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| Title : In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)m ethanone (JJKK-048) - Aaltonen_2016_J.Pharmacol.Exp.Ther_359_62 |
| Author(s) : Aaltonen N , Kedzierska E , Orzelska-Gorka J , Lehtonen M , Navia-Paldanius D , Jakupovic H , Savinainen JR , Nevalainen T , Laitinen JT , Parkkari T , Gynther M |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 359 :62 , 2016 |
| Abstract : Aaltonen_2016_J.Pharmacol.Exp.Ther_359_62 |
| ESTHER : Aaltonen_2016_J.Pharmacol.Exp.Ther_359_62 |
| PubMedSearch : Aaltonen_2016_J.Pharmacol.Exp.Ther_359_62 |
| PubMedID: 27451409 |
| Title : Discovery of Triterpenoids as Reversible Inhibitors of alpha\/beta-hydrolase Domain Containing 12 (ABHD12) - Parkkari_2014_PLoS.One_9_e98286 |
| Author(s) : Parkkari T , Haavikko R , Laitinen T , Navia-Paldanius D , Rytilahti R , Vaara M , Lehtonen M , Alakurtti S , Yli-Kauhaluoma J , Nevalainen T , Savinainen JR , Laitinen JT |
| Ref : PLoS ONE , 9 :e98286 , 2014 |
| Abstract : Parkkari_2014_PLoS.One_9_e98286 |
| ESTHER : Parkkari_2014_PLoS.One_9_e98286 |
| PubMedSearch : Parkkari_2014_PLoS.One_9_e98286 |
| PubMedID: 24879289 |
| Gene_locus related to this paper: human-ABHD12 |
| Title : Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5\/ABHD16A) - Savinainen_2014_PLoS.One_9_e109869 |
| Author(s) : Savinainen JR , Patel JZ , Parkkari T , Navia-Paldanius D , Marjamaa JJ , Laitinen T , Nevalainen T , Laitinen JT |
| Ref : PLoS ONE , 9 :e109869 , 2014 |
| Abstract : Savinainen_2014_PLoS.One_9_e109869 |
| ESTHER : Savinainen_2014_PLoS.One_9_e109869 |
| PubMedSearch : Savinainen_2014_PLoS.One_9_e109869 |
| PubMedID: 25290914 |
| Gene_locus related to this paper: human-ABHD16A , mouse-Abhd16a |
| Title : Robust Hydrolysis of Prostaglandin Glycerol Esters by Human Monoacylglycerol Lipase (MAGL) - Savinainen_2014_Mol.Pharmacol_86_522 |
| Author(s) : Savinainen JR , Kansanen E , Pantsar T , Navia-Paldanius D , Parkkari T , Lehtonen M , Laitinen T , Nevalainen T , Poso A , Levonen AL , Laitinen JT |
| Ref : Molecular Pharmacology , 86 :522 , 2014 |
| Abstract : Savinainen_2014_Mol.Pharmacol_86_522 |
| ESTHER : Savinainen_2014_Mol.Pharmacol_86_522 |
| PubMedSearch : Savinainen_2014_Mol.Pharmacol_86_522 |
| PubMedID: 25140003 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-MGLL |
| Title : Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase - Aaltonen_2013_Chem.Biol_20_379 |
| Author(s) : Aaltonen N , Savinainen JR , Ribas CR , Ronkko J , Kuusisto A , Korhonen J , Navia-Paldanius D , Hayrinen J , Takabe P , Kasnanen H , Pantsar T , Laitinen T , Lehtonen M , Pasonen-Seppanen S , Poso A , Nevalainen T , Laitinen JT |
| Ref : Chemical Biology , 20 :379 , 2013 |
| Abstract : Aaltonen_2013_Chem.Biol_20_379 |
| ESTHER : Aaltonen_2013_Chem.Biol_20_379 |
| PubMedSearch : Aaltonen_2013_Chem.Biol_20_379 |
| PubMedID: 23521796 |
| Gene_locus related to this paper: human-MGLL |
| Title : 1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling - Kasnanen_2013_Eur.J.Pharm.Sci_49_423 |
| Author(s) : Kasnanen H , Minkkila A , Taupila S , Patel JZ , Parkkari T , Lahtela-Kakkonen M , Saario SM , Nevalainen T , Poso A |
| Ref : Eur J Pharm Sci , 49 :423 , 2013 |
| Abstract : Kasnanen_2013_Eur.J.Pharm.Sci_49_423 |
| ESTHER : Kasnanen_2013_Eur.J.Pharm.Sci_49_423 |
| PubMedSearch : Kasnanen_2013_Eur.J.Pharm.Sci_49_423 |
| PubMedID: 23557840 |
| Gene_locus related to this paper: human-MGLL |
| Title : Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescence-based technique - Savinainen_2010_Anal.Biochem_399_132 |
| Author(s) : Savinainen JR , Yoshino M , Minkkila A , Nevalainen T , Laitinen JT |
| Ref : Analytical Biochemistry , 399 :132 , 2010 |
| Abstract : Savinainen_2010_Anal.Biochem_399_132 |
| ESTHER : Savinainen_2010_Anal.Biochem_399_132 |
| PubMedSearch : Savinainen_2010_Anal.Biochem_399_132 |
| PubMedID: 20005861 |
| Gene_locus related to this paper: human-MGLL |
| Title : Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors - Minkkila_2010_Curr.Top.Med.Chem_10_828 |
| Author(s) : Minkkila A , Saario SM , Nevalainen T |
| Ref : Curr Top Med Chem , 10 :828 , 2010 |
| Abstract : Minkkila_2010_Curr.Top.Med.Chem_10_828 |
| ESTHER : Minkkila_2010_Curr.Top.Med.Chem_10_828 |
| PubMedSearch : Minkkila_2010_Curr.Top.Med.Chem_10_828 |
| PubMedID: 20370710 |
| Title : Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors - |
| Author(s) : Minkkila A , Savinainen JR , Kasnanen H , Xhaard H , Nevalainen T , Laitinen JT , Poso A , Leppanen J , Saario SM |
| Ref : ChemMedChem , 4 :1253 , 2009 |
| PubMedID: 19472270 |
| Title : Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors - Myllymaki_2007_J.Med.Chem_50_4236 |
| Author(s) : Myllymaki MJ , Saario SM , Kataja AO , Castillo-Melendez JA , Nevalainen T , Juvonen RO , Jarvinen T , Koskinen AM |
| Ref : Journal of Medicinal Chemistry , 50 :4236 , 2007 |
| Abstract : Myllymaki_2007_J.Med.Chem_50_4236 |
| ESTHER : Myllymaki_2007_J.Med.Chem_50_4236 |
| PubMedSearch : Myllymaki_2007_J.Med.Chem_50_4236 |
| PubMedID: 17665899 |
| Title : Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes - Saario_2005_Chem.Biol_12_649 |
| Author(s) : Saario SM , Salo OM , Nevalainen T , Poso A , Laitinen JT , Jarvinen T , Niemi R |
| Ref : Chemical Biology , 12 :649 , 2005 |
| Abstract : Saario_2005_Chem.Biol_12_649 |
| ESTHER : Saario_2005_Chem.Biol_12_649 |
| PubMedSearch : Saario_2005_Chem.Biol_12_649 |
| PubMedID: 15975510 |