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| Title : A-series agent A-234: initial in vitro and in vivo characterization - Hrabinova_2024_Arch.Toxicol__ |
| Author(s) : Hrabinova M , Pejchal J , Hepnarova V , Muckova L , Junova L , Opravil J , Zdarova Karasova J , Rozsypal T , Dlabkova A , Rehulkova H , Kucera T , Vecera Z , Caisberger F , Schmidt M , Soukup O , Jun D |
| Ref : Archives of Toxicology , : , 2024 |
| Abstract : Hrabinova_2024_Arch.Toxicol__ |
| ESTHER : Hrabinova_2024_Arch.Toxicol__ |
| PubMedSearch : Hrabinova_2024_Arch.Toxicol__ |
| PubMedID: 38446233 |
| Title : Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition - Misiachna_2024_Eur.J.Med.Chem_266_116130 |
| Author(s) : Misiachna A , Svobodova B , Netolicky J , Chvojkova M , Kleteckova L , Prchal L , Novak M , Hrabinova M , Kucera T , Muckova L , Moravcova Z , Karasova JZ , Pejchal J , Blazek F , Malinak D , Hakenova K , Krausova BH , Kolcheva M , Ladislav M , Korabecny J , Pahnke J , Vales K , Horak M , Soukup O |
| Ref : Eur Journal of Medicinal Chemistry , 266 :116130 , 2024 |
| Abstract : Misiachna_2024_Eur.J.Med.Chem_266_116130 |
| ESTHER : Misiachna_2024_Eur.J.Med.Chem_266_116130 |
| PubMedSearch : Misiachna_2024_Eur.J.Med.Chem_266_116130 |
| PubMedID: 38218127 |
| Title : The measured CSF\/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24h after donepezil treatment in patients with Alzheimer's disease - Valis_2023_Biomed.Pharmacother_159_114223 |
| Author(s) : Valis M , Dlabkova A , Hort J , Angelucci F , Pejchal J , Kuca K , Pavelek Z , Karasova JZ , Novotny M |
| Ref : Biomed Pharmacother , 159 :114223 , 2023 |
| Abstract : Valis_2023_Biomed.Pharmacother_159_114223 |
| ESTHER : Valis_2023_Biomed.Pharmacother_159_114223 |
| PubMedSearch : Valis_2023_Biomed.Pharmacother_159_114223 |
| PubMedID: 36630846 |
| Title : A-agents, misleadingly known as Novichoks: a narrative review - Opravil_2023_Arch.Toxicol__ |
| Author(s) : Opravil J , Pejchal J , Finger V , Korabecny J , Rozsypal T , Hrabinova M , Muckova L , Hepnarova V , Konecny J , Soukup O , Jun D |
| Ref : Archives of Toxicology , : , 2023 |
| Abstract : Opravil_2023_Arch.Toxicol__ |
| ESTHER : Opravil_2023_Arch.Toxicol__ |
| PubMedSearch : Opravil_2023_Arch.Toxicol__ |
| PubMedID: 37612377 |
| Title : UHPLC-HRMS study of pharmacokinetics of a novel hybrid cholinesterase inhibitor K1234: A comparison between in silico, in vitro and in vivo data - Mzik_2022_J.Pharm.Biomed.Anal_219_114898 |
| Author(s) : Mzik M , Sestak V , Mezeiova E , Korabecny J , Hroch M , Pejchal J , Karasova-Zdarova J |
| Ref : J Pharm Biomed Anal , 219 :114898 , 2022 |
| Abstract : Mzik_2022_J.Pharm.Biomed.Anal_219_114898 |
| ESTHER : Mzik_2022_J.Pharm.Biomed.Anal_219_114898 |
| PubMedSearch : Mzik_2022_J.Pharm.Biomed.Anal_219_114898 |
| PubMedID: 35779353 |
| Title : Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870 - Karasova_2022_Food.Chem.Toxicol__113236 |
| Author(s) : Karasova JZ , Kassa J , Hepnarova V , Pejchal J , Junova L , Andrys R , Malinak D , Bzonek P , Kohoutova Z , Musilek K |
| Ref : Food & Chemical Toxicology , :113236 , 2022 |
| Abstract : Karasova_2022_Food.Chem.Toxicol__113236 |
| ESTHER : Karasova_2022_Food.Chem.Toxicol__113236 |
| PubMedSearch : Karasova_2022_Food.Chem.Toxicol__113236 |
| PubMedID: 35738326 |
| Title : Neurotoxicity evoked by organophosphates and available countermeasures - Pulkrabkova_2022_Arch.Toxicol__ |
| Author(s) : Pulkrabkova L , Svobodova B , Konecny J , Kobrlova T , Muckova L , Janousek J , Pejchal J , Korabecny J , Soukup O |
| Ref : Archives of Toxicology , : , 2022 |
| Abstract : Pulkrabkova_2022_Arch.Toxicol__ |
| ESTHER : Pulkrabkova_2022_Arch.Toxicol__ |
| PubMedSearch : Pulkrabkova_2022_Arch.Toxicol__ |
| PubMedID: 36335468 |
| Title : Non-covalent acetylcholinesterase inhibitors: In vitro screening and molecular modeling for novel selective insecticides - Hepnarova_2022_Toxicol.In.Vitro__105463 |
| Author(s) : Hepnarova V , Hrabinova M , Muckova L , Kucera T , Schmidt M , Dolezal R , Gorecki L , Hrabcova V , Korabecny J , Mezeiova E , Jun D , Pejchal J |
| Ref : Toxicol In Vitro , :105463 , 2022 |
| Abstract : Hepnarova_2022_Toxicol.In.Vitro__105463 |
| ESTHER : Hepnarova_2022_Toxicol.In.Vitro__105463 |
| PubMedSearch : Hepnarova_2022_Toxicol.In.Vitro__105463 |
| PubMedID: 36041654 |
| Title : Determination of K869, a novel oxime reactivator of acetylcholinesterase, in rat body fluids and tissues by liquid-chromatography methods: Pharmacokinetic study - Vanova_2021_J.Pharm.Sci__ |
| Author(s) : Vanova N , Hojna A , Pejchal J , Herman D , Malinak D , Prchalova E , Musilek K , Karasova JZ |
| Ref : J Pharm Sci , : , 2021 |
| Abstract : Vanova_2021_J.Pharm.Sci__ |
| ESTHER : Vanova_2021_J.Pharm.Sci__ |
| PubMedSearch : Vanova_2021_J.Pharm.Sci__ |
| PubMedID: 33545185 |
| Title : Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease - Gorecki_2021_ACS.Chem.Neurosci__ |
| Author(s) : Gorecki L , Uliassi E , Bartolini M , Janockova J , Hrabinova M , Hepnarova V , Prchal L , Muckova L , Pejchal J , Karasova JZ , Mezeiova E , Benkova M , Kobrlova T , Soukup O , Petralla S , Monti B , Korabecny J , Bolognesi ML |
| Ref : ACS Chem Neurosci , : , 2021 |
| Abstract : Gorecki_2021_ACS.Chem.Neurosci__ |
| ESTHER : Gorecki_2021_ACS.Chem.Neurosci__ |
| PubMedSearch : Gorecki_2021_ACS.Chem.Neurosci__ |
| PubMedID: 33852284 |
| Title : A Comparison of the Neuroprotective and Reactivating Efficacy of a Novel Bispyridinium Oxime K870 with Commonly Used Pralidoxime and the Oxime HI-6 in Tabun-Poisoned Rats - Kassa_2021_Acta.Medica.(Hradec.Kralove)_64_145 |
| Author(s) : Kassa J , Hatlapatkova J , Karasova JZ , Hepnarova V , Caisberger F , Pejchal J |
| Ref : Acta Medica (Hradec Kralove) , 64 :145 , 2021 |
| Abstract : Kassa_2021_Acta.Medica.(Hradec.Kralove)_64_145 |
| ESTHER : Kassa_2021_Acta.Medica.(Hradec.Kralove)_64_145 |
| PubMedSearch : Kassa_2021_Acta.Medica.(Hradec.Kralove)_64_145 |
| PubMedID: 34779379 |
| Title : Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness - Karasova_2020_Toxicol.Lett_320_64 |
| Author(s) : Karasova JZ , Hepnarova V , Andrys R , Lisa M , Jost P , Muckova L , Pejchal J , Herman D , Jun D , Kassa J , Kuca K |
| Ref : Toxicol Lett , 320 :64 , 2020 |
| Abstract : Karasova_2020_Toxicol.Lett_320_64 |
| ESTHER : Karasova_2020_Toxicol.Lett_320_64 |
| PubMedSearch : Karasova_2020_Toxicol.Lett_320_64 |
| PubMedID: 31794810 |
| Title : Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators - Hepnarova_2019_Toxicol.Appl.Pharmacol__114776 |
| Author(s) : Hepnarova V , Muckova L , Ring A , Pejchal J , Herman D , Misik J , Hrabinova M , Jun D , Soukup O |
| Ref : Toxicol Appl Pharmacol , :114776 , 2019 |
| Abstract : Hepnarova_2019_Toxicol.Appl.Pharmacol__114776 |
| ESTHER : Hepnarova_2019_Toxicol.Appl.Pharmacol__114776 |
| PubMedSearch : Hepnarova_2019_Toxicol.Appl.Pharmacol__114776 |
| PubMedID: 31629733 |
| Title : Oxidative stress induced by oxime reactivators of acetylcholinesterase in vitro - Muckova_2019_Toxicol.In.Vitro_56_110 |
| Author(s) : Muckova L , Vanova N , Misik J , Herman D , Pejchal J , Jun D |
| Ref : Toxicol In Vitro , 56 :110 , 2019 |
| Abstract : Muckova_2019_Toxicol.In.Vitro_56_110 |
| ESTHER : Muckova_2019_Toxicol.In.Vitro_56_110 |
| PubMedSearch : Muckova_2019_Toxicol.In.Vitro_56_110 |
| PubMedID: 30682493 |
| Title : Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease - Chalupova_2019_Eur.J.Med.Chem_168_491 |
| Author(s) : Chalupova K , Korabecny J , Bartolini M , Monti B , Lamba D , Caliandro R , Pesaresi A , Brazzolotto X , Gastellier AJ , Nachon F , Pejchal J , Jarosova M , Hepnarova V , Jun D , Hrabinova M , Dolezal R , Karasova JZ , Mzik M , Kristofikova Z , Misik J , Muckova L , Jost P , Soukup O , Benkova M , Setnicka V , Habartova L , Chvojkova M , Kleteckova L , Vales K , Mezeiova E , Uliassi E , Valis M , Nepovimova E , Bolognesi ML , Kuca K |
| Ref : Eur Journal of Medicinal Chemistry , 168 :491 , 2019 |
| Abstract : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| ESTHER : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| PubMedSearch : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| PubMedID: 30851693 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings - Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| Author(s) : Kuca K , Karasova JZ , Soukup O , Kassa J , Novotna E , Sepsova V , Horova A , Pejchal J , Hrabinova M , Vodakova E , Jun D , Nepovimova E , Valis M , Musilek K |
| Ref : Drug Des Devel Ther , 12 :505 , 2018 |
| Abstract : Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| ESTHER : Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| PubMedSearch : Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| PubMedID: 29563775 |
| Title : Cytotoxicity of acetylcholinesterase reactivators evaluated in vitro and its relation to their structure - Muckova_2018_Drug.Chem.Toxicol__1 |
| Author(s) : Muckova L , Pejchal J , Jost P , Vanova N , Herman D , Jun D |
| Ref : Drug & Chemical Toxicology , :1 , 2018 |
| Abstract : Muckova_2018_Drug.Chem.Toxicol__1 |
| ESTHER : Muckova_2018_Drug.Chem.Toxicol__1 |
| PubMedSearch : Muckova_2018_Drug.Chem.Toxicol__1 |
| PubMedID: 29421945 |
| Title : Oxidative stress in organophosphate poisoning: role of standard antidotal therapy - Vanova_2018_J.Appl.Toxicol_38_1058 |
| Author(s) : Vanova N , Pejchal J , Herman D , Dlabkova A , Jun D |
| Ref : J Appl Toxicol , 38 :1058 , 2018 |
| Abstract : Vanova_2018_J.Appl.Toxicol_38_1058 |
| ESTHER : Vanova_2018_J.Appl.Toxicol_38_1058 |
| PubMedSearch : Vanova_2018_J.Appl.Toxicol_38_1058 |
| PubMedID: 29516527 |
| Title : Cholinesterase inhibitor 6-chlorotacrine - in vivo toxicological profile and behavioural effects - Misik_2018_Curr.Alzheimer.Res_15_552 |
| Author(s) : Misik J , Nepovimova E , Pejchal J , Kassa J , Korabecny J , Soukup O |
| Ref : Curr Alzheimer Res , 15 :552 , 2018 |
| Abstract : Misik_2018_Curr.Alzheimer.Res_15_552 |
| ESTHER : Misik_2018_Curr.Alzheimer.Res_15_552 |
| PubMedSearch : Misik_2018_Curr.Alzheimer.Res_15_552 |
| PubMedID: 29231138 |
| Title : The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats-A Comparison with Trimedoxime and the Oxime K203 - Kassa_2017_Molecules_22_ |
| Author(s) : Kassa J , Misik J , Hatlapatkova J , Karasova JZ , Sepsova V , Caisberger F , Pejchal J |
| Ref : Molecules , 22 : , 2017 |
| Abstract : Kassa_2017_Molecules_22_ |
| ESTHER : Kassa_2017_Molecules_22_ |
| PubMedSearch : Kassa_2017_Molecules_22_ |
| PubMedID: 28696367 |
| Title : HI-6 treatment does not reactivate sarin inhibited acetylcholinesterase activity in dog brain when administered in human therapeutical dose 30 minutes after the poisoning - Caisberger_2016_Mil.Med.Sci.Lett_85_2 |
| Author(s) : Caisberger F , Novotny L , Hajek P , Misik J , Kassa J , Pejchal J |
| Ref : Military Medical Science Letters , 85 :2 , 2016 |
| Abstract : Caisberger_2016_Mil.Med.Sci.Lett_85_2 |
| ESTHER : Caisberger_2016_Mil.Med.Sci.Lett_85_2 |
| PubMedSearch : Caisberger_2016_Mil.Med.Sci.Lett_85_2 |
| PubMedID: |
| Title : Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX - Kuca_2013_Med.Chem_9_689 |
| Author(s) : Kuca K , Musilek K , Jun D , Karasova J , Soukup O , Pejchal J , Hrabinova M |
| Ref : Med Chem , 9 :689 , 2013 |
| Abstract : Kuca_2013_Med.Chem_9_689 |
| ESTHER : Kuca_2013_Med.Chem_9_689 |
| PubMedSearch : Kuca_2013_Med.Chem_9_689 |
| PubMedID: 22779796 |
| Title : Modulation of ionising radiation generated oxidative stress by HI-6 (asoxime) in a laboratory rat model - Pohanka_2010_Neuro.Endocrinol.Lett_31 Suppl 2_62 |
| Author(s) : Pohanka M , Pejchal J , Horackova S , Kuca K , Bandouchova H , Damkova V , Pikula J |
| Ref : Neuro Endocrinol Lett , 31 Suppl 2 :62 , 2010 |
| Abstract : Pohanka_2010_Neuro.Endocrinol.Lett_31 Suppl 2_62 |
| ESTHER : Pohanka_2010_Neuro.Endocrinol.Lett_31 Suppl 2_62 |
| PubMedSearch : Pohanka_2010_Neuro.Endocrinol.Lett_31 Suppl 2_62 |
| PubMedID: 21187825 |