Full name : Renard Pierre-Yves
First name : Pierre-Yves
Mail : University of Rouen\; UMR 6014 CNRS COBRA\; Bioorganic chemistry team\; IRCOF rue Tesniere\; Mont-Saint-Aignan\; 76130
Zip Code :
City :
Country : France
Email : pierre-yves.renard@univ-rouen.fr
Phone : +33235522476
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Website :
Directory :
| Title : A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning - Da Silva_2022_J.Med.Chem_65_4649 |
| Author(s) : Da Silva O , Probst N , Landry C , Hanak AS , Warnault P , Coisne C , Calas AG , Gosselet F , Courageux C , Gastellier AJ , Trancart M , Baati R , Dehouck MP , Jean L , Nachon F , Renard PY , Dias J |
| Ref : Journal of Medicinal Chemistry , 65 :4649 , 2022 |
| Abstract : Da Silva_2022_J.Med.Chem_65_4649 |
| ESTHER : Da Silva_2022_J.Med.Chem_65_4649 |
| PubMedSearch : Da Silva_2022_J.Med.Chem_65_4649 |
| PubMedID: 35255209 |
| Gene_locus related to this paper: human-ACHE |
| Title : Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP\/PS1 Mice - Viayna_2021_J.Med.Chem_64_812 |
| Author(s) : Viayna E , Coquelle N , Cieslikiewicz-Bouet M , Cisternas P , Oliva CA , Sanchez-Lopez E , Ettcheto M , Bartolini M , De Simone A , Ricchini M , Rendina M , Pons M , Firuzi O , Perez B , Saso L , Andrisano V , Nachon F , Brazzolotto X , Garcia ML , Camins A , Silman I , Jean L , Inestrosa NC , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 64 :812 , 2021 |
| Abstract : Viayna_2021_J.Med.Chem_64_812 |
| ESTHER : Viayna_2021_J.Med.Chem_64_812 |
| PubMedSearch : Viayna_2021_J.Med.Chem_64_812 |
| PubMedID: 33356266 |
| Gene_locus related to this paper: human-ACHE |
| Title : Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor - Cieslikiewicz-Bouet_2020_Biochem.Pharmacol__114010 |
| Author(s) : Cieslikiewicz-Bouet M , Naldi M , Bartolini M , Perez B , Servent D , Jean L , Araoz R , Renard PY |
| Ref : Biochemical Pharmacology , :114010 , 2020 |
| Abstract : Cieslikiewicz-Bouet_2020_Biochem.Pharmacol__114010 |
| ESTHER : Cieslikiewicz-Bouet_2020_Biochem.Pharmacol__114010 |
| PubMedSearch : Cieslikiewicz-Bouet_2020_Biochem.Pharmacol__114010 |
| PubMedID: 32360492 |
| Title : Pharmacokinetic evaluation of brain penetrating morpholine-3-hydroxy-2-pyridine oxime as an antidote for nerve agent poisoning - Zorbaz_2020_ACS.Chem.Neurosci__ |
| Author(s) : Zorbaz T , Misetic P , Probst N , Zunec S , Zandona A , Mendas G , Micek V , Macek Hrvat N , Katalinic M , Braiki A , Jean L , Renard PY , Gabelica Markovic V , Kovarik Z |
| Ref : ACS Chem Neurosci , : , 2020 |
| Abstract : Zorbaz_2020_ACS.Chem.Neurosci__ |
| ESTHER : Zorbaz_2020_ACS.Chem.Neurosci__ |
| PubMedSearch : Zorbaz_2020_ACS.Chem.Neurosci__ |
| PubMedID: 32105443 |
| Title : Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 - Oukoloff_2019_Eur.J.Med.Chem_168_58 |
| Author(s) : Oukoloff K , Coquelle N , Bartolini M , Naldi M , Le Guevel R , Bach S , Josselin B , Ruchaud S , Catto M , Pisani L , Denora N , Iacobazzi RM , Silman I , Sussman JL , Buron F , Colletier JP , Jean L , Routier S , Renard PY |
| Ref : Eur Journal of Medicinal Chemistry , 168 :58 , 2019 |
| Abstract : Oukoloff_2019_Eur.J.Med.Chem_168_58 |
| ESTHER : Oukoloff_2019_Eur.J.Med.Chem_168_58 |
| PubMedSearch : Oukoloff_2019_Eur.J.Med.Chem_168_58 |
| PubMedID: 30798053 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection - Pashirova_2018_J.Control.Release_290_102 |
