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| Title : Identification of Potent Acetylcholinesterase Inhibitors as New Candidates for Alzheimer Disease via Virtual Screening, Molecular Docking, Dynamic Simulation, and Molecular Mechanics-Poisson-Boltzmann Surface Area Calculations - Chennai_2024_Molecules_29_ |
| Author(s) : Chennai HY , Belaidi S , Bourougaa L , Ouassaf M , Sinha L , Samadi A , Chtita S |
| Ref : Molecules , 29 : , 2024 |
| Abstract : Chennai_2024_Molecules_29_ |
| ESTHER : Chennai_2024_Molecules_29_ |
| PubMedSearch : Chennai_2024_Molecules_29_ |
| PubMedID: 38542869 |
| Title : QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy - Ramos_2019_Molecules_24_ |
| Author(s) : Ramos E , Palomino-Antolin A , Bartolini M , Iriepa I , Moraleda I , Diez-Iriepa D , Samadi A , Cortina CV , Chioua M , Egea J , Romero A , Marco-Contelles J |
| Ref : Molecules , 24 : , 2019 |
| Abstract : Ramos_2019_Molecules_24_ |
| ESTHER : Ramos_2019_Molecules_24_ |
| PubMedSearch : Ramos_2019_Molecules_24_ |
| PubMedID: 30999586 |
| Title : The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease - Serrano_2017_J.Psychiatry.Neurosci_42_59 |
| Author(s) : Serrano MP , Herrero-Labrador R , Futch HS , Serrano J , Romero A , Fernandez AP , Samadi A , Unzeta M , Marco-Contelles J , Martinez-Murillo R |
| Ref : J Psychiatry Neurosci , 42 :59 , 2017 |
| Abstract : Serrano_2017_J.Psychiatry.Neurosci_42_59 |
| ESTHER : Serrano_2017_J.Psychiatry.Neurosci_42_59 |
| PubMedSearch : Serrano_2017_J.Psychiatry.Neurosci_42_59 |
| PubMedID: 27636528 |
| Title : Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease - Wang_2014_Eur.J.Med.Chem_80_543 |
| Author(s) : Wang L , Esteban G , Ojima M , Bautista-Aguilera OM , Inokuchi T , Moraleda I , Iriepa I , Samadi A , Youdim MB , Romero A , Soriano E , Herrero R , Fernandez Fernandez AP , Ricardo Martinez M , Marco-Contelles J , Unzeta M |
| Ref : Eur Journal of Medicinal Chemistry , 80 :543 , 2014 |
| Abstract : Wang_2014_Eur.J.Med.Chem_80_543 |
| ESTHER : Wang_2014_Eur.J.Med.Chem_80_543 |
| PubMedSearch : Wang_2014_Eur.J.Med.Chem_80_543 |
| PubMedID: 24813882 |
| Title : Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease - Esteban_2014_Biochim.Biophys.Acta_1844_1104 |
| Author(s) : Esteban G , Allan J , Samadi A , Mattevi A , Unzeta M , Marco-Contelles J , Binda C , Ramsay RR |
| Ref : Biochimica & Biophysica Acta , 1844 :1104 , 2014 |
| Abstract : Esteban_2014_Biochim.Biophys.Acta_1844_1104 |
| ESTHER : Esteban_2014_Biochim.Biophys.Acta_1844_1104 |
| PubMedSearch : Esteban_2014_Biochim.Biophys.Acta_1844_1104 |
| PubMedID: 24642166 |
| Title : Effects of novel monoamine oxidases and cholinesterases targeting compounds on brain neurotransmitters and behavior in rat model of vascular dementia - Stasiak_2014_Curr.Pharm.Des_20_161 |
| Author(s) : Stasiak A , Mussur M , Unzeta M , Samadi A , Marco-Contelles JL , Fogel WA , Marco-Contelles J |
| Ref : Curr Pharm Des , 20 :161 , 2014 |
| Abstract : Stasiak_2014_Curr.Pharm.Des_20_161 |
| ESTHER : Stasiak_2014_Curr.Pharm.Des_20_161 |
| PubMedSearch : Stasiak_2014_Curr.Pharm.Des_20_161 |
| PubMedID: 23701539 |
| Title : Multipotent cholinesterase\/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids - Bautista-Aguilera_2014_Drug.Des.Devel.Ther_8_1893 |
| Author(s) : Bautista-Aguilera OM , Esteban G , Chioua M , Nikolic K , Agbaba D , Moraleda I , Iriepa I , Soriano E , Samadi A , Unzeta M , Marco-Contelles J |
| Ref : Drug Des Devel Ther , 8 :1893 , 2014 |
