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| Title : Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca(2)(+) channel blockers with analgesic activity - Beebe_2012_Bioorg.Med.Chem_20_4128 |
| Author(s) : Beebe X , Darczak D , Henry RF , Vortherms T , Janis R , Namovic M , Donnelly-Roberts D , Kage KL , Surowy C , Milicic I , Niforatos W , Swensen A , Marsh KC , Wetter JM , Franklin P , Baker S , Zhong C , Simler G , Gomez E , Boyce-Rustay JM , Zhu CZ , Stewart AO , Jarvis MF , Scott VE |
| Ref : Bioorganic & Medicinal Chemistry , 20 :4128 , 2012 |
| Abstract : Beebe_2012_Bioorg.Med.Chem_20_4128 |
| ESTHER : Beebe_2012_Bioorg.Med.Chem_20_4128 |
| PubMedSearch : Beebe_2012_Bioorg.Med.Chem_20_4128 |
| PubMedID: 22626552 |
| Title : Structure-activity studies of diazabicyclo[3.3.0]octane-substituted pyrazines and pyridines as potent alpha4beta2 nicotinic acetylcholine receptor ligands - Scanio_2011_J.Med.Chem_54_7678 |
| Author(s) : Scanio MJ , Shi L , Bunnelle WH , Anderson DJ , Helfrich RJ , Malysz J , Thorin-Hagene KK , Van Handel CE , Marsh KC , Lee CH , Gopalakrishnan M |
| Ref : Journal of Medicinal Chemistry , 54 :7678 , 2011 |
| Abstract : Scanio_2011_J.Med.Chem_54_7678 |
| ESTHER : Scanio_2011_J.Med.Chem_54_7678 |
| PubMedSearch : Scanio_2011_J.Med.Chem_54_7678 |
| PubMedID: 21962147 |
| Title : Role of alpha7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-alpha (TNF-alpha) as revealed by subtype selective agonists - Li_2011_J.Neuroimmunol_239_37 |
| Author(s) : Li J , Mathieu SL , Harris R , Ji J , Anderson DJ , Malysz J , Bunnelle WH , Waring JF , Marsh KC , Murtaza A , Olson LM , Gopalakrishnan M |
| Ref : Journal of Neuroimmunology , 239 :37 , 2011 |
| Abstract : Li_2011_J.Neuroimmunol_239_37 |
| ESTHER : Li_2011_J.Neuroimmunol_239_37 |
| PubMedSearch : Li_2011_J.Neuroimmunol_239_37 |
| PubMedID: 21911260 |
| Title : Pharmacokinetic modeling and [(1)(2)(3)]5-IA-85380 single photon emission computed tomography imaging in baboons: optimization of dosing regimen for ABT-089 - Chin_2011_J.Pharmacol.Exp.Ther_336_716 |
| Author(s) : Chin CL , Carr RA , Llano DA , Barret O , Xu H , Batis J , Koren AO , Seibyl JP , Marsh KC , Tamagnan G , Decker MW , Day M , Fox GB |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 336 :716 , 2011 |
| Abstract : Chin_2011_J.Pharmacol.Exp.Ther_336_716 |
| ESTHER : Chin_2011_J.Pharmacol.Exp.Ther_336_716 |
| PubMedSearch : Chin_2011_J.Pharmacol.Exp.Ther_336_716 |
| PubMedID: 21172907 |
| Title : In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease - Bitner_2010_J.Pharmacol.Exp.Ther_334_875 |
| Author(s) : Bitner RS , Bunnelle WH , Decker MW , Drescher KU , Kohlhaas KL , Markosyan S , Marsh KC , Nikkel AL , Browman K , Radek R , Anderson DJ , Buccafusco JJ , Gopalakrishnan M |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 334 :875 , 2010 |
| Abstract : Bitner_2010_J.Pharmacol.Exp.Ther_334_875 |
| ESTHER : Bitner_2010_J.Pharmacol.Exp.Ther_334_875 |
| PubMedSearch : Bitner_2010_J.Pharmacol.Exp.Ther_334_875 |
| PubMedID: 20504913 |
