Full name :
First name :
Mail :
Zip Code :
City :
Country :
Email :
Phone :
Fax :
Website :
Directory :
| Title : Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models - O'Donnell_2010_J.Med.Chem_53_1222 |
| Author(s) : O'Donnell CJ , Rogers BN , Bronk BS , Bryce DK , Coe JW , Cook KK , Duplantier AJ , Evrard E , Hajos M , Hoffmann WE , Hurst RS , Maklad N , Mather RJ , McLean S , Nedza FM , O'Neill BT , Peng L , Qian W , Rottas MM , Sands SB , Schmidt AW , Shrikhande AV , Spracklin DK , Wong DF , Zhang A , Zhang L |
| Ref : Journal of Medicinal Chemistry , 53 :1222 , 2010 |
| Abstract : O'Donnell_2010_J.Med.Chem_53_1222 |
| ESTHER : O'Donnell_2010_J.Med.Chem_53_1222 |
| PubMedSearch : O'Donnell_2010_J.Med.Chem_53_1222 |
| PubMedID: 20043678 |
| Title : Poster: Low efficacy partial agonists of the alpha4\/beta2 nicotinic acetylcholine receptor (nAChR). Does functional efficacy govern in vivo response? - |
| Author(s) : Coe JW , Brooks PR , Wirtz MC , Vetelino MG , Arnold EP , Sands SB , Davis TI , Lebel LA , Fox CB , Shrikhande A , Mansbach RS , Chambers LK , Rovetti CC , Schulz DW , Tingley Iii FD , ONeill BT , Rollema H |
| Ref : Biochemical Pharmacology , 78 :919 , 2009 |
| PubMedID: |
| Title : Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists - O'Donnell_2009_Bioorg.Med.Chem.Lett_19_4747 |
| Author(s) : O'Donnell CJ , Peng L , O'Neill BT , Arnold EP , Mather RJ , Sands SB , Shrikhande A , Lebel LA , Spracklin DK , Nedza FM |
| Ref : Bioorganic & Medicinal Chemistry Lett , 19 :4747 , 2009 |
| Abstract : O'Donnell_2009_Bioorg.Med.Chem.Lett_19_4747 |
| ESTHER : O'Donnell_2009_Bioorg.Med.Chem.Lett_19_4747 |
| PubMedSearch : O'Donnell_2009_Bioorg.Med.Chem.Lett_19_4747 |
| PubMedID: 19576766 |
| Title : Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid - Rollema_2007_Neuropharmacol_52_985 |
| Author(s) : Rollema H , Chambers LK , Coe JW , Glowa J , Hurst RS , Lebel LA , Lu Y , Mansbach RS , Mather RJ , Rovetti CC , Sands SB , Schaeffer E , Schulz DW , Tingley FD, 3rd , Williams KE |
| Ref : Neuropharmacology , 52 :985 , 2007 |
| Abstract : Rollema_2007_Neuropharmacol_52_985 |
| ESTHER : Rollema_2007_Neuropharmacol_52_985 |
| PubMedSearch : Rollema_2007_Neuropharmacol_52_985 |
| PubMedID: 17157884 |
| Title : Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship - Wishka_2006_J.Med.Chem_49_4425 |
| Author(s) : Wishka DG , Walker DP , Yates KM , Reitz SC , Jia S , Myers JK , Olson KL , Jacobsen EJ , Wolfe ML , Groppi VE , Hanchar AJ , Thornburgh BA , Cortes-Burgos LA , Wong EH , Staton BA , Raub TJ , Higdon NR , Wall TM , Hurst RS , Walters RR , Hoffmann WE , Hajos M , Franklin S , Carey G , Gold LH , Cook KK , Sands SB , Zhao SX , Soglia JR , Kalgutkar AS , Arneric SP , Rogers BN |
| Ref : Journal of Medicinal Chemistry , 49 :4425 , 2006 |
| Abstract : Wishka_2006_J.Med.Chem_49_4425 |
| ESTHER : Wishka_2006_J.Med.Chem_49_4425 |
| PubMedSearch : Wishka_2006_J.Med.Chem_49_4425 |
| PubMedID: 16821801 |
| Title : Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation - Coe_2005_J.Med.Chem_48_3474 |
| Author(s) : Coe JW , Brooks PR , Vetelino MG , Wirtz MC , Arnold EP , Huang J , Sands SB , Davis TI , Lebel LA , Fox CB , Shrikhande A , Heym JH , Schaeffer E , Rollema H , Lu Y , Mansbach RS , Chambers LK , Rovetti CC , Schulz DW , Tingley FD, 3rd , O'Neill BT |
| Ref : Journal of Medicinal Chemistry , 48 :3474 , 2005 |
| Abstract : Coe_2005_J.Med.Chem_48_3474 |
| ESTHER : Coe_2005_J.Med.Chem_48_3474 |
| PubMedSearch : Coe_2005_J.Med.Chem_48_3474 |
| PubMedID: 15887955 |
| Title : 3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation - Coe_2005_Bioorg.Med.Chem.Lett_15_4889 |
| Author(s) : Coe JW , Brooks PR , Wirtz MC , Bashore CG , Bianco KE , Vetelino MG , Arnold EP , Lebel LA , Fox CB , Tingley FD, 3rd , Schulz DW , Davis TI , Sands SB , Mansbach RS , Rollema H , O'Neill BT |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :4889 , 2005 |
| Abstract : Coe_2005_Bioorg.Med.Chem.Lett_15_4889 |
| ESTHER : Coe_2005_Bioorg.Med.Chem.Lett_15_4889 |
| PubMedSearch : Coe_2005_Bioorg.Med.Chem.Lett_15_4889 |
| PubMedID: 16171993 |
| Title : In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine - Coe_2005_Bioorg.Med.Chem.Lett_15_2974 |
| Author(s) : Coe JW , Vetelino MG , Bashore CG , Wirtz MC , Brooks PR , Arnold EP , Lebel LA , Fox CB , Sands SB , Davis TI , Schulz DW , Rollema H , Tingley FD, 3rd , O'Neill BT |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :2974 , 2005 |
| Abstract : Coe_2005_Bioorg.Med.Chem.Lett_15_2974 |
| ESTHER : Coe_2005_Bioorg.Med.Chem.Lett_15_2974 |
| PubMedSearch : Coe_2005_Bioorg.Med.Chem.Lett_15_2974 |
| PubMedID: 15908213 |
| Title : Barium permeability of neuronal nicotinic receptor alpha 7 expressed in Xenopus oocytes - Sands_1993_Biophys.J_65_2614 |
| Author(s) : Sands SB , Costa AC , Patrick JW |
| Ref : Biophysical Journal , 65 :2614 , 1993 |
| Abstract : Sands_1993_Biophys.J_65_2614 |
| ESTHER : Sands_1993_Biophys.J_65_2614 |
| PubMedSearch : Sands_1993_Biophys.J_65_2614 |
| PubMedID: 8312496 |