L, Salerno A, de Melo Viana Teixeira S, Nachon F, Chantegreil F, Soukup O, Prchal L and Bolognesi ML <6 more author(s)>
    Ref: Journal of Medicinal Chemistry, 64:4972, 2021 : PubMed

            

    Title: Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease
    Vrabec R, Marikova J, Locarek M, Korabecny J, Hulcova D, Hosalkova A, Kunes J, Chlebek J, Kucera T and Cahlikova L <8 more author(s)>
    Ref: Phytochemistry, 194:113017, 2021 : PubMed

            

    Title: Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties
    de Andrade Ramos G, Souza de Oliveira A, Bartolini M, Naldi M, Liparulo I, Bergamini C, Uliassi E, Wu L, Fraser PE and Soares Romeiro LA <9 more author(s)>
    Ref: RSC Med Chem, 12:1154, 2021 : PubMed

            

    Title: Effect of P-glycoprotein on the availability of oxime reactivators in the brain
    Kobrlova T, Soukup O
    Ref: Toxicology, :152541, 2020 : PubMed

            

    Title: Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists
    Konecny J, Misiachna A, Hrabinova M, Pulkrabkova L, Benkova M, Prchal L, Kucera T, Kobrlova T, Finger V and Korabecny J <6 more author(s)>
    Ref: Biomolecules, 11:, 2020 : PubMed

            

    Title: From orexin receptor agonist YNT-185 to novel antagonists with drug-like properties for the treatment of insomnia
    Mezeiova E, Janockova J, Konecny J, Kobrlova T, Benkova M, Dolezal R, Prchal L, Karasova-Zdarova J, Soukup O, Korabecny J
    Ref: Bioorg Chem, 103:104179, 2020 : PubMed

            

    Title: Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimes drugs dealing with cholinergic, amyloid and mitochondrial systems
    Nepovimova E, Svobodova L, Dolezal R, Hepnarova V, Junova L, Jun D, Korabecny J, Kucera T, Gazova Z and Kuca K <20 more author(s)>
    Ref: Bioorg Chem, 107:104596, 2020 : PubMed

            

    Title: Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile
    Sobolova K, Hrabinova M, Hepnarova V, Kucera T, Kobrlova T, Benkova M, Janockova J, Dolezal R, Prchal L and Korabecny J <4 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 203:112593, 2020 : PubMed

            

    Title: Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase
    AlFadly ED, Elzahhar PA, Tramarin A, Elkazaz S, Shaltout H, Abu-Serie MM, Janockova J, Soukup O, Ghareeb DA and Belal ASF <8 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 167:161, 2019 : PubMed

            

    Title: Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
    Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ and Kuca K <25 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 168:491, 2019 : PubMed

            

    Title: Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy
    Dgachi Y, Martin H, Malek R, Jun D, Janockova J, Sepsova V, Soukup O, Iriepa I, Moraleda I and Ismaili L <5 more author(s)>
    Ref: J Enzyme Inhib Med Chem, 34:163, 2019 : PubMed

            

    Title: Oxime K203: a drug candidate for the treatment of tabun intoxication
    Gorecki L, Soukup O, Kucera T, Malinak D, Jun D, Kuca K, Musilek K, Korabecny J
    Ref: Archives of Toxicology, 93:673, 2019 : PubMed

            

    Title: Tacroximes: novel unique compounds for the recovery of organophosphorus-inhibited acetylcholinesterase
    Gorecki L, Junova L, Kucera T, Hepnarova V, Prchal L, Kobrlova T, Muckova L, Soukup O, Korabecny J
    Ref: Future Med Chem, 11:2625, 2019 : PubMed

            

    Title: Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators
    Hepnarova V, Muckova L, Ring A, Pejchal J, Herman D, Misik J, Hrabinova M, Jun D, Soukup O
    Ref: Toxicol Appl Pharmacol, :114776, 2019 : PubMed

            

