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| Title : Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity - Zhou_2010_J.Med.Chem_53_7251 |
| Author(s) : Zhou C , Garcia-Calvo M , Pinto S , Lombardo M , Feng Z , Bender K , Pryor KD , Bhatt UR , Chabin RM , Geissler WM , Shen Z , Tong X , Zhang Z , Wong KK , Roy RS , Chapman KT , Yang L , Xiong Y |
| Ref : Journal of Medicinal Chemistry , 53 :7251 , 2010 |
| Abstract : Zhou_2010_J.Med.Chem_53_7251 |
| ESTHER : Zhou_2010_J.Med.Chem_53_7251 |
| PubMedSearch : Zhou_2010_J.Med.Chem_53_7251 |
| PubMedID: 20857914 |
| Gene_locus related to this paper: human-PRCP |
| Title : Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes - Mu_2009_Eur.J.Pharmacol_623_148 |
| Author(s) : Mu J , Petrov A , Eiermann GJ , Woods J , Zhou YP , Li Z , Zycband E , Feng Y , Zhu L , Roy RS , Howard AD , Li C , Thornberry NA , Zhang BB |
| Ref : European Journal of Pharmacology , 623 :148 , 2009 |
| Abstract : Mu_2009_Eur.J.Pharmacol_623_148 |
| ESTHER : Mu_2009_Eur.J.Pharmacol_623_148 |
| PubMedSearch : Mu_2009_Eur.J.Pharmacol_623_148 |
| PubMedID: 19765579 |
| Title : Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors - Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097 |
| Author(s) : Edmondson SD , Mastracchio A , Cox JM , Eiermann GJ , He H , Lyons KA , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Xu S , Zhu B , Thornberry NA , Roy RS , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 19 :4097 , 2009 |
| Abstract : Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097 |
| ESTHER : Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097 |
| PubMedSearch : Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097 |
| PubMedID: 19539471 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines - Kim_2008_J.Med.Chem_51_589 |
| Author(s) : Kim D , Kowalchick JE , Brockunier LL , Parmee ER , Eiermann GJ , Fisher MH , He H , Leiting B , Lyons K , Scapin G , Patel SB , Petrov A , Pryor KD , Roy RS , Wu JK , Zhang X , Wyvratt MJ , Zhang BB , Zhu L , Thornberry NA , Weber AE |
| Ref : Journal of Medicinal Chemistry , 51 :589 , 2008 |
| Abstract : Kim_2008_J.Med.Chem_51_589 |
| ESTHER : Kim_2008_J.Med.Chem_51_589 |
| PubMedSearch : Kim_2008_J.Med.Chem_51_589 |
| PubMedID: 18201067 |
| Title : Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes - Mu_2006_Diabetes_55_1695 |
| Author(s) : Mu J , Woods J , Zhou YP , Roy RS , Li Z , Zycband E , Feng Y , Zhu L , Li C , Howard AD , Moller DE , Thornberry NA , Zhang BB |
| Ref : Diabetes , 55 :1695 , 2006 |
| Abstract : Mu_2006_Diabetes_55_1695 |
| ESTHER : Mu_2006_Diabetes_55_1695 |
| PubMedSearch : Mu_2006_Diabetes_55_1695 |
| PubMedID: 16731832 |
| Title : (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]tr iazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Edmondson_2006_J.Med.Chem_49_3614 |
| Author(s) : Edmondson SD , Mastracchio A , Mathvink RJ , He J , Harper B , Park YJ , Beconi M , Di Salvo J , Eiermann GJ , He H , Leiting B , Leone JF , Levorse DA , Lyons K , Patel RA , Patel SB , Petrov A , Scapin G , Shang J , Roy RS , Smith A , Wu JK , Xu S , Zhu B , Thornberry NA , Weber AE |
| Ref : Journal of Medicinal Chemistry , 49 :3614 , 2006 |
| Abstract : Edmondson_2006_J.Med.Chem_49_3614 |
| ESTHER : Edmondson_2006_J.Med.Chem_49_3614 |
| PubMedSearch : Edmondson_2006_J.Med.Chem_49_3614 |
| PubMedID: 16759103 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9 - Lankas_2005_Diabetes_54_2988 |
| Author(s) : Lankas GR , Leiting B , Roy RS , Eiermann GJ , Beconi MG , Biftu T , Chan CC , Edmondson S , Feeney WP , He H , Ippolito DE , Kim D , Lyons KA , Ok HO , Patel RA , Petrov AN , Pryor KA , Qian X , Reigle L , Woods A , Wu JK , Zaller D , Zhang X , Zhu L , Weber AE , Thornberry NA |
| Ref : Diabetes , 54 :2988 , 2005 |
| Abstract : Lankas_2005_Diabetes_54_2988 |
| ESTHER : Lankas_2005_Diabetes_54_2988 |
| PubMedSearch : Lankas_2005_Diabetes_54_2988 |
| PubMedID: 16186403 |
| Title : (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)- yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Kim_2005_J.Med.Chem_48_141 |
| Author(s) : Kim D , Wang L , Beconi M , Eiermann GJ , Fisher MH , He H , Hickey GJ , Kowalchick JE , Leiting B , Lyons K , Marsilio F , McCann ME , Patel RA , Petrov A , Scapin G , Patel SB , Roy RS , Wu JK , Wyvratt MJ , Zhang BB , Zhu L , Thornberry NA , Weber AE |
| Ref : Journal of Medicinal Chemistry , 48 :141 , 2005 |
| Abstract : Kim_2005_J.Med.Chem_48_141 |
| ESTHER : Kim_2005_J.Med.Chem_48_141 |
| PubMedSearch : Kim_2005_J.Med.Chem_48_141 |
| PubMedID: 15634008 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance - Conarello_2003_Proc.Natl.Acad.Sci.U.S.A_100_6825 |
| Author(s) : Conarello SL , Li Z , Ronan J , Roy RS , Zhu L , Jiang G , Liu F , Woods J , Zycband E , Moller DE , Thornberry NA , Zhang BB |
| Ref : Proc Natl Acad Sci U S A , 100 :6825 , 2003 |
| Abstract : Conarello_2003_Proc.Natl.Acad.Sci.U.S.A_100_6825 |
| ESTHER : Conarello_2003_Proc.Natl.Acad.Sci.U.S.A_100_6825 |
| PubMedSearch : Conarello_2003_Proc.Natl.Acad.Sci.U.S.A_100_6825 |
| PubMedID: 12748388 |
| Gene_locus related to this paper: mouse-dpp4 |