| Author(s) : Pashirova TN , Braiki A , Zueva IV , Petrov KA , Babaev VM , Burilova EA , Samarkina DA , Rizvanov IK , Souto EB , Jean L , Renard PY , Masson P , Zakharova LY , Sinyashin OG |
| Ref : J Control Release , 290 :102 , 2018 |
| Abstract : Pashirova_2018_J.Control.Release_290_102 |
| ESTHER : Pashirova_2018_J.Control.Release_290_102 |
| PubMedSearch : Pashirova_2018_J.Control.Release_290_102 |
| PubMedID: 30308259 |
| Title : Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis - Galdeano_2018_Molecules_23_ |
| Author(s) : Galdeano C , Coquelle N , Cieslikiewicz-Bouet M , Bartolini M , Perez B , Clos MV , Silman I , Jean L , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Molecules , 23 : , 2018 |
| Abstract : Galdeano_2018_Molecules_23_ |
| ESTHER : Galdeano_2018_Molecules_23_ |
| PubMedSearch : Galdeano_2018_Molecules_23_ |
| PubMedID: 29534488 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents - Santoni_2018_J.Med.Chem_61_7630 |
| Author(s) : Santoni G , de Sousa J , De la Mora E , Dias J , Jean L , Sussman JL , Silman I , Renard PY , Brown RCD , Weik M , Baati R , Nachon F |
| Ref : Journal of Medicinal Chemistry , 61 :7630 , 2018 |
| Abstract : Santoni_2018_J.Med.Chem_61_7630 |
| ESTHER : Santoni_2018_J.Med.Chem_61_7630 |
| PubMedSearch : Santoni_2018_J.Med.Chem_61_7630 |
| PubMedID: 30125110 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration - Zorbaz_2018_Chemistry_24_9675 |
| Author(s) : Zorbaz T , Braiki A , Marakovic N , Renou J , De la Mora E , Macek Hrvat N , Katalinic M , Silman I , Sussman JL , Mercey G , Gomez C , Mougeot R , Perez B , Baati R , Nachon F , Weik M , Jean L , Kovarik Z , Renard PY |
| Ref : Chemistry , 24 :9675 , 2018 |
| Abstract : Zorbaz_2018_Chemistry_24_9675 |
| ESTHER : Zorbaz_2018_Chemistry_24_9675 |
| PubMedSearch : Zorbaz_2018_Chemistry_24_9675 |
| PubMedID: 29672968 |
| Gene_locus related to this paper: torca-ACHE |
| Title : On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM\/MM Approach - Driant_2017_Chembiochem_18_666 |
| Author(s) : Driant T , Nachon F , Ollivier C , Renard PY , Derat E |
| Ref : Chembiochem , 18 :666 , 2017 |
| Abstract : Driant_2017_Chembiochem_18_666 |
| ESTHER : Driant_2017_Chembiochem_18_666 |
| PubMedSearch : Driant_2017_Chembiochem_18_666 |
| PubMedID: 28106328 |
| Title : An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice - Calas_2017_Chem.Biol.Interact_267_11 |
| Author(s) : Calas AG , Dias J , Rousseau C , Arboleas M , Touvrey-Loiodice M , Mercey G , Jean L , Renard PY , Nachon F |
| Ref : Chemico-Biological Interactions , 267 :11 , 2017 |
| Abstract : Calas_2017_Chem.Biol.Interact_267_11 |
| ESTHER : Calas_2017_Chem.Biol.Interact_267_11 |
| PubMedSearch : Calas_2017_Chem.Biol.Interact_267_11 |
| PubMedID: 26972668 |
| Title : A selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging - Chao_2016_Chem.Commun.(Camb)_52_11599 |
| Author(s) : Chao S , Krejci E , Bernard V , Leroy J , Jean L , Renard PY |
| Ref : Chem Commun (Camb) , 52 :11599 , 2016 |
| Abstract : Chao_2016_Chem.Commun.(Camb)_52_11599 |
| ESTHER : Chao_2016_Chem.Commun.(Camb)_52_11599 |
| PubMedSearch : Chao_2016_Chem.Commun.(Camb)_52_11599 |
| PubMedID: 27604478 |
