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| Title : Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives - Pachon_2020_Int.J.Mol.Sci_21_ |
| Author(s) : Pachon Angona I , Martin H , Daniel S , Moraleda I , Bonet A , Wnorowski A , Maj M , Jozwiak K , Iriepa I , Refouvelet B , Marco-Contelles J , Ismaili L |
| Ref : Int J Mol Sci , 21 : , 2020 |
| Abstract : Pachon_2020_Int.J.Mol.Sci_21_ |
| ESTHER : Pachon_2020_Int.J.Mol.Sci_21_ |
| PubMedSearch : Pachon_2020_Int.J.Mol.Sci_21_ |
| PubMedID: 33081112 |
| Title : Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase - AlFadly_2019_Eur.J.Med.Chem_167_161 |
| Author(s) : AlFadly ED , Elzahhar PA , Tramarin A , Elkazaz S , Shaltout H , Abu-Serie MM , Janockova J , Soukup O , Ghareeb DA , El-Yazbi AF , Rafeh RW , Bakkar NZ , Kobeissy F , Iriepa I , Moraleda I , Saudi MNS , Bartolini M , Belal ASF |
| Ref : Eur Journal of Medicinal Chemistry , 167 :161 , 2019 |
| Abstract : AlFadly_2019_Eur.J.Med.Chem_167_161 |
| ESTHER : AlFadly_2019_Eur.J.Med.Chem_167_161 |
| PubMedSearch : AlFadly_2019_Eur.J.Med.Chem_167_161 |
| PubMedID: 30771604 |
| Title : New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition - Malek_2019_J.Med.Chem_62_11416 |
| Author(s) : Malek R , Arribas RL , Palomino-Antolin A , Totoson P , Demougeot C , Kobrlova T , Soukup O , Iriepa I , Moraleda I , Diez-Iriepa D , Godyn J , Panek D , Malawska B , Gluch-Lutwin M , Mordyl B , Siwek A , Chabchoub F , Marco-Contelles J , Kiec-Kononowicz K , Egea J , de los Rios C , Ismaili L |
| Ref : Journal of Medicinal Chemistry , 62 :11416 , 2019 |
| Abstract : Malek_2019_J.Med.Chem_62_11416 |
| ESTHER : Malek_2019_J.Med.Chem_62_11416 |
| PubMedSearch : Malek_2019_J.Med.Chem_62_11416 |
| PubMedID: 31724859 |
| Title : Synthesis and Biological Evaluation of Novel Chromone+Donepezil Hybrids for Alzheimer's Disease Therapy - Malek_2019_Curr.Alzheimer.Res_16_815 |
| Author(s) : Malek R , Refouvelet B , Benchekroun M , Iriepa I , Moraleda I , Andrys R , Musilek K , Marco-Contelles J , Ismaili L |
| Ref : Curr Alzheimer Res , 16 :815 , 2019 |
| Abstract : Malek_2019_Curr.Alzheimer.Res_16_815 |
| ESTHER : Malek_2019_Curr.Alzheimer.Res_16_815 |
| PubMedSearch : Malek_2019_Curr.Alzheimer.Res_16_815 |
| PubMedID: 31660831 |
| Title : QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy - Ramos_2019_Molecules_24_ |
| Author(s) : Ramos E , Palomino-Antolin A , Bartolini M , Iriepa I , Moraleda I , Diez-Iriepa D , Samadi A , Cortina CV , Chioua M , Egea J , Romero A , Marco-Contelles J |
| Ref : Molecules , 24 : , 2019 |
| Abstract : Ramos_2019_Molecules_24_ |
| ESTHER : Ramos_2019_Molecules_24_ |
| PubMedSearch : Ramos_2019_Molecules_24_ |
| PubMedID: 30999586 |
| Title : Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy - Pachon-Angona_2019_J.Enzyme.Inhib.Med.Chem_34_479 |
| Author(s) : Pachon-Angona I , Refouvelet B , Andrys R , Martin H , Luzet V , Iriepa I , Moraleda I , Diez-Iriepa D , Oset-Gasque MJ , Marco-Contelles J , Musilek K , Ismaili L |
| Ref : J Enzyme Inhib Med Chem , 34 :479 , 2019 |
| Abstract : Pachon-Angona_2019_J.Enzyme.Inhib.Med.Chem_34_479 |
| ESTHER : Pachon-Angona_2019_J.Enzyme.Inhib.Med.Chem_34_479 |
| PubMedSearch : Pachon-Angona_2019_J.Enzyme.Inhib.Med.Chem_34_479 |
| PubMedID: 30712420 |
| Title : Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment - Montanari_2019_Eur.J.Med.Chem_178_243 |
| Author(s) : Montanari S , Mahmoud AM , Pruccoli L , Rabbito A , Naldi M , Petralla S , Moraleda I , Bartolini M , Monti B , Iriepa I , Belluti F , Gobbi S , Di Marzo V , Bisi A , Tarozzi A , Ligresti A , Rampa A |