| Abstract : Bautista-Aguilera_2014_Drug.Des.Devel.Ther_8_1893 |
| ESTHER : Bautista-Aguilera_2014_Drug.Des.Devel.Ther_8_1893 |
| PubMedSearch : Bautista-Aguilera_2014_Drug.Des.Devel.Ther_8_1893 |
| PubMedID: 25378907 |
| Title : Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase\/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease - Bautista-Aguilera_2014_Eur.J.Med.Chem_75C_82 |
| Author(s) : Bautista-Aguilera OM , Esteban G , Bolea I , Nikolic K , Agbaba D , Moraleda I , Iriepa I , Samadi A , Soriano E , Unzeta M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 75C :82 , 2014 |
| Abstract : Bautista-Aguilera_2014_Eur.J.Med.Chem_75C_82 |
| ESTHER : Bautista-Aguilera_2014_Eur.J.Med.Chem_75C_82 |
| PubMedSearch : Bautista-Aguilera_2014_Eur.J.Med.Chem_75C_82 |
| PubMedID: 24530494 |
| Title : N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2- yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor - Bautista-Aguilera_2014_J.Med.Chem_57_10455 |
| Author(s) : Bautista-Aguilera OM , Samadi A , Chioua M , Nikolic K , Filipic S , Agbaba D , Soriano E , de Andres L , Rodriguez-Franco MI , Alcaro S , Ramsay RR , Ortuso F , Yanez M , Marco-Contelles J |
| Ref : Journal of Medicinal Chemistry , 57 :10455 , 2014 |
| Abstract : Bautista-Aguilera_2014_J.Med.Chem_57_10455 |
| ESTHER : Bautista-Aguilera_2014_J.Med.Chem_57_10455 |
| PubMedSearch : Bautista-Aguilera_2014_J.Med.Chem_57_10455 |
| PubMedID: 25418133 |
| Title : Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase\/butyrylcholinesterase inhibitors: effect against amyloid-beta-induced neurotoxicity - Silva_2013_ACS.Chem.Neurosci_4_547 |
| Author(s) : Silva D , Chioua M , Samadi A , Agostinho P , Garcao P , Lajarin-Cuesta R , de los Rios C , Iriepa I , Moraleda I , Gonzalez-Lafuente L , Mendes E , Perez C , Rodriguez-Franco MI , Marco-Contelles J , Carmo Carreiras M |
| Ref : ACS Chem Neurosci , 4 :547 , 2013 |
| Abstract : Silva_2013_ACS.Chem.Neurosci_4_547 |
| ESTHER : Silva_2013_ACS.Chem.Neurosci_4_547 |
| PubMedSearch : Silva_2013_ACS.Chem.Neurosci_4_547 |
| PubMedID: 23379636 |
| Title : Multipotent, permeable drug ASS234 inhibits Abeta aggregation, possesses antioxidant properties and protects from Abeta-induced apoptosis in vitro - Bolea_2013_Curr.Alzheimer.Res_10_797 |
| Author(s) : Bolea I , Gella A , Monjas L , Perez C , Rodriguez-Franco MI , Marco-Contelles J , Samadi A , Unzeta M |
| Ref : Curr Alzheimer Res , 10 :797 , 2013 |
| Abstract : Bolea_2013_Curr.Alzheimer.Res_10_797 |
| ESTHER : Bolea_2013_Curr.Alzheimer.Res_10_797 |
| PubMedSearch : Bolea_2013_Curr.Alzheimer.Res_10_797 |
| PubMedID: 23919774 |
| Title : PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice - Lorrio_2013_ACS.Chem.Neurosci_4_1267 |
| Author(s) : Lorrio S , Romero A , Gonzalez-Lafuente L , Lajarin-Cuesta R , Martinez-Sanz FJ , Estrada M , Samadi A , Marco-Contelles J , Rodriguez-Franco MI , Villarroya M , Lopez MG , de los Rios C |
| Ref : ACS Chem Neurosci , 4 :1267 , 2013 |
| Abstract : Lorrio_2013_ACS.Chem.Neurosci_4_1267 |
| ESTHER : Lorrio_2013_ACS.Chem.Neurosci_4_1267 |
| PubMedSearch : Lorrio_2013_ACS.Chem.Neurosci_4_1267 |
| PubMedID: 23763493 |
| Title : Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease - Samadi_2013_Eur.J.Med.Chem_67_64 |
| Author(s) : Samadi A , de la Fuente Revenga M , Perez C , Iriepa I , Moraleda I , Rodriguez-Franco MI , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 67 :64 , 2013 |
| Abstract : Samadi_2013_Eur.J.Med.Chem_67_64 |
| ESTHER : Samadi_2013_Eur.J.Med.Chem_67_64 |
| PubMedSearch : Samadi_2013_Eur.J.Med.Chem_67_64 |
| PubMedID: 23838422 |
| Title : A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BCHE - Esteban_2013_J.Neural.Transm_120_911 |
| Author(s) : Esteban G , Bolea I , Sun P , Sole M , Samadi A , Marco-Contelles J , Unzeta M |
| Ref : J Neural Transm , 120 :911 , 2013 |
| Abstract : Esteban_2013_J.Neural.Transm_120_911 |
| ESTHER : Esteban_2013_J.Neural.Transm_120_911 |
| PubMedSearch : Esteban_2013_J.Neural.Transm_120_911 |
| PubMedID: 23263540 |
| Title : Nontoxic and neuroprotective beta-naphthotacrines for Alzheimer's disease - Esquivias-Perez_2013_Chem.Res.Toxicol_26_986 |
| Author(s) : Esquivias-Perez M , Maalej E , Romero A , Chabchoub F , Samadi A , Marco-Contelles J , Oset-Gasque MJ |
| Ref : Chemical Research in Toxicology , 26 :986 , 2013 |
| Abstract : Esquivias-Perez_2013_Chem.Res.Toxicol_26_986 |
| ESTHER : Esquivias-Perez_2013_Chem.Res.Toxicol_26_986 |
| PubMedSearch : Esquivias-Perez_2013_Chem.Res.Toxicol_26_986 |
| PubMedID: 23676090 |
| Title : Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling - Samadi_2012_Eur.J.Med.Chem_57C_296 |
| Author(s) : Samadi A , Estrada M , Perez C , Rodriguez-Franco MI , Iriepa I , Moraleda I , Chioua M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 57C :296 , 2012 |
| Abstract : Samadi_2012_Eur.J.Med.Chem_57C_296 |
| ESTHER : Samadi_2012_Eur.J.Med.Chem_57C_296 |
| PubMedSearch : Samadi_2012_Eur.J.Med.Chem_57C_296 |
| PubMedID: 23078965 |
| Title : Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine - Samadi_2012_Eur.J.Med.Chem_52_251 |
| Author(s) : Samadi A , de los Rios C , Bolea I , Chioua M , Iriepa I , Moraleda I , Bartolini M , Andrisano V , Galvez E , Valderas C , Unzeta M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 52 :251 , 2012 |
| Abstract : Samadi_2012_Eur.J.Med.Chem_52_251 |
| ESTHER : Samadi_2012_Eur.J.Med.Chem_52_251 |
| PubMedSearch : Samadi_2012_Eur.J.Med.Chem_52_251 |
| PubMedID: 22503231 |
| Title : Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity - Pereira_2011_Eur.J.Pharmacol_660_411 |
| Author(s) : Pereira JD , Caricati-Neto A , Miranda-Ferreira R , Smaili SS , Godinho RO , de los Rios C , Leon R , Villaroya M , Samadi A , Marco-Contelles J , Jurkiewicz NH , Garcia AG , Jurkiewicz A |
| Ref : European Journal of Pharmacology , 660 :411 , 2011 |
| Abstract : Pereira_2011_Eur.J.Pharmacol_660_411 |
| ESTHER : Pereira_2011_Eur.J.Pharmacol_660_411 |
| PubMedSearch : Pereira_2011_Eur.J.Pharmacol_660_411 |
| PubMedID: 21497158 |
| Title : Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines - Maalej_2011_Bioorg.Med.Chem.Lett_21_2384 |
| Author(s) : Maalej E , Chabchoub F , Samadi A , de los Rios C , Perona A , Morreale A , Marco-Contelles J |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :2384 , 2011 |
| Abstract : Maalej_2011_Bioorg.Med.Chem.Lett_21_2384 |
| ESTHER : Maalej_2011_Bioorg.Med.Chem.Lett_21_2384 |
| PubMedSearch : Maalej_2011_Bioorg.Med.Chem.Lett_21_2384 |
| PubMedID: 21411323 |
| Title : Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase\/monoamine oxidase inhibitors for the treatment of Alzheimer's disease - Bolea_2011_J.Med.Chem_54_8251 |
| Author(s) : Bolea I , Juarez-Jimenez J , de los Rios C , Chioua M , Pouplana R , Luque FJ , Unzeta M , Marco-Contelles J , Samadi A |
| Ref : Journal of Medicinal Chemistry , 54 :8251 , 2011 |
| Abstract : Bolea_2011_J.Med.Chem_54_8251 |
| ESTHER : Bolea_2011_J.Med.Chem_54_8251 |
| PubMedSearch : Bolea_2011_J.Med.Chem_54_8251 |
| PubMedID: 22023459 |
| Title : Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives - Silva_2011_Eur.J.Med.Chem_46_4676 |
| Author(s) : Silva D , Chioua M , Samadi A , Carmo Carreiras M , Jimeno ML , Mendes E , Rios Cde L , Romero A , Villarroya M , Lopez MG , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 46 :4676 , 2011 |
| Abstract : Silva_2011_Eur.J.Med.Chem_46_4676 |
| ESTHER : Silva_2011_Eur.J.Med.Chem_46_4676 |
| PubMedSearch : Silva_2011_Eur.J.Med.Chem_46_4676 |
| PubMedID: 21715067 |
| Title : Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists - Tomassoli_2011_Eur.J.Med.Chem_46_1 |
| Author(s) : Tomassoli I , Ismaili L , Pudlo M , de los Rios C , Soriano E , Colmena I , Gandia L , Rivas L , Samadi A , Marco-Contelles J , Refouvelet B |
| Ref : Eur Journal of Medicinal Chemistry , 46 :1 , 2011 |
| Abstract : Tomassoli_2011_Eur.J.Med.Chem_46_1 |
| ESTHER : Tomassoli_2011_Eur.J.Med.Chem_46_1 |
| PubMedSearch : Tomassoli_2011_Eur.J.Med.Chem_46_1 |
| PubMedID: 21111515 |
| Title : Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues - Martins_2011_Eur.J.Med.Chem_46_6119 |
| Author(s) : Martins C , Carreiras MC , Leon R , de los Rios C , Bartolini M , Andrisano V , Iriepa I , Moraleda I , Galvez E , Garcia M , Egea J , Samadi A , Chioua M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 46 :6119 , 2011 |
| Abstract : Martins_2011_Eur.J.Med.Chem_46_6119 |
| ESTHER : Martins_2011_Eur.J.Med.Chem_46_6119 |
| PubMedSearch : Martins_2011_Eur.J.Med.Chem_46_6119 |
| PubMedID: 22000936 |
| Title : Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease - Samadi_2011_Eur.J.Med.Chem_46_4665 |
| Author(s) : Samadi A , Chioua M , Bolea I , de los Rios C , Iriepa I , Moraleda I , Bastida A , Esteban G , Unzeta M , Galvez E , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 46 :4665 , 2011 |
| Abstract : Samadi_2011_Eur.J.Med.Chem_46_4665 |
| ESTHER : Samadi_2011_Eur.J.Med.Chem_46_4665 |
| PubMedSearch : Samadi_2011_Eur.J.Med.Chem_46_4665 |
| PubMedID: 21669479 |
| Title : Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles - Samadi_2010_Bioorg.Med.Chem_18_5861 |
| Author(s) : Samadi A , Marco-Contelles J , Soriano E , Alvarez-Perez M , Chioua M , Romero A , Gonzalez-Lafuente L , Gandia L , Roda JM , Lopez MG , Villarroya M , Garcia AG , Rios Cde L |
| Ref : Bioorganic & Medicinal Chemistry , 18 :5861 , 2010 |
| Abstract : Samadi_2010_Bioorg.Med.Chem_18_5861 |
| ESTHER : Samadi_2010_Bioorg.Med.Chem_18_5861 |
| PubMedSearch : Samadi_2010_Bioorg.Med.Chem_18_5861 |
| PubMedID: 20656495 |
| Title : Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate - Soriano_2010_Bioorg.Med.Chem.Lett_20_2950 |
| Author(s) : Soriano E , Samadi A , Chioua M , de los Rios C , Marco-Contelles J |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :2950 , 2010 |
| Abstract : Soriano_2010_Bioorg.Med.Chem.Lett_20_2950 |
| ESTHER : Soriano_2010_Bioorg.Med.Chem.Lett_20_2950 |
| PubMedSearch : Soriano_2010_Bioorg.Med.Chem.Lett_20_2950 |
| PubMedID: 20350807 |
| Title : Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives - de Los Rios_2010_J.Med.Chem_53_5129 |
| Author(s) : de los Rios C , Egea J , Marco-Contelles J , Leon R , Samadi A , Iriepa I , Moraleda I , Galvez E , Garcia AG , Lopez MG , Villarroya M , Romero A |
| Ref : Journal of Medicinal Chemistry , 53 :5129 , 2010 |
| Abstract : de Los Rios_2010_J.Med.Chem_53_5129 |
| ESTHER : de Los Rios_2010_J.Med.Chem_53_5129 |
| PubMedSearch : de Los Rios_2010_J.Med.Chem_53_5129 |
| PubMedID: 20575555 |