| Title : Poster: Multi-target directed ligands: Electrophysiological characterization of an anticholinesterase inhibitor coupled to an agonist of alpha7 nicotinic acetylcholine receptor - |
| Author(s) : Araoz R , Bouet m , Bartolini M , Coquelle N , Colletier JP , Servent D , Molgo J , Jean L , Renard PY |
| Ref : Biochemical Pharmacology , 97 :621 , 2015 |
| PubMedID: |
| Title : Reaction site-driven regioselective synthesis of AChE inhibitors - Oueis_2014_Org.Biomol.Chem_12_156 |
| Author(s) : Oueis E , Santoni G , Ronco C , Syzgantseva O , Tognetti V , Joubert L , Romieu A , Weik M , Jean L , Sabot C , Nachon F , Renard PY |
| Ref : Org Biomol Chem , 12 :156 , 2014 |
| Abstract : Oueis_2014_Org.Biomol.Chem_12_156 |
| ESTHER : Oueis_2014_Org.Biomol.Chem_12_156 |
| PubMedSearch : Oueis_2014_Org.Biomol.Chem_12_156 |
| PubMedID: 24216754 |
| Title : Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase - Kliachyna_2014_Eur.J.Med.Chem_78C_455 |
| Author(s) : Kliachyna M , Santoni G , Nussbaum V , Renou J , Sanson B , Colletier JP , Arboleas M , Loiodice M , Weik M , Jean L , Renard PY , Nachon F , Baati R |
| Ref : Eur Journal of Medicinal Chemistry , 78C :455 , 2014 |
| Abstract : Kliachyna_2014_Eur.J.Med.Chem_78C_455 |
| ESTHER : Kliachyna_2014_Eur.J.Med.Chem_78C_455 |
| PubMedSearch : Kliachyna_2014_Eur.J.Med.Chem_78C_455 |
| PubMedID: 24704618 |
| Title : First enzymatic hydrolysis\/thio-Michael addition cascade route to synthesis of AChE inhibitors - Oueis_2014_Chem.Commun.(Camb)_50_2043 |
| Author(s) : Oueis E , Nachon F , Sabot C , Renard PY |
| Ref : Chem Commun (Camb) , 50 :2043 , 2014 |
| Abstract : Oueis_2014_Chem.Commun.(Camb)_50_2043 |
| ESTHER : Oueis_2014_Chem.Commun.(Camb)_50_2043 |
| PubMedSearch : Oueis_2014_Chem.Commun.(Camb)_50_2043 |
| PubMedID: 24418813 |
| Title : Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases - Renou_2014_Chem.Commun.(Camb)_50_3947 |
| Author(s) : Renou J , Loiodice M , Arboleas M , Baati R , Jean L , Nachon F , Renard PY |
| Ref : Chem Commun (Camb) , 50 :3947 , 2014 |
| Abstract : Renou_2014_Chem.Commun.(Camb)_50_3947 |
| ESTHER : Renou_2014_Chem.Commun.(Camb)_50_3947 |
| PubMedSearch : Renou_2014_Chem.Commun.(Camb)_50_3947 |
| PubMedID: 24599312 |
| Title : Strategies for the selection of catalytic antibodies against organophosphorus nerve agents - Smirnov_2013_Chem.Biol.Interact_203_196 |
| Author(s) : Smirnov IV , Belogurov AA, Jr. , Friboulet A , Masson P , Gabibov AG , Renard PY |
| Ref : Chemico-Biological Interactions , 203 :196 , 2013 |
| Abstract : Smirnov_2013_Chem.Biol.Interact_203_196 |
| ESTHER : Smirnov_2013_Chem.Biol.Interact_203_196 |
| PubMedSearch : Smirnov_2013_Chem.Biol.Interact_203_196 |
| PubMedID: 23123255 |
| Title : Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase - Nachon_2013_Biochem.J_453_393 |
| Author(s) : Nachon F , Carletti E , Ronco C , Trovaslet M , Nicolet Y , Jean L , Renard PY |
| Ref : Biochemical Journal , 453 :393 , 2013 |
| Abstract : Nachon_2013_Biochem.J_453_393 |
| ESTHER : Nachon_2013_Biochem.J_453_393 |
| PubMedSearch : Nachon_2013_Biochem.J_453_393 |
| PubMedID: 23679855 |
| Gene_locus related to this paper: human-ACHE , human-BCHE |
| Title : Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents - Renou_2013_Chem.Biol.Interact_203_81 |
| Author(s) : Renou J , Mercey G , Verdelet T , Paunescu E , Gillon E , Arboleas M , Loiodice M , Kliachyna M , Baati R , Nachon F , Jean L , Renard PY |