| Title : Poster: Role of alpha-7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-alpha (TNF-alpha) as Revealed by subtype selective agonists - |
| Author(s) : Li J , Mathieu SL , Harris R , Ji J , Anderson DJ , Malysz J , Bunnelle WH , Waring JF , Marsh KC , Murtaza A , Olson LM , Gopalakrishnan M |
| Ref : Biochemical Pharmacology , 78 :924 , 2009 |
| PubMedID: |
| Title : Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor - Faghih_2009_J.Med.Chem_52_3377 |
| Author(s) : Faghih R , Gopalakrishnan SM , Gronlien JH , Malysz J , Briggs CA , Wetterstrand C , Ween H , Curtis MP , Sarris KA , Gfesser GA , El-Kouhen R , Robb HM , Radek RJ , Marsh KC , Bunnelle WH , Gopalakrishnan M |
| Ref : Journal of Medicinal Chemistry , 52 :3377 , 2009 |
| Abstract : Faghih_2009_J.Med.Chem_52_3377 |
| ESTHER : Faghih_2009_J.Med.Chem_52_3377 |
| PubMedSearch : Faghih_2009_J.Med.Chem_52_3377 |
| PubMedID: 19419141 |
| Title : Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties - Tietje_2008_CNS.Neurosci.Ther_14_65 |
| Author(s) : Tietje KR , Anderson DJ , Bitner RS , Blomme EA , Brackemeyer PJ , Briggs CA , Browman KE , Bury D , Curzon P , Drescher KU , Frost JM , Fryer RM , Fox GB , Gronlien JH , Hakerud M , Gubbins EJ , Halm S , Harris R , Helfrich RJ , Kohlhaas KL , Law D , Malysz J , Marsh KC , Martin RL , Meyer MD , Molesky AL , Nikkel AL , Otte S , Pan L , Puttfarcken PS , Radek RJ , Robb HM , Spies E , Thorin-Hagene K , Waring JF , Ween H , Xu H , Gopalakrishnan M , Bunnelle WH |
| Ref : CNS Neurosci Ther , 14 :65 , 2008 |
| Abstract : Tietje_2008_CNS.Neurosci.Ther_14_65 |
| ESTHER : Tietje_2008_CNS.Neurosci.Ther_14_65 |
| PubMedSearch : Tietje_2008_CNS.Neurosci.Ther_14_65 |
| PubMedID: 18482100 |
| Title : A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models - Ji_2007_Biochem.Pharmacol_74(8)_1253 |
| Author(s) : Ji J , Bunnelle WH , Anderson DJ , Faltynek C , Dyhring T , Ahring PK , Rueter LE , Curzon P , Buckley MJ , Marsh KC , Kempf-Grote A , Meyer MD |
| Ref : Biochemical Pharmacology , 74 :1253 , 2007 |
| Abstract : Ji_2007_Biochem.Pharmacol_74(8)_1253 |
| ESTHER : Ji_2007_Biochem.Pharmacol_74(8)_1253 |
| PubMedSearch : Ji_2007_Biochem.Pharmacol_74(8)_1253 |
| PubMedID: 17854775 |
| Title : 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction - Kolasa_2006_J.Med.Chem_49_5093 |
| Author(s) : Kolasa T , Matulenko MA , Hakeem AA , Patel MV , Mortell K , Bhatia P , Henry R , Nakane M , Hsieh GC , Terranova MA , Uchic ME , Miller LN , Chang R , Donnelly-Roberts D , Namovic MT , Hollingsworth PR , Martino B , El Kouhen O , Marsh KC , Wetter JM , Moreland RB , Brioni JD , Stewart AO |
| Ref : Journal of Medicinal Chemistry , 49 :5093 , 2006 |
| Abstract : Kolasa_2006_J.Med.Chem_49_5093 |
| ESTHER : Kolasa_2006_J.Med.Chem_49_5093 |
| PubMedSearch : Kolasa_2006_J.Med.Chem_49_5093 |
| PubMedID: 16913699 |
| Title : Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzam ide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction - Patel_2006_J.Med.Chem_49_7450 |
