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| Title : Estimation of plasma IC50 of donepezil hydrochloride for brain acetylcholinesterase inhibition in monkey using N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) and PET - Shiraishi_2005_Neuropsychopharmacology_30_2154 |
| Author(s) : Shiraishi T , Kikuchi T , Fukushi K , Shinotoh H , Nagatsuka S , Tanaka N , Ota T , Sato K , Hirano S , Tanada S , Iyo M , Irie T |
| Ref : Neuropsychopharmacology , 30 :2154 , 2005 |
| Abstract : Shiraishi_2005_Neuropsychopharmacology_30_2154 |
| ESTHER : Shiraishi_2005_Neuropsychopharmacology_30_2154 |
| PubMedSearch : Shiraishi_2005_Neuropsychopharmacology_30_2154 |
| PubMedID: 15920507 |
| Title : A simple method for the detection of abnormal brain regions in Alzheimer's disease patients using [11C]MP4A: comparison with [123I]IMP SPECT - Ota_2004_Ann.Nucl.Med_18_187 |
| Author(s) : Ota T , Shinotoh H , Fukushi K , Nagatsuka S , Namba H , Iyo M , Aotsuka A , Tanaka N , Sato K , Shiraishi T , Tanada S , Arai H , Irie T |
| Ref : Ann Nucl Med , 18 :187 , 2004 |
| Abstract : Ota_2004_Ann.Nucl.Med_18_187 |
| ESTHER : Ota_2004_Ann.Nucl.Med_18_187 |
| PubMedSearch : Ota_2004_Ann.Nucl.Med_18_187 |
| PubMedID: 15233279 |
| Title : Acetylcholinesterase imaging: its use in therapy evaluation and drug design - Shinotoh_2004_Curr.Pharm.Des_10_1505 |
| Author(s) : Shinotoh H , Fukushi K , Nagatsuka S , Irie T |
| Ref : Curr Pharm Des , 10 :1505 , 2004 |
| Abstract : Shinotoh_2004_Curr.Pharm.Des_10_1505 |
| ESTHER : Shinotoh_2004_Curr.Pharm.Des_10_1505 |
| PubMedSearch : Shinotoh_2004_Curr.Pharm.Des_10_1505 |
| PubMedID: 15134572 |
| Title : Evaluation of simplified kinetic analyses for measurement of brain acetylcholinesterase activity using N-[11C]Methylpiperidin-4-yl propionate and positron emission tomography - Sato_2004_J.Cereb.Blood.Flow.Metab_24_600 |
| Author(s) : Sato K , Fukushi K , Shinotoh H , Nagatsuka S , Tanaka N , Aotsuka A , Ota T , Shiraishi T , Tanada S , Iyo M , Irie T |
| Ref : Journal of Cerebral Blood Flow & Metabolism , 24 :600 , 2004 |
| Abstract : Sato_2004_J.Cereb.Blood.Flow.Metab_24_600 |
| ESTHER : Sato_2004_J.Cereb.Blood.Flow.Metab_24_600 |
| PubMedSearch : Sato_2004_J.Cereb.Blood.Flow.Metab_24_600 |
| PubMedID: 15181367 |
| Title : The amygdala and Alzheimer's disease: positron emission tomographic study of the cholinergic system - Shinotoh_2003_Ann.N.Y.Acad.Sci_985_411 |
| Author(s) : Shinotoh H , Fukushi K , Nagatsuka S , Tanaka N , Aotsuka A , Ota T , Namba H , Tanada S , Irie T |
| Ref : Annals of the New York Academy of Sciences , 985 :411 , 2003 |
| Abstract : Shinotoh_2003_Ann.N.Y.Acad.Sci_985_411 |
| ESTHER : Shinotoh_2003_Ann.N.Y.Acad.Sci_985_411 |
| PubMedSearch : Shinotoh_2003_Ann.N.Y.Acad.Sci_985_411 |
| PubMedID: 12724174 |
| Title : Positron emission tomography: quantitative measurement of brain acetylcholinesterase activity using radiolabeled substrates - Namba_2002_Methods_27_242 |
| Author(s) : Namba H , Fukushi K , Nagatsuka S , Iyo M , Shinotoh H , Tanada S , Irie T |
| Ref : Methods , 27 :242 , 2002 |
| Abstract : Namba_2002_Methods_27_242 |
| ESTHER : Namba_2002_Methods_27_242 |
| PubMedSearch : Namba_2002_Methods_27_242 |
| PubMedID: 12183113 |
| Title : Positron emission tomographic measurement of brain acetylcholinesterase activity using N-[(11)C]methylpiperidin-4-yl acetate without arterial blood sampling: methodology of shape analysis and its diagnostic power for Alzheimer's disease - Tanaka_2001_J.Cereb.Blood.Flow.Metab_21_295 |
| Author(s) : Tanaka N , Fukushi K , Shinotoh H , Nagatsuka S , Namba H , Iyo M , Aotsuka A , Ota T , Tanada S , Irie T |
| Ref : Journal of Cerebral Blood Flow & Metabolism , 21 :295 , 2001 |
