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Author Report for: Nepovimova E

Contact information:

Nepovimova Eugenie
Charles University in Prague; Faculty of Pharmacy in Hradec Kralove; Department of Toxicology and Military Pharmacy; Trebesska 1575; 500 05 Hradec Kralove
Czech Republic
Phone : +420608324886
Fax :
Send E-Mail to Nepovimova Eugenie





    Title: Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups
    Bibi S, Habib R, Shafiq S, Abbas SS, Khan S, Eqani S, Nepovimova E, Khan MS, Kuca K, Nurulain SM
    Ref: Sci Total Environ, :163359, 2023 : PubMed

            

    Title: Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes
    Jacevic V, Dumanovic J, Grujic-Milanovic J, Milovanovic Z, Amidzic L, Vojinovic N, Nezic L, Markovic B, Dobricic V and Kuca K <2 more author(s)>
    Ref: Chemico-Biological Interactions, :110658, 2023 : PubMed

            

    Title: Pralidoxime-like reactivator with increased lipophilicity - Molecular modeling and in vitro study
    Kuca K, Valle da Silva JA, Nepovimova E, Pham NL, Wu W, Valis M, Wu Q, Franca TCC
    Ref: Chemico-Biological Interactions, :110734, 2023 : PubMed

            

    Title: Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities
    Chrienova Z, Nepovimova E, Andrys R, Dolezal R, Janockova J, Muckova L, Fabova L, Soukup O, Oleksak P and Kuca K <3 more author(s)>
    Ref: J Enzyme Inhib Med Chem, 37:2605, 2022 : PubMed

            

    Title: Dysregulation of butyrylcholinesterase, BCHE gene SNP rs1803274, and pro-inflammatory cytokines in occupational workers
    Khan SA, Leonel Javeres MN, Abbas Shah ST, Bibi N, Muneer Z, Hussain S, Nepovimova E, Kuca K, Nurulain SM
    Ref: Environ Research, :115195, 2022 : PubMed

            

    Title: Theoretical assessment of the performances of commercial oximes on the reactivation of acetylcholinesterase inhibited by the nerve agent A-242 (novichok)
    Santos MC, Botelho FD, Goncalves AS, Kuca K, Nepovimova E, Cavalcante SFA, Lima ALS, Franca TCC
    Ref: Food & Chemical Toxicology, :113084, 2022 : PubMed

            

    Title: Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series?
    Santos MC, Botelho FD, Goncalves AS, Kitagawa DAS, Borges CVN, Carvalho-Silva T, Bernardo LB, Ferreira CN, Rodrigues RB and Cavalcante SFA <6 more author(s)>
    Ref: Archives of Toxicology, :, 2022 : PubMed

            

    Title: Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators
    Kitagawa DAS, Rodrigues RB, Silva TN, Dos Santos WV, da Rocha VCV, de Almeida JSFD, Bernardo LB, Carvalho-Silva T, Ferreira CN and Cavalcante SFA <5 more author(s)>
    Ref: J Enzyme Inhib Med Chem, 36:1370, 2021 : PubMed

            

    Title: Cannabis Constituents and Acetylcholinesterase Interaction: Molecular Docking, In Vitro Studies and Association with CNR1 rs806368 and ACHE rs17228602
    Furqan T, Batool S, Habib R, Shah M, Kalasz H, Darvas F, Kuca K, Nepovimova E, Nurulain SM
    Ref: Biomolecules, 10:, 2020 : PubMed

            

    Title: Analysis of PON1 gene polymorphisms (rs662 and rs854560) and inflammatory markers in organophosphate pesticides exposed cohorts from two distinct populations
    Leonel Javeres MN, Habib R, Judith N, Iqbal M, Nepovimova E, Kuca K, Batool S, Nurulain SM
    Ref: Environ Research, :110210, 2020 : PubMed

            

    Title: Oxidative Stress and Analysis of Selected SNPs of ACHE (rs 2571598), BCHE (rs 3495), CAT (rs 7943316), SIRT1 (rs 10823108), GSTP1 (rs 1695), and Gene GSTM1, GSTT1 in Chronic Organophosphates Exposed Groups from Cameroon and Pakistan
    Mbah Ntepe LJ, Habib R, Judith Laure N, Raza S, Nepovimova E, Kuca K, Batool S, Muhammad Nurulain S
    Ref: Int J Mol Sci, 21:, 2020 : PubMed

            

    Title: Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimes drugs dealing with cholinergic, amyloid and mitochondrial systems
    Nepovimova E, Svobodova L, Dolezal R, Hepnarova V, Junova L, Jun D, Korabecny J, Kucera T, Gazova Z and Kuca K <20 more author(s)>
    Ref: Bioorg Chem, 107:104596, 2020 : PubMed

            