    Title: In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers
    Janockova J, Korabecny J, Plsikova J, Babkova K, Konkolova E, Kucerova D, Vargova J, Koval J, Jendzelovsky R and Kozurkova M <7 more author(s)>
    Ref: J Enzyme Inhib Med Chem, 34:877, 2019 : PubMed

            

    Title: Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives
    Jonczyk J, Lodarski K, Staszewski M, Godyn J, Zareba P, Soukup O, Janockova J, Korabecny J, Salat K and Bajda M <6 more author(s)>
    Ref: Bioorg Chem, 90:103084, 2019 : PubMed

            

    Title: Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease
    Kaniakova M, Nepovimova E, Kleteckova L, Skrenkova K, Holubova K, Chrienova Z, Hepnarova V, Kucera T, Kobrlova T and Horak M <3 more author(s)>
    Ref: Curr Alzheimer Res, 16:821, 2019 : PubMed

            

    Title: Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats
    Karasova JZ, Soukup O, Korabecny J, Hroch M, Krejciova M, Hrabinova M, Misik J, Novotny L, Hepnarova V, Kuca K
    Ref: Drug & Chemical Toxicology, :1, 2019 : PubMed

            

    Title: Current approaches to enhancing oxime reactivator delivery into the brain
    Kobrlova T, Korabecny J, Soukup O
    Ref: Toxicology, 423:75, 2019 : PubMed

            

    Title: A Systematic Review on Donepezil-based Derivatives as Potential Cholinesterase Inhibitors for Alzheimer's Disease
    Korabecny J, Spilovska K, Mezeiova E, Benek O, Juza R, Kaping D, Soukup O
    Ref: Curr Med Chem, 26:5625, 2019 : PubMed

            

    Title: New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition
    Malek R, Arribas RL, Palomino-Antolin A, Totoson P, Demougeot C, Kobrlova T, Soukup O, Iriepa I, Moraleda I and Ismaili L <12 more author(s)>
    Ref: Journal of Medicinal Chemistry, 62:11416, 2019 : PubMed

            

    Title: Donepezil Derivatives Targeting Amyloid-beta Cascade in Alzheimer's Disease
    Mezeiova E, Chalupova K, Nepovimova E, Gorecki L, Prchal L, Malinak D, Kuca K, Soukup O, Korabecny J
    Ref: Curr Alzheimer Res, 16:772, 2019 : PubMed

            

    Title: N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy
    Nepovimova E, Korabecny J, Hepnarova V, Jun D, Dolezal R, Muckova L, Jost P, Soukup O, Janockova J and Kuca K <3 more author(s)>
    Ref: Curr Alzheimer Res, 16:333, 2019 : PubMed

            

    Title: Orexin supplementation in narcolepsy treatment: A review
    Nepovimova E, Janockova J, Misik J, Kubik S, Stuchlik A, Vales K, Korabecny J, Mezeiova E, Dolezal R and Kuca K <5 more author(s)>
    Ref: Med Res Rev, 39:961, 2019 : PubMed

            

    Title: Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors
    Svobodova B, Mezeiova E, Hepnarova V, Hrabinova M, Muckova L, Kobrlova T, Jun D, Soukup O, Jimeno ML and Korabecny J <1 more author(s)>
    Ref: Biomolecules, 9:, 2019 : PubMed

            

    Title: Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier
    Hamulakova S, Janovec L, Soukup O, Jun D, Janockova J, Hrabinova M, Sepsova V, Kuca K
    Ref: Curr Alzheimer Res, 15:1096, 2018 : PubMed

            

    Title: The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease
    Hepnarova V, Korabecny J, Matouskova L, Jost P, Muckova L, Hrabinova M, Vykoukalova N, Kerhartova M, Kucera T and Soukup O <9 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 150:292, 2018 : PubMed

            

    Title: Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods
    Janockova J, Dolezal R, Nepovimova E, Kobrlova T, Benkova M, Kuca K, Konecny J, Mezeiova E, Melikova M and Korabecny J <3 more author(s)>
    Ref: Molecules, 23:, 2018 : PubMed

