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Author Report for: Mannisto PT

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    Title: Mechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases: Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins?
    Mannisto PT, Garcia-Horsman JA
    Ref: Front Aging Neurosci, 9:27, 2017 : PubMed


    Title: The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse
    Savolainen MH, Richie CT, Harvey BK, Mannisto PT, Maguire-Zeiss KA, Myohanen TT
    Ref: Neurobiol Dis, 68:1, 2014 : PubMed


    Title: Alteration of prolyl oligopeptidase and activated alpha-2-macroglobulin in multiple sclerosis subtypes and in the clinically isolated syndrome
    Tenorio-Laranga J, Peltonen I, Keskitalo S, Duran-Torres G, Natarajan R, Mannisto PT, Nurmi A, Vartiainen N, Airas L and Garcia-Horsman JA <1 more author(s)>
    Ref: Biochemical Pharmacology, 85:1783, 2013 : PubMed


    Title: Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase.
    Kaszuba K, Rog T, Danne R, Canning P, Fulop V, Juhasz T, Szeltner Z, St Pierre JF, Garcia-Horsman A and Bunker A <3 more author(s)>
    Ref: Biochimie, 94:1398, 2012 : PubMed


    Title: A prolyl oligopeptidase inhibitor, KYP-2047, reduces alpha-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease
    Myohanen TT, Hannula MJ, Van Elzen R, Gerard M, Van der Veken P, Garcia-Horsman JA, Baekelandt V, Mannisto PT, Lambeir AM
    Ref: British Journal of Pharmacology, 166:1097, 2012 : PubMed


    Title: Distribution of prolyl oligopeptidase in human peripheral tissues and in ovarian and colorectal tumors
    Myohanen TT, Pyykko E, Mannisto PT, Carpen O
    Ref: Journal of Histochemistry & Cytochemistry, 60:706, 2012 : PubMed


    Title: Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner
    Myohanen TT, Tenorio-Laranga J, Jokinen B, Vazquez-Sanchez R, Moreno-Baylach MJ, Garcia-Horsman JA, Mannisto PT
    Ref: British Journal of Pharmacology, 163:1666, 2011 : PubMed


    Title: Effects of diverse psychopharmacological substances on the activity of brain prolyl oligopeptidase
    Peltonen I, Mannisto PT
    Ref: Basic Clin Pharmacol Toxicol, 108:46, 2011 : PubMed


    Title: Association of prolyl oligopeptidase with conventional neurotransmitters in the brain
    Peltonen I, Myohanen TT, Mannisto PT
    Ref: CNS Neurol Disord Drug Targets, 10:311, 2011 : PubMed


    Title: Hunting for peptide substrates of prolyl oligopeptidase: classical versus non-classical bioactive peptides
    Tenorio-Laranga J, Mannisto PT, Garcia-Horsman JA
    Ref: CNS Neurol Disord Drug Targets, 10:319, 2011 : PubMed


    Title: Characterization of membrane-bound prolyl endopeptidase from brain
    Tenorio-Laranga J, Venalainen JI, Mannisto PT, Garcia-Horsman JA
    Ref: Febs J, 275:4415, 2008 : PubMed


    Title: On the role of prolyl oligopeptidase in health and disease
    Garcia-Horsman JA, Mannisto PT, Venalainen JI
    Ref: Neuropeptides, 41:1, 2007 : PubMed


    Title: Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease
    Garcia-Horsman JA, Venalainen JI, Lohi O, Auriola IS, Korponay-Szabo IR, Kaukinen K, Maki M, Mannisto PT
    Ref: Scand J Gastroenterol, 42:562, 2007 : PubMed


    Title: Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions
    Jarho EM, Wallen EA, Christiaans JA, Forsberg MM, Venalainen JI, Mannisto PT, Gynther J, Poso A
    Ref: Journal of Medicinal Chemistry, 48:4772, 2005 : PubMed


    Title: Evolutionary relationships of the prolyl oligopeptidase family enzymes
    Venalainen JI, Juvonen RO, Mannisto PT
    Ref: European Journal of Biochemistry, 271:2705, 2004 : PubMed


    Title: Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819
    Venalainen JI, Juvonen RO, Forsberg MM, Garcia-Horsman A, Poso A, Wallen EA, Gynther J, Mannisto PT
    Ref: Biochemical Pharmacology, 64:463, 2002 : PubMed


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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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