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| Title : Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults - Samarelli_2024_Eur.J.Med.Chem_270_116353 |
| Author(s) : Samarelli F , Purgatorio R , Lopopolo G , Deruvo C , Catto M , Andresini M , Carrieri A , Nicolotti O , De Palma A , Miniero DV , de Candia M , Altomare CD |
| Ref : Eur Journal of Medicinal Chemistry , 270 :116353 , 2024 |
| Abstract : Samarelli_2024_Eur.J.Med.Chem_270_116353 |
| ESTHER : Samarelli_2024_Eur.J.Med.Chem_270_116353 |
| PubMedSearch : Samarelli_2024_Eur.J.Med.Chem_270_116353 |
| PubMedID: 38579622 |
| Title : Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo - Mugnaini_2024_ACS.Chem.Neurosci__ |
| Author(s) : Mugnaini C , Brizzi A , Paolino M , Scarselli E , Castelli R , de Candia M , Gambacorta N , Nicolotti O , Kostrzewa M , Kumar P , Mahmoud AM , Borgonetti V , Iannotta M , Morace A , Galeotti N , Maione S , Altomare CD , Ligresti A , Corelli F |
| Ref : ACS Chem Neurosci , : , 2024 |
| Abstract : Mugnaini_2024_ACS.Chem.Neurosci__ |
| ESTHER : Mugnaini_2024_ACS.Chem.Neurosci__ |
| PubMedSearch : Mugnaini_2024_ACS.Chem.Neurosci__ |
| PubMedID: 38372253 |
| Title : Investigation on Novel E\/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity - Paolino_2023_Molecules_28_ |
| Author(s) : Paolino M , de Candia M , Purgatorio R , Catto M , Saletti M , Tondo AR , Nicolotti O , Cappelli A , Brizzi A , Mugnaini C , Corelli F , Altomare CD |
| Ref : Molecules , 28 : , 2023 |
| Abstract : Paolino_2023_Molecules_28_ |
| ESTHER : Paolino_2023_Molecules_28_ |
| PubMedSearch : Paolino_2023_Molecules_28_ |
| PubMedID: 37570828 |
| Title : A twenty-year journey exploring coumarin-based derivatives as bioactive molecules - Pisani_2022_Front.Chem_10_1002547 |
| Author(s) : Pisani L , Catto M , Muncipinto G , Nicolotti O , Carrieri A , Rullo M , Stefanachi A , Leonetti F , Altomare CD |
| Ref : Front Chem , 10 :1002547 , 2022 |
| Abstract : Pisani_2022_Front.Chem_10_1002547 |
| ESTHER : Pisani_2022_Front.Chem_10_1002547 |
| PubMedSearch : Pisani_2022_Front.Chem_10_1002547 |
| PubMedID: 36300022 |
| Title : Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases - Purgatorio_2022_Molecules_27_ |
| Author(s) : Purgatorio R , Gambacorta N , Samarelli F , Lopopolo G , de Candia M , Catto M , Nicolotti O , Altomare CD |
| Ref : Molecules , 27 : , 2022 |
| Abstract : Purgatorio_2022_Molecules_27_ |
| ESTHER : Purgatorio_2022_Molecules_27_ |
| PubMedSearch : Purgatorio_2022_Molecules_27_ |
| PubMedID: 35807514 |
| Title : Halogenated Coumarin-Chalcones as Multifunctional Monoamine Oxidase-B and Butyrylcholinesterase Inhibitors - Rehuman_2021_ACS.Omega_6_28182 |
| Author(s) : Rehuman NA , Oh JM , Nath LR , Khames A , Abdelgawad MA , Gambacorta N , Nicolotti O , Jat RK , Kim H , Mathew B |
| Ref : ACS Omega , 6 :28182 , 2021 |
| Abstract : Rehuman_2021_ACS.Omega_6_28182 |
| ESTHER : Rehuman_2021_ACS.Omega_6_28182 |
| PubMedSearch : Rehuman_2021_ACS.Omega_6_28182 |
| PubMedID: 34723016 |
| Title : Piperazine-substituted chalcones: a new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders - Mathew_2021_Environ.Sci.Pollut.Res.Int__1 |
| Author(s) : Mathew B , Oh JM , Baty RS , Batiha GE , Parambi DGT , Gambacorta N , Nicolotti O , Kim H |
| Ref : Environ Sci Pollut Res Int , :1 , 2021 |
| Abstract : Mathew_2021_Environ.Sci.Pollut.Res.Int__1 |
| ESTHER : Mathew_2021_Environ.Sci.Pollut.Res.Int__1 |
| PubMedSearch : Mathew_2021_Environ.Sci.Pollut.Res.Int__1 |
| PubMedID: 33743158 |
| Title : Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential - Nevskaya_2021_Molecules_26_ |
| Author(s) : Nevskaya AA , Anikina LV , Purgatorio R , Catto M , Nicolotti O , de Candia M , Pisani L , Borisova TN , Miftyakhova AR , Varlamov AV , Nevskaya EY , Borisov RS , Voskressensky LG , Altomare CD |
| Ref : Molecules , 26 : , 2021 |
| Abstract : Nevskaya_2021_Molecules_26_ |
| ESTHER : Nevskaya_2021_Molecules_26_ |
| PubMedSearch : Nevskaya_2021_Molecules_26_ |
| PubMedID: 33445600 |
| Title : First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease - Purgatorio_2021_Molecules_26_ |
| Author(s) : Purgatorio R , Gambacorta N , de Candia M , Catto M , Rullo M , Pisani L , Nicolotti O , Altomare CD |
| Ref : Molecules , 26 : , 2021 |
| Abstract : Purgatorio_2021_Molecules_26_ |
| ESTHER : Purgatorio_2021_Molecules_26_ |
| PubMedSearch : Purgatorio_2021_Molecules_26_ |
| PubMedID: 34500640 |
| Title : Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations - Sasidharan_2021_J.Enzyme.Inhib.Med.Chem_36_188 |
| Author(s) : Sasidharan R , Eom BH , Heo JH , Park JE , Abdelgawad MA , Musa A , Gambacorta N , Nicolotti O , Manju SL , Mathew B , Kim H |
| Ref : J Enzyme Inhib Med Chem , 36 :188 , 2021 |
| Abstract : Sasidharan_2021_J.Enzyme.Inhib.Med.Chem_36_188 |
| ESTHER : Sasidharan_2021_J.Enzyme.Inhib.Med.Chem_36_188 |
| PubMedSearch : Sasidharan_2021_J.Enzyme.Inhib.Med.Chem_36_188 |
| PubMedID: 33430657 |
| Title : Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents - Titov_2021_ACS.Chem.Neurosci__ |
| Author(s) : Titov AA , Kobzev MS , Catto M , de Candia M , Gambacorta N , Denora N , Pisani L , Nicolotti O , Borisova TN , Varlamov AV , Voskressensky LG , Altomare CD |
| Ref : ACS Chem Neurosci , : , 2021 |
| Abstract : Titov_2021_ACS.Chem.Neurosci__ |
| ESTHER : Titov_2021_ACS.Chem.Neurosci__ |
| PubMedSearch : Titov_2021_ACS.Chem.Neurosci__ |
| PubMedID: 33395258 |
| Title : De novo drug design of targeted chemical libraries based on artificial intelligence and pair based multi-objective optimization - Alberga_2020_J.Chem.Inf.Model_60_4582 |
| Author(s) : Alberga D , Gambacorta N , Trisciuzzi D , Ciriaco F , Amoroso N , Nicolotti O |
| Ref : J Chem Inf Model , 60 :4582 , 2020 |
| Abstract : Alberga_2020_J.Chem.Inf.Model_60_4582 |
| ESTHER : Alberga_2020_J.Chem.Inf.Model_60_4582 |
| PubMedSearch : Alberga_2020_J.Chem.Inf.Model_60_4582 |
| PubMedID: 32845150 |
| Title : Selected 1,3-Benzodioxine-Containing Chalcones as Multipotent Oxidase and Acetylcholinesterase Inhibitors - Jeong_2020_ChemMedChem_15_2257 |
| Author(s) : Jeong GS , Kaipakasseri S , Lee SR , Marraiki N , Batiha GE , Dev S , Palakkathondi A , Kavully FS , Gambacorta N , Nicolotti O , Mathew B , Kim H |
| Ref : ChemMedChem , 15 :2257 , 2020 |
| Abstract : Jeong_2020_ChemMedChem_15_2257 |
| ESTHER : Jeong_2020_ChemMedChem_15_2257 |
| PubMedSearch : Jeong_2020_ChemMedChem_15_2257 |
| PubMedID: 32924264 |
| Title : Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor - Catto_2020_ACS.Med.Chem.Lett_11_869 |
| Author(s) : Catto M , Pisani L , De la Mora E , Belviso BD , Mangiatordi GF , Pinto A , Palma A , Denora N , Caliandro R , Colletier JP , Silman I , Nicolotti O , Altomare CD |
| Ref : ACS Med Chem Lett , 11 :869 , 2020 |
| Abstract : Catto_2020_ACS.Med.Chem.Lett_11_869 |
| ESTHER : Catto_2020_ACS.Med.Chem.Lett_11_869 |
| PubMedSearch : Catto_2020_ACS.Med.Chem.Lett_11_869 |
| PubMedID: 32435398 |
| Title : Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors - Oh_2020_Molecules_25_ |
| Author(s) : Oh JM , Rangarajan TM , Chaudhary R , Singh RP , Singh M , Tondo AR , Gambacorta N , Nicolotti O , Mathew B , Kim H |
| Ref : Molecules , 25 : , 2020 |
| Abstract : Oh_2020_Molecules_25_ |
| ESTHER : Oh_2020_Molecules_25_ |
| PubMedSearch : Oh_2020_Molecules_25_ |
| PubMedID: 32443652 |
| Title : (Hetero-)(arylidene)arylhydrazides as Multitarget-Directed Monoamine Oxidase Inhibitors - Palakkathondi_2020_ACS.Comb.Sci_22_592 |
| Author(s) : Palakkathondi A , Oh JM , Dev S , Rangarajan TM , Kaipakasseri S , Kavully FS , Gambacorta N , Nicolotti O , Kim H , Mathew B |
| Ref : ACS Comb Sci , 22 :592 , 2020 |
| Abstract : Palakkathondi_2020_ACS.Comb.Sci_22_592 |
| ESTHER : Palakkathondi_2020_ACS.Comb.Sci_22_592 |
| PubMedSearch : Palakkathondi_2020_ACS.Comb.Sci_22_592 |
| PubMedID: 33047950 |
| Title : Ethyl Acetohydroxamate Incorporated Chalcones: Unveiling a Novel Class of Chalcones for Multitarget Monoamine Oxidase-B Inhibitors Against Alzheimer's Disease - Reeta_2019_CNS.Neurol.Disord.Drug.Targets_18_643 |
| Author(s) : Reeta , Baek SC , Lee JP , Rangarajan TM , Ayushee , Singh RP , Singh M , Mangiatordi GF , Nicolotti O , Kim H , Mathew B |
| Ref : CNS Neurol Disord Drug Targets , 18 :643 , 2019 |
| Abstract : Reeta_2019_CNS.Neurol.Disord.Drug.Targets_18_643 |
| ESTHER : Reeta_2019_CNS.Neurol.Disord.Drug.Targets_18_643 |
| PubMedSearch : Reeta_2019_CNS.Neurol.Disord.Drug.Targets_18_643 |
| PubMedID: 31550216 |
| Title : Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl)hydrazone: A water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity - Pisani_2017_Eur.J.Pharm.Sci_109_381 |
| Author(s) : Pisani L , De Palma A , Giangregorio N , Miniero DV , Pesce P , Nicolotti O , Campagna F , Altomare CD , Catto M |
| Ref : Eur J Pharm Sci , 109 :381 , 2017 |
| Abstract : Pisani_2017_Eur.J.Pharm.Sci_109_381 |
| ESTHER : Pisani_2017_Eur.J.Pharm.Sci_109_381 |
| PubMedSearch : Pisani_2017_Eur.J.Pharm.Sci_109_381 |
| PubMedID: 28801274 |
| Title : Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents - Pisani_2016_J.Med.Chem_59_6791 |
| Author(s) : Pisani L , Farina R , Catto M , Iacobazzi RM , Nicolotti O , Cellamare S , Mangiatordi GF , Denora N , Soto-Otero R , Siragusa L , Altomare CD , Carotti A |
| Ref : Journal of Medicinal Chemistry , 59 :6791 , 2016 |
| Abstract : Pisani_2016_J.Med.Chem_59_6791 |
| ESTHER : Pisani_2016_J.Med.Chem_59_6791 |
| PubMedSearch : Pisani_2016_J.Med.Chem_59_6791 |
| PubMedID: 27347731 |
| Title : Searching for Multi-Targeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif - Pisani_2016_Molecules_21_ |
| Author(s) : Pisani L , Farina R , Soto-Otero R , Denora N , Mangiatordi GF , Nicolotti O , Mendez-Alvarez E , Altomare CD , Catto M , Carotti A |
| Ref : Molecules , 21 : , 2016 |
| Abstract : Pisani_2016_Molecules_21_ |
| ESTHER : Pisani_2016_Molecules_21_ |
| PubMedSearch : Pisani_2016_Molecules_21_ |
| PubMedID: 26999091 |
| Title : Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases - Farina_2015_J.Med.Chem_58_5561 |
| Author(s) : Farina R , Pisani L , Catto M , Nicolotti O , Gadaleta D , Denora N , Soto-Otero R , Mendez-Alvarez E , Passos CS , Muncipinto G , Altomare CD , Nurisso A , Carrupt PA , Carotti A |
| Ref : Journal of Medicinal Chemistry , 58 :5561 , 2015 |
| Abstract : Farina_2015_J.Med.Chem_58_5561 |
| ESTHER : Farina_2015_J.Med.Chem_58_5561 |
| PubMedSearch : Farina_2015_J.Med.Chem_58_5561 |
| PubMedID: 26107513 |
| Title : Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase - Catto_2013_Bioorg.Med.Chem_21_146 |
| Author(s) : Catto M , Pisani L , Leonetti F , Nicolotti O , Pesce P , Stefanachi A , Cellamare S , Carotti A |
| Ref : Bioorganic & Medicinal Chemistry , 21 :146 , 2013 |
| Abstract : Catto_2013_Bioorg.Med.Chem_21_146 |
| ESTHER : Catto_2013_Bioorg.Med.Chem_21_146 |
| PubMedSearch : Catto_2013_Bioorg.Med.Chem_21_146 |
| PubMedID: 23199476 |
| Title : Targeting monoamine oxidases with multipotent ligands: an emerging strategy in the search of new drugs against neurodegenerative diseases - Pisani_2011_Curr.Med.Chem_18_4568 |
| Author(s) : Pisani L , Catto M , Leonetti F , Nicolotti O , Stefanachi A , Campagna F , Carotti A |
| Ref : Curr Med Chem , 18 :4568 , 2011 |
| Abstract : Pisani_2011_Curr.Med.Chem_18_4568 |
| ESTHER : Pisani_2011_Curr.Med.Chem_18_4568 |
| PubMedSearch : Pisani_2011_Curr.Med.Chem_18_4568 |
| PubMedID: 21864289 |
| Title : Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity - Conejo-Garcia_2011_J.Med.Chem_54_2627 |
| Author(s) : Conejo-Garcia A , Pisani L , Nunez Mdel C , Catto M , Nicolotti O , Leonetti F , Campos JM , Gallo MA , Espinosa A , Carotti A |
| Ref : Journal of Medicinal Chemistry , 54 :2627 , 2011 |
| Abstract : Conejo-Garcia_2011_J.Med.Chem_54_2627 |
| ESTHER : Conejo-Garcia_2011_J.Med.Chem_54_2627 |
| PubMedSearch : Conejo-Garcia_2011_J.Med.Chem_54_2627 |
| PubMedID: 21417225 |
| Title : Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease - Tasso_2011_Eur.J.Med.Chem_46_2170 |
| Author(s) : Tasso B , Catto M , Nicolotti O , Novelli F , Tonelli M , Giangreco I , Pisani L , Sparatore A , Boido V , Carotti A , Sparatore F |
| Ref : Eur Journal of Medicinal Chemistry , 46 :2170 , 2011 |
| Abstract : Tasso_2011_Eur.J.Med.Chem_46_2170 |
| ESTHER : Tasso_2011_Eur.J.Med.Chem_46_2170 |
| PubMedSearch : Tasso_2011_Eur.J.Med.Chem_46_2170 |
| PubMedID: 21459491 |
| Title : Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors - Pisani_2010_ChemMedChem_5_1616 |
| Author(s) : Pisani L , Catto M , Giangreco I , Leonetti F , Nicolotti O , Stefanachi A , Cellamare S , Carotti A |
| Ref : ChemMedChem , 5 :1616 , 2010 |
| Abstract : Pisani_2010_ChemMedChem_5_1616 |
| ESTHER : Pisani_2010_ChemMedChem_5_1616 |
| PubMedSearch : Pisani_2010_ChemMedChem_5_1616 |
| PubMedID: 20677317 |
| Title : Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors - Leonetti_2008_Bioorg.Med.Chem_16_7450 |
| Author(s) : Leonetti F , Catto M , Nicolotti O , Pisani L , Cappa A , Stefanachi A , Carotti A |
| Ref : Bioorganic & Medicinal Chemistry , 16 :7450 , 2008 |
| Abstract : Leonetti_2008_Bioorg.Med.Chem_16_7450 |
| ESTHER : Leonetti_2008_Bioorg.Med.Chem_16_7450 |
| PubMedSearch : Leonetti_2008_Bioorg.Med.Chem_16_7450 |
| PubMedID: 18585045 |