            

    Title: A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase
    Kuca K, Musilek K, Jun D, Karasova JZ, Nepovimova E, Soukup O, Hrabinova M, Mikler J, Franca TCC and Ramalho TC <3 more author(s)>
    Ref: BMC Pharmacol Toxicol, 19:8, 2018 : PubMed

            

    Title: Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings
    Kuca K, Karasova JZ, Soukup O, Kassa J, Novotna E, Sepsova V, Horova A, Pejchal J, Hrabinova M and Musilek K <4 more author(s)>
    Ref: Drug Des Devel Ther, 12:505, 2018 : PubMed

            

    Title: A Review of the Synthesis of Quaternary Acetylcholinesterase Reactivators
    Malinak D, Korabecny J, Soukup O, Gorecki L, Nepovimova E, Psotka M, Dolezal R, Nguyen TD, Mezeiova E and Kuca K <1 more author(s)>
    Ref: Current Organic Chemistry, 22":1619, 2018 : PubMed

            

    Title: Profiling donepezil template into multipotent hybrids with antioxidant properties
    Mezeiova E, Spilovska K, Nepovimova E, Gorecki L, Soukup O, Dolezal R, Malinak D, Janockova J, Jun D and Korabecny J <1 more author(s)>
    Ref: J Enzyme Inhib Med Chem, 33:583, 2018 : PubMed

            

    Title: Cholinesterase inhibitor 6-chlorotacrine - in vivo toxicological profile and behavioural effects
    Misik J, Nepovimova E, Pejchal J, Kassa J, Korabecny J, Soukup O
    Ref: Curr Alzheimer Res, 15:552, 2018 : PubMed

            

    Title: Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents
    Panek D, Wieckowska A, Jonczyk J, Godyn J, Bajda M, Wichur T, Pasieka A, Knez D, Pislar A and Malawska B <6 more author(s)>
    Ref: ACS Chem Neurosci, 9:1074, 2018 : PubMed

            

    Title: In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
    Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R and Kuca K <12 more author(s)>
    Ref: Med Chem, 14:281, 2018 : PubMed

            

    Title: Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer's Disease
    Wieckowska A, Wichur T, Godyn J, Bucki A, Marcinkowska M, Siwek A, Wieckowski K, Zareba P, Knez D and Malawska B <10 more author(s)>
    Ref: ACS Chem Neurosci, 9:1195, 2018 : PubMed

            

    Title: Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents
    Zorbaz T, Malinak D, Marakovic N, Macek Hrvat N, Zandona A, Novotny M, Skarka A, Andrys R, Benkova M and Musilek K <4 more author(s)>
    Ref: Journal of Medicinal Chemistry, 61:10753, 2018 : PubMed

            

    Title: Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors
    Babkova K, Korabecny J, Soukup O, Nepovimova E, Jun D, Kuca K
    Ref: Future Med Chem, 9:1015, 2017 : PubMed

            

    Title: Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases
    Bautista-Aguilera OM, Hagenow S, Palomino-Antolin A, Farre-Alins V, Ismaili L, Joffrin PL, Jimeno ML, Soukup O, Janockova J and Stark H <11 more author(s)>
    Ref: Angew Chem Int Ed Engl, 56:12765, 2017 : PubMed

            

    Title: Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment
    Gazova Z, Soukup O, Sepsova V, Siposova K, Drtinova L, Jost P, Spilovska K, Korabecny J, Nepovimova E and Kuca K <5 more author(s)>
    Ref: Biochimica & Biophysica Acta Mol Basis Dis, 1863:607, 2017 : PubMed

            

    Title: Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016)
    Gorecki L, Korabecny J, Musilek K, Nepovimova E, Malinak D, Kucera T, Dolezal R, Jun D, Soukup O, Kuca K
    Ref: Expert Opin Ther Pat, 27:971, 2017 : PubMed

            