    Title: Interaction of Synthesized Nitrogen enriched Graphene Quantum Dots with Novel Anti-Alzheimer's Drugs: Spectroscopic Insights
    Sharma S, Singh N, Nepovimova E, Korabecny J, Kuca K, Satnami ML, Ghosh KK
    Ref: J Biomol Struct Dyn, 38:1822, 2020 : PubMed

            

    Title: An update on T-2 toxin and its modified forms: metabolism, immunotoxicity mechanism, and human exposure assessment
    Wu Q, Qin Z, Kuca K, You L, Zhao Y, Liu A, Musilek K, Chrienova Z, Nepovimova E and Wang X <2 more author(s)>
    Ref: Archives of Toxicology, 94:3645, 2020 : PubMed

            

    Title: Understanding the Interaction Modes and Reactivity of Trimedoxime toward MmAChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects
    de Castro AA, Polisel DA, Pereira BTL, da Cunha EFF, Kuca K, Nepovimova E, Ramalho TC
    Ref: Int J Mol Sci, 21:, 2020 : PubMed

            

    Title: Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
    Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ and Kuca K <25 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 168:491, 2019 : PubMed

            

    Title: Novichoks: The Dangerous Fourth Generation of Chemical Weapons
    Franca TCC, Kitagawa DAS, Cavalcante SFA, da Silva JAV, Nepovimova E, Kuca K
    Ref: Int J Mol Sci, 20:, 2019 : PubMed

            

    Title: Toxic Injury to Muscle Tissue of Rats Following Acute Oximes Exposure
    Jacevic V, Nepovimova E, Kuca K
    Ref: Sci Rep, 9:1457, 2019 : PubMed

            

    Title: Interspecies and intergender differences in acute toxicity of K-oximes drug candidates
    Jacevic V, Nepovimova E, Kuca K
    Ref: Chemico-Biological Interactions, 308:312, 2019 : PubMed

            

    Title: Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease
    Kaniakova M, Nepovimova E, Kleteckova L, Skrenkova K, Holubova K, Chrienova Z, Hepnarova V, Kucera T, Kobrlova T and Horak M <3 more author(s)>
    Ref: Curr Alzheimer Res, 16:821, 2019 : PubMed

            

    Title: Donepezil Derivatives Targeting Amyloid-beta Cascade in Alzheimer's Disease
    Mezeiova E, Chalupova K, Nepovimova E, Gorecki L, Prchal L, Malinak D, Kuca K, Soukup O, Korabecny J
    Ref: Curr Alzheimer Res, 16:772, 2019 : PubMed

            

    Title: N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy
    Nepovimova E, Korabecny J, Hepnarova V, Jun D, Dolezal R, Muckova L, Jost P, Soukup O, Janockova J and Kuca K <3 more author(s)>
    Ref: Curr Alzheimer Res, 16:333, 2019 : PubMed

            

    Title: Orexin supplementation in narcolepsy treatment: A review
    Nepovimova E, Janockova J, Misik J, Kubik S, Stuchlik A, Vales K, Korabecny J, Mezeiova E, Dolezal R and Kuca K <5 more author(s)>
    Ref: Med Res Rev, 39:961, 2019 : PubMed

            

    Title: Traditional Ayurvedic and herbal remedies for Alzheimer's disease: from bench to bedside
    Sharma R, Kuca K, Nepovimova E, Kabra A, Rao MM, Prajapati PK
    Ref: Expert Rev Neurother, 19:359, 2019 : PubMed

            

    Title: Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach
    da Silva JAV, Nepovimova E, Ramalho TC, Kuca K, Franca TCC
    Ref: J Enzyme Inhib Med Chem, 34:1018, 2019 : PubMed

            

    Title: Molecular modelling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime with VX-inhibited human acetylcholinesterase. A near attack approach to assess different spacer-lengths
    da Silva JAV, Nepovimova E, Ramalho TC, Kuca K, Franca TCC
    Ref: Chemico-Biological Interactions, 307:195, 2019 : PubMed

            

    Title: Non-conventional compounds with potential therapeutic effects against Alzheimer's disease
    de Castro AA, Soares FV, Pereira AF, Polisel DA, Caetano MS, Leal DHS, da Cunha EFF, Nepovimova E, Kuca K, Ramalho TC
    Ref: Expert Rev Neurother, 19:375, 2019 : PubMed

            

    Title: Quantification through TLC-densitometric analysis, repellency and anticholinesterase activity of the homemade extract of Indian cloves
    Affonso RS, Lima JA, Lessa BM, Caetano JVO, Obara MT, Nobrega AB, Nepovimova E, Musilek K, Kuca K and Franca TCC <1 more author(s)>
    Ref: Biomedical Chromatography, 32:, 2018 : PubMed

            

