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| Title : WaterMap guided structure-based virtual screening for acetylcholinesterase inhibitors - Targowska-Duda_2022_ChemMedChem__ |
| Author(s) : Targowska-Duda KM , Maj M , Draczkowski P , Budzynska B , Boguszewska-Czubara A , Wrobel TM , Laitinen T , Kaczmar P , Poso A , Kaczor AA |
| Ref : ChemMedChem , : , 2022 |
| Abstract : Targowska-Duda_2022_ChemMedChem__ |
| ESTHER : Targowska-Duda_2022_ChemMedChem__ |
| PubMedSearch : Targowska-Duda_2022_ChemMedChem__ |
| PubMedID: 35157366 |
| Title : Comparative molecular field analysis and molecular dynamics studies of alpha\/beta hydrolase domain containing 6 (ABHD6) inhibitors - Kaczor_2015_J.Mol.Model_21_2789 |
| Author(s) : Kaczor AA , Targowska-Duda KM , Patel JZ , Laitinen T , Parkkari T , Adams Y , Nevalainen TJ , Poso A |
| Ref : J Mol Model , 21 :2789 , 2015 |
| Abstract : Kaczor_2015_J.Mol.Model_21_2789 |
| ESTHER : Kaczor_2015_J.Mol.Model_21_2789 |
| PubMedSearch : Kaczor_2015_J.Mol.Model_21_2789 |
| PubMedID: 26350245 |
| Title : Robust Hydrolysis of Prostaglandin Glycerol Esters by Human Monoacylglycerol Lipase (MAGL) - Savinainen_2014_Mol.Pharmacol_86_522 |
| Author(s) : Savinainen JR , Kansanen E , Pantsar T , Navia-Paldanius D , Parkkari T , Lehtonen M , Laitinen T , Nevalainen T , Poso A , Levonen AL , Laitinen JT |
| Ref : Molecular Pharmacology , 86 :522 , 2014 |
| Abstract : Savinainen_2014_Mol.Pharmacol_86_522 |
| ESTHER : Savinainen_2014_Mol.Pharmacol_86_522 |
| PubMedSearch : Savinainen_2014_Mol.Pharmacol_86_522 |
| PubMedID: 25140003 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL |
| Title : Mutation of cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency - Laitinen_2014_Mol.Pharmacol_85_510 |
| Author(s) : Laitinen T , Navia-Paldanius D , Rytilahti R , Marjamaa JJ , Karizkova J , Parkkari T , Pantsar T , Poso A , Laitinen JT , Savinainen JR |
| Ref : Molecular Pharmacology , 85 :510 , 2014 |
| Abstract : Laitinen_2014_Mol.Pharmacol_85_510 |
| ESTHER : Laitinen_2014_Mol.Pharmacol_85_510 |
| PubMedSearch : Laitinen_2014_Mol.Pharmacol_85_510 |
| PubMedID: 24368842 |
| Gene_locus related to this paper: human-MGLL |
| Title : 1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling - Kasnanen_2013_Eur.J.Pharm.Sci_49_423 |
| Author(s) : Kasnanen H , Minkkila A , Taupila S , Patel JZ , Parkkari T , Lahtela-Kakkonen M , Saario SM , Nevalainen T , Poso A |
| Ref : Eur J Pharm Sci , 49 :423 , 2013 |
| Abstract : Kasnanen_2013_Eur.J.Pharm.Sci_49_423 |
| ESTHER : Kasnanen_2013_Eur.J.Pharm.Sci_49_423 |
| PubMedSearch : Kasnanen_2013_Eur.J.Pharm.Sci_49_423 |
| PubMedID: 23557840 |
| Gene_locus related to this paper: human-MGLL |
| Title : Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase - Aaltonen_2013_Chem.Biol_20_379 |