    Title: Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids
    Hamulakova S, Janovec L, Soukup O, Jun D, Kuca K
    Ref: Int J Biol Macromol, 104:333, 2017 : PubMed

            

    Title: The pharmacology of tacrine at N-methyl-d-aspartate receptors
    Horak M, Holubova K, Nepovimova E, Krusek J, Kaniakova M, Korabecny J, Vyklicky L, Kuca K, Stuchlik A and Soukup O <2 more author(s)>
    Ref: Prog Neuropsychopharmacol Biological Psychiatry, 75:54, 2017 : PubMed

            

    Title: Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy
    Mezeiova E, Korabecny J, Sepsova V, Hrabinova M, Jost P, Muckova L, Kucera T, Dolezal R, Misik J and Kuca K <7 more author(s)>
    Ref: Molecules, 22:, 2017 : PubMed

            

    Title: HLo-7 - A review of acetylcholinesterase reactivator against organophosphorus intoxication
    Psotka M, Malinak D, Gorecki L, Nguyen TD, Soukup O, Jun D, Kuca K, Musilek K, Korabecny J
    Ref: Military Medical Science Letters, 86:70, 2017 : PubMed

            

    Title: Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment
    Soukup O, Winder M, Killi UK, Wsol V, Jun D, Kuca K, Tobin G
    Ref: Curr Neuropharmacol, 15:637, 2017 : PubMed

            

    Title: Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation
    Spilovska K, Korabecny J, Sepsova V, Jun D, Hrabinova M, Jost P, Muckova L, Soukup O, Janockova J and Kuca K <4 more author(s)>
    Ref: Molecules, 22:, 2017 : PubMed

            

    Title: Multitarget Tacrine Hybrids with Neuroprotective Properties to Confront Alzheimer's Disease
    Spilovska K, Korabecny J, Nepovimova E, Dolezal R, Mezeiova E, Soukup O, Kuca K
    Ref: Curr Top Med Chem, 17:1006, 2017 : PubMed

            

    Title: The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators
    Benchekroun M, Romero A, Egea J, Leon R, Michalska P, Buendia I, Jimeno ML, Jun D, Janockova J and Ismaili L <6 more author(s)>
    Ref: Journal of Medicinal Chemistry, 59:9967, 2016 : PubMed

            

    Title: Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease
    Benek O, Soukup O, Pasdiorova M, Hroch L, Sepsova V, Jost P, Hrabinova M, Jun D, Kuca K and Musilek K <3 more author(s)>
    Ref: ChemMedChem, 11:1264, 2016 : PubMed

            

    Title: Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease
    Dgachi Y, Bautista-Aguilera OM, Benchekroun M, Martin H, Bonet A, Knez D, Godyn J, Malawska B, Gobec S and Ismaili L <5 more author(s)>
    Ref: Molecules, 21:, 2016 : PubMed

            

    Title: Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy
    Dgachi Y, Sokolov O, Luzet V, Godyn J, Panek D, Bonet A, Martin H, Iriepa I, Moraleda I and Ismaili L <7 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 126:576, 2016 : PubMed

            

    Title: Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies
    Dolezal R, Soukup O, Malinak D, Savedra RML, Marek J, Dolezalova M, Pasdiorova M, Salajkova S, Korabecny J and Kuca K <2 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 121:699, 2016 : PubMed

            

    Title: SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides
    Gorecki L, Korabecny J, Musilek K, Malinak D, Nepovimova E, Dolezal R, Jun D, Soukup O, Kuca K
    Ref: Archives of Toxicology, 90:2831, 2016 : PubMed

            

    Title: Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules
    Hamulakova S, Poprac P, Jomova K, Brezova V, Lauro P, Drostinova L, Jun D, Sepsova V, Hrabinova M and Valko M <5 more author(s)>
    Ref: J Inorg Biochem, 161:52, 2016 : PubMed

            