| Ref : Chemico-Biological Interactions , 203 :81 , 2013 |
| Abstract : Renou_2013_Chem.Biol.Interact_203_81 |
| ESTHER : Renou_2013_Chem.Biol.Interact_203_81 |
| PubMedSearch : Renou_2013_Chem.Biol.Interact_203_81 |
| PubMedID: 23111374 |
| Title : Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography - Ronco_2012_ChemMedChem_7_400 |
| Author(s) : Ronco C , Carletti E , Colletier JP , Weik M , Nachon F , Jean L , Renard PY |
| Ref : ChemMedChem , 7 :400 , 2012 |
| Abstract : Ronco_2012_ChemMedChem_7_400 |
| ESTHER : Ronco_2012_ChemMedChem_7_400 |
| PubMedSearch : Ronco_2012_ChemMedChem_7_400 |
| PubMedID: 22052791 |
| Gene_locus related to this paper: mouse-ACHE |
| Title : Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents - Mercey_2012_Acc.Chem.Res_45_756 |
| Author(s) : Mercey G , Verdelet T , Renou J , Kliachyna M , Baati R , Nachon F , Jean L , Renard PY |
| Ref : Acc Chem Res , 45 :756 , 2012 |
| Abstract : Mercey_2012_Acc.Chem.Res_45_756 |
| ESTHER : Mercey_2012_Acc.Chem.Res_45_756 |
| PubMedSearch : Mercey_2012_Acc.Chem.Res_45_756 |
| PubMedID: 22360473 |
| Title : Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure - Brazzolotto_2012_Febs.J_279_2905 |
| Author(s) : Brazzolotto X , Wandhammer M , Ronco C , Trovaslet M , Jean L , Lockridge O , Renard PY , Nachon F |
| Ref : Febs J , 279 :2905 , 2012 |
| Abstract : Brazzolotto_2012_Febs.J_279_2905 |
| ESTHER : Brazzolotto_2012_Febs.J_279_2905 |
| PubMedSearch : Brazzolotto_2012_Febs.J_279_2905 |
| PubMedID: 22726956 |
| Gene_locus related to this paper: human-BCHE |
| Title : Screening of new huprines--inhibitors of acetylcholinesterases by electrospray ionization ion trap mass spectrometry - Ziemianin_2012_J.Pharm.Biomed.Anal_70_1 |
| Author(s) : Ziemianin A , Ronco C , Dole R , Jean L , Renard PY , Lange CM |
| Ref : J Pharm Biomed Anal , 70 :1 , 2012 |
| Abstract : Ziemianin_2012_J.Pharm.Biomed.Anal_70_1 |
| ESTHER : Ziemianin_2012_J.Pharm.Biomed.Anal_70_1 |
| PubMedSearch : Ziemianin_2012_J.Pharm.Biomed.Anal_70_1 |
| PubMedID: 22677656 |
| Title : Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase - Mercey_2012_J.Med.Chem_55_10791 |
| Author(s) : Mercey G , Renou J , Verdelet T , Kliachyna M , Baati R , Gillon E , Arboleas M , Loiodice M , Nachon F , Jean L , Renard PY |
| Ref : Journal of Medicinal Chemistry , 55 :10791 , 2012 |
| Abstract : Mercey_2012_J.Med.Chem_55_10791 |
| ESTHER : Mercey_2012_J.Med.Chem_55_10791 |
| PubMedSearch : Mercey_2012_J.Med.Chem_55_10791 |
| PubMedID: 23148598 |
| Title : First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase - Mercey_2011_Chem.Commun.(Camb)_47_5295 |
| Author(s) : Mercey G , Verdelet T , Saint-Andre G , Gillon E , Wagner A , Baati R , Jean L , Nachon F , Renard PY |
| Ref : Chem Commun (Camb) , 47 :5295 , 2011 |
| Abstract : Mercey_2011_Chem.Commun.(Camb)_47_5295 |
| ESTHER : Mercey_2011_Chem.Commun.(Camb)_47_5295 |
| PubMedSearch : Mercey_2011_Chem.Commun.(Camb)_47_5295 |
| PubMedID: 21451868 |
| Title : New huprine derivatives functionalized at position 9 as highly potent acetylcholinesterase inhibitors - Ronco_2011_ChemMedChem_6_876 |
| Author(s) : Ronco C , Foucault R , Gillon E , Bohn P , Nachon F , Jean L , Renard PY |
| Ref : ChemMedChem , 6 :876 , 2011 |
| Abstract : Ronco_2011_ChemMedChem_6_876 |
| ESTHER : Ronco_2011_ChemMedChem_6_876 |