| Ref : Eur Journal of Medicinal Chemistry , 178 :243 , 2019 |
| Abstract : Montanari_2019_Eur.J.Med.Chem_178_243 |
| ESTHER : Montanari_2019_Eur.J.Med.Chem_178_243 |
| PubMedSearch : Montanari_2019_Eur.J.Med.Chem_178_243 |
| PubMedID: 31185414 |
| Title : Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy - Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163 |
| Author(s) : Dgachi Y , Martin H , Malek R , Jun D , Janockova J , Sepsova V , Soukup O , Iriepa I , Moraleda I , Maalej E , Carreiras MC , Refouvelet B , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : J Enzyme Inhib Med Chem , 34 :163 , 2019 |
| Abstract : Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163 |
| ESTHER : Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163 |
| PubMedSearch : Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163 |
| PubMedID: 30482062 |
| Title : Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile - Bautista-Aguilera_2018_J.Med.Chem_61_6937 |
| Author(s) : Bautista-Aguilera OM , Budni J , Mina F , Medeiros EB , Deuther-Conrad W , Entrena JM , Moraleda I , Iriepa I , Lopez-Munoz F , Marco-Contelles J |
| Ref : Journal of Medicinal Chemistry , 61 :6937 , 2018 |
| Abstract : Bautista-Aguilera_2018_J.Med.Chem_61_6937 |
| ESTHER : Bautista-Aguilera_2018_J.Med.Chem_61_6937 |
| PubMedSearch : Bautista-Aguilera_2018_J.Med.Chem_61_6937 |
| PubMedID: 29969030 |
| Title : Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer's Disease - Rampa_2018_Molecules_23_ |
| Author(s) : Rampa A , Bartolini M , Pruccoli L , Naldi M , Iriepa I , Moraleda I , Belluti F , Gobbi S , Tarozzi A , Bisi A |
| Ref : Molecules , 23 : , 2018 |
| Abstract : Rampa_2018_Molecules_23_ |
| ESTHER : Rampa_2018_Molecules_23_ |
| PubMedSearch : Rampa_2018_Molecules_23_ |
| PubMedID: 30061534 |
| Title : Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease - Chioua_2018_Eur.J.Med.Chem_155_839 |
| Author(s) : Chioua M , Buzzi E , Moraleda I , Iriepa I , Maj M , Wnorowski A , Giovannini C , Tramarin A , Portali F , Ismaili L , Lopez-Alvarado P , Bolognesi ML , Jozwiak K , Menendez JC , Marco-Contelles J , Bartolini M |
| Ref : Eur Journal of Medicinal Chemistry , 155 :839 , 2018 |
| Abstract : Chioua_2018_Eur.J.Med.Chem_155_839 |
| ESTHER : Chioua_2018_Eur.J.Med.Chem_155_839 |
| PubMedSearch : Chioua_2018_Eur.J.Med.Chem_155_839 |
| PubMedID: 29958119 |
| Title : Synthesis and biological assessment of racemic benzochromenopyrimidinetriones as promising agents for Alzheimer's disease therapy - Dgachi_2017_Future.Med.Chem_9_715 |
| Author(s) : Dgachi Y , Martin H , Bonet A , Chioua M , Iriepa I , Moraleda I , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : Future Med Chem , 9 :715 , 2017 |
| Abstract : Dgachi_2017_Future.Med.Chem_9_715 |
| ESTHER : Dgachi_2017_Future.Med.Chem_9_715 |
| PubMedSearch : Dgachi_2017_Future.Med.Chem_9_715 |
| PubMedID: 28504912 |
| Title : Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases - Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| Author(s) : Bautista-Aguilera OM , Hagenow S , Palomino-Antolin A , Farre-Alins V , Ismaili L , Joffrin PL , Jimeno ML , Soukup O , Janockova J , Kalinowsky L , Proschak E , Iriepa I , Moraleda I , Schwed JS , Romero Martinez A , Lopez-Munoz F , Chioua M , Egea J , Ramsay RR , Marco-Contelles J , Stark H |
| Ref : Angew Chem Int Ed Engl , 56 :12765 , 2017 |
| Abstract : Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| ESTHER : Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| PubMedSearch : Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| PubMedID: 28861918 |
| Title : Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy - Dgachi_2016_Eur.J.Med.Chem_126_576 |
| Author(s) : Dgachi Y , Sokolov O , Luzet V , Godyn J , Panek D , Bonet A , Martin H , Iriepa I , Moraleda I , Garcia-Iriepa C , Janockova J , Richert L , Soukup O , Malawska B , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : Eur Journal of Medicinal Chemistry , 126 :576 , 2016 |
| Abstract : Dgachi_2016_Eur.J.Med.Chem_126_576 |
| ESTHER : Dgachi_2016_Eur.J.Med.Chem_126_576 |
| PubMedSearch : Dgachi_2016_Eur.J.Med.Chem_126_576 |
| PubMedID: 27918993 |
| Title : Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy - Boulebd_2016_Molecules_21_ |
| Author(s) : Boulebd H , Ismaili L , Bartolini M , Bouraiou A , Andrisano V , Martin H , Bonet A , Moraleda I , Iriepa I , Chioua M , Belfaitah A , Marco-Contelles J |
| Ref : Molecules , 21 : , 2016 |
| Abstract : Boulebd_2016_Molecules_21_ |
| ESTHER : Boulebd_2016_Molecules_21_ |
| PubMedSearch : Boulebd_2016_Molecules_21_ |
| PubMedID: 27023499 |
| Title : Harmaline and hispidin from Peganum harmala and Inonotus hispidus with binding affinity to Candida rugosa lipase: In silico and in vitro studies - Benarous_2015_Bioorg.Chem_62_1 |
| Author(s) : Benarous K , Bombarda I , Iriepa I , Moraleda I , Gaetan H , Linani A , Tahri D , Sebaa M , Yousfi M |
| Ref : Bioorg Chem , 62 :1 , 2015 |
| Abstract : Benarous_2015_Bioorg.Chem_62_1 |
| ESTHER : Benarous_2015_Bioorg.Chem_62_1 |
| PubMedSearch : Benarous_2015_Bioorg.Chem_62_1 |
| PubMedID: 26151548 |
| Title : Pyranopyrazolotacrines as nonneurotoxic, Abeta-anti-aggregating and neuroprotective agents for Alzheimer's disease - Chioua_2015_Future.Med.Chem_7_845 |
| Author(s) : Chioua M , Perez-Pena J , Garcia-Font N , Moraleda I , Iriepa I , Soriano E , Marco-Contelles J , Oset-Gasque MJ |
| Ref : Future Med Chem , 7 :845 , 2015 |
| Abstract : Chioua_2015_Future.Med.Chem_7_845 |
| ESTHER : Chioua_2015_Future.Med.Chem_7_845 |
| PubMedSearch : Chioua_2015_Future.Med.Chem_7_845 |
| PubMedID: 26061104 |
| Title : Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease - Wang_2014_Eur.J.Med.Chem_80_543 |
| Author(s) : Wang L , Esteban G , Ojima M , Bautista-Aguilera OM , Inokuchi T , Moraleda I , Iriepa I , Samadi A , Youdim MB , Romero A , Soriano E , Herrero R , Fernandez Fernandez AP , Ricardo Martinez M , Marco-Contelles J , Unzeta M |
| Ref : Eur Journal of Medicinal Chemistry , 80 :543 , 2014 |
| Abstract : Wang_2014_Eur.J.Med.Chem_80_543 |
| ESTHER : Wang_2014_Eur.J.Med.Chem_80_543 |
| PubMedSearch : Wang_2014_Eur.J.Med.Chem_80_543 |
| PubMedID: 24813882 |
| Title : Multipotent cholinesterase\/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids - Bautista-Aguilera_2014_Drug.Des.Devel.Ther_8_1893 |
| Author(s) : Bautista-Aguilera OM , Esteban G , Chioua M , Nikolic K , Agbaba D , Moraleda I , Iriepa I , Soriano E , Samadi A , Unzeta M , Marco-Contelles J |
| Ref : Drug Des Devel Ther , 8 :1893 , 2014 |
| Abstract : Bautista-Aguilera_2014_Drug.Des.Devel.Ther_8_1893 |
| ESTHER : Bautista-Aguilera_2014_Drug.Des.Devel.Ther_8_1893 |
| PubMedSearch : Bautista-Aguilera_2014_Drug.Des.Devel.Ther_8_1893 |
| PubMedID: 25378907 |
| Title : Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase\/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease - Bautista-Aguilera_2014_Eur.J.Med.Chem_75C_82 |
| Author(s) : Bautista-Aguilera OM , Esteban G , Bolea I , Nikolic K , Agbaba D , Moraleda I , Iriepa I , Samadi A , Soriano E , Unzeta M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 75C :82 , 2014 |
| Abstract : Bautista-Aguilera_2014_Eur.J.Med.Chem_75C_82 |
| ESTHER : Bautista-Aguilera_2014_Eur.J.Med.Chem_75C_82 |
| PubMedSearch : Bautista-Aguilera_2014_Eur.J.Med.Chem_75C_82 |
| PubMedID: 24530494 |
| Title : Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase\/butyrylcholinesterase inhibitors: effect against amyloid-beta-induced neurotoxicity - Silva_2013_ACS.Chem.Neurosci_4_547 |
| Author(s) : Silva D , Chioua M , Samadi A , Agostinho P , Garcao P , Lajarin-Cuesta R , de los Rios C , Iriepa I , Moraleda I , Gonzalez-Lafuente L , Mendes E , Perez C , Rodriguez-Franco MI , Marco-Contelles J , Carmo Carreiras M |
| Ref : ACS Chem Neurosci , 4 :547 , 2013 |
| Abstract : Silva_2013_ACS.Chem.Neurosci_4_547 |
| ESTHER : Silva_2013_ACS.Chem.Neurosci_4_547 |
| PubMedSearch : Silva_2013_ACS.Chem.Neurosci_4_547 |
| PubMedID: 23379636 |
| Title : Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease - Samadi_2013_Eur.J.Med.Chem_67_64 |
| Author(s) : Samadi A , de la Fuente Revenga M , Perez C , Iriepa I , Moraleda I , Rodriguez-Franco MI , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 67 :64 , 2013 |
| Abstract : Samadi_2013_Eur.J.Med.Chem_67_64 |
| ESTHER : Samadi_2013_Eur.J.Med.Chem_67_64 |
| PubMedSearch : Samadi_2013_Eur.J.Med.Chem_67_64 |
| PubMedID: 23838422 |
| Title : Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling - Samadi_2012_Eur.J.Med.Chem_57C_296 |
| Author(s) : Samadi A , Estrada M , Perez C , Rodriguez-Franco MI , Iriepa I , Moraleda I , Chioua M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 57C :296 , 2012 |
| Abstract : Samadi_2012_Eur.J.Med.Chem_57C_296 |
| ESTHER : Samadi_2012_Eur.J.Med.Chem_57C_296 |
| PubMedSearch : Samadi_2012_Eur.J.Med.Chem_57C_296 |
| PubMedID: 23078965 |
| Title : Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine - Samadi_2012_Eur.J.Med.Chem_52_251 |
| Author(s) : Samadi A , de los Rios C , Bolea I , Chioua M , Iriepa I , Moraleda I , Bartolini M , Andrisano V , Galvez E , Valderas C , Unzeta M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 52 :251 , 2012 |
| Abstract : Samadi_2012_Eur.J.Med.Chem_52_251 |
| ESTHER : Samadi_2012_Eur.J.Med.Chem_52_251 |
| PubMedSearch : Samadi_2012_Eur.J.Med.Chem_52_251 |
| PubMedID: 22503231 |
| Title : Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues - Martins_2011_Eur.J.Med.Chem_46_6119 |
| Author(s) : Martins C , Carreiras MC , Leon R , de los Rios C , Bartolini M , Andrisano V , Iriepa I , Moraleda I , Galvez E , Garcia M , Egea J , Samadi A , Chioua M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 46 :6119 , 2011 |
| Abstract : Martins_2011_Eur.J.Med.Chem_46_6119 |
| ESTHER : Martins_2011_Eur.J.Med.Chem_46_6119 |
| PubMedSearch : Martins_2011_Eur.J.Med.Chem_46_6119 |
| PubMedID: 22000936 |
| Title : Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease - Samadi_2011_Eur.J.Med.Chem_46_4665 |
| Author(s) : Samadi A , Chioua M , Bolea I , de los Rios C , Iriepa I , Moraleda I , Bastida A , Esteban G , Unzeta M , Galvez E , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 46 :4665 , 2011 |
| Abstract : Samadi_2011_Eur.J.Med.Chem_46_4665 |
| ESTHER : Samadi_2011_Eur.J.Med.Chem_46_4665 |
| PubMedSearch : Samadi_2011_Eur.J.Med.Chem_46_4665 |
| PubMedID: 21669479 |
| Title : Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives - de Los Rios_2010_J.Med.Chem_53_5129 |
| Author(s) : de los Rios C , Egea J , Marco-Contelles J , Leon R , Samadi A , Iriepa I , Moraleda I , Galvez E , Garcia AG , Lopez MG , Villarroya M , Romero A |
| Ref : Journal of Medicinal Chemistry , 53 :5129 , 2010 |
| Abstract : de Los Rios_2010_J.Med.Chem_53_5129 |
| ESTHER : de Los Rios_2010_J.Med.Chem_53_5129 |
| PubMedSearch : de Los Rios_2010_J.Med.Chem_53_5129 |
| PubMedID: 20575555 |