    Title: Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity
    Janockova J, Zilecka E, Kasparkova J, Brabec V, Soukup O, Kuca K, Kozurkova M
    Ref: Mol Biosyst, 12:2910, 2016 : PubMed

            

    Title: Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease
    Jerabek J, Uliassi E, Guidotti L, Korabecny J, Soukup O, Sepsova V, Hrabinova M, Kuca K, Bartolini M and Bolognesi ML <4 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 127:250, 2016 : PubMed

            

    Title: Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1
    Kristofikova Z, Ricny J, Soukup O, Korabecny J, Nepovimova E, Kuca K, Ripova D
    Ref: Dementia & Geriatric Cognitive Disorders, 43:45, 2016 : PubMed

            

    Title: A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication
    Nepovimova E, Korabecny J, Dolezal R, Nguyen TD, Jun D, Soukup O, Pasdiorova M, Jost P, Muckova L and Kuca K <3 more author(s)>
    Ref: Toxicol Res (Camb), 5:1012, 2016 : PubMed

            

    Title: Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation
    Panek D, Wieckowska A, Wichur T, Bajda M, Godyn J, Jonczyk J, Mika K, Janockova J, Soukup O and Malawska B <3 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 125:676, 2016 : PubMed

            

    Title: Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease
    Prati F, Bergamini C, Fato R, Soukup O, Korabecny J, Andrisano V, Bartolini M, Bolognesi ML
    Ref: ChemMedChem, 11:1284, 2016 : PubMed

            

    Title: 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment
    Korabecny J, Andrs M, Nepovimova E, Dolezal R, Babkova K, Horova A, Malinak D, Mezeiova E, Gorecki L and Kuca K <4 more author(s)>
    Ref: Molecules, 20:22084, 2015 : PubMed

            

    Title: Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE
    Kuca K, Hrabinova M, Jun D, Musilek K, Penhaker M, Krejcar O, Soukup O
    Ref: Med Chem, 11:683, 2015 : PubMed

            

    Title: Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease
    Lemes LF, de Andrade Ramos G, de Oliveira AS, da Silva FM, de Castro Couto G, da Silva Boni M, Guimaraes MJ, Souza IN, Bartolini M and Romeiro LA <9 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 108:687, 2015 : PubMed

            

    Title: Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity
    Nepovimova E, Korabecny J, Dolezal R, Babkova K, Ondrejicek A, Jun D, Sepsova V, Horova A, Hrabinova M and Kuca K <7 more author(s)>
    Ref: Journal of Medicinal Chemistry, 58:8985, 2015 : PubMed

            

    Title: Cholinergic properties of new 7-methoxytacrine-donepezil derivatives
    Sepsova V, Karasova JZ, Tobin G, Jun D, Korabecny J, Cabelova P, Janska K, Krusek J, Skrenkova K and Soukup O <1 more author(s)>
    Ref: Gen Physiol Biophys, 34:189, 2015 : PubMed

            

    Title: In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat
    Killi UK, Wsol V, Soukup O, Kuca K, Winder M, Tobin G
    Ref: Clinical & Experimental Pharmacology & Physiology, 41:139, 2014 : PubMed

            

    Title: From Pyridinium-based to Centrally Active Acetylcholinesterase Reactivators
    Korabecny J, Soukup O, Dolezal R, Spilovska K, Nepovimova E, Andrs M, Nguyen TD, Jun D, Musilek K and Kuca K <1 more author(s)>
    Ref: Mini Rev Med Chem, 14:215, 2014 : PubMed

            

    Title: The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor
    Sepsova V, Krusek J, Karasova JZ, Zemek F, Musilek K, Kuca K, Soukup O
    Ref: Physiol Res, 63:771, 2014 : PubMed

            

    Title: Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX
    Kuca K, Musilek K, Jun D, Karasova J, Soukup O, Pejchal J, Hrabinova M
    Ref: Med Chem, 9:689, 2013 : PubMed

            