    Title: The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease
    Hepnarova V, Korabecny J, Matouskova L, Jost P, Muckova L, Hrabinova M, Vykoukalova N, Kerhartova M, Kucera T and Soukup O <9 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 150:292, 2018 : PubMed

            

    Title: Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods
    Janockova J, Dolezal R, Nepovimova E, Kobrlova T, Benkova M, Kuca K, Konecny J, Mezeiova E, Melikova M and Korabecny J <3 more author(s)>
    Ref: Molecules, 23:, 2018 : PubMed

            

    Title: Newly Developed Drugs for Alzheimer's Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission
    Korabecny J, Nepovimova E, Cikankova T, Spilovska K, Vaskova L, Mezeiova E, Kuca K, Hroudova J
    Ref: Neuroscience, 370:191, 2018 : PubMed

            

    Title: A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase
    Kuca K, Musilek K, Jun D, Karasova JZ, Nepovimova E, Soukup O, Hrabinova M, Mikler J, Franca TCC and Ramalho TC <3 more author(s)>
    Ref: BMC Pharmacol Toxicol, 19:8, 2018 : PubMed

            

    Title: Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings
    Kuca K, Karasova JZ, Soukup O, Kassa J, Novotna E, Sepsova V, Horova A, Pejchal J, Hrabinova M and Musilek K <4 more author(s)>
    Ref: Drug Des Devel Ther, 12:505, 2018 : PubMed

            

    Title: Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon
    Kuca K, Jun D, Junova L, Musilek K, Hrabinova M, da Silva JAV, Ramalho TC, Valko M, Wu Q and Franca TCC <1 more author(s)>
    Ref: Molecules, 23:, 2018 : PubMed

            

    Title: Novel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking Study
    Malinak D, Nepovimova E, Jun D, Musilek K, Kuca K
    Ref: Molecules, 23:, 2018 : PubMed

            

    Title: A Review of the Synthesis of Quaternary Acetylcholinesterase Reactivators
    Malinak D, Korabecny J, Soukup O, Gorecki L, Nepovimova E, Psotka M, Dolezal R, Nguyen TD, Mezeiova E and Kuca K <1 more author(s)>
    Ref: Current Organic Chemistry, 22":1619, 2018 : PubMed

            

    Title: Profiling donepezil template into multipotent hybrids with antioxidant properties
    Mezeiova E, Spilovska K, Nepovimova E, Gorecki L, Soukup O, Dolezal R, Malinak D, Janockova J, Jun D and Korabecny J <1 more author(s)>
    Ref: J Enzyme Inhib Med Chem, 33:583, 2018 : PubMed

            

    Title: Cholinesterase inhibitor 6-chlorotacrine - in vivo toxicological profile and behavioural effects
    Misik J, Nepovimova E, Pejchal J, Kassa J, Korabecny J, Soukup O
    Ref: Curr Alzheimer Res, 15:552, 2018 : PubMed

            

    Title: Chemical warfare agent NOVICHOK - mini-review of available data
    Nepovimova E, Kuca K
    Ref: Food & Chemical Toxicology, 121:343, 2018 : PubMed

            

    Title: In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
    Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R and Kuca K <12 more author(s)>
    Ref: Med Chem, 14:281, 2018 : PubMed

            

    Title: The New Acetylcholinesterase Inhibitors PC-37 and PC-48 (7-Methoxytacrine-Donepezil-Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics and In Vivo Formation of the Major Metabolites in Rats
    Karasova JZ, Mzik M, Hroch M, Korabecny J, Nepovimova E, Vorisek V, Palicka V, Kuca K
    Ref: Basic Clin Pharmacol Toxicol, 122:373, 2018 : PubMed

            

    Title: Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon
    de Paula RL, de Almeida JSFD, Cavalcante SFA, Goncalves AS, Simas ABC, Franca TCC, Valis M, Kuca K, Nepovimova E, Granjeiro JM
    Ref: Molecules, 23:, 2018 : PubMed

            

    Title: Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors
    Babkova K, Korabecny J, Soukup O, Nepovimova E, Jun D, Kuca K
    Ref: Future Med Chem, 9:1015, 2017 : PubMed

            

    Title: Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment
    Gazova Z, Soukup O, Sepsova V, Siposova K, Drtinova L, Jost P, Spilovska K, Korabecny J, Nepovimova E and Kuca K <5 more author(s)>
    Ref: Biochimica & Biophysica Acta Mol Basis Dis, 1863:607, 2017 : PubMed

            

    Title: Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016)
    Gorecki L, Korabecny J, Musilek K, Nepovimova E, Malinak D, Kucera T, Dolezal R, Jun D, Soukup O, Kuca K
    Ref: Expert Opin Ther Pat, 27:971, 2017 : PubMed

            