| Author(s) : Patel MV , Kolasa T , Mortell K , Matulenko MA , Hakeem AA , Rohde JJ , Nelson SL , Cowart MD , Nakane M , Miller LN , Uchic ME , Terranova MA , El-Kouhen OF , Donnelly-Roberts D , Namovic MT , Hollingsworth PR , Chang R , Martino BR , Wetter JM , Marsh KC , Martin R , Darbyshire JF , Gintant G , Hsieh GC , Moreland RB , Sullivan JP , Brioni JD , Stewart AO |
| Ref : Journal of Medicinal Chemistry , 49 :7450 , 2006 |
| Abstract : Patel_2006_J.Med.Chem_49_7450 |
| ESTHER : Patel_2006_J.Med.Chem_49_7450 |
| PubMedSearch : Patel_2006_J.Med.Chem_49_7450 |
| PubMedID: 17149874 |
| Title : Central mechanisms regulating penile erection in conscious rats: the dopaminergic systems related to the proerectile effect of apomorphine - Hsieh_2004_J.Pharmacol.Exp.Ther_308_330 |
| Author(s) : Hsieh GC , Hollingsworth PR , Martino B , Chang R , Terranova MA , O'Neill AB , Lynch JJ , Moreland RB , Donnelly-Roberts D , Kolasa T , Mikusa JP , McVey JM , Marsh KC , Sullivan JP , Brioni JD |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 308 :330 , 2004 |
| Abstract : Hsieh_2004_J.Pharmacol.Exp.Ther_308_330 |
| ESTHER : Hsieh_2004_J.Pharmacol.Exp.Ther_308_330 |
| PubMedSearch : Hsieh_2004_J.Pharmacol.Exp.Ther_308_330 |
| PubMedID: 14569075 |
| Title : Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo - Briggs_1997_Pharmacol.Biochem.Behav_57_231 |
| Author(s) : Briggs CA , Anderson DJ , Brioni JD , Buccafusco JJ , Buckley MJ , Campbell JE , Decker MW , Donnelly-Roberts D , Elliott RL , Gopalakrishnan M , Holladay MW , Hui YH , Jackson WJ , Kim DJ , Marsh KC , O'Neill A , Prendergast MA , Ryther KB , Sullivan JP , Arneric SP |
| Ref : Pharmacol Biochem Behav , 57 :231 , 1997 |
| Abstract : Briggs_1997_Pharmacol.Biochem.Behav_57_231 |
| ESTHER : Briggs_1997_Pharmacol.Biochem.Behav_57_231 |
| PubMedSearch : Briggs_1997_Pharmacol.Biochem.Behav_57_231 |
| PubMedID: 9164577 |
| Title : Development of a sensitive method for quantitation of ABT-089 in plasma using fluorescence labeling with 7-fluoro-4-nitrobenzo-2-oxa-1,3-diazole - Hui_1997_J.Chromatogr.B.Biomed.Sci.Appl_695_337 |
| Author(s) : Hui YH , Carroll S , Marsh KC |
| Ref : Journal of Chromatography B Biomed Sci Appl , 695 :337 , 1997 |
| Abstract : Hui_1997_J.Chromatogr.B.Biomed.Sci.Appl_695_337 |
| ESTHER : Hui_1997_J.Chromatogr.B.Biomed.Sci.Appl_695_337 |
| PubMedSearch : Hui_1997_J.Chromatogr.B.Biomed.Sci.Appl_695_337 |
| PubMedID: 9300870 |
| Title : Potential treatment of Alzheimer disease using cholinergic channel activators (ChCAs) with cognitive enhancement, anxiolytic-like, and cytoprotective properties - Arneric_1995_Alzheimer.Dis.Assoc.Disord_9 Suppl 2_50 |
| Author(s) : Arneric SP , Sullivan JP , Decker MW , Brioni JD , Bannon AW , Briggs CA , Donnelly-Roberts D , Radek RJ , Marsh KC , Kyncl J , Williams M , Buccafusco JJ |
| Ref : Alzheimer Disease & Associated Disorders , 9 Suppl 2 :50 , 1995 |
| Abstract : Arneric_1995_Alzheimer.Dis.Assoc.Disord_9 Suppl 2_50 |
| ESTHER : Arneric_1995_Alzheimer.Dis.Assoc.Disord_9 Suppl 2_50 |
| PubMedSearch : Arneric_1995_Alzheimer.Dis.Assoc.Disord_9 Suppl 2_50 |
| PubMedID: 8534424 |