    Title: Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides
    Kuca K, Jun D, Musilek K, Pohanka M, Karasova JZ, Soukup O
    Ref: Mini Rev Med Chem, 13:2102, 2013 : PubMed

            

    Title: The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors
    Soukup O, Jun D, Tobin G, Kuca K
    Ref: Archives of Toxicology, 87:711, 2013 : PubMed

            

    Title: A Resurrection of 7-MEOTA: A Comparison with Tacrine
    Soukup O, Jun D, Karasova JZ, Patocka J, Musilek K, Korabecny J, Krusek J, Kaniakova M, Sepsova V and Kuca K <6 more author(s)>
    Ref: Curr Alzheimer Res, 10:893, 2013 : PubMed

            

    Title: 7-methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in alzheimer's disease treatment, synthesis, biological evaluation and molecular modeling studies
    Spilovska K, Korabecny J, Kral J, Horova A, Musilek K, Soukup O, Drtinova L, Gazova Z, Siposova K, Kuca K
    Ref: Molecules, 18:2397, 2013 : PubMed

            

    Title: [Tacrine and its derivatives in the therapy of Alzheimers disease]
    Korabecny J, Spilovska K, Benek O, Musilek K, Soukup O, Kuca K
    Ref: Ceska a Slovenska Farmacie, 61:210, 2012 : PubMed

            

    Title: The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers
    Soukup O, Kristofikova Z, Jun D, Tambor V, Ripova D, Kuca K
    Ref: Toxicol Lett, 212:315, 2012 : PubMed

            

    Title: On the universality of oxime Hl-7 - antidote for case of the nerve agent poisoning
    Kuca K, Musilek K, Karasova J, Jun D, Soukup O, Pohanka M, Ghosh KK, Hrabinova M
    Ref: Military Medical Science Letters, 80:80, 2011 : PubMed

            

    Title: The effect of oxime reactivators on muscarinic receptors: functional and binding examinations
    Soukup O, Kumar UK, Proska J, Bratova L, Adem A, Jun D, Fusek J, Kuca K, Tobin G
    Ref: Environ Toxicol Pharmacol, 31:364, 2011 : PubMed

            

    Title: Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors
    Soukup O, Krusek J, Kaniakova M, Kumar UK, Oz M, Jun D, Fusek J, Kuca K, Tobin G
    Ref: Physiol Res, 60:679, 2011 : PubMed

            

    Title: Pralidoxime--the gold standard of acetylcholinesterase reactivators--reactivation in vitro efficacy
    Kuca K, Hrabinova M, Soukup O, Tobin G, Karasova J, Pohanka M
    Ref: Bratislavske Lekarske Listy, 111:502, 2010 : PubMed

            

    Title: Novel acetylcholinesterase reactivator K112 and its cholinergic properties
    Soukup O, Kristofikova Z, Proska J, Tobin G, Patocka J, Marek J, Jun D, Fusek J, Ripova D, Kuca K
    Ref: Biomed Pharmacother, 64:541, 2010 : PubMed

            

    Title: Interaction of nerve agent antidotes with cholinergic systems
    Soukup O, Tobin G, Kumar UK, Binder J, Proska J, Jun D, Fusek J, Kuca K
    Ref: Curr Med Chem, 17:1708, 2010 : PubMed

            

    Title: Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder
    Soukup O, Tobin G, Kumar UK, Jun D, Fusek J, Kuca K
    Ref: Toxicol Mech Methods, 20:428, 2010 : PubMed

            

    Title: Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127
    Kuca K, Cabal J, Jung YS, Musilek K, Soukup O, Jun D, Pohanka M, Musilova L, Karasova J and Hrabinova M <1 more author(s)>
    Ref: Basic Clin Pharmacol Toxicol, 105:207, 2009 : PubMed

            

    Title: The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder
    Soukup O, Pohanka M, Tobin G, Jun D, Fusek J, Musilek K, Marek J, Kassa J, Kuca K
    Ref: Neuro Endocrinol Lett, 29:759, 2008 : PubMed

            


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