| PubMedSearch : Ronco_2011_ChemMedChem_6_876 |
| PubMedID: 21344648 |
| Title : Optimized strategies to synthesize beta-cyclodextrin-oxime conjugates as a new generation of organophosphate scavengers - Le Provost_2011_Org.Biomol.Chem_9_3026 |
| Author(s) : Le Provost R , Wille T , Louise L , Masurier N , Muller S , Reiter G , Renard PY , Lafont O , Worek F , Estour F |
| Ref : Org Biomol Chem , 9 :3026 , 2011 |
| Abstract : Le Provost_2011_Org.Biomol.Chem_9_3026 |
| ESTHER : Le Provost_2011_Org.Biomol.Chem_9_3026 |
| PubMedSearch : Le Provost_2011_Org.Biomol.Chem_9_3026 |
| PubMedID: 21373706 |
| Title : A HTS assay for the detection of organophosphorus nerve agent scavengers - Louise-Leriche_2010_Chemistry_16_3510 |
| Author(s) : Louise-Leriche L , Paunescu E , Saint-Andre G , Baati R , Romieu A , Wagner A , Renard PY |
| Ref : Chemistry , 16 :3510 , 2010 |
| Abstract : Louise-Leriche_2010_Chemistry_16_3510 |
| ESTHER : Louise-Leriche_2010_Chemistry_16_3510 |
| PubMedSearch : Louise-Leriche_2010_Chemistry_16_3510 |
| PubMedID: 20143367 |
| Title : Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors - Ronco_2009_Bioorg.Med.Chem_17_4523 |
| Author(s) : Ronco C , Sorin G , Nachon F , Foucault R , Jean L , Romieu A , Renard PY |
| Ref : Bioorganic & Medicinal Chemistry , 17 :4523 , 2009 |
| Abstract : Ronco_2009_Bioorg.Med.Chem_17_4523 |
| ESTHER : Ronco_2009_Bioorg.Med.Chem_17_4523 |
| PubMedSearch : Ronco_2009_Bioorg.Med.Chem_17_4523 |
| PubMedID: 19473849 |
| Title : Design and synthesis of chemiluminescent probes for the detection of cholinesterase activity - Sabelle_2002_J.Am.Chem.Soc_124_4874 |
| Author(s) : Sabelle S , Renard PY , Pecorella K , de Suzzoni-Dezard S , Creminon C , Grassi J , Mioskowski C |
| Ref : Journal of the American Chemical Society , 124 :4874 , 2002 |
| Abstract : Sabelle_2002_J.Am.Chem.Soc_124_4874 |
| ESTHER : Sabelle_2002_J.Am.Chem.Soc_124_4874 |
| PubMedSearch : Sabelle_2002_J.Am.Chem.Soc_124_4874 |
| PubMedID: 11971738 |
| Title : Easy access to phosphonothioates - Renard_2002_Chemistry_8_2910 |
| Author(s) : Renard PY , Schwebel H , Vayron P , Josien L , Valleix A , Mioskowski C |
| Ref : Chemistry , 8 :2910 , 2002 |
| Abstract : Renard_2002_Chemistry_8_2910 |
| ESTHER : Renard_2002_Chemistry_8_2910 |
| PubMedSearch : Renard_2002_Chemistry_8_2910 |
| PubMedID: 12489219 |
| Title : Synthesis and pharmacological evaluation of imidazoline sites I1 and I2 selective ligands - Anastassiadou_2001_Bioorg.Med.Chem_9_585 |
| Author(s) : Anastassiadou M , Danoun S , Crane L , Baziard-Mouysset G , Payard M , Caignard DH , Rettori MC , Renard PY |
| Ref : Bioorganic & Medicinal Chemistry , 9 :585 , 2001 |
| Abstract : Anastassiadou_2001_Bioorg.Med.Chem_9_585 |
| ESTHER : Anastassiadou_2001_Bioorg.Med.Chem_9_585 |
| PubMedSearch : Anastassiadou_2001_Bioorg.Med.Chem_9_585 |
| PubMedID: 11310592 |
| Title : Toward antibody-catalyzed hydrolysis of organophosphorus poisons - Vayron_2000_Proc.Natl.Acad.Sci.U.S.A_97_7058 |
| Author(s) : Vayron P , Renard PY , Taran F , Creminon C , Frobert Y , Grassi J , Mioskowski C |
| Ref : Proc Natl Acad Sci U S A , 97 :7058 , 2000 |
| Abstract : Vayron_2000_Proc.Natl.Acad.Sci.U.S.A_97_7058 |
| ESTHER : Vayron_2000_Proc.Natl.Acad.Sci.U.S.A_97_7058 |
| PubMedSearch : Vayron_2000_Proc.Natl.Acad.Sci.U.S.A_97_7058 |
| PubMedID: 10860971 |