| Abstract : Tanaka_2001_J.Cereb.Blood.Flow.Metab_21_295 |
| ESTHER : Tanaka_2001_J.Cereb.Blood.Flow.Metab_21_295 |
| PubMedSearch : Tanaka_2001_J.Cereb.Blood.Flow.Metab_21_295 |
| PubMedID: 11295884 |
| Title : Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET - Shinotoh_2001_Neurology_56_408 |
| Author(s) : Shinotoh H , Aotsuka A , Fukushi K , Nagatsuka S , Tanaka N , Ota T , Tanada S , Irie T |
| Ref : Neurology , 56 :408 , 2001 |
| Abstract : Shinotoh_2001_Neurology_56_408 |
| ESTHER : Shinotoh_2001_Neurology_56_408 |
| PubMedSearch : Shinotoh_2001_Neurology_56_408 |
| PubMedID: 11171913 |
| Title : Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: a positron emission tomography study - Shinotoh_2000_Ann.Neurol_48_194 |
| Author(s) : Shinotoh H , Namba H , Fukushi K , Nagatsuka S , Tanaka N , Aotsuka A , Ota T , Tanada S , Irie T |
| Ref : Annals of Neurology , 48 :194 , 2000 |
| Abstract : Shinotoh_2000_Ann.Neurol_48_194 |
| ESTHER : Shinotoh_2000_Ann.Neurol_48_194 |
| PubMedSearch : Shinotoh_2000_Ann.Neurol_48_194 |
| PubMedID: 10939570 |
| Title : Brain acetylcholinesterase activity in Alzheimer disease measured by positron emission tomography - Shinotoh_2000_Alzheimer.Dis.Assoc.Disord_14 Suppl 1_S114 |
| Author(s) : Shinotoh H , Namba H , Fukushi K , Nagatsuka S , Tanaka N , Aotsuka A , Tanada S , Irie T |
| Ref : Alzheimer Disease & Associated Disorders , 14 Suppl 1 :S114 , 2000 |
| Abstract : Shinotoh_2000_Alzheimer.Dis.Assoc.Disord_14 Suppl 1_S114 |
| ESTHER : Shinotoh_2000_Alzheimer.Dis.Assoc.Disord_14 Suppl 1_S114 |
| PubMedSearch : Shinotoh_2000_Alzheimer.Dis.Assoc.Disord_14 Suppl 1_S114 |
| PubMedID: 10850739 |
| Title : Human cerebral acetylcholinesterase activity measured with positron emission tomography: procedure, normal values and effect of age - Namba_1999_Eur.J.Nucl.Med_26_135 |
| Author(s) : Namba H , Iyo M , Fukushi K , Shinotoh H , Nagatsuka S , Suhara T , Sudo Y , Suzuki K , Irie T |
| Ref : Eur J Nucl Med , 26 :135 , 1999 |
| Abstract : Namba_1999_Eur.J.Nucl.Med_26_135 |
| ESTHER : Namba_1999_Eur.J.Nucl.Med_26_135 |
| PubMedSearch : Namba_1999_Eur.J.Nucl.Med_26_135 |
| PubMedID: 9933347 |
| Title : Positron emission tomographic measurement of acetylcholinesterase activity reveals differential loss of ascending cholinergic systems in Parkinson's disease and progressive supranuclear palsy - Shinotoh_1999_Ann.Neurol_46_62 |
| Author(s) : Shinotoh H , Namba H , Yamaguchi M , Fukushi K , Nagatsuka S , Iyo M , Asahina M , Hattori T , Tanada S , Irie T |
| Ref : Annals of Neurology , 46 :62 , 1999 |
| Abstract : Shinotoh_1999_Ann.Neurol_46_62 |
| ESTHER : Shinotoh_1999_Ann.Neurol_46_62 |
| PubMedSearch : Shinotoh_1999_Ann.Neurol_46_62 |
| PubMedID: 10401781 |
| Title : Preserved acetylcholinesterase activity in aged cerebral cortex [letter] - |
| Author(s) : Namba H , Iyo M , Shinotoh H , Nagatsuka S , Fukushi K , Irie T |
| Ref : Lancet , 351 :881 , 1998 |
| PubMedID: 9525373 |
| Title : Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease - Iyo_1997_Lancet_349_1805 |
| Author(s) : Iyo M , Namba H , Fukushi K , Shinotoh H , Nagatsuka S , Suhara T , Sudo Y , Suzuki K , Irie T |
| Ref : Lancet , 349 :1805 , 1997 |
| Abstract : Iyo_1997_Lancet_349_1805 |
| ESTHER : Iyo_1997_Lancet_349_1805 |
| PubMedSearch : Iyo_1997_Lancet_349_1805 |
| PubMedID: 9269216 |
| Title : Brain acetylcholinesterase activity: validation of a PET tracer in a rat model of Alzheimer's disease - Irie_1996_J.Nucl.Med_37_649 |
| Author(s) : Irie T , Fukushi K , Namba H , Iyo M , Tamagami H , Nagatsuka S , Ikota N |
| Ref : J Nucl Med , 37 :649 , 1996 |
| Abstract : Irie_1996_J.Nucl.Med_37_649 |
| ESTHER : Irie_1996_J.Nucl.Med_37_649 |
| PubMedSearch : Irie_1996_J.Nucl.Med_37_649 |
| PubMedID: 8691261 |