| Author(s) : Aaltonen N , Savinainen JR , Ribas CR , Ronkko J , Kuusisto A , Korhonen J , Navia-Paldanius D , Hayrinen J , Takabe P , Kasnanen H , Pantsar T , Laitinen T , Lehtonen M , Pasonen-Seppanen S , Poso A , Nevalainen T , Laitinen JT |
| Ref : Chemical Biology , 20 :379 , 2013 |
| Abstract : Aaltonen_2013_Chem.Biol_20_379 |
| ESTHER : Aaltonen_2013_Chem.Biol_20_379 |
| PubMedSearch : Aaltonen_2013_Chem.Biol_20_379 |
| PubMedID: 23521796 |
| Gene_locus related to this paper: human-MGLL |
| Title : Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors - |
| Author(s) : Minkkila A , Savinainen JR , Kasnanen H , Xhaard H , Nevalainen T , Laitinen JT , Poso A , Leppanen J , Saario SM |
| Ref : ChemMedChem , 4 :1253 , 2009 |
| PubMedID: 19472270 |
| Title : Identification of inhibitors of the nicotine metabolising CYP2A6 enzyme--an in silico approach - Rahnasto_2008_Pharmacogenomics.J_8_328 |
| Author(s) : Rahnasto M , Wittekindt C , Juvonen RO , Turpeinen M , Petsalo A , Pelkonen O , Poso A , Stahl G , Holtje HD , Raunio H |
| Ref : Pharmacogenomics J , 8 :328 , 2008 |
| Abstract : Rahnasto_2008_Pharmacogenomics.J_8_328 |
| ESTHER : Rahnasto_2008_Pharmacogenomics.J_8_328 |
| PubMedSearch : Rahnasto_2008_Pharmacogenomics.J_8_328 |
| PubMedID: 17923852 |
| Title : Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system - Saario_2006_J.Med.Chem_49_4650 |
| Author(s) : Saario SM , Poso A , Juvonen RO , Jarvinen T , Salo-Ahen OM |
| Ref : Journal of Medicinal Chemistry , 49 :4650 , 2006 |
| Abstract : Saario_2006_J.Med.Chem_49_4650 |
| ESTHER : Saario_2006_J.Med.Chem_49_4650 |
| PubMedSearch : Saario_2006_J.Med.Chem_49_4650 |
| PubMedID: 16854070 |
| Title : Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes - Saario_2005_Chem.Biol_12_649 |
| Author(s) : Saario SM , Salo OM , Nevalainen T , Poso A , Laitinen JT , Jarvinen T , Niemi R |
| Ref : Chemical Biology , 12 :649 , 2005 |
| Abstract : Saario_2005_Chem.Biol_12_649 |
| ESTHER : Saario_2005_Chem.Biol_12_649 |
| PubMedSearch : Saario_2005_Chem.Biol_12_649 |
| PubMedID: 15975510 |
| Title : Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions - Jarho_2005_J.Med.Chem_48_4772 |
| Author(s) : Jarho EM , Wallen EA , Christiaans JA , Forsberg MM , Venalainen JI , Mannisto PT , Gynther J , Poso A |
| Ref : Journal of Medicinal Chemistry , 48 :4772 , 2005 |
| Abstract : Jarho_2005_J.Med.Chem_48_4772 |
| ESTHER : Jarho_2005_J.Med.Chem_48_4772 |
| PubMedSearch : Jarho_2005_J.Med.Chem_48_4772 |
| PubMedID: 16033257 |
| Title : Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819 - Venalainen_2002_Biochem.Pharmacol_64_463 |
| Author(s) : Venalainen JI , Juvonen RO , Forsberg MM , Garcia-Horsman A , Poso A , Wallen EA , Gynther J , Mannisto PT |
| Ref : Biochemical Pharmacology , 64 :463 , 2002 |
| Abstract : Venalainen_2002_Biochem.Pharmacol_64_463 |
| ESTHER : Venalainen_2002_Biochem.Pharmacol_64_463 |
| PubMedSearch : Venalainen_2002_Biochem.Pharmacol_64_463 |
| PubMedID: 12147298 |