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| Title : Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties - Basagni_2023_Eur.J.Med.Chem_261_115803 |
| Author(s) : Basagni F , Ortega JA , Bertozzi SM , Armirotti A , Summa M , Bertorelli R , Bartolini M , Mellor IR , Bedeschi M , Bottegoni G , Lembo V , Minarini A , Cavalli A , Rosini M |
| Ref : Eur Journal of Medicinal Chemistry , 261 :115803 , 2023 |
| Abstract : Basagni_2023_Eur.J.Med.Chem_261_115803 |
| ESTHER : Basagni_2023_Eur.J.Med.Chem_261_115803 |
| PubMedSearch : Basagni_2023_Eur.J.Med.Chem_261_115803 |
| PubMedID: 37734258 |
| Title : Merging memantine and ferulic acid to probe connections between NMDA receptors, oxidative stress and amyloid-beta peptide in Alzheimer's disease - Rosini_2019_Eur.J.Med.Chem_180_111 |
| Author(s) : Rosini M , Simoni E , Caporaso R , Basagni F , Catanzaro M , Abu IF , Fagiani F , Fusco F , Masuzzo S , Albani D , Lanni C , Mellor IR , Minarini A |
| Ref : Eur Journal of Medicinal Chemistry , 180 :111 , 2019 |
| Abstract : Rosini_2019_Eur.J.Med.Chem_180_111 |
| ESTHER : Rosini_2019_Eur.J.Med.Chem_180_111 |
| PubMedSearch : Rosini_2019_Eur.J.Med.Chem_180_111 |
| PubMedID: 31301562 |
| Title : Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation - Simoni_2017_Future.Med.Chem_9_953 |
| Author(s) : Simoni E , Bartolini M , Abu IF , Blockley A , Gotti C , Bottegoni G , Caporaso R , Bergamini C , Andrisano V , Cavalli A , Mellor IR , Minarini A , Rosini M |
| Ref : Future Med Chem , 9 :953 , 2017 |
| Abstract : Simoni_2017_Future.Med.Chem_9_953 |
| ESTHER : Simoni_2017_Future.Med.Chem_9_953 |
| PubMedSearch : Simoni_2017_Future.Med.Chem_9_953 |
| PubMedID: 28632446 |
| Title : The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti-Alzheimer Multitarget Profile of Dimebon - Rosini_2013_ChemMedChem_8_1276 |
| Author(s) : Rosini M , Simoni E , Bartolini M , Soriano E , Marco-Contelles J , Andrisano V , Monti B , Windisch M , Hutter-Paier B , McClymont DW , Mellor IR , Bolognesi ML |
| Ref : ChemMedChem , 8 :1276 , 2013 |
| Abstract : Rosini_2013_ChemMedChem_8_1276 |
| ESTHER : Rosini_2013_ChemMedChem_8_1276 |
| PubMedSearch : Rosini_2013_ChemMedChem_8_1276 |
| PubMedID: 23824986 |
| Title : Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush - Rosini_2008_J.Med.Chem_51_4381 |
| Author(s) : Rosini M , Simoni E , Bartolini M , Cavalli A , Ceccarini L , Pascu N , McClymont DW , Tarozzi A , Bolognesi ML , Minarini A , Tumiatti V , Andrisano V , Mellor IR , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 51 :4381 , 2008 |
| Abstract : Rosini_2008_J.Med.Chem_51_4381 |
| ESTHER : Rosini_2008_J.Med.Chem_51_4381 |
| PubMedSearch : Rosini_2008_J.Med.Chem_51_4381 |
| PubMedID: 18605718 |
| Title : Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors - Mellor_2003_Neuropharmacol_44_70 |
| Author(s) : Mellor IR , Brier TJ , Pluteanu F , Stromgaard K , Saghyan A , Eldursi N , Brierley MJ , Andersen K , Jaroszewski JW , Krogsgaard-Larsen P , Usherwood PN |
| Ref : Neuropharmacology , 44 :70 , 2003 |
| Abstract : Mellor_2003_Neuropharmacol_44_70 |
| ESTHER : Mellor_2003_Neuropharmacol_44_70 |
| PubMedSearch : Mellor_2003_Neuropharmacol_44_70 |
| PubMedID: 12559123 |
| Title : Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist - Stromgaard_2002_Bioorg.Med.Chem.Lett_12_1159 |
| Author(s) : Stromgaard K , Mellor IR , Andersen K , Neagoe I , Pluteanu F , Usherwood PN , Krogsgaard-Larsen P , Jaroszewski JW |
| Ref : Bioorganic & Medicinal Chemistry Lett , 12 :1159 , 2002 |
| Abstract : Stromgaard_2002_Bioorg.Med.Chem.Lett_12_1159 |
| ESTHER : Stromgaard_2002_Bioorg.Med.Chem.Lett_12_1159 |
| PubMedSearch : Stromgaard_2002_Bioorg.Med.Chem.Lett_12_1159 |
| PubMedID: 11934578 |
| Title : Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues - Stromgaard_2000_J.Med.Chem_43_4526 |
| Author(s) : Stromgaard K , Brier TJ , Andersen K , Mellor IR , Saghyan A , Tikhonov D , Usherwood PN , Krogsgaard-Larsen P , Jaroszewski JW |
| Ref : Journal of Medicinal Chemistry , 43 :4526 , 2000 |
| Abstract : Stromgaard_2000_J.Med.Chem_43_4526 |
| ESTHER : Stromgaard_2000_J.Med.Chem_43_4526 |
| PubMedSearch : Stromgaard_2000_J.Med.Chem_43_4526 |
| PubMedID: 11087577 |
| Title : Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor - Stromgaard_1999_J.Med.Chem_42_5224 |
| Author(s) : Stromgaard K , Brierley MJ , Andersen K , Slok FA , Mellor IR , Usherwood PN , Krogsgaard-Larsen P , Jaroszewski JW |
| Ref : Journal of Medicinal Chemistry , 42 :5224 , 1999 |
| Abstract : Stromgaard_1999_J.Med.Chem_42_5224 |
| ESTHER : Stromgaard_1999_J.Med.Chem_42_5224 |
| PubMedSearch : Stromgaard_1999_J.Med.Chem_42_5224 |
| PubMedID: 10602707 |
| Title : Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists - Rosini_1999_J.Med.Chem_42_5212 |
| Author(s) : Rosini M , Budriesi R , Bixel MG , Bolognesi ML , Chiarini A , Hucho F , Krogsgaard-Larsen P , Mellor IR , Minarini A , Tumiatti V , Usherwood PN , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 42 :5212 , 1999 |
| Abstract : Rosini_1999_J.Med.Chem_42_5212 |
| ESTHER : Rosini_1999_J.Med.Chem_42_5212 |
| PubMedSearch : Rosini_1999_J.Med.Chem_42_5212 |
| PubMedID: 10602706 |