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| Title : Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling - Rea_2017_Eur.J.Med.Chem_139_482 |
| Author(s) : Rea D , Van Elzen R , De Winter H , Van Goethem S , Landuyt B , Luyten W , Schoofs L , Van der Veken P , Augustyns K , De Meester I , Fulop V , Lambeir AM |
| Ref : Eur Journal of Medicinal Chemistry , 139 :482 , 2017 |
| Abstract : Rea_2017_Eur.J.Med.Chem_139_482 |
| ESTHER : Rea_2017_Eur.J.Med.Chem_139_482 |
| PubMedSearch : Rea_2017_Eur.J.Med.Chem_139_482 |
| PubMedID: 28826083 |
| Gene_locus related to this paper: porgi-DPP |
| Title : Crystal structures of Trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes - Canning_2013_PLoS.One_8_e79349 |
| Author(s) : Canning P , Rea D , Morty RE , Fulop V |
| Ref : PLoS ONE , 8 :e79349 , 2013 |
| Abstract : Canning_2013_PLoS.One_8_e79349 |
| ESTHER : Canning_2013_PLoS.One_8_e79349 |
| PubMedSearch : Canning_2013_PLoS.One_8_e79349 |
| PubMedID: 24265767 |
| Gene_locus related to this paper: trybr-PEPTB |
| Title : P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy - Van der Veken_2012_J.Med.Chem_55_9856 |
| Author(s) : Van der Veken P , Fulop V , Rea D , Gerard M , Van Elzen R , Joossens J , Cheng JD , Baekelandt V , De Meester I , Lambeir AM , Augustyns K |
| Ref : Journal of Medicinal Chemistry , 55 :9856 , 2012 |
| Abstract : Van der Veken_2012_J.Med.Chem_55_9856 |
| ESTHER : Van der Veken_2012_J.Med.Chem_55_9856 |
| PubMedSearch : Van der Veken_2012_J.Med.Chem_55_9856 |
| PubMedID: 23121075 |
| Gene_locus related to this paper: pig-ppce |
| Title : The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity - Szeltner_2012_Biochim.Biophys.Acta_1834_98 |
| Author(s) : Szeltner Z , Juhasz T , Szamosi I , Rea D , Fulop V , Modos K , Juliano L , Polgar L |
| Ref : Biochimica & Biophysica Acta , 1834 :98 , 2012 |
| Abstract : Szeltner_2012_Biochim.Biophys.Acta_1834_98 |
| ESTHER : Szeltner_2012_Biochim.Biophys.Acta_1834_98 |
| PubMedSearch : Szeltner_2012_Biochim.Biophys.Acta_1834_98 |
| PubMedID: 22940581 |
| Gene_locus related to this paper: pig-ppce |
| Title : Prolyl oligopeptidase structure and dynamics - Rea_2011_CNS.Neurol.Disord.Drug.Targets_10_306 |
| Author(s) : Rea D , Fulop V |
| Ref : CNS Neurol Disord Drug Targets , 10 :306 , 2011 |
| Abstract : Rea_2011_CNS.Neurol.Disord.Drug.Targets_10_306 |
| ESTHER : Rea_2011_CNS.Neurol.Disord.Drug.Targets_10_306 |
| PubMedSearch : Rea_2011_CNS.Neurol.Disord.Drug.Targets_10_306 |
| PubMedID: 21222626 |
| Title : Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide - Racys_2010_Bioorg.Med.Chem_18_4775 |
| Author(s) : Racys DT , Rea D , Fulop V , Wills M |
| Ref : Bioorganic & Medicinal Chemistry , 18 :4775 , 2010 |
| Abstract : Racys_2010_Bioorg.Med.Chem_18_4775 |
| ESTHER : Racys_2010_Bioorg.Med.Chem_18_4775 |
| PubMedSearch : Racys_2010_Bioorg.Med.Chem_18_4775 |
| PubMedID: 20627594 |
| Gene_locus related to this paper: pig-ppce |
| Title : Structure-function properties of prolyl oligopeptidase family enzymes - Rea_2006_Cell.Biochem.Biophys_44_349 |
| Author(s) : Rea D , Fulop V |
| Ref : Cell Biochem Biophys , 44 :349 , 2006 |
| Abstract : Rea_2006_Cell.Biochem.Biophys_44_349 |
| ESTHER : Rea_2006_Cell.Biochem.Biophys_44_349 |
| PubMedSearch : Rea_2006_Cell.Biochem.Biophys_44_349 |
| PubMedID: 16679522 |
| Title : Expression, purification and preliminary crystallographic analysis of dipeptidyl peptidase IV from Porphyromonas gingivalis - Rea_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_1871 |
| Author(s) : Rea D , Lambeir AM , Kumagai Y , De Meester I , Scharpe S , Fulop V |
| Ref : Acta Crystallographica D Biol Crystallogr , 60 :1871 , 2004 |
| Abstract : Rea_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_1871 |
| ESTHER : Rea_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_1871 |
| PubMedSearch : Rea_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_1871 |
| PubMedID: 15388936 |
| Gene_locus related to this paper: porgi-DPP |
| Title : Concerted structural changes in the peptidase and the propeller domains of prolyl oligopeptidase are required for substrate binding - Szeltner_2004_J.Mol.Biol_340_627 |
| Author(s) : Szeltner Z , Rea D , Juhasz T , Renner V , Fulop V , Polgar L |
| Ref : Journal of Molecular Biology , 340 :627 , 2004 |
| Abstract : Szeltner_2004_J.Mol.Biol_340_627 |
| ESTHER : Szeltner_2004_J.Mol.Biol_340_627 |
| PubMedSearch : Szeltner_2004_J.Mol.Biol_340_627 |
| PubMedID: 15210359 |
| Gene_locus related to this paper: pig-q6q2c2 |
| Title : Exploration of the active site of dipeptidyl peptidase IV from Porphyromonas gingivalis. Comparison with the human enzyme - |
| Author(s) : Lambeir AM , Rea D , Fulop V , Kumagai Y , Augustyns K , De Meester I , Haemers A , Scharpe S |
| Ref : Advances in Experimental Medicine & Biology , 524 :29 , 2003 |
| PubMedID: 12675220 |
| Title : Electrostatic environment at the active site of prolyl oligopeptidase is highly influential during substrate binding - Szeltner_2003_J.Biol.Chem_278_48786 |
| Author(s) : Szeltner Z , Rea D , Renner V , Juliano L , Fulop V , Polgar L |
| Ref : Journal of Biological Chemistry , 278 :48786 , 2003 |
| Abstract : Szeltner_2003_J.Biol.Chem_278_48786 |
| ESTHER : Szeltner_2003_J.Biol.Chem_278_48786 |
| PubMedSearch : Szeltner_2003_J.Biol.Chem_278_48786 |
| PubMedID: 14514675 |
| Gene_locus related to this paper: pig-ppce |
| Title : Electrostatic effects and binding determinants in the catalysis of prolyl oligopeptidase. Site specific mutagenesis at the oxyanion binding site - Szeltner_2002_J.Biol.Chem_277_42613 |
| Author(s) : Szeltner Z , Rea D , Renner V , Fulop V , Polgar L |
| Ref : Journal of Biological Chemistry , 277 :42613 , 2002 |
| Abstract : Szeltner_2002_J.Biol.Chem_277_42613 |
| ESTHER : Szeltner_2002_J.Biol.Chem_277_42613 |
| PubMedSearch : Szeltner_2002_J.Biol.Chem_277_42613 |
| PubMedID: 12202494 |
| Gene_locus related to this paper: pig-ppce |
| Title : Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase - Szeltner_2002_J.Biol.Chem_277_44597 |
| Author(s) : Szeltner Z , Rea D , Juhasz T , Renner V , Mucsi Z , Orosz G , Fulop V , Polgar L |
| Ref : Journal of Biological Chemistry , 277 :44597 , 2002 |
| Abstract : Szeltner_2002_J.Biol.Chem_277_44597 |
| ESTHER : Szeltner_2002_J.Biol.Chem_277_44597 |
| PubMedSearch : Szeltner_2002_J.Biol.Chem_277_44597 |
| PubMedID: 12228249 |
| Gene_locus related to this paper: pig-ppce |