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| Title : From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease - Brown_2021_Cell_184_5886 |
| Author(s) : Brown AJH , Bradley SJ , Marshall FH , Brown GA , Bennett KA , Brown J , Cansfield JE , Cross DM , de Graaf C , Hudson BD , Dwomoh L , Dias JM , Errey JC , Hurrell E , Liptrot J , Mattedi G , Molloy C , Nathan PJ , Okrasa K , Osborne G , Patel JC , Pickworth M , Robertson N , Shahabi S , Bundgaard C , Phillips K , Broad LM , Goonawardena AV , Morairty SR , Browning M , Perini F , Dawson GR , Deakin JFW , Smith RT , Sexton PM , Warneck J , Vinson M , Tasker T , Tehan BG , Teobald B , Christopoulos A , Langmead CJ , Jazayeri A , Cooke RM , Rucktooa P , Congreve MS , Weir M , Tobin AB |
| Ref : Cell , 184 :5886 , 2021 |
| Abstract : Brown_2021_Cell_184_5886 |
| ESTHER : Brown_2021_Cell_184_5886 |
| PubMedSearch : Brown_2021_Cell_184_5886 |
| PubMedID: 34822784 |
| Title : Assembly of a pi-pi stack of ligands in the binding site of an acetylcholine-binding protein - Stornaiuolo_2013_Nat.Commun_4_1875 |
| Author(s) : Stornaiuolo M , De Kloe GE , Rucktooa P , Fish A , van Elk R , Edink ES , Bertrand D , Smit AB , de Esch IJ , Sixma TK |
| Ref : Nat Commun , 4 :1875 , 2013 |
| Abstract : Stornaiuolo_2013_Nat.Commun_4_1875 |
| ESTHER : Stornaiuolo_2013_Nat.Commun_4_1875 |
| PubMedSearch : Stornaiuolo_2013_Nat.Commun_4_1875 |
| PubMedID: 23695669 |
| Title : Dimeric alpha-cobratoxin X-ray structure: localization of intermolecular disulfides and possible mode of binding to nicotinic acetylcholine receptors - Osipov_2012_J.Biol.Chem_287_6725 |
| Author(s) : Osipov AV , Rucktooa P , Kasheverov IE , Filkin SY , Starkov VG , Andreeva TV , Sixma TK , Bertrand D , Utkin YN , Tsetlin VI |
| Ref : Journal of Biological Chemistry , 287 :6725 , 2012 |
| Abstract : Osipov_2012_J.Biol.Chem_287_6725 |
| ESTHER : Osipov_2012_J.Biol.Chem_287_6725 |
| PubMedSearch : Osipov_2012_J.Biol.Chem_287_6725 |
| PubMedID: 22223648 |
| Title : Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein - Rucktooa_2012_J.Biol.Chem_287_23283 |
| Author(s) : Rucktooa P , Haseler CA , van Elk R , Smit AB , Gallagher T , Sixma TK |
| Ref : Journal of Biological Chemistry , 287 :23283 , 2012 |
| Abstract : Rucktooa_2012_J.Biol.Chem_287_23283 |
| ESTHER : Rucktooa_2012_J.Biol.Chem_287_23283 |
| PubMedSearch : Rucktooa_2012_J.Biol.Chem_287_23283 |
| PubMedID: 22553201 |
| Title : Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors - Akdemir_2011_Bioorg.Med.Chem_19_6107 |
| Author(s) : Akdemir A , Rucktooa P , Jongejan A , Elk R , Bertrand S , Sixma TK , Bertrand D , Smit AB , Leurs R , de Graaf C , de Esch IJ |
| Ref : Bioorganic & Medicinal Chemistry , 19 :6107 , 2011 |
| Abstract : Akdemir_2011_Bioorg.Med.Chem_19_6107 |
| ESTHER : Akdemir_2011_Bioorg.Med.Chem_19_6107 |
| PubMedSearch : Akdemir_2011_Bioorg.Med.Chem_19_6107 |
| PubMedID: 21920761 |
| Title : Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis - Edink_2011_J.Am.Chem.Soc_133_5363 |
| Author(s) : Edink E , Rucktooa P , Retra K , Akdemir A , Nahar T , Zuiderveld O , van Elk R , Janssen E , van Nierop P , van Muijlwijk-Koezen J , Smit AB , Sixma TK , Leurs R , de Esch IJ |
| Ref : J Am Chem Soc , 133 :5363 , 2011 |
| Abstract : Edink_2011_J.Am.Chem.Soc_133_5363 |
| ESTHER : Edink_2011_J.Am.Chem.Soc_133_5363 |
| PubMedSearch : Edink_2011_J.Am.Chem.Soc_133_5363 |
| PubMedID: 21322593 |
| Title : Interaction of alpha-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor - Kasheverov_2009_J.Neurochem_111_934 |
| Author(s) : Kasheverov IE , Zhmak MN , Fish A , Rucktooa P , Khruschov AY , Osipov AV , Ziganshin RH , D'Hoedt D , Bertrand D , Sixma TK , Smit AB , Tsetlin VI |
| Ref : Journal of Neurochemistry , 111 :934 , 2009 |
| Abstract : Kasheverov_2009_J.Neurochem_111_934 |
| ESTHER : Kasheverov_2009_J.Neurochem_111_934 |
| PubMedSearch : Kasheverov_2009_J.Neurochem_111_934 |
| PubMedID: 19712060 |
| Title : Insight in nAChR subtype selectivity from AChBP crystal structures - Rucktooa_2009_Biochem.Pharmacol_78(7)_777 |
| Author(s) : Rucktooa P , Smit AB , Sixma TK |
| Ref : Biochemical Pharmacology , 78 :777 , 2009 |
| Abstract : Rucktooa_2009_Biochem.Pharmacol_78(7)_777 |
| ESTHER : Rucktooa_2009_Biochem.Pharmacol_78(7)_777 |
| PubMedSearch : Rucktooa_2009_Biochem.Pharmacol_78(7)_777 |
| PubMedID: 19576182 |