    Title: The pharmacology of tacrine at N-methyl-d-aspartate receptors
    Horak M, Holubova K, Nepovimova E, Krusek J, Kaniakova M, Korabecny J, Vyklicky L, Kuca K, Stuchlik A and Soukup O <2 more author(s)>
    Ref: Prog Neuropsychopharmacol Biological Psychiatry, 75:54, 2017 : PubMed

            

    Title: The Evaluation of Benefit of Newly Prepared Reversible Inhibitors of Acetylcholinesterase and Commonly Used Pyridostigmine as Pharmacological Pretreatment of Soman-Poisoned Mice
    Kassa J, Korabecny J, Nepovimova E
    Ref: Acta Medica (Hradec Kralove), 60:37, 2017 : PubMed

            

    Title: Multitarget Tacrine Hybrids with Neuroprotective Properties to Confront Alzheimer's Disease
    Spilovska K, Korabecny J, Nepovimova E, Dolezal R, Mezeiova E, Soukup O, Kuca K
    Ref: Curr Top Med Chem, 17:1006, 2017 : PubMed

            

    Title: SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides
    Gorecki L, Korabecny J, Musilek K, Malinak D, Nepovimova E, Dolezal R, Jun D, Soukup O, Kuca K
    Ref: Archives of Toxicology, 90:2831, 2016 : PubMed

            

    Title: Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1
    Kristofikova Z, Ricny J, Soukup O, Korabecny J, Nepovimova E, Kuca K, Ripova D
    Ref: Dementia & Geriatric Cognitive Disorders, 43:45, 2016 : PubMed

            

    Title: Effects of novel tacrine-related cholinesterase inhibitors in the reversal of 3-quinuclidinyl benzilate-induced cognitive deficit in rats-Is there a potential for Alzheimer's disease treatment?
    Misik J, Korabecny J, Nepovimova E, Kracmarova A, Kassa J
    Ref: Neuroscience Letters, 612:261, 2016 : PubMed

            

    Title: An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study
    Mzik M, Korabecny J, Nepovimova E, Vorisek V, Palicka V, Kuca K, Karasova JZ
    Ref: Journal of Chromatography B Analyt Technol Biomed Life Sciences, 1020:85, 2016 : PubMed

            

    Title: A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication
    Nepovimova E, Korabecny J, Dolezal R, Nguyen TD, Jun D, Soukup O, Pasdiorova M, Jost P, Muckova L and Kuca K <3 more author(s)>
    Ref: Toxicol Res (Camb), 5:1012, 2016 : PubMed

            

    Title: 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment
    Korabecny J, Andrs M, Nepovimova E, Dolezal R, Babkova K, Horova A, Malinak D, Mezeiova E, Gorecki L and Kuca K <4 more author(s)>
    Ref: Molecules, 20:22084, 2015 : PubMed

            

    Title: The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test
    Misik J, Korabecny J, Nepovimova E, Cabelova P, Kassa J
    Ref: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 159:547, 2015 : PubMed

            

    Title: Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity
    Nepovimova E, Korabecny J, Dolezal R, Babkova K, Ondrejicek A, Jun D, Sepsova V, Horova A, Hrabinova M and Kuca K <7 more author(s)>
    Ref: Journal of Medicinal Chemistry, 58:8985, 2015 : PubMed

            

    Title: 7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies
    Korabecny J, Dolezal R, Cabelova P, Horova A, Hruba E, Ricny J, Sedlacek L, Nepovimova E, Spilovska K and Kuca K <5 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 82C:426, 2014 : PubMed

            

    Title: From Pyridinium-based to Centrally Active Acetylcholinesterase Reactivators
    Korabecny J, Soukup O, Dolezal R, Spilovska K, Nepovimova E, Andrs M, Nguyen TD, Jun D, Musilek K and Kuca K <1 more author(s)>
    Ref: Mini Rev Med Chem, 14:215, 2014 : PubMed

            

    Title: Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects
    Nepovimova E, Uliassi E, Korabecny J, Pena-Altamira LE, Samez S, Pesaresi A, Garcia GE, Bartolini M, Andrisano V and Bolognesi ML <6 more author(s)>
    Ref: Journal of Medicinal Chemistry, 57:8576, 2014 : PubMed

            

    Title: Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine
    Zemek F, Drtinova L, Nepovimova E, Sepsova V, Korabecny J, Klimes J, Kuca K
    Ref: Expert Opin Drug Safety, 13:759, 2014 : PubMed

            

    Title: Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties
    Korabecny J, Musilek K, Zemek F, Horova A, Holas O, Nepovimova E, Opletalova V, Hroudova J, Fisar Z and Kuca K <1 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 21:6563, 2011 : PubMed

            

    Title: Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment
    Korabecny J, Musilek K, Holas O, Nepovimova E, Jun D, Zemek F, Opletalova V, Patocka J, Dohnal V and Kuca K <3 more author(s)>
    Ref: Molecules, 15:8804, 2010 